ライフサイエンスコーパス: resistance to

1 od cells carry the chimeric proteins exhibit resistance to 10,000 times the lethal dose (LD50) of BoN

2 ants tir1-1 and axr1-12, which show enhanced resistance to 2,4-D compared with IAA for inhibition of

3 le mutant aar1-1 tir1-1 also showed enhanced resistance to 2,4-D-induced inhibition of root growth an

4 ent in IHCs displaying fast inactivation and resistance to 20 mum nifedipine, a l-type Ca(2+) channel

5 cancer chemotherapy, yet development of drug resistance to 5-fluorouracil in colorectal cancer cells

6 -4,7,10,13-tetraenoic acid) induces systemic resistance to a broad range of DNA-damaging chemotherape

7 Patient fibroblasts also exhibit decreased resistance to a hypo-osmotic challenge, suggesting the f

8 with the highest chance to be responsible of resistance to a particular targeted cancer therapy.

9 d at one centre in the AURA study, had shown resistance to a previous EGFR TKI, and had EGFR-activati

10 c killifish that have evolved a gradation of resistance to a ubiquitous pollutant-polycyclic aromatic

11 However, with the detection of resistance to ACT, innovative compounds active against m

12 on signature in p53-deficient hearts confers resistance to acute biomechanical stress.

13 oring lysosomal functionality might overcome resistance to ADC-based therapies and improve their effe

14 Our results demonstrate how resistance to agonist toxins can evolve and that such ge

15 -stimulated gene expression and to increased resistance to all viruses tested to date.

16 alian cells, and finally, why development of resistance to AMPs is less prevalent than developed resi

17 enes, which if accumulated would confer full resistance to an otherwise susceptible strain.

18 drivers, can maintain resilience and promote resistance to and recovery from disease drivers.

19 The film demonstrated high resistance to annealing above 850 degrees C without degr

20 s, proliferation, invasion through Matrigel, resistance to anoikis, and CBS-dependent tumorigenesis i

21 cer stem cell viability and differentiation, resistance to anoikis, epithelial-to-mesenchymal transit

22 tion requirement, seed alkaloid content, and resistance to anthracnose and Phomopsis stem blight; and

23 Additional loss of Trp53 causes resistance to antiandrogen therapy.

24 esis drugs may be a new strategy to overcome resistance to antiangiogenesis therapy.

25 Resistance to antiangiogenic therapy in glioblastoma (GB

26 eradicate because of their unusually robust resistance to antibiotics, disinfectants, and desiccatio

27 Due to their resistance to antibiotics, treatment is often very chall

28 pumps significantly contribute for bacteria resistance to antibiotics.

29 f enzymes that plays a key role in bacterial resistance to antibiotics.

30 garnering notoriety in an era of increasing resistance to antibiotics.

31 us CD4 more efficiently, while retaining its resistance to antibodies and sera from infected macaques

32 demic strains, other HA mutations can confer resistance to antibodies that recognize the K166 area, l

33 These findings indicate that increased resistance to antibody-dependent complement-mediated kil

34 ver, the role of HOTAIR in pancreatic cancer resistance to anticancer agents is unknown.

35 When resistance to anticancer or antimicrobial drugs evolves

36 be required for Yersinia pseudotuberculosis resistance to antimicrobial chemokines and survival duri

37 ical" intervention can slow the evolution of resistance to antimicrobial drugs, even when resistant p

38 w CD4 cell counts because of poor adherence, resistance to antiretroviral drugs, or both.

39 rrently, microRNAs (miRNAs) involved in host resistance to APEC are unknown.

40 ults help illuminate the structural basis of resistance to apoptosis, immune evasion, and loss of cel

41 rg mutation in Wag31 was sufficient to cause resistance to APYS1, however, neither overexpression nor

42 Resistance to Arg starvation is often developed through

43 d ASNS protein expression is associated with resistance to asparaginase therapy in childhood acute ly

44 n the frequency of self-reactive T cells and resistance to autoimmunity.

45 ory receptor CTLA-4 that was associated with resistance to autoimmunity.

46 l challenge is further exacerbated by tumour resistance to available medicines.

47 ilitate the development cotton with improved resistance to BBC.

48 JAK inhibitors to counteract stroma-induced resistance to BCL2 inhibitors in AML.

49 causing an increase in the vesicle density, resistance to being solubilized by detergent and quenchi

50 Although resistance to BET inhibitors has been documented in prec

51 y and also provide a molecular mechanism for resistance to BET inhibitors in individuals with prostat

52 ll recycling/repair and the manifestation of resistance to beta-lactam antibiotics in many Enterobact

53 Resistance to beta-lactam antibiotics mediated by metall

54 e to the role of these kinases in regulating resistance to beta-lactam antibiotics.

55 In this study, we define mechanisms of resistance to bile salts and build on previous research

56 actor in rice that confers non-race-specific resistance to blast.

57 9A, N462K, N462H, G464E, and I483R conferred resistance to both FIP and AS-48 without compromising me

58 t, upon recruitment of an activator, mediate resistance to BRAF inhibitors in human melanoma cells.

59 icance: Identification of miRNAs that enable resistance to BRAF inhibitors in melanoma suggests a mec

60 pha) that contributed to the increased tumor resistance to BRAF inhibitors.

61 These data suggest that resistance to BRAF or MEK inhibitors is probably inevita

62 of the interaction between CRAF and PHB1 in resistance to BRAF-targeting agents.

63 el pathway that is associated with intrinsic resistance to BRAFi and immunotherapy, as Abl/Arg and Ak

64 nsistent with previous studies, we show that resistance to BRAFi is mediated by ERK pathway reactivat

65 utations and indels that are associated with resistance to cancer therapies and provide patients pers

66 the corresponding Mtb gene tlyA, which cause resistance to capreomycin, our current structural and me

67 This resistance to CD4-induced conformational changes was ass

68 X-M and NDM, two genes that confer bacterial resistance to cephalosporins and carbapenems, respective

69 In agreement, we demonstrate that primary resistance to cetuximab is dependent upon both KRAS muta

70 identify those that synergize with or cause resistance to checkpoint blockade.

71 We discovered that resistance to chemotherapeutic drugs in these lines broa

72 Development of resistance to chemotherapy treatments is a major challen

73 f these two important molecules in multidrug resistance to chemotherapy.

74 s also associated with cancer stem cells and resistance to chemotherapy.

75 mbers enables evasion of apoptosis and tumor resistance to chemotherapy.

76 Here, we generated echovirus 11 (E11) with resistance to chlorine dioxide (ClO2) by experimental ev

77 NK1 homolog, which is necessary for cellular resistance to chronic malfunction of the UPR(MT) Given t

78 However, drug resistance to CIBM is inevitable and the drug resistance

79 le strand annealing (SSA), and in conferring resistance to cisplatin and olaparib in human cancer cel

80 unction of ClbS, a gene product that confers resistance to colibactin toxicity in host bacteria and w

81 increased eIF4E phosphorylation that induced resistance to combinations of AR and mTOR inhibitors by

82 In this study, we identified mechanisms of resistance to combined inhibition of HER2 and PI3K.

83 nt-derived melanoma cell lines with acquired resistance to combined treatment with the BRAF inhibitor

84 In animal models of breast cancer, resistance to continuous use of letrozole can be reverse

85 nce to AMPs is less prevalent than developed resistance to conventional antibiotics.

86 T4, associated with tumor aggressiveness and resistance to conventional anticancer treatments.

87 al squamous cell carcinoma (OPSCC) has shown resistance to conventional concurrent chemoradiation (CR

88 cell proliferation and display an increased resistance to conventional drug therapies compared with

89 ver, in this work we show that field-evolved resistance to Cry1Fa Bt corn in Puerto Rico is closely l

90 tency factor NANOG and autophagy involved in resistance to CTL under hypoxia.

91 pro-apoptotic signaling, leading to cellular resistance to cytotoxic chemotherapies and ionizing radi

92 ith HCV genotype 3, Y93H was associated with resistance to daclatasvir, but no RASs were associated w

93 e was mutated to alanine, greatly increasing resistance to DCV.

94 centration is set by the balance between the resistances to diffusive loading from the source and con

95 phisms at codon 146 of the goat PRNP gene on resistance to disease.

96 s of self-organization to increase ecosystem resistance to disturbance.

97 3 (U-ISGF3), which was previously linked to resistance to DNA damage.

98 ditionally, Muscodor isolates exhibit higher resistance to DNA methylation compared with other fungi.

99 order to gain a better understanding of how resistance to DNA methylation from the A2UCOE is conferr

100 establish SETD2 alteration as a mechanism of resistance to DNA-damaging chemotherapy, consistent with

101 We hypothesize that this high range edge resistance to drought is driven primarily by local envir

102 ision family that is essential for bacterial resistance to drugs and toxic metals.

103 ocyte progenitors, SPNs displayed pronounced resistance to early or delayed cell death from hypoxia o

104 There was no emergent resistance to either regimen.

105 re than 100 cells per muL, and no history of resistance to elvitegravir, emtricitabine, tenofovir ala

106 Resistance to endocrine therapy remains a major clinical

107 ha (ERalpha)-positive breast cancers develop resistance to endocrine therapy via mutation of ERs whos

108 Breast cancer cells often develop resistance to endocrine therapy via restoration of the E

109 positive breast cancer and the mechanisms of resistance to endocrine therapy.

110 to therapeutic AMPs could be associated with resistance to endogenous host-defense peptides.

111 ted a major role for the HPA pathway in host resistance to endotoxin-induced septic shock.

112 n-regulation of miR-214 may reverse acquired resistance to erlotinib in NSCLC through mediating its d

113 We found resistance to erythromycin in 36% of the strains, and 33

114 increasing prevalence of acquired bacterial resistance to existing classes of antibiotics and with t

115 x (MTI) and stickiness, whereas decrease the resistance to extension.

116 New findings also connect insulin resistance to extensive metabolic cross-talk between the

117 82, the transgenic plants exhibited enhanced resistance to F. virguliforme, the pathogen that causes

118 oci accounted for the majority of phenotypic resistance to first- and second-line drugs in MDR and XD

119 ered in patients with a history of treatment resistance to first-line drugs relative to treatment res

120 gnostic for survival in many cancers and for resistance to fluoropyrimidines in early colon cancer.

121 tional coatings have on the BRE capacity and resistance to fouling from blood plasma.

122 face after O2 plasma etching provided better resistance to fouling than unmodified or antistatic gun

123 m-estrogen-deprivation (LTED) and subsequent resistance to fulvestrant (ICIR).

124 efficiency, tolerance to abiotic stressors, resistance to fungal pathogens and grain quality.

125 The tomato-paste purified TCMPs retained the resistance to gastrointestinal digestion and the inhibit

126 establishes a widely prevalent mechanism of resistance to gemcitabine in pancreatic cancer, whereby

127 anistically, elevated ILF2 expression exerts resistance to genotoxic agents by modulating YB-1 nuclea

128 PSGs enhance resistance to genotoxic stress and confer fitness during

129 VanA-type resistance to glycopeptide antibiotics in clinical enter

130 lethal insults through conferring apoptosis resistance to hepatocytes.

131 ma, with dynamic assessments of response and resistance to histone deacetylase inhibitor therapy.

132 link between eIF5A hypusination and cellular resistance to hypoxia/anoxia.

133 t in 16% of patients (5 of 31) and predicted resistance to ibrutinib with only wild-type patients res

134 the ice-bed interface and form drag, and the resistance to ice flow that arises as ice deforms to neg

135 We found that primary resistance to ICIs can be attributed to abnormal gut mic

136 t HIV-1 strains exhibit different degrees of resistance to IFITM3 and that these HIV-1 envelope prote

137 rategy may be useful in patients who develop resistance to imatinib and other TKIs used to treat this

138 defined by either resistance or intermediate resistance to imipenem).

139 However, mCRPC showed overwhelming de novo resistance to immune checkpoint blockade, motivating a s

140 coding neoantigens as potential mediators of resistance to immune checkpoint therapy.

141 8(+) T-cell infiltration and confers partial resistance to immunotherapies.

142 Exercise bypasses insulin resistance to increase glucose uptake in skeletal muscle

143 4-DCAF15 increase RBM39 stability and confer resistance to indisulam's cytotoxicity.

144 This study examined resistance to infection at the cellular level with the m

145 Fourteen accessions showed resistance to infection by Pst DC3000.

146 quantitative trait loci for germination and resistance to infection by the fungus Albugo laibachii,

147 Vs) occurs worldwide, but the basis of human resistance to infection remains incompletely understood.

148 ial density, cytoplasmic incompatibility, or resistance to infection with Zika virus.

149 ted depletion of the microbiota reduces host resistance to infection.

150 ost-associated microbiota affects later-life resistance to infections by manipulating the microbiota

151 that CLIPA2 knockdown (kd) enhances mosquito resistance to infections with fungi, bacteria, and Plasm

152 moters of inhA and eis genes responsible for resistance to INH, the fluoroquinolone (FQ) drugs, amika

153 anscription factors that modulate epithelial resistance to injury is necessary for understanding inte

154 or shows 21 nM (4.4 ppb) limit of detection, resistance to interfering metals such as cadmium (Cd) an

155 proliferation and differentiation as well as resistance to invading microbes.

156 ellular oxidative stress that contributes to resistance to invading T. gondii, and they thus unveil n

157 nities can differentially alter local biotic resistance to invasion.

158 , and eukaryotic species are known for their resistance to ionizing radiation.

159 H) by the ciliary processes and hydrodynamic resistance to its outflow through the conventional outfl

160 In the field of veterinary medicine, resistance to ivermectin is now widespread, but the mech

161 24N/V165I/T174I) confers marked (>2000-fold) resistance to KF116.

162 rasite replication in macrophages, and mouse resistance to L. amazonensis infection in vivo.

163 previously described endosomal TLR-mediated resistance to L. major infection.

164 ate that autophagy contributes to macrophage resistance to L. major replication, and mechanistically

165 the presence of alkenes and tree growth and resistance to leaf spot.

166 eplication and effectively accounts for host resistance to Leishmania infection.

167 SR1-positive cell lines after acquisition of resistance to long-term-estrogen-deprivation (LTED) and

168 spatus and Clostridium orbiscindens) promote resistance to lung infection through Nod2 and GM-CSF.

169 rily advantageous, most likely by augmenting resistance to malaria.

170 cluding skin color, lactase persistence, and resistance to malaria.

171 d to promote long-lived humoral immunity and resistance to malaria.

172 ding cassette (ABC) transporter that confers resistance to many anticancer drugs and plays a role in

173 of AfarsM1 in an Escherichia coli conferred resistance to MAs(III) but not As(III).

174 cholerae show striking differences in their resistance to membrane disrupting cationic antimicrobial

175 Cancer cells acquiring resistance to MET oncogene-targeted drugs invariably und

176 's cells with wild-type FANCM improved their resistance to MMC re-establishing FANCD2 monoubiquitinat

177 s a trypanolytic protein that confers innate resistance to most African trypanosomes, but not Trypano

178 Bacterial resistance to most antibiotics in clinical use has reach

179 phenotype is sustained through adaptation or resistance to mTOR inhibition remains unknown.

180 on has been linked to cancer progression and resistance to mTOR inhibitors, but the mechanism underly

181 The extracellular function, important for resistance to mycobacterial disease, has remained bioche

182 Selection for cellular resistance to nab-paclitaxel in cell culture correlated

183 ncing productivity, litter decomposition and resistance to natural enemies.

184 The transgenic plants displayed more resistance to nematode attacks (Tylenculus semipenetrans

185 uced by motor activity is opposed by passive resistance to network deformation.

186 e, the modA2 ON status resulted in decreased resistance to neutrophil-mediated killing, which resulte

187 resensitized TBNC cells, which had acquired resistance to niraparib.

188 The prevalence of resistance to non-nucleoside reverse transcriptase inhib

189 brane, we identified a mutant with increased resistance to novobiocin.

190 ses and suggest a role for CDK19 in cellular resistance to nutlin-3.

191 determine mechanisms of durable response and resistance to olaparib therapy, we performed an analysis

192 HIV-1 drug resistance to older thymidine analogue nucleoside revers

193 ics completely suppresses the development of resistance to one of the antibiotics.

194 spectrum beta-lactamase (BlaC) that mediates resistance to one of the highly effective antibacterials

195 Resistance to outcome devaluation (the defining feature

196 like mycoredoxin that promotes mycobacterial resistance to oxidative stress and reacts with free myco

197 ed with the Bacillus subtilis homologue, and resistance to oxidative stress required the canonical CX

198 In PB, hNoV GI and MNV exhibited comparable resistance to PAA and monochloramine with CT values for

199 However, as with other targeted therapies, resistance to PARPi arises in advanced disease.

200 of immune cell development, influencing both resistance to pathogens and tolerance.

201 At all pH levels unheated beta-lg showed resistance to peptic digestion with high antigenic value

202 y colored materials are often used for their resistance to photobleaching and their complex viewing-d

203 photoanode materials, mainly owing to their resistance to photocorrosion, non-toxicity, natural abun

204 at amino acids 28, 30, or 31 had no apparent resistance to pibrentasvir, and HCV with RAS at amino ac

205 deletion of amino acid 32 led to significant resistance to pibrentasvir.

206 ces associated with the development of HIV-1 resistance to PIs, we traced viral evolution under the p

207 Recessive resistances to plant viruses in the Potyvirus genus have

208 inetes and exhibited significantly increased resistance to Plasmodium infections as well as to system

209 aberrations have been implicated in acquired resistance to platinum drugs in ovarian cancer.

210 ables its abilities to promote HR and confer resistance to platinum salts and PARP inhibitors.

211 ascades to promote malignant progression and resistance to PLX4720 treatment.

212 cific activation response, including extreme resistance to Potato virus X in potato shoots.

213 est suppression, partly because evolution of resistance to predators and parasitoids is prevented by

214 induces apoptosis in MM cells and overcomes resistance to proteasome inhibitor bortezomib.

215 lys-2 activity accounts for biofilm-mediated resistance to Pseudomonas aeruginosa killing.

216 tively decrease and increase the Arabidopsis resistance to Pst DC3000, indicating that the gene promo

217 >40% of dorsal root ganglia neurons, display resistance to rabies infection.

218 s have increased prostasphere formation with resistance to radiation induced cell death.

219 , acetyl-coenzyme A (AcCoA) and/or substrate Resistance to Ralstonia solanacearum 1 (RRS1-R)WRKY.

220 pervasiveness of heroin addiction, including resistance to recovery from addiction, provide a compell

221 (N6m)A into 9 g DNA as confirmed by partial resistance to restriction and by liquid chromatography-m

222 ting loci associated with species typing and resistance to rifampin, isoniazid and fluoroquinolone an

223 sporting PfATP6 as a putative determinant of resistance to SC81458 and SC83288.

224 Moreover, ZmTrxh-mediated maize resistance to SCMV showed no obvious correlation with th

225 tify soybean WRKY genes that promote soybean resistance to SCN, we first screened soybean WRKY genes

226 tes that GmSNAP11 contributes to an additive resistance to SCN.

227 mary of the current level of the insecticide resistance to selected organophosphates, pyrethroids, an

228 that, when interrupted, result in increased resistance to serum killing.

229 that the Campylobacter population developed resistance to several antibiotics coinciding with period

230 n hardening ability gives rise to remarkable resistance to shear localization, which makes this mater

231 um lacks any compressive strength but offers resistance to shear.

232 gal drugs are available, so the emergence of resistance to single drug classes and now multidrug resi

233 may be explored to prevent or overcome drug resistance to single targeting agents.

234 Lack of synergy was predicted by resistance to single-agent venetoclax and high BCL-XL ex

235 We discovered that resistance to sonication is a reliable indicator of the

236 ently, GmSNAP18 has been reported to mediate resistance to soybean cyst nematode (SCN).

237 g signatures that indicate susceptibility or resistance to specific antibiotics.

238 Increased cell viability and resistance to specific drug classes in the BM stroma-der

239 olume in response to sunitinib, and acquired resistance to sunitinib was not associated with a parall

240 changes in an established model of lapatinib resistance to systematically investigate initial inhibit

241 We postulate that resistance to T-DM1 occurs through multiple mechanisms,

242 In melanoma, resistance to targeted therapy has been linked to expres

243 to interrogate mechanisms of sensitivity or resistance to taxanes in men with chemotherapy-naive, me

244 screening data provide strong evidence that resistance to TC1507 in fall armyworm maps to the SfABCC

245 f resistance and inhibits the development of resistance to the agents themselves.

246 models to show that these tumors can develop resistance to the antiandrogen drug enzalutamide by a ph

247 In prostate cancer, resistance to the antiandrogen enzalutamide (Enz) can oc

248 herapeutic response in a murine model of mBC resistance to the antiangiogenic tyrosine kinase inhibit

249 im of this study was to evaluate the role of resistance to the antilipolytic effect of insulin (adipo

250 While resistance to the BCN polymers was developed only very s

251 acetyltransferase (PAT) genes, which convey resistance to the broad-spectrum herbicide phosphinothri

252 F4E(S209) phosphorylation is associated with resistance to the combination.

253 ne marrow-derived macrophages (BMDM) confers resistance to the development of glioma.

254 a D or S residue at this position conferred resistance to the disease.

255 lines cultured on the T-MOC showed increased resistance to the drug compared to 2D culture where MDA-

256 Despite its efficacy, resistance to the drug is increasing.

257 squamous cell carcinomas (HNSCC) exhibiting resistance to the EGFR-targeting drug cetuximab poses a

258 Desirable oil characteristics and resistance to the fungal disease Verticillium wilt are t

259 elope protein that are associated with viral resistance to the IFITM3 protein.

260 is virus (MHV) ExoN activity is required for resistance to the innate immune response, and antiviral

261 nsp14 ExoN activity in the induction of and resistance to the innate immune response.

262 We show that resistance to the invasive alga, Sargassum horneri, in a

263 s interaction with P2Y2R provides allosteric resistance to the membrane-normal motion associated with

264 ctopic expression of PS improves Arabidopsis resistance to the necrotrophic fungus Botrytis cinerea,

265 North China cratonic crust acts as a strong resistance to the northward growth of the plateau, forci

266 Resistance to the selective estrogen receptor modulator

267 itor minimal residual disease, assess tumour resistance to therapeutic agents, and potentially screen

268 ical use of AMPs has raised the concern that resistance to therapeutic AMPs could be associated with

269 B2M loss is likely a common mechanism of resistance to therapies targeting CTLA4 or PD1.

270 r formation and are linked to metastasis and resistance to therapies.

271 roteins contributes to tumor development and resistance to therapy by suppressing BAX and its activat

272 tial endocrine interventions are successful, resistance to therapy often arises.

273 CD patients with more complicated disease or resistance to therapy, defined in part by failed respons

274 erapy, and this drives tumorigenesis and the resistance to therapy.

275 tion, and increased angiogenesis, leading to resistance to therapy.

276 pHe), which promotes tumor growth and builds resistance to therapy.

277 commonly associated with poor prognosis and resistance to therapy.

278 dowing tumors with aggressive properties and resistance to therapy.

279 However, resistance to these compounds has begun to emerge often

280 rugs mainly target the viral polymerase, and resistance to these drugs has appeared.

281 umors treated with AIs almost always develop resistance to these drugs via the upregulation of altern

282 om the wetland compared to feces, suggesting resistance to this antibiotic may not be well maintained

283 ns internalization by host cells and in host resistance to this deadly infection.

284 with RAS at amino acid 93 had a low level of resistance to this drug.

285 Genetic resistance to this parasitic weed is the most economical

286 cts because many patients eventually develop resistance to this treatment.

287 However, most patients develop resistance to TKI through BCR-ABL1-dependent and -indepe

288 integrin beta1/Src blocked collagen-induced resistance to TPB and inhibited growth of drug-resistant

289 of Dyn1, TRAIL-DR endocytosis, and increased resistance to TRAIL-induced apoptosis.

290 molecular determinants that confer this high resistance to transmissible spongiform encephalopathies.

291 e central to the chronicity, recurrence, and resistance to treatment of multiple human respiratory tr

292 vivo, inducing intratumor heterogeneity and resistance to treatment.

293 s the consumption of thymidine and increases resistance to trimethoprim under both aerobic and anaero

294 the versatility of NB-LRR genes to generate resistance to unrelated pathogens with completely differ

295 oduction of virulence factors and conferring resistance to various antibiotics in pathogenic microbes

296 pts the p53/MDM2 regulatory axis, conferring resistance to various chemotherapeutics.

297 ected due to its biocompatibility, excellent resistance to various organic solvents, and its ability

298 Because cellular resistance to viral replication is marked by expression

299 ns supporting virus replication or enhancing resistance to virus infection.

300 Resistance to xenobiotic nucleosides used to treat acute