ライフサイエンスコーパス: residence time

1 namically than cohesin ( 1-2 min vs. 22 min residence time).

2 putational tools for predicting kinetics and residence time.

3 or genome editing via radical alterations in residence time.

4 h as evaporation, precipitation, mixing, and residence time.

5 y proteinaceous material with a 100-200-year residence time.

6 were negative exponentially correlated with residence time.

7 t role that on-rates can play in drug-target residence time.

8 of mRNAs near the membrane, as well as their residence time.

9 undesirable biodistribution and short blood residence time.

10 deeper the delivery, the more prolonged the residence time.

11 ly ATP-competitive and shows just a moderate residence time.

12 eaction sequence in a good yield and a short residence time.

13 arge, vegetation, river morphology and water residence time.

14 found in the LMEs with the longest seawater residence times.

15 basis of the extent of current blockades and residence times.

16 e arylated products in high yields and short residence times.

17 ross LMEs, largely due to different seawater residence times.

18 cosystem metabolism, shallow water, and long residence times.

19 mputationally estimating and predicting drug residence times.

20 hroughout, leading to a shortening of carbon residence times.

21 based estimates of organ and red marrow (RM) residence times.

22 uncertainties in projected changes in carbon residence times.

23 as smaller aerosols have longer atmospheric residence times.

24 velocities of 0.50 m/s (flow rate, 30 L/min; residence time, 0.36 s) and 0.25 m/s (flow rate, 15 L/mi

25 , 0.36 s) and 0.25 m/s (flow rate, 15 L/min; residence time, 0.72 s), respectively.

26 ion mechanisms such as filter depth and long residence time (45 min vs 24 +/- 8.5 h), the establishme

27 has to be attributed to the extended target-residence time, a phenomenon of relevance in drug resear

28 riking across-specimens differences in fluid residence times affecting humidification and warming per

29 ile pumped through heated tubing for a given residence time, after which they pass over a substrate.

30 obic sediments is also likely to have a long residence time, although it too will eventually be biode

31 roperties, groundwater recharge, groundwater residence time and aquifer-river exchanges from few hour

32 ive diagnosis of system properties such as C residence time and attribution of global change impacts

33 When the residence time and conditions are chosen judiciously, 2D

34 ficantly increased plasma half-life and mean residence time and correspondingly decreased oral cleara

35 inetic profile of MRX34, showing a favorable residence time and exposure of the miRNA mimic in whole

36 Besides, the empty bed residence time and inlet load range of biofilter were se

37 ter than in summer, due to shorter hydraulic residence time and lower temperature in winter.

38 s that this step lowers transcription factor residence time and non-specific collisions during sampli

39 t tier of experiments: reaction temperature, residence time and reagent ratio.

40 The relative contributions of residence time and rotational tumbling to the total effe

41 The modeled residence time and storage capacity of the aquifer indic

42 ctions as a switch to modulate the endosomal residence time and subsequent intracellular signaling of

43 tomistic computer simulation to predict this residence time and the associated dissociation process i

44 We propose that receptor residence time and the duration of receptor signaling co

45 cribing the relationship between the analyte residence time and the width of the peaks in the current

46 rate that p53 acetylation modulates promoter residence time and transcriptional activity.

47 R improves our sensitivity of detection, the residence time and transport of eDNA does not follow the

48 terms of digestion efficiency at comparable residence time and, using a 3D-printed interface, be dir

49 ions in groundwater samples to indicators of residence time and/or electron donor availability using

50 relates with picomolar affinities, increased residence times and an absence of the peroxide productio

51 nsumption dictated by subsurface (hyporheic) residence times and biological nitrogen reduction rates.

52 rs onto micropillars which necessitates long residence times and causes damage to clusters during rel

53 otential implications for radiative forcing, residence times and other aerosol characteristics.

54 the polyhistidine molecule, since the event residence times and/or blockage amplitudes for these met

55 on from stream sediments requires subsurface residence times (and microbially mediated reduction rate

56 nic compounds (VOCs), energy density, plasma residence time, and background gas, on the removal effic

57 eractions, exhibit bioadhesion for prolonged residence time, and be rapidly recognized and internaliz

58 ea are likely outweighed by the much shorter residence time, and hence integrated environmental impac

59 1 exhibits higher tumor uptake, longer tumor residence time, and improved tumor-to-kidney dose ratio

60 rapid determination of the k(off) constant, residence time, and kinetic efficiency for ERK (extracel

61 mprovements in cellular potency, drug target residence time, and pharmacokinetic parameters.

62 standing of plant carbon allocation, stocks, residence times, and carbon use efficiency.

63 Several binding pockets with rather long ion residence times are described, both for the monovalent i

64 trates that buried water molecules with long residence times are spread all along the rear of the ina

65 sed Random Bridge kernel estimates linked to residence time as a surrogate for memory and tested four

66 of the Fab' fragment had an influence on its residence time as well and the anti-IL-17A Fab' benefite

67 w values used for FCI and takes into account residence time as well.

68 we are able to estimate yeast TBP-chromatin residence times as short as 1.3 minutes, demonstrating t

69 These couplings required residence times as short as 3 minutes to effect completi

70 -range atmospheric transport and atmospheric residence times, as it suggests that without size-specif

71 broad range of angular displacements with no residence time at any given site.

72 CO-1686, which takes advantage of increased residence time at EGFR by alkylating Cys797 and thereby

73 However, vinculin residence time at FAs varied linearly with applied force

74 In contrast, paxillin residence time at FAs was independent of local applied f

75 Paxillin recruitment and residence time at FAs, however, were dependent on cytosk

76 ble resonance spectroscopy to record surface residence times at selected final velocities of the deso

77 bearing different functional groups applying residence times below 30 min.

78 We solve the mechanism of the target residence time by comparing functional off-rates in vitr

79 improving the specific activity, prolonging residence time by introducing an osmotic agent, and vary

80 network also showed significantly prolonged residence time compared to the other tested inhibitors.

81 Patterns of camp residence times conformed well with the predictions of t

82 adsorbed water in locations and with partial residence times consistent with experimentally determine

83 We coupled measurements of beach pore water residence time, determined using the radioisotopic trace

84 Residence time did not affect the carbon specific iron-b

85 chronic biodistribution profiles, and organ residence time differences between two nanoparticles, i.

86 ilestones along the pore, and how to control residence time, direction and the sequence of spatio-tem

87 edform include the pore water flushing rate, residence time distribution, and relative rates of respi

88 range in mean residence times to model radon residence time distributions (RTDs), and integrated them

89 This permits significant Golgi residence time during which COX-2 can function catalytic

90 defined to derive individual and mean organ residence times; effective dose was calculated with OLIN

91 itor of ITK and RLK, and its extended target residence time enables durable attenuation of effector c

92 e and cluster plays an important role in the residence time enhancement, which suggests the cluster-b

93 hance drug delivery by increasing precorneal residence time, enhancing corneal permeation and lowerin

94 influence of the various process conditions (residence time, enzyme concentration, substrate concentr

95 While the absolute residence times estimates can depend on imaging acquisit

96 Live biomass and dead organic carbon residence times exhibit contrasting spatial features (r

97 x 10(9) g V/y inputs and outputs, and a mean residence time for dissolved V in seawater of about 130,

98 The residence time for each organ was derived by dividing th

99 rates of fixed N input and loss and a longer residence time for oceanic fixed N-a "sluggish" ocean N

100 are able to derive the physical half-life or residence time for TATA-binding protein (TBP) across the

101 Results: The mean residence times for (11)C-nicotine in the liver, red mar

102 ngly on the bilayer composition, with longer residence times for bilayers that have a higher DSPC con

103 curves were generated and used to determine residence times for dosimetry calculations.

104 tribution profiles, tumor uptake, and tissue residence times for each nano-based system.

105 BRET revealed remarkably long intracellular residence times for FK228 at HDAC1, explaining the protr

106 le molecule study shows comparable chromatin residence times for FoxA1 and steroid receptors.

107 vity curves of the blood and the whole body, residence times for the blood self-irradiation and the i

108 2 partial pressure at 900 degrees C in short residence times for the milled limestone whereas complet

109 he guide RNA seed sequence reduce the target residence time from >3 h to as low as <2 min in a nucleo

110 The residence time from formation of the trichloroacetyl com

111 Variation of the residence times (from 3 ms to 3 s) of antibody solutions

112 ghly inefficient due to rapid clearance (low residence time) from ocular surface.

113 ere found in deeper, older groundwater (mean residence time >300 y).

114 trance and stable carbon with millenary mean residence times have been observed.

115 We show that TFs with short DNA residence times have no footprints at bound motif elemen

116 biomass are much more driven by patterns of residence times (i.e. tree mortality rates) than by spat

117 ucleosomal access rather than an exceptional residence time in chromatin.

118 Vinculin residence time in FAs correlated with applied force, sup

119 he whole body was calculated by entering the residence time in OLINDA/EXM 1.0 software to model the e

120 ce the resulting peptide profile such as the residence time in the autosampler at 4 degrees C, stoppi

121 factor influencing a drug's efficacy is its residence time in the binding pocket of the host protein

122 on of the incoming Pb had a relatively short residence time in the catchments, on the order of decade

123 y of delivering its payload due to its short residence time in the cell, or low cellular association,

124 yet coalescence is prevented by the limited residence time in the CTCVD system.

125 ugh a suspended microdroplet flow, where the residence time in the dynamic reaction zone was limited

126 r levels of nutrients, and have a far longer residence time in the environment.

127 Post-MI leukocyte density, residence time in the infarcted area, and exit from the

128 7.2/3 heteromeric channels by prolonging the residence time in the open state.

129 The residence time in the remainder of the body was calculat

130 Next, we evaluated silver residence time in the sinus cavity after intranasal deli

131 Biochar has a long residence time in the soil and hence comprehensive studi

132 e digestibility value, which also depends on residence time in the stomach.

133 by their rate of association and not by the residence time in their respective binding sites.

134 h hotspots is made up for by enhanced tracer residence time in their vicinity due to diffusion toward

135 substantially during the overall groundwater residence times in the aquifer.

136 investigation of low affinity molecules with residence times in the micro- to millisecond time regime

137 toring of embedded SWCNT sensors also allows residence times in the roots, stems and leaves to be est

138 m compared to 5ppm), and significantly lower residence times in the sinus cavity (AgNP concentrations

139 le for PFP the process is slower with longer residence times in the solution and gel phase.

140 on, chemotaxis may work to enhance bacterial residence times in zones of contamination, thereby impro

141 ad, Si : DIN increased slightly as reservoir residence time increased.

142 ed, all ecosystems fall along a single line: residence time increases linearly with slope = 1.0 with

143 eochemical tracers combined with groundwater residence time indicators to investigate the sources of

144 rectly, and on the other hand, shortened the residence time induced by the flattened free energy surf

145 h at least 5-fold higher potency and doubled residence time inside both the human and rodent sEH enzy

146 The concept of drug-target residence time is becoming an invaluable parameter for d

147 s of copper-binding capacity with increasing residence time is caused by intracolloidal interactions

148 Ligand-target residence time is emerging as a key drug discovery param

149 d therefore the optimization of affinity and residence time is highly correlated.

150 for their overall productivity and that (v) residence time is the primary driver in the productivity

151 tic parameters such as association rates and residence times, kinetic experiments also reveal insight

152 t least for one type of tested biofilm for a residence time </=2 h: amphetamine, 6-acetylcodeine, and

153 and a flow rate of 1.5 mL min(-1) (hydraulic residence time <2 s) resulted in an oxidative flux of 0.

154 er, and suggest that biochar's environmental residence time may be underestimated when based on natur

155 The increased tracer residence time may explain the large vertical fluxes of

156 alysis procedures that significantly improve residence time measurements by accounting for fluorophor

157 of surface reactions, the velocity-selected residence time method, and demonstrate it for thermal de

158 requiring nucleolytic rescue, and its short residence time minimizes RNAP inhibition.

159 body was calculated as the maximum possible residence time minus the sum of residence time of source

160 ar fluid showed significant increase in mean residence time (MRT) and area under curve (AUC), with TM

161 (hepatic extraction fraction [HEF] and mean residence time [MRT]) were obtained by means of deconvol

162 igh-resolution ( approximately 10 m) maps of residence time, nitrate, and other parameters that showe

163 ighly transient and dynamic (with an average residence time of 1.5 sec).

164 cleared rapidly from the blood, with a mean residence time of 2.4 +/- 1.1 min/L.

165 us mode with mineral salt medium at a biogas residence time of 30 min in the absorption column, the s

166 of measles therapeutic, AS-136A, in a total residence time of 31.7 min (1.76 g h(-1) ).

167 mpounds I and II exhibited a prolonged serum residence time of 48 hours and concentration maximum (Cm

168 on on PCDD/F formation in a N2 bath gas at a residence time of 5 s.

169 Within a total residence time of 9 min, the sodium salt of ciprofloxaci

170 duce a methodology to control the copies and residence time of a gene product delivered in host human

171 evealed that GR increases the number and DNA residence time of a portion of chromatin-bound CREB1 mol

172 these empirical simulations, we compute the residence time of a receptor in dendritic spines that ac

173 based approach could be used to increase the residence time of a wide variety of charged analyte mole

174 20kDa or 40kDa, had a moderate effect on the residence time of an anti-IL-17A Fab' fragment in the lu

175 PEGylation has been shown to increase the residence time of anti-interleukin (IL)-17A and anti-IL-

176 highly dynamic inside cells, with an average residence time of approximately 0.2 s.

177 CH3NH3PbI3 crystals with a room temperature residence time of approximately 14 ps.

178 ently, a progressive upslope increase in the residence time of bedrock in the weathered zone.

179 ly 689+/-53 (14)C-yr increase in the average residence time of carbon in the deep ocean at the LGM.

180 period, primarily due to an increase in the residence time of carbon in the deep ocean, rather than

181 The theory predicts how the average residence time of carbon molecules, total system through

182 first direct experimental observation of the residence time of Cd(2+) coordinated water in any system

183 strial biosphere and atmosphere and infers a residence time of CO2 of 1.9 +/- 0.3 years (upper limit)

184 The longer synaptic residence time of CPX arose from both synaptic vesicle a

185 cal weathering on timescales longer than the residence time of DSi (< approximately 100 Kyr).

186 tions of eDNA in a lotic system, measure the residence time of eDNA compared to a conservative tracer

187 lycan-mediated interactions regulate surface residence time of glycoproteins and endocytosis.

188 Surprisingly, we find that the average residence time of lymphocytes is similar in lymph nodes

189 ecause this interval is far shorter than the residence time of marine sulfate, any change in the sulf

190 The subsequent residence time of model permeants in tissue after ultras

191 The findings provide strong support for the residence time of paused Pol II elongation complexes bei

192 e is known about the factors that affect the residence time of PEGylated antibody fragments in the lu

193 alpha-hemolysin (alphaHL) nanopore, the mean residence time of polyethylene glycol (PEG) within the p

194 etic competition between DNA opening and the residence time of Rad4/XPC per site.

195 one (BTL), likely a result of prolonging the residence time of reaction intermediates in the hydrophi

196 spring background values indicates that the residence time of released nanomaterials in the water co

197 r, fast clearance mechanisms result in short residence time of small molecule drugs in the lungs.

198 mum possible residence time minus the sum of residence time of source organs, assuming no excretion d

199 both membrane penetration and the increased residence time of synaptotagmin-1 at the plasma membrane

200 the spleen (2.5 hours) and a longer average residence time of TDLs in major lymph nodes and Peyer's

201 del also predicts a relatively short average residence time of TDLs in the spleen (2.5 hours) and a l

202 n products produced, (2) control the average residence time of the active solutes, and (3) have the a

203 ute lung inflammation slightly shortened the residence time of the anti-IL-17A and anti-IL-13 Fab' fr

204 The residence time of the Cd(2+)-bound water molecule is ten

205 binding rate k off is computed from the mean residence time of the ligand.

206 y and characterize an analyte depends on the residence time of the molecule within the pore.

207 ess under temperature conditions of a finite residence time of the molecule, the reactand diffusion c

208 The mean residence time of the O state is approximately 100 ps fo

209 o HA (200kDa) with the aim of prolonging the residence time of the polypeptide in the joint space by

210 rge of the protein allowed increasing of the residence time of the protein inside the nanopore.

211 By tuning the residence time of the reactants in a flow microreactor a

212 ewer degradation could occur during the mean residence time of the sewer network.

213 Here, we show that the estimated residence time of the short-residence molecules is essen

214 me settlement success (p > 0.05); and 4) the residence time of the sperm within the bank was not impo

215 In a total residence time of three minutes, ibuprofen was assembled

216 The residence time of ubiquitin bound to the surface of both

217 tions and an in-line purification in a total residence time of under 10 min, effectively doubling the

218 The residence time of volcanic aerosol from strong eruptions

219 ffects both the equilibrium constant and the residence time of water, while, surprisingly, the metal

220 ibitors of DprE1 with slow on rates and long residence times of approximately 100 min on the enzyme.

221 However, the residence times of cardiolipin molecules with the ring w

222 Our results show that the abundance and residence times of Cl(-) and Clorg after 30 years were h

223 ility to tune the binding affinities and the residence times of covalent inhibitors.

224 terplay between pollution sources, sinks and residence times of different polymers at sea.

225 Our hypothesis is supported by the extended residence times of DNA duplexes within the pore when a m

226 iation rates are determined from interfacial residence times of individual DNA duplexes.

227 rmore, hydrogen-bond analysis shows that the residence times of lipid-water hydrogen bonds depend str

228 pe signatures combined with mean groundwater residence times of more than 300 years for groundwater w

229 The residence times of PFAS in the surface ocean, assuming t

230 quantify the influence of chemotaxis on the residence times of pollutant-degrading bacteria within h

231 stimated, calculated to be 8.3 min (combined residence times of root and stem) and 1.9 min mm(-1) lea

232 roteins on the membrane surface, we measured residence times of single fluorescently labeled proteins

233 Long residence times of soil organic matter have been attribu

234 srupt transcription initiation) and variable residence times of TBP complexes at a promoter.

235 Furthermore, the residence times of water on the surface of the protein i

236 ysis of these data suggests that drug-target residence time (off-rate) may be an important attribute

237 decrease malaria prevalence by reducing fly residence time on infected birds or increase disease pre

238 -containing diphenyl ether with an increased residence time on InhA due to transition-state destabili

239 dition, we identify a novel inhibitor with a residence time on InhA of 220 min, which is 3.5-fold lon

240 PRN694 exhibits extended target residence time on ITK and RLK and is highly selective fo

241 arger pool of newcomer SGs that undergoes no residence time on plasma membrane before fusion and, to

242 erences were found in migration distance, or residence time on summer ranges.

243 activity by tuning the transcription factor residence time on target sites.Both transcription bindin

244 rmine whether 15a, an antagonist with a long residence time on the human CCR2, is effective in inhibi

245 easured timing and distance of migration and residence time on the summer range.

246 The modulation of p53 residence times on chromatin requires C-terminal acetyla

247 The capability to measure residence time over single tidal cycles in estuaries wil

248 -10 ms) compared with typical submillisecond residence times per base pair site reported for various

249 D-based protocol, which showed potential for residence time prediction in drug discovery.

250 The conversion/residence time profiles at several temperatures were use

251 N2O emissions; only specific, intermediate, residence times (reaction rates) will both produce and r

252 Ds), and integrated them with modeled DIN vs residence time relationships (DIN-temporal evolution, or

253 input variables, such as chamber volumetric residence time, relative humidity, initial concentration

254 We found hA3R antagonists with very short residence time (RT) at the receptor (2.2 min for 5) and

255 h-quality resource areas by increasing their residence time (RT) in and/or decreasing their time to r

256 d affinity, kinetic parameters kon, koff and residence time (RT) were determined.

257 ent probe endowed with improved affinity and residence time (RT).

258 ation rate constants of these molecules with residence times (RTs) of a few minutes only.

259 system that primer-primase complexes have a residence time similar to the timescale of Okazaki fragm

260 va in digesters operated at different solids residence times (SRT) or feeding frequencies.

261 have been introduced to optimize absorption, residence time, stability, route of delivery and frequen

262 nity of COF films is observed only at longer residence times, suggesting that oligomeric and polymeri

263 The baseline residence time (tau'E) was stable for each biome, rangin

264 In estuarine aquatic habitats, residence time (tau) is a major driver of biogeochemical

265 tor that determines carbon storage capacity, residence time (tauE) is not well constrained in terrest

266 d by quantitative calculations of whole-body residence time (TBRT) and visual examination of whole-bo

267 ifices to membrane proteins will have higher residence times than those in the bulk lipid bilayer and

268 des a unique means of monitoring ligand A3AR residence times that are significantly reduced as a cons

269 We used this range in mean residence times to model radon residence time distributi

270 hes help optimizing target affinity and drug residence time toward improved drug efficacy.

271 The resulting shortened residence time translates into the observed decrease in

272 gradually decrease with increasing hydraulic residence time (travel time) of the water in the catchme

273 secondary role to floc-encapsulation during residence times typical of electrochemical treatment.

274 er processes under all tested conditions and residence times up to 12 h.

275 that depending on the type of the spine, the residence time varies from 1 to 5 min.

276 e diaryliodonium salts on a gram scale, with residence times varying from 2 to 60 s (44 examples).

277 The tumor residence time was 15.6 h (13.4-17.7) for (177)Lu-OPS201

278 ligand, was 0.75 x 10(-4) when the reservoir residence time was 5 h but 0.34 x 10(-4) when it was 25

279 thermal shift assay (CETSA), and drug-target residence time was determined via SPR.

280 we found that average terrestrial organic C residence time was reduced by ~50% as compared to refere

281 In contrast, a long receptor residence time was responsible for the prolonged effects

282 Dispersion per unit residence time was singularly large for HS-2.

283 onstrained model estimates of OMZ water-mass residence time, we find that previous estimates for sulp

284 , 10 years before interview, and across past residences (time-weighted average).

285 Parallel TDs that vary in temperature and residence time were used with an evaporation-kinetics mo

286 lly, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EX

287 Time-activity curves were generated, and the residence times were calculated.

288 Long-term reductions in SOC mean residence times were coupled to litter inputs.

289 Residence times were determined from multiexponential re

290 Residence times were determined from time-activity curve

291 At these low concentrations, marine sulfate residence times were likely 10(3) to 10(4) years, and su

292 olipin molecules at this site increased, but residence times were not changed greatly.

293 Mean pore water residence times were positively correlated with tidal am

294 each organ normalized to injected activity (residence times) were calculated as the area under the c

295 Lipids increase gastric residence time, which could increase iron absorption, pa

296 oscillatory flow strategy enables a flexible residence time while preserving the mixing and heat tran

297 s, we could significantly prolong the target residence time with one example to 3663 s, along with an

298 within the lungs had a major impact on their residence time, with the deeper the delivery, the more p

299 Although residence times within different ecosystems vary by orde

300 We posit that the longer residence times within the subterranean estuary during t