ライフサイエンスコーパス: resection

1 ormed preoperatively and during the surgical resection.

2 ed from the index admission to 90 days after resection.

3 scopic biopsy or previous surgical biopsy or resection.

4 oes not confer an advantage in rectal cancer resection.

5 = 0.14) or overall survival (P = 0.11) after resection.

6 he single-stranded gap and terminate further resection.

7 systemic therapy and ineligible for surgical resection.

8 cancer surgery with the aim to achieve a R0 resection.

9 volume and inpatient mortality after hepatic resection.

10 e chemotherapy first and proceed to surgical resection.

11 Tumor resection.

12 ed with high NLR (>5) 3 months after hepatic resection.

13 l, independent of sepsis, after colon cancer resection.

14 , 3.6; 95% CI: 1.0, 12.8) were predictive of resection.

15 .001) were observed after laparoscopic liver resection.

16 been caused by residual lymphatic flow after resection.

17 to 9.0 mm is not an indication for immediate resection.

18 preoperative clinic and throughout surgical resection.

19 t the absence of GreA limits RecBCD-mediated resection.

20 which brain regions should be considered for resection.

21 ate surgical performance in major esophageal resection.

22 lves trans-arterial embolization or surgical resection.

23 90-day mortality rates compared with sigmoid resection.

24 evicted from ssDNA after in vitro chromatin resection.

25 s clinical liver dysfunction following liver resection.

26 aining the exonuclease on DNA for long-range resection.

27 tors for 30-day readmission after pancreatic resection.

28 nt repair, and need for intraoperative bowel resection.

29 but is thought to be dispensable for DNA end resection.

30 /T3 gallbladder adenocarcinoma who underwent resection.

31 were 659 patients (1.9%) underwent surgical resection.

32 e performed during open standard oncological resection.

33 DNA, a process commonly referred to as fork resection.

34 rotomy, suture repair of intestine, or bowel resection.

35 recludes the possibility of safe and radical resection.

36 ents with primarily resectable PDAC after R0 resection.

37 tions of human pancreas obtained from cancer resections.

38 re less likely to receive minimally invasive resections.

39 ovement in EFS with more extensive or serial resections.

40 9%) R1 (</=1 mm) and 326 (58.1%) R1 (direct) resections.

41 NHEJ-mediated repair deficiencies and hyper-resection 0.15 kb from the DSB that was dependent on the

42 r AS (58% vs 22%, P < 0.01), margin-negative resection (100% vs 73%, P < 0.01), reconstructive surger

43 o -0.5%; P = .03) and higher cost of hepatic resection (13.4%; 95% CI, 8.2% to 18.8%; P < .001).

44 ears]) and 52284 patients undergoing hepatic resection (46.8% men and 53.2% women; median age, 59 yea

45 %; P= 0.95) and lower rates of cross-over to resection (5% vs 11%; P< 0.0001) and development of carc

46 was associated with lower cost of pancreatic resection (-5.4%; 95% CI, -10.0% to -0.5%; P = .03) and

47 tals of 38711 patients undergoing pancreatic resection (50.8% men and 49.2% women; median age, 65 yea

48 Comparable rates of R0 resection (88% vs 88%, P = 0.999), median recurrence-fre

49 Percentages of R0 resections (93%) did not differ between groups.

50 umor suppressor CtIP is critical for DSB end resection, a key initial event of HR repair, the mechani

51 616 patients with a microscopically complete resection (according to local pathologists), included in

52 The 3' ssDNA protrusion formed through resection activates the ATR-dependent DNA damage respons

53 Here we report that APE2 resection activity is regulated by DNA interactions in i

54 t therapy appears to be superior to extended resection alone in the short term and may serve as a pot

55 l recurrence compared with that for surgical resection alone.

56 becomes important in cases where pancreatic resection/anastomosis is planned, because of varying duc

57 checkpoint immunotherapies, and early tumor resection and (neo)adjuvant chemotherapy fails to improv

58 P = .04) for patients undergoing colorectal resection and 0.67 (95% CI, 0.45-0.99, P = .05) for pati

59 ion margin status for survival outcome after resection and adjuvant therapy for pancreatic cancer.

60 OS in patients with CRC undergoing curative resection and appears to be superior to pre-existing bio

61 onclusion Patients with NSCLC who undergo R0 resection and are found to have pN2 disease have improve

62 analysis, and had undergone maximal surgical resection and completion of standard chemoradiation with

63 w cells deal with a range of barriers to end resection and highlight the crucial role of Sae2 in acti

64 ic replication stress by stimulating DNA end resection and homologous recombination (HR).

65 the structure that Exo1 requires for 5' end resection and HR initiation.

66 e decreased nodal involvement at the time of resection and increased survival compared with typical p

67 ons: patients undergoing elective colorectal resection and patients undergoing emergency hip fracture

68 herapy; cohort one included patients with R0 resection and pN2 disease, whereas cohort two included p

69 underwent a hepato-pancreatic or colorectal resection and received >/=1 unit of PRBCs between 2009 a

70 ticulitis has conventionally been managed by resection and stoma formation.

71 interval between non-small-cell lung cancer resection and the initiation of postoperative chemothera

72 ceived neoadjuvant therapy (NAT) followed by resection and those who received upfront resection (UR)-

73 colorectal cancer (CRC) undergoing curative resection and to compare it to established biomarkers in

74 rect cost of the hospitalization for primary resection and total direct cost (including readmission/i

75 ecombination, but its relationship to 5' end resection and/or 3' end extension is poorly understood.

76 165 patients (42.4%) underwent nonanatomical resections and 140 (36.0%) presented with KRAS-mutated C

77 s, data on tumor stage, location (at time of resection), and survival status were collected for all i

78 Mre11 exonuclease, EXD2, and Exo1 execute resection, and Artemis endonuclease functions to complet

79 and Rad51 focus formation, decreased DNA end resection, and decreased HR repair in the DR-GFP DSB rep

80 stigate how the invasion front is delayed by resection, and how this depends on the density and behav

81 age, Karnofsky Performance Status, extent of resection, and neurological function) were incorporated

82 se pathways is largely based on 5' to 3' DNA resection, and NHEJ proceeds only if resection has not b

83 debulking, wide local excision, whole-organ resection, and peritoneal metastases.

84 Patients underwent surgical resection, and tumor samples underwent immunohistochemis

85 atients who underwent a margin-negative (R0) resection, and who had previously undergone pathologic r

86 Although biopsies and tumor resection are prognostically beneficial for glioblastoma

87 onstrated robust potential to guide surgical resections, as all peak tumor-to-background ratios were

88 lant homeodomain finger 11 (PHF11) in 5' end resection at DNA double-strand breaks (DSBs).

89 tion and genome-wide DNA damage, reduced end resection at sites of DNA damage, resulted in compromise

90 all patients with colon cancer who underwent resection between January 1, 2002, and December 31, 2008

91 Patients undergoing elective colon resection between January 1, 2012, and December 31, 2013

92 ession of pro-inflammatory mediators in peri-resection brain tissue was reduced with VPC.

93 mammals regenerate their hearts after apical resection by cardiomyocyte proliferation.

94 Dpb11 mediates opposing roles in DNA end resection by coordinating both the stabilization and exc

95 n requires Chk1 activation following DNA end-resection by Exonuclease 1.

96 survival often prolonged if margin-negative resection can be accomplished during cancer surgery.

97 endpoint was time to local recurrence in the resection cavity, assessed by blinded central review of

98 TCA was induced by laparoscopic liver lobe resection combined with arterial catheter blood withdraw

99 For pancreatic resections, costs were 5.5% higher (95% CI, 0.1% to 11.1

100 Thus, the use of SRS after brain metastasis resection could be an alternative to whole-brain radioth

101 Resection-dependent c-NHEJ significantly contributes to

102 n executed, Artemis is essential to complete resection-dependent c-NHEJ.

103 act metastases undergoing complete, curative resection derived the greatest benefit, with a median OS

104 If resection does not commence, then repair can ensue by c-

105 er after duodenum-preserving pancreatic head resection (DPPHR) than after partial pancreatoduodenecto

106 heir successful intraoperative detection and resection during first-in-human RGS.

107 cosal dissection than for endoscopic mucosal resection (EMR).

108 To address this lack, we mapped resection endpoints genome-wide at high resolution in Sa

109 Among patients undergoing colorectal resection, ERAS implementation was associated with decre

110 ed repair; however, the precise mechanism of resection, especially the initiation step, remains incom

111 Concordance between surgeons' assessments of resection extent and central image-guided review was low

112 central imaging review-based assessments of resection extent.

113 To estimate the cost-effectiveness of liver resection followed by adjuvant systemic therapy relative

114 included 103 patients who underwent surgical resection for a preoperative diagnosis of MD or mixed IP

115 mechanism that limits the extent of DNA end resection for accurate DNA repair.

116 Among the 103 patients undergoing resection for an MD or mixed IPMN (59 men [57.3%]; 44 wo

117 The optimal time interval for re-resection for both patient selection and long-term survi

118 dure (closure after > 12 weeks) after rectal resection for cancer.

119 nts undergoing preoperative chemotherapy and resection for colorectal liver metastases (CLM).

120 ical outcomes of laparoscopic and open liver resection for colorectal liver metastases in the elderly

121 s cell carcinoma undergoing upfront surgical resection for curative intent were identified in the Nat

122 The optimal time interval for re-resection for incidentally discovered gallbladder cancer

123 were queried for patients who had undergone resection for pancreatic adenocarcinoma.

124 of IPMN; and (2) 10 patients who underwent a resection for PDAC and had a concomitant IPMN.

125 ected anastomotic leakage after low anterior resection for rectal cancer, and the proportion of leaka

126 The current recommendation is to perform re-resection for select patients with incidentally discover

127 All elective resections for a T1-3N0-2M0 stage colorectal cancer were

128 MIS (laparoscopic or robotic) or open rectal resections for stage I to III rectal adenocarcinoma were

129 ecimens from patients who underwent surgical resection from 2002 through 2008.

130 ples from 59 patients who underwent surgical resection from November 2013 through May 2017, along wit

131 were queried for stage I to III colon cancer resections from 2004 to 2011.

132 the regulation of a key single-strand break resection function of APE2, and also reveal topologic si

133 in the lavage group and 13/148 (8.8%) in the resection group (relative risk 3.01, 95% confidence inte

134 of sick leave were 3.4 days (SD 7.1) in the resection group versus 1.4 days (4.7) in the infliximab

135 Dindo scale occurred in four patients in the resection group.

136 Laparoscopic resection has developed as a commonly accepted surgical

137 3' DNA resection, and NHEJ proceeds only if resection has not been initiated.

138 Although nonanatomical liver resections have been demonstrated as a viable approach f

139 et analysis of patients with margin-negative resection (HR, 0.97; 95% CI, 0.66-1.45; P = .88).

140 e was no association between type of gastric resection (ie, anatomic v partial/wedge) and EFS ( P = .

141 compare the incidence of bowel repair and/or resection in a large cohort of patients with adhesive sm

142 Thus, resection in G1 differs from the process in G2 that lead

143 ter saline load before and after pericardial resection in normal canines with open (n=3) and closed c

144 hallenged the survival benefit of additional resection in patients with pancreatic cancer in case of

145 outcomes of laparoscopic lavage and sigmoid resection in perforated diverticulitis with purulent per

146 d may serve as a potential alternative to re-resection in select high-risk individuals.

147 project, data from registered rectal cancer resections in the Dutch Surgical Colorectal Audit in 201

148 0.0%) had R0 and 449 patients (80.0%) had R1 resections, including 123 (21.9%) R1 (</=1 mm) and 326 (

149 In patients undergoing hepatic resection, increased annual volume did not confer a mort

150 ates its helicase activity, promotes DNA end resection, increases HR and cell survival after ionizing

151 pass the cell cycle regulation of long-range resection, indicating that chromatin remodelling during

152 ated by raised survival in a lethal model of resection-induced liver failure.

153 MRN also facilitates resection initiation by promoting the recruitment of Dna

154 RN together with CtIP mediate an alternative resection initiation pathway where the nuclease activity

155 A promotes both Dna2- and CtIP-MRN-dependent resection initiation, but a RPA mutant can distinguish b

156 Tel1 also promotes efficient and timely resection initiation.

157 Activation of DNA end resection involves phosphorylation of the 5' to 3' exonu

158 For patients with liver cancer, surgical resection is a principal treatment modality that offers

159 Readmission after pancreatic resection is common and can largely be attributed to inf

160 ality anatomic surgery to minimize RLI after resection is essential.

161 Endoscopic ablation and resection is highly effective for treating dysplastic BE

162 denocarcinoma (PDAC) after complete surgical resection is often followed by distant metastatic relaps

163 However, surgical resection is recommended for patients with an MPD diamet

164 onserving surgeries, efficient tumour margin resection is required for minimizing tumour recurrence.

165 unctional SWI/SNF, the initiation of DNA end resection is significantly delayed.

166 Currently, surgical resection is the most effective way to manage symptomati

167 indicating that chromatin remodelling during resection is underlying DSB repair pathway choice.

168 t lid height: treatment using levator muscle resection (LMR) (adjusted odds ratio [OR], 1.76; P = .04

169 -Sae2 creates entry sites for the long-range resection machinery.

170 nvestigate the impact of the circumferential resection margin (CRM) in esophageal cancer on survival

171 Data were stratified by resection margin (group I: FS-R0 --> PS-R0; group II: FS

172 s the infiltration of the proximal or distal resection margin is associated with poor survival and hi

173 s looking at the role of the circumferential resection margin on survival and local recurrence after

174 postoperative complications, circumferential resection margin positivity (CRM+) and other pathologica

175 nd a regression analysis to analyze positive resection margin rates reported in the literature.

176 A significant decrease in positive resection margin rates was identified over time for abdo

177 of the study was to assess the relevance of resection margin status for survival after resection of

178 To assess the relevance of resection margin status for survival outcome after resec

179 alysis was performed to assess the impact of resection margin status on survival, and a regression an

180 In the context of adjuvant therapy, the resection margin status remains an important independent

181 tion, presence of residual disease, T stage, resection margin status, lymph node involvement, and pos

182 eas: (1) residual microscopic disease at the resection margin, (2) intraparenchymal spread of neoplas

183 o significant effect of negative microscopic resection margins (AHR, 0.9; 95% CI, 0.4 to 2.2; P = 0.8

184 Information about positive resection margins and subsequent treatment failure was p

185 ting the surgeon's ability to best determine resection margins during prostatectomy.

186 Here, resection margins were positive in 23 cases (11.8%) in t

187 =18.0% for readmission, </=3.1% for positive resection margins, and >/=23 for lymph node yield.

188 BM result in residual tumor at neurosurgical resection margins, representing the source of relapse in

189 Lung resection material from a separate group of subjects wit

190 e recommended treatment, although a sublobar resection may be considered in select clinical scenarios

191 k highlights that Nej1 inhibits 5' DNA hyper-resection mediated by Dna2-Sgs1, a function distinct fro

192 recombination (HR), which begins with 5' end resection, mediated by exonuclease complexes, one of whi

193 ure and clinical trials identified 3 primary resection methods for utilizing FGS: (1) debulking, (2)

194 vivo, using a clinically relevant orthotopic resection model of primary glioblastoma and engineered s

195 g, and tumor delineation to guide biopsy and resection; monitoring treatment response; and targeting

196 nd N1, higher grade, perineural invasion, R1 resections, more positive lymph nodes, and higher lymph

197 primary tumour types obtained from surgical resections, much less comprehensive molecular analysis i

198 intact abdominal wall undergoing colorectal resection (n = 18).

199 neurysm (AAA) repair (n = 71,422), pulmonary resection (n = 93,056), or colectomy (n = 277,619) from

200 nts can be suppressed by inactivation of the resection nuclease Exo1.

201 In 1 of the 2 patients, subsequent resection of a brain metastasis proved HER2-positive dis

202 After resection of a brain metastasis, SRS radiosurgery should

203 gous recombination (HR) posit that extensive resection of a DNA double-strand break (DSB) by a multis

204 a simultaneous sternotomy was performed for resection of bilateral lung metastases.

205 al therapy (TMT) that combines transurethral resection of bladder tumor, chemotherapy for radiation s

206 Our results strongly suggest that resection of blocked and clean DSBs is initiated via dis

207 re to improve intracranial control following resection of brain metastasis.

208 hat the Dna2 nuclease directly initiates the resection of clean DSBs by cleaving the 5' strand DNA ap

209 Methods Patients who underwent a complete resection of CLM between 1992 and 2012 were included fro

210 entified 202 patients who underwent curative resection of CLMs between January 1, 2008, and December

211 survival (OS) in patients who had a complete resection of colorectal liver metastases (CLM).

212 evance of remnant liver ischemia (RLI) after resection of colorectal liver metastases (CLMs) is unkno

213 of the study was to evaluate outcomes after resection of colorectal liver metastases (CRLM) and conc

214 Nucleolytic resection of DNA double-strand breaks (DSBs) is essentia

215 ess, BRCA1-BARD1 facilitates the nucleolytic resection of DNA ends to generate a single-stranded temp

216 Resection of double-strand breaks (DSBs) plays a critica

217 nd thus is required for efficient long-range resection of DSBs.

218 LPPS is a novel 2-stage hepatectomy enabling resection of extensive hepatic tumors.

219 Purpose After curative resection of gastric or gastroesophageal junction adenoc

220 t between normal and malignant tissue during resection of high grade gliomas.

221 Five patients awaiting surgical resection of histologically proven or radiologically sus

222 rogression in the remnant pancreas following resection of IPMN; and (2) 10 patients who underwent a r

223 using (18)F-FDG followed by Cerenkov-guided resection of lymph nodes in healthy mice has previously

224 e survival benefit achieved through surgical resection of melanoma metastatic to the abdominal viscer

225 ies reduce the risk of disease relapse after resection of murine PDAC, suggesting this concept for fu

226 mide is the standard of care after biopsy or resection of newly diagnosed glioblastoma in patients up

227 f resection margin status for survival after resection of pancreatic-head ductal adenocarcinoma.

228 ing the added value of this technique in the resection of small tumors.

229 ), after a staging lymphadenectomy including resection of SNs related to the ovary, SPECT/CT was perf

230 2012, who underwent hepatectomy for CRLM and resection of synchronous EHD.

231 Adjuvant therapy prolongs survival after resection of T2/T3 tumors.

232 Resection of the bulk of a tumour often cannot eliminate

233 So far, resection of the epileptogenic focus represents the only

234 resection of the primary tumor, and surgical resection of the metastases offers the only opportunity

235 We hypothesized that resection of the pericardium using a minimally invasive

236 rectal cancer develop liver metastases after resection of the primary tumor, and surgical resection o

237 Patients underwent surgical resection of the target lesions, and tissues were staine

238 ing system and is the rationale for surgical resection of tumor-draining lymph nodes.

239 Endoscopic mucosal resection of two polyps from the cardia and duodenal bul

240 tered patients, 998 underwent a low anterior resection, of whom 88.8% received any form of neoadjuvan

241 luated the impact of extent of primary tumor resection on local progression and survival and assessed

242 upper rectum) or low (total rectum) anterior resection or abdominoperineal resection (rectum and peri

243 h liver metastases not suitable for curative resection or ablation were randomly assigned (1:1) to ei

244 iver is essential for recovery from surgical resection or injuries induced by trauma or toxins.

245 t to preserve the larynx by using endoscopic resection or radiation therapy, with either leading to s

246 using the terms "laparoscopy" AND ("primary resection" OR "Hartmann procedure", OR "sigmoidectomy"),

247 entially curative therapies (local ablation, resection, or transplantation).

248 Loss of either the Exo1 or Sgs1 long-range resection pathway significantly shortened hetDNA, sugges

249 ve cohort study in adult elective colorectal resection patients after conventional (n = 46) and ERAS

250 65 (1.529-2.276) in centers performing </=25 resections per year and 1.234 (1.031-1.478) in those per

251 high-volume (HV) cancer surgeon status (>/=5 resections per year) upon 30-day and 90-day mortality fr

252 year): compared with centers performing >65 resections per year, the adjusted OR of mortality was 1.

253 4 (1.031-1.478) in those performing 26 to 65 resections per year.

254 ntional (n = 234) laparoscopic rectal cancer resection, performed by either high (upper rectum) or lo

255 similar for baseline demographics, extent of resection, presence of residual disease, T stage, resect

256 additional lesions at the DSB site, undergo resection prior to repair by c-NHEJ and not alt-NHEJ.

257 NA in lung tissue from patients who had lung resection procedures (n=1111).

258 The surgical resection procedures such as the radical pancreaticoduod

259 5'-3' helicase activity, is involved in the resection process.

260 R1 resection rate was 2.7%.

261 R0-resection rates decreased from 75% to 35% when changing

262 total number of resected lymph nodes, and R0 resection rates.

263 Our data show that apical resection rather transiently accelerates centrosome disa

264 ctum) anterior resection or abdominoperineal resection (rectum and perineum).

265 whether the procedure is equivalent to open resection regarding oncologic outcomes.

266 ereas cohort two included patients with R1-2 resection regardless of nodal status.

267 s implications for repair pathway choice and resection regulation upon DSB formation.

268 tion in Saccharomyces cerevisiae Full-length resection requires Exo1 exonuclease and the DSB-responsi

269 Eye regeneration following eye-specific resection resulted from homeostatic rates of eye progeni

270 at intraoperative frozen section (FS) and re-resection results to achieve R0 status are associated wi

271 rectal adenocarcinoma suitable for curative resection, robotic-assisted laparoscopic surgery, as com

272 to treatment, increased length of intestinal resection, shorter time to repeat surgery, and high Rutg

273 FS analysis with intraoperative re-resection should be performed routinely in patients unde

274 retreatment pathological tumor extent in the resection specimen after neoadjuvant chemoradiotherapy (

275 onal changes and residual tumor cells in the resection specimen.

276 based on tumor regression grade (TRG) in the resection specimen.

277 In histologic analyses of gastric resection specimens from 10 patients with adenocarcinoma

278 Complete resection (stages I and II) was achieved in 32 patients,

279 inct and could be used for guided lymph node resection, such as by using Cerenkov luminescence imagin

280 lant recipients at the time of any operative resection, such as stoma closure or revision.

281 EXO1 must also be restrained to prevent over-resection that is known to hamper optimal HR and trigger

282 e of stalled replication forks to permit end resection, the identity of such an endonuclease remains

283 ith similar oncologic outcomes to anatomical resections, this may not be the case for the subset of K

284 concept study demonstrates that pericardial resection through a minimally invasive percutaneous appr

285 evaluated by comparing three different tail-resection treatments (intact, 'short tail', 'long tail')

286 by resection and those who received upfront resection (UR)-as well as a subgroup of UR patients who

287 Results Surgeon-assessed extent of resection was >/= 90% in 154 (70%) patients and < 90% in

288 Lymph node recurrence following CRLM resection was associated with high expression of VEGFC a

289 On multivariable analysis, >/= 90% resection was associated with longer EFS after adjustmen

290 Seizure outcome following resection was correctly predicted by EEG-fMRI GM in 8 of

291 In 2 children, the hepatic resection was performed under cardiopulmonary bypass bec

292 Survival after resection was stratified by RLI grade.

293 Younger age (</=60 years) and gross total resection were associated with increased survival.

294 uvant chemoradiotherapy followed by surgical resection were included.

295 ho underwent NAT followed by curative-intent resection were matched by propensity score with patients

296 -specific survival (CSS) rates after hepatic resection were worse in patients with RLI grade 2 or hig

297 dels (unilateral femoral artery ligation and resection) were conducted to examine the role of miR93-i

298 degradation-resistant EXO1 resulted in hyper-resection, which attenuated both NHEJ and HR and severel

299 ns to favor NHEJ over HDR by suppressing end resection, which is the rate-limiting step in the initia

300 r many tumors, primary treatment is surgical resection with negative margins, which corresponds to im