ライフサイエンスコーパス: resistance

1 s an important means of spreading antibiotic resistance .

2 ic content improved the dough stability and -resistance.

3 d to health concerns or potential antibiotic resistance.

4 ntially serve as reservoirs of antimicrobial resistance.

5 and homeostasis model assessment of insulin resistance.

6 eficial role for host survival and apoptosis resistance.

7 njugation-assisted persistence of antibiotic resistance.

8 in phenotype during disease progression, and resistance.

9 nary blood flow and minimal microcirculatory resistance.

10 e facets of this Mphi Fv3 susceptibility and resistance.

11 ic systems, leading to the superior ablation resistance.

12 etween hyperinsulinemia, obesity and insulin resistance.

13 time-dependent frequency shift and motional resistance.

14 l genes not previously associated with serum resistance.

15 mmunity, revealing the complex nature of SSR resistance.

16 ontributes to tumor initiation and treatment resistance.

17 of known genetic events linked to cetuximab resistance.

18 on the country-specific prevalence of NNRTI resistance.

19 for enriching proteins pivotal to glyphosate resistance.

20 elial FcgammaRIIB in obesity-induced insulin resistance.

21 ells and whether this contributes to therapy resistance.

22 psychotics, and development of antipsychotic resistance.

23 omonas fluorescens induces C. elegans stress resistance.

24 herapeutic strategy to prevent acquired drug resistance.

25 eir clinical utility has been compromised by resistance.

26 ids and phenylpropanoids during early blight resistance.

27 changes in the phloem that reduce transport resistance.

28 ential to reduce the burden of antimicrobial resistance.

29 utcome and promotes the spread of antibiotic resistance.

30 partment as molecular basis for blinatumomab resistance.

31 is and severe whole-body and hepatic insulin resistance.

32 volution, intratumor heterogeneity, and drug resistance.

33 r of tumor cells that may acquire or exhibit resistance.

34 volution, progression, and emergence of drug resistance.

35 associated with high economic costs and drug resistance.

36 (>99%) based on the most recent estimates of resistance.

37 n sporadic BCCs, with minimal development of resistance.

38 layer that would contribute to overall spore resistance.

39 g protein kinases (CIPKs) are involved in Al resistance.

40 vity in CRC cells with intrinsic or acquired resistance.

41 rimarily in stationary phase and boosts heat resistance 100-fold when expressed in Escherichia coli T

42 ohms per square showed only a 4% increase in resistance after 4000 bending cycles.

43 to the variety of bacteria causing it, their resistance against classical antibiotics, the formation

44 intestinal microbiota provides colonization resistance against many orally acquired pathogens, and a

45 rugs, detailing the recurrence of 301 unique resistance alleles across 1934 drug-resistant tumours.

46 r farm type (broiler vs. layer), the odds of resistance (although not statistically significant) to a

47 our assay for rapid detection of antifungal resistance, although the MS-AFST assay performed at 3 h

48 ly 20 m), an exceptionally large range of pH resistance among MOFs.

49 data on the molecular basis of antimicrobial resistance (AMR), with an emphasis on the genes, protein

50 support dynamic alteration of DT caliber and resistance analogous to the role of blood vessel tone in

51 ) neurons consistently exhibit reduced input resistance and action potential firing.

52 evelop and progress in parallel with insulin resistance and could be a clinically relevant predictor

53 ave been shown to be associated with insulin resistance and diabetes risk.

54 ease of MCL cells from TME, reversal of drug resistance and enhanced anti-MCL activity in MCL patient

55 nase II, which promoted both hepatic insulin resistance and gluconeogenesis.

56 enabling materials with a greater oxidation resistance and hence a higher temperature capability to

57 ssette (ABCC) transporters mediate multidrug resistance and ion conductance regulation.

58 gonist, enzalutamide, prolongs survival, but resistance and lethal disease eventually prevail.

59 transduction pathways which promote therapy resistance and metastatic dissemination is the key to su

60 capable of featuring simultaneously high CO2 resistance and O2 permeability and the exploitation of p

61 e key pathophysiological features of insulin resistance and obesity.

62 identified several genes involved in disease resistance and pathogen defense.

63 multistage nature of the acquisition of drug resistance and provides a framework for understanding re

64 onment promotes disease progression, therapy resistance and relapse.

65 tem atrophy is associated with brain insulin resistance and showed increased expression of the key do

66 Underlying drug resistance and the acquisition of drug resistance during

67 genetically determined levels of host-plant resistance and tolerance.

68 hese (n = 38) were further characterised for resistance and virulence genes, SCCmec and spa typing.

69 imicking Atf1 mutant display enhanced stress resistance, and although expression of the Pap1-dependen

70 ethal cell killing that can impart treatment resistance, and cause problematic off-target effects.

71 chemotherapy, suggest mechanisms of clinical resistance, and inform development of clinically relevan

72 to examine trends in rates of antimicrobial resistance, and negative binomial regression to examine

73 e functionally important in terms of disease-resistance, and that Bd prevalence and/or host species i

74 s to produce colony-level disease avoidance, resistance, and tolerance.

75 Type 2 diabetes and insulin resistance are associated with reduced glucose utilizati

76 e, the cases of recurrence and acquired drug resistance are concerning and highlight the need for lon

77 Tumor development and therapeutic resistance are linked with tumor-associated macrophage (

78 e know that this is largely ineffective with resistance arising in most tumors following exposure to

79 Resistance associated with the Tyr181Cys mutation in HIV

80 etect C. glabrata isolates with echinocandin resistance-associated FKS2 mutations.

81 terest, with the most likely levels of least resistance being the interdigitation zone or between the

82 mobile elements are capable of transferring resistance between lineages.

83 We then screened it for pyrazinamide resistance both in vitro and in an infected animal model

84 e addition of LDR significantly reduced drug resistance both in vitro and in computational model.

85 s as a therapeutically important "antibiotic-resistance-breaker," which enhances the bactericidal act

86 ulated metabolism can broadly affect therapy resistance by influencing compensatory signaling and exp

87 bone, demonstrating a reversal of paclitaxel resistance by rubone.

88 ry inhibitors to minimize the development of resistance by viral mutations.

89 that CRISPR-Cas activity and acquisition of resistance can be modulated by administration of pro- an

90 targeted drugs, which by selecting for drug resistance can drive metastatic progression, this study

91 Diets promoting obesity and insulin resistance can lead to severe metabolic diseases, while

92 tion and the consequent loss of colonization resistance can result in intestinal domination with vanc

93 e is increasingly compounded by partner drug resistance, causing high failure rates of artemisinin co

94 lish connections between chirality, protease resistance, cellular penetration, and intracellular acti

95 were 43%, 94%, and 72% in children with IIS resistance, complete remission, and partial remission, r

96 mulated glucose disposal, and muscle insulin resistance confers many negative health outcomes.

97 The Comprehensive Antibiotic Resistance Database is a manually curated resource conta

98 Overall, the charge-transfer resistance decreased after antibody binding, because the

99 r ciprofloxacin (n = 1) in addition to known resistance determinants, collectively termed the "second

100 iniamycin at two M1:S1 ratios did not induce resistance development in four out of five E. faecium st

101 We also found that the interfacial resistance did not change with increase in the thickness

102 Multiple different species can exhibit resistance due to many different mechanisms, and many di

103 t evidence of glucose intolerance or insulin resistance during pregnancy.

104 drug resistance and the acquisition of drug resistance during treatment were included.

105 e and provides a framework for understanding resistance dynamics in single cells.

106 ns were used to estimate arteriolar afferent resistance, efferent resistance (RE), and glomerular hyd

107 Widespread antibiotic resistance, especially of Gram-negative bacteria, has be

108 rulent strains and acquisition of antibiotic resistance exacerbates pathogenesis; however, the surviv

109 Resistance exercise training (RET) has a beneficial effe

110 In bilayer graphene, the resistance exhibits a monotonic decrease with increasing

111 The contact resistance extracted by the transfer length method is 0.

112 mannii in NHS, including already known serum resistance factors, and many novel genes not previously

113 We show that upon cooling down the resistance first decreases linearly with temperature and

114 In acute myeloid leukemia (AML), therapy resistance frequently occurs, leading to high mortality

115 d of human immunodeficiency virus (HIV) drug resistance from antiretroviral roll-out programs remain

116 the electrical transport behavior of a small-resistance GaSb sample and explained the discontinuous c

117 to displace their resistant counterparts if resistance genes are costly.

118 y emerge mainly by acquisition of antibiotic-resistance genes from other S. aureus strains or even fr

119 ces could help reduce the load of antibiotic-resistance genes in the environment.

120 n immunodeficiency virus type 1 (HIV-1) drug resistance genotyping is recommended to help in the sele

121 he combination group than in the aerobic and resistance groups (27.9 to 33.4 points [21% increase] vs

122 ate with stem cell pluripotency, cancer drug resistance, GSL storage disorders and other diseases.

123 (34%) also had increased pulmonary vascular resistance >3.0 WU.

124 A combination of virus resistance, HA interaction, and molecular dynamics simul

125 The study was not designed to assess whether resistance had an impact on LLINs.

126 s) in 24% of runs, while in those runs where resistance had spread to high levels by 500 generations,

127 ng constraints on the evolution of increased resistance has been a major goal of researchers of plant

128 endously decreased, and transmission of drug resistance has merely stabilized in recent years.

129 e of human immunodeficiency virus (HIV) drug resistance has tremendously decreased, and transmission

130 While environmental impacts on resistance have been extensively, recorded their impacts

131 are usually ascribed to low fitness costs of resistance in absence of the drug.

132 e acquisition of transendothelial electrical resistance in an all-human, in vitro, 3-dimensional, blo

133 to oral azoles, drug interactions, and azole resistance in Aspergillus spp limit therapy.

134 The dissemination of carbapenem resistance in Escherichia coli has major implications fo

135 ortant drivers of metastasis and therapeutic resistance in human cancers.

136 ight be involved in protein-mediated insulin resistance in humans.

137 dysregulation is a mechanism for vemurafenib resistance in melanoma.

138 al dysfunction, hepatosteatosis, and insulin resistance in mice.

139 gnant transformation and development of drug resistance in ovarian cancer.

140 -like cells and leading to endocrine therapy resistance in OXPHOS-dependent breast cancer.

141 ate how such conditions promote chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC).

142 ing conventional therapies and overcoming GC resistance in pediatric T-ALL patients.

143 fectiveness has been reduced by evolution of resistance in pests.

144 The charge transfer resistance in the impedimetric measurement and the power

145 The immobilization improved biofouling resistance in the membranes, whose flux had a decline of

146 i; however, the presence of high aerodynamic resistance in the natural field and lower canopy tempera

147 t contributes to soybean cyst nematode (SCN) resistance in the Peking-type resistance of soybean (Gly

148 However, the direct impact of antibiotic resistance in the severity and outcomes of P. aeruginosa

149 ifies Vps34 as a new drug target for insulin resistance in Type-2 diabetes, in which the unmet therap

150 Mechanisms of resistance include activation of the mTOR, histone deace

151 ks, and clinically significant antimicrobial resistance increased.

152 An estimated cerebrovascular resistance index was then calculated as the ratio of mea

153 atabolism, obesity, and/or increased insulin resistance (IR) or impaired tissue metabolism is unknown

154 e relation among metabolic syndrome, insulin resistance (IR), and dementia has recently been question

155 Insulin resistance is a key mediator of obesity-related cardiome

156 ng human metastatic cancers, but therapeutic resistance is a practical limitation and most tumors eve

157 Greater Mekong subregion (GMS), artemisinin resistance is increasingly compounded by partner drug re

158 ostate cancer, the development of castration resistance is pivotal in progression to aggressive disea

159 riguing opportunity to address antimicrobial resistance is represented by the inhibition of efflux pu

160 cated Plasmodium falciparum malaria, but ACT resistance is spreading across Southeast Asia.

161 rbohydrate metabolism resulting from insulin resistance leads to hyperglycemia, the hallmark of type

162 minority of gonorrhoea cases without raising resistance levels.

163 dings suggest that increased cerebrovascular resistance may represent a previously unrecognized contr

164 -1 gene was identified as a plasmid-mediated resistance mechanism in human and animal Enterobacteriac

165 nd challenges in the treatment of antibiotic resistance mechanisms at both bacterial cell and communi

166 Resistance mechanisms for Candida and Aspergillus specie

167 chnology is the direct detection of specific resistance mechanisms that evolve during therapy.

168 inical models, treatments targeting specific resistance mechanisms to sensitize ICBT-resistant tumors

169 mplicates a key role for non-mutational drug resistance mechanisms underlying the survival of residua

170 l trials and have suggested the existence of resistance mechanisms with the need to identify predicti

171 ial strains possessing high level vancomycin resistance mediated by the reprogramming of peptidoglyca

172 V inhibitors, we have integrated a signature resistance mutation into a recombinant RSV virus and app

173 ed drugs and genes, COSMIC v78 contains wide resistance mutation profiles across 20 drugs, detailing

174 iteria included prior EGFR-TKI use, EGFR-TKI resistance mutation, failure to receive EGFR-TKI after W

175 side reverse transcriptase inhibitor (NNRTI) resistance mutations are associated with an increased ri

176 The characterized feedback resistance mutations caused increased free BCAA levels i

177 s and evolutionary trade-offs created by the resistance mutations.

178 contains the major immune epitopes and drug resistance mutations.

179 erconductor exhibits a negative differential resistance (NDR) transition from a steady flow to an imm

180 A 28-nanometer-thick gold foil with a sheet resistance of 7 ohms per square showed only a 4% increas

181 redict relapse based on increased cytarabine resistance of a KRAS wild-type subclone.

182 The fouling resistance of activated/BRE-functionalized pCB is shown

183 s and the protease during the development of resistance of HIV-1 to PIs.

184 global decline in pollinators attenuates the resistance of natural areas and agro-environments to dis

185 underlying the evolution of therapy-induced resistance of prostate cancer either in the form of cast

186 programming underlie the innate and adaptive resistance of RISC cells, and both need to be targeted t

187 y studied, there is little information about resistance of skin microbiota in the biofilm form to ant

188 nematode (SCN) resistance in the Peking-type resistance of soybean (Glycine max), which also requires

189 om the large surface area and low electrical resistance of the AFFs.

190 tly demonstrated that the increased lysozyme resistance of the DeltagpsB mutant was PgdA-dependent an

191 Given the resistance of the respiratory system to develop toleranc

192 r together, and also underlies the sintering resistance of these clusters during the hydrogenation of

193 t temperature dependence of the normal state resistance often referred to as the N-shaped temperature

194 olorectal cancer than in melanoma and causes resistance only in the former.

195 ot provide satisfactory efficacy due to drug resistance or reduced EGFR level.

196 l cells with astrocytes yielded the greatest resistance over time.

197 a metabolic phenotype (p < 0.05) and insulin resistance (p < 0.001).

198 ns of analysis of transepithelial electrical resistance, paracellular flux, mRNA expression, Western

199 to treat the rising threat of antimicrobial resistance, particularly in Gram-negative hospital patho

200 that occur before the emergence of multidrug resistance, particularly katG p.Ser315Thr, into molecula

201 With our evolving understanding of intrinsic resistance, people have successfully tested, in preclini

202 ntative ZrPP-1 not only exhibits strong acid resistance (pH = 1, HCl) but also remains intact even wh

203 ected to a parasitism assay to determine its resistance phenotype and in a second experiment, a subse

204 an affinity for acquiring and disseminating resistance plasmids, particularly variants of the K. pne

205 d seven molecular assays and has resulted in resistance profiles being reported to physicians an aver

206 ents and significantly induced breast cancer resistance protein (BCRP) gene transcription.

207 ate arteriolar afferent resistance, efferent resistance (RE), and glomerular hydrostatic pressure (PG

208 notypically distinct, and that increased IFN resistance represents their most distinguishing property

209 g rotating speed reduces the charge transfer resistance resulting in the lower detectable level for A

210 opographic gradient according to their input resistance (Rin) at different swimming strengths and spe

211 cular genotyping to assess antimalarial drug resistance selection and spread in the Greater Mekong su

212 , homeostasis model of assessment of insulin resistance, serum ferritin, lipid profile, and liver fun

213 exhibit up to two orders of magnitude higher resistance-switching ratio at 300 K, which is attributed

214 Hepatic insulin resistance, synergistically with lowered insulin secreti

215 ificantly reduces transepithelial electrical resistance (TEER), indicating an increase of paracellula

216 mplification testing including antimicrobial resistance testing in men with symptoms of NGU as well a

217 tive viral load monitoring and point-of-care resistance tests could help to mitigate the emergence an

218 may be less susceptible to the emergence of resistance than traditional antibiotics.

219 is the first comprehensive assessment of the resistance that PAs provide against biological invasions

220 This model offers a depiction of concomitant resistance that provides an improved theoretical basis f

221 th soil-borne pathogens or induce a systemic resistance that shares early signaling components with t

222 s for the routine surveillance of antibiotic resistance that would be helpful for a better understand

223 ad bridges were found to have relatively low resistances that were not solely dominated by the number

224 e of antimicrobials and combat antimicrobial resistance, the workgroup provides recommendations for a

225 oke or transient ischemic attack and insulin resistance, those at higher risk for future stroke or my

226 ty promotes cancer cell invasion and anoikis resistance through redox homeostasis.

227 od cells carry the chimeric proteins exhibit resistance to 10,000 times the lethal dose (LD50) of BoN

228 ants tir1-1 and axr1-12, which show enhanced resistance to 2,4-D compared with IAA for inhibition of

229 d at one centre in the AURA study, had shown resistance to a previous EGFR TKI, and had EGFR-activati

230 -stimulated gene expression and to increased resistance to all viruses tested to date.

231 cer stem cell viability and differentiation, resistance to anoikis, epithelial-to-mesenchymal transit

232 Additional loss of Trp53 causes resistance to antiandrogen therapy.

233 pumps significantly contribute for bacteria resistance to antibiotics.

234 f enzymes that plays a key role in bacterial resistance to antibiotics.

235 rrently, microRNAs (miRNAs) involved in host resistance to APEC are unknown.

236 n the frequency of self-reactive T cells and resistance to autoimmunity.

237 ory receptor CTLA-4 that was associated with resistance to autoimmunity.

238 pha) that contributed to the increased tumor resistance to BRAF inhibitors.

239 These data suggest that resistance to BRAF or MEK inhibitors is probably inevita

240 unction of ClbS, a gene product that confers resistance to colibactin toxicity in host bacteria and w

241 nt-derived melanoma cell lines with acquired resistance to combined treatment with the BRAF inhibitor

242 tency factor NANOG and autophagy involved in resistance to CTL under hypoxia.

243 ith HCV genotype 3, Y93H was associated with resistance to daclatasvir, but no RASs were associated w

244 e was mutated to alanine, greatly increasing resistance to DCV.

245 order to gain a better understanding of how resistance to DNA methylation from the A2UCOE is conferr

246 re than 100 cells per muL, and no history of resistance to elvitegravir, emtricitabine, tenofovir ala

247 ted a major role for the HPA pathway in host resistance to endotoxin-induced septic shock.

248 establishes a widely prevalent mechanism of resistance to gemcitabine in pancreatic cancer, whereby

249 lethal insults through conferring apoptosis resistance to hepatocytes.

250 t in 16% of patients (5 of 31) and predicted resistance to ibrutinib with only wild-type patients res

251 coding neoantigens as potential mediators of resistance to immune checkpoint therapy.

252 quantitative trait loci for germination and resistance to infection by the fungus Albugo laibachii,

253 Vs) occurs worldwide, but the basis of human resistance to infection remains incompletely understood.

254 ted depletion of the microbiota reduces host resistance to infection.

255 spatus and Clostridium orbiscindens) promote resistance to lung infection through Nod2 and GM-CSF.

256 rily advantageous, most likely by augmenting resistance to malaria.

257 The extracellular function, important for resistance to mycobacterial disease, has remained bioche

258 HIV-1 drug resistance to older thymidine analogue nucleoside revers

259 spectrum beta-lactamase (BlaC) that mediates resistance to one of the highly effective antibacterials

260 In PB, hNoV GI and MNV exhibited comparable resistance to PAA and monochloramine with CT values for

261 inetes and exhibited significantly increased resistance to Plasmodium infections as well as to system

262 aberrations have been implicated in acquired resistance to platinum drugs in ovarian cancer.

263 , acetyl-coenzyme A (AcCoA) and/or substrate Resistance to Ralstonia solanacearum 1 (RRS1-R)WRKY.

264 (N6m)A into 9 g DNA as confirmed by partial resistance to restriction and by liquid chromatography-m

265 ting loci associated with species typing and resistance to rifampin, isoniazid and fluoroquinolone an

266 mary of the current level of the insecticide resistance to selected organophosphates, pyrethroids, an

267 that, when interrupted, result in increased resistance to serum killing.

268 Increased cell viability and resistance to specific drug classes in the BM stroma-der

269 We postulate that resistance to T-DM1 occurs through multiple mechanisms,

270 In melanoma, resistance to targeted therapy has been linked to expres

271 im of this study was to evaluate the role of resistance to the antilipolytic effect of insulin (adipo

272 Despite its efficacy, resistance to the drug is increasing.

273 is virus (MHV) ExoN activity is required for resistance to the innate immune response, and antiviral

274 s interaction with P2Y2R provides allosteric resistance to the membrane-normal motion associated with

275 itor minimal residual disease, assess tumour resistance to therapeutic agents, and potentially screen

276 r formation and are linked to metastasis and resistance to therapies.

277 roteins contributes to tumor development and resistance to therapy by suppressing BAX and its activat

278 tial endocrine interventions are successful, resistance to therapy often arises.

279 However, resistance to these compounds has begun to emerge often

280 the versatility of NB-LRR genes to generate resistance to unrelated pathogens with completely differ

281 oduction of virulence factors and conferring resistance to various antibiotics in pathogenic microbes

282 Because cellular resistance to viral replication is marked by expression

283 blished linking viral infection to herbicide resistance, transcriptome sequencing showed a high incid

284 nt to hepatic steatosis, obesity and insulin resistance under a lipogenic diet.

285 ns of delamination and geometrically scaling resistance under moderate uniaxial tension and fatigue.

286 ing from the extremely low equivalent series resistance value of 0.27 Omega (2.49 microOmega m(2) or

287 The resulting fibres display sheet resistance values as low as 600 Omegasq(-1), demonstrati

288 yocyte metabolism, and contribute to insulin resistance via paracrine effects.

289 Colistin resistance was detected in 25/38 (65.8%) cases for which

290 The resistance was linked to an improved capacity of E11 to

291 five E. faecium strains; however, increased resistance was observed in the fifth one under 0.25 and

292 The prevalence of triple-class resistance was relatively low at 12%.

293 ing of the mechanism by which IreB regulates resistance, we initiated a structure-function study on I

294 y increases in the odds of pretreatment drug resistance were 23% (95% CI 16-29) in southern Africa, 1

295 n a PZA resistant strain does not confer PZA resistance when reconstructed in a laboratory strain.

296 oliated ML flakes due to the reduced contact resistance which mainly resulted from direct contact bet

297 ose tissues, glucose intolerance and insulin resistance while exhibiting suppressed aromatase (Cyp19a

298 virus in 2-18 days with no evidence of drug resistance, while 41 of 93 (44%) treated subjects experi

299 t epistatic interactions associated with SSR resistance, with candidate genes involved in a wide rang

300 ciety Conference, and the International Drug Resistance Workshop for the period Jan 1, 2001, to Dec 3