ライフサイエンスコーパス: resistin

1 tissues from adult rat hearts overexpressing resistin.

2 /EBPbeta) expression vectors with or without resistin.

3 an articular chondrocytes were cultured with resistin.

4 may be transduced, in part, by its impact on resistin.

5 al and high-molecular-weight adiponectin and resistin.

6 The RETN gene encodes the adipokine resistin.

7 eptor, also prevented the effects of central resistin.

8 due to reduced expression and circulation of resistin.

9 en applied to the rigorous quantification of resistin.

10 ate pituitaries expressed leptin/adiponectin/resistin.

11 ormal T cell expressed and secreted PDGF and RESISTIN.

12 n (hRTN(+/-)(/-)) but are deficient in mouse resistin.

13 fold, angiotensinogen 3-fold, leptin 2-fold, resistin 4-fold, and adiponectin 4-fold; P<0.01 compared

14 onectin concentrations, as well as 16% lower resistin, 41% lower CRP, 19% lower sE-selectin, and 24%

15 ximally adjusted model, each SD increment in resistin (7.45 ng/ml) was associated with a 26% increase

16 Resistin, a cysteine-rich 12.5 kDa polypeptide, is a rec

17 Resistin, a cysteine-rich adipocytokine, proposed as a l

18 Resistin, a plasma protein, induces insulin resistance i

19 Plasma levels of resistin, a proinflammatory cytokine and uremic toxin, w

20 d inflammation and suggest that hypothalamic resistin action can contribute to hyperglycemia in type

21 that bi-directional changes in hypothalamic resistin action have dramatic effects on GP and proinfla

22 Conversely, central antagonism of resistin action markedly diminished the ability of circu

23 Together, these results suggest that resistin action on NPY neurons is an important regulator

24 We compared serum concentrations of leptin, resistin, adiponectin, and visfatin in 167 RA patients a

25 al and circulating levels of adipocytokines (resistin, adiponectin, leptin, tumor necrosis factor [TN

26 ly improved by the simultaneous inclusion of resistin, adipsin, and total adiponectin (c-statistic: 0

27 Resistin, adipsin, and total adiponectin provided increm

28 Higher plasma levels of resistin, adipsin, and total adiponectin were associated

29 roperties of 4 plasma adipocytokines, namely resistin, adipsin, leptin, and total adiponectin, with r

30 amined whether the human-specific variant of resistin affects neutrophil activation and the severity

31 Resistin also stimulated the activation of p70(S6K), a d

32 Resistin, an adipokine/cytokine, is involved in inflamma

33 Serum levels of resistin, an adipose tissue-derived adipokine, are incre

34 tion was assessed by measurement of secreted resistin, an azurophilic granule marker, and by determin

35 Growing evidence indicates that resistin-an obesity-related cytokine-is upregulated in b

36 Resistin and acetaminophen levels were comparable in bot

37 We tested the association of the adipokines resistin and adiponectin with incident heart failure.

38 mainly influenced the circulating levels of resistin and adiponectin, whereas both obesity and perio

39 The data further show that repression of resistin and angiotensinogen expression involves recruit

40 lso results in elevated circulating level of Resistin and development of hepatic steatosis.

41 of cytokine signaling-3 (Socs3), a target of resistin and hepcidin implicated in insulin resistance.

42 ship between inflammatory increases in human resistin and insulin resistance.

43 t an altered adipokine profile, with reduced resistin and leptin levels.

44 he role of three key adipokines-adiponectin, resistin and leptin-as potential predictors of response

45 Change in diet score was unrelated to resistin and several cytokines.

46 l growth factor, myeloperoxidase, prolactin, resistin and soluble tumor necrosis factor alpha recepto

47 asma GIP, GLP-1, glucose, insulin, glucagon, resistin, and acetaminophen levels.

48 HPCs express adiponectin, resistin, and GLP-1, which become available to resident

49 PC-expressing adipokines (e.g., adiponectin, resistin, and glucagon-like peptide 1 [GLP-1]) were coun

50 romoters of white fat-specific genes such as resistin, and is abolished in the genetic absence of CtB

51 Resistin, and its closely related homologs, the resistin

52 fat transplants contained increased leptin, resistin, and monocyte chemoattractant protein-1 compare

53 Serum glucose, insulin, IL-6, resistin, and OVA-specific IgE levels were quantified.

54 n sensitivity and the levels of adiponectin, resistin, and serum RBP (RBP4).

55 Expression of galectin-12, resistin, and SREBP-1 in SZ95 sebocytes was confirmed by

56 a caused hypoglycemia in mice lacking murine resistin, and this was attenuated in BAC-Retn mice.

57 4-h serum interleukin-6, C-reactive protein, resistin, and tumor necrosis factor-alpha levels by 3-29

58 nd serum adipocytokine (leptin, adiponectin, resistin, and visfatin) concentrations were determined i

59 necrosis factor-alpha, adiponectin, leptin, resistin, and vitamin D were measured at baseline.

60 fat genes ("visceral white"), including the resistin, angiotensinogen, and chemerin genes, in additi

61 Resistin antagonizes insulin action in mouse, making it

62 Resistin appears to have effects on substrate metabolism

63 t reports suggest that circulating levels of resistin are elevated in obese and insulin-resistant rod

64 Adiponectin and resistin are recently discovered adipokines that may pro

65 ignificantly less inflammatory cytokines and resistin as compared with MIF(+/+) mice and failed to de

66 n concentrations and lower concentrations of resistin, as well as biomarkers of inflammation, endothe

67 (24 h) with the following: 1) purified human resistin at various concentrations, with and without lov

68 Resistin, at physiological levels observed in human obes

69 Here we show that in 3T3-L1 adipocytes, resistin attenuates multiple effects of insulin, includi

70 erial artificial chromosome containing human resistin (BAC-Retn), whose expression was similar to tha

71 ciation kinetics of hRes subunits pointed to resistin being a molecular chaperone.

72 ory states, we generated mice lacking murine resistin but transgenic for a bacterial artificial chrom

73 Resistin by itself was able to induce acute kidney injur

74 A significant difference was observed in GCF resistin concentrations from group 1 versus group 2 (P =

75 Furthermore, recombinant human resistin could bind misfolded proteins only.

76 Only resistin (cut-off value 13.7 ng/ml) and IL-6 (cut-off va

77 Resistin deficiency enhanced Akt phosphorylation in musc

78 Nevertheless, resistin deficiency improved glucose tolerance and insul

79 nduced obesity but wild-type leptin alleles, resistin deficiency reduced hepatic glucose production a

80 Here we demonstrate that in normal mice resistin delivered in the lateral cerebral ventricle inc

81 Furthermore, resistin diminished statin-mediated up-regulation of the

82 ltration rate) using the lowest third of the resistin distribution as the referent, the hazard ratios

83 Interestingly, we also show that resistin effects were abolished in TLR4 knockout mice an

84 sitize neutrophils to LPS stimulation, human resistin enhanced neutrophil extracellular trap formatio

85 Resistin expression in HPCs increased in pNAFLD and was

86 LV resistin expression was markedly elevated in POH, mildly

87 genes including tumor necrosis factor alpha, resistin, FABP4, and PPARgamma.

88 elationship between the CRD of PCSK9 and the resistin family is not observed in primary sequence comp

89 HF diet-induced elevations of plasma leptin, resistin, fed-state and fasting insulin and increased ex

90 lasma peptide YY (PYY), leptin, ghrelin, and resistin for all subjects.

91 d the expression of known adipogenic factors resistin, galectin-12, sterol response-element-binding p

92 To better understand how mouse resistin gene (Retn) expression is restricted to fat tis

93 two SNPs were significantly associated with resistin gene (RETN) mRNA levels in white blood cells fr

94 ited to the transcription loci and regulates resistin gene expression upon insulin stimulation.

95 In addition it causes IR, higher hepatic resistin gene expression, and up-regulation of hepatic i

96 ably, unlike native resistin, monomeric C26A resistin had no effect on basal or insulin-stimulated gl

97 ent study was initiated to determine whether resistin has additional roles in GIP-regulated adipocyte

98 The chemistry of resistin has also been the subject of investigation and

99 Resistin has been associated with inflammation and risk

100 Resistin has been suggested to be involved in the develo

101 Resistin has diverse effects on gene expression in human

102 obesity, recent studies also suggested that resistin has proinflammatory properties.

103 roup box (HMGB)-1, B7 Homolog 1, S100A4, and resistin have been detected in tissues of dermatomyositi

104 Because human and mouse resistin have distinct patterns of tissue distribution,

105 , plasminogen activator inhibitor-1 (PAI-1), resistin, hepatocyte growth factor, interleukin-6 (IL-6)

106 ed for the qualitative analysis of the human resistin homodimer from normal (healthy) plasma samples.

107 wing a distinct structural similarity to the resistin homotrimer, a small cytokine associated with ob

108 Resistin (HR, 1.88; 95% confidence interval [CI], 1.16-3

109 ses the need for additional assays for human resistin (hRES) by developing a rational progression of

110 We earlier reported that human resistin (hRes), a trimer, was resistant to heat and ure

111 Human resistin (hRetn) is an immune cell-derived protein that

112 resistin mice that exclusively express human resistin (hRTN(+/-)(/-)) but are deficient in mouse resi

113 i) serum hormone concentrations (leptin and resistin), ii) adipose tissue mRNA expression of inflamm

114 The hormone resistin impairs the response to insulin in liver and ot

115 lating higher molecular weight structures of resistin in both rodent and human serum.

116 e are still unravelling the functionality of resistin in human biology in respect to glucose metaboli

117 The findings suggest a role for resistin in human disease and a novel pathway to heart f

118 d by antibody-immunoprecipitation removal of resistin in human serum, which decreased serum stimulati

119 However, the function of resistin in humans is enigmatic.

120 Emerging evidence suggests a role for resistin in inflammation and vascular dysfunction, which

121 vide strong support for an important role of resistin in insulin resistance and diabetes associated w

122 The quantitatively important role of human resistin in LDLR expression was demonstrated by antibody

123 ht on the function and purpose of multimeric resistin in mice.

124 Here, we have determined the role of resistin in ob/ob mice that are obese and insulin resist

125 or galectin-12 and SREBP-1 in the nuclei and resistin in the cytoplasm of basal sebocytes, and stearo

126 e results strongly support the role of human resistin in the development of insulin resistance in inf

127 udy is to estimate and compare the levels of resistin in the gingival crevicular fluid (GCF) in healt

128 learly identify TLR4 as the binding site for resistin in the hypothalamus and bring new insight into

129 p-regulation of the LDLR by 60%, implicating resistin in the relative ineffectiveness of statins in s

130 an altered adipokine response (i.e., higher resistin increase and an adiponectin fall), and hepatocy

131 and did not alter LH/FSH/TSH-release; and 3) resistin increased ACTH-release and did not alter PRL/LH

132 Loss of resistin increased obesity in ob/ob mice by further lowe

133 ally, we report that intracerebroventricular resistin increased plasma FGF21 levels and downregulated

134 Furthermore, resistin increased serine phosphorylation of insulin rec

135 normal-weight bone explant with recombinant resistin increased the Type I collagen alpha1/alpha2 rat

136 n of primary OA osteoblasts with recombinant resistin increased Wnt signalling activation, osteoblast

137 Central resistin induced expression of proinflammatory cytokines

138 to elucidate the mechanisms associated with resistin-induced cardiac hypertrophy and myocardial insu

139 ith rapamycin or mTOR siRNA attenuated these resistin-induced changes.

140 trally mediated mechanisms partially control resistin-induced expression of TNF-alpha, IL-6, and SOCS

141 ranscriptional up-regulation are involved in resistin-induced gene expression in human chondrocytes.

142 ht into the molecular mechanisms involved in resistin-induced inflammation and insulin resistance in

143 NF-kappaB and C/EBPbeta were involved in the resistin-induced up-regulation.

144 These data demonstrate that resistin induces cardiac hypertrophy and myocardial insu

145 Resistin induces PTEN expression by activating stress si

146 We show that chronic intracerebroventricular resistin infusion downregulated both hypothalamic and he

147 In the current study, we report that chronic resistin infusion in the lateral cerebral ventricle of n

148 In agreement, central resistin inhibited Akt phosphorylation and increased the

149 In the current study, we observed that resistin inhibited insulin signaling and eNOS activation

150 A key mechanism by which human resistin inhibited LDLR levels was by increased cellular

151 Resistin inhibited neutrophilic-differentiated NB4 cell

152 Expression of human resistin inhibited the activation of AMP-activated prote

153 receptors (TLR)2, TLR4, and TLR9, as well as resistin, interleukins (IL)-1beta, IL-4, and IL-6 and ox

154 These findings provide clear evidence that resistin is a clinically relevant endogenous ligand for

155 These results reveal for the first time that resistin is a highly attractive therapeutic target in am

156 Resistin is a polypeptide hormone that was reported to b

157 rease in resistin was also observed; because resistin is a potent pro-inflammatory compound, this dec

158 Current evidence appears to suggest that resistin is a pro-inflammatory cytokine.

159 Resistin is an adipocyte hormone that modulates glucose

160 Resistin is associated with local and systemic inflammat

161 We recently reported that resistin is expressed in diabetic hearts and promotes ca

162 Resistin is greatly elevated during acute kidney injury,

163 In vitro, resistin is induced by angiotensin II and induces CTGF i

164 tes, independent of body mass index, whereas resistin is not.

165 ne in this region is the structural gene for resistin, itself.

166 onectin, an insulin-sensitizing hormone, and resistin, known to promote insulin resistance, constitut

167 luding tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, an

168 ' side of RETN were strongly associated with resistin levels (all minor alleles associated with highe

169 of hypertension, but the association between resistin levels and incident hypertension is unknown.

170 us acute kidney injury still showed elevated resistin levels and inhibited neutrophilic-differentiate

171 We examined the association between plasma resistin levels and the risk for incident hypertension a

172 Resistin levels are increased in CP and T2DM.

173 Resistin levels are increased in obesity, and hyperresis

174 ) and the NDST4 gene (4q25), associated with resistin levels at a genome-wide significant level, best

175 Only admission resistin levels could serve as an early predictor for SA

176 In this study, we observed that high serum resistin levels in breast cancer patients positively cor

177 -wide association (GWA) study on circulating resistin levels in individuals of European ancestry draw

178 After adjustment for potential confounders, resistin levels in the highest tertile conferred a 75% h

179 In stratified analysis, resistin levels in the highest tertile significantly inc

180 In conclusion, higher plasma resistin levels independently associate with an increase

181 Hence, GCF resistin levels may be considered as a potential inflamm

182 atin; and 2) obese human serum with elevated resistin levels or serum from which resistin was removed

183 all the samples were analyzed together, GCF resistin levels positively correlated with GI, PD, PI, R

184 association of SNP -420C/G (rs1862513) with resistin levels remained significant (P = 0.0009) but wi

185 for these biomarkers and C-reactive protein, resistin levels remained significantly associated with i

186 lammatory and endothelial biomarkers, plasma resistin levels significantly correlated with IL-6, solu

187 GCF (4 muL) was collected and analyzed for resistin levels using an enzyme-linked immunosorbent ass

188 ariate model without body mass index, higher resistin levels were associated with a higher risk for d

189 In serum, resistin levels were higher whereas adiponectin levels w

190 irculating insulin, adiponectin, leptin, and resistin levels were measured in 36 patients with advanc

191 We found that BAC-Retn mice have circulating resistin levels within the normal human range, and simil

192 in the 3' region of RETN are associated with resistin levels, and one of them is also associated with

193 Framingham Offspring Study participants for resistin levels, glycemic phenotypes, and incident diabe

194 in RETN and tested associations with plasma resistin levels, risk of diabetes, and glycemic traits.

195 Associations of RETN with plasma resistin levels, type 2 diabetes, and related metabolic

196 be involved in the regulation of circulating resistin levels.

197 lipopolysaccharide markedly increased serum resistin levels.

198 (which have elevated levels of the cytokine resistin-like beta, RELMbeta, and are extremely sensitiv

199 sensitivity and a marked reduction in serum Resistin-like molecule (RELM) alpha, a multifunctional c

200 of Arginase 1, chitinase-like molecules, and resistin-like molecule (RELM) alpha/FIZZ1; however, the

201 differentiate into goblet cells that secrete resistin-like molecule (RELM) beta.

202 in inflammatory zone (FIZZ) 2, also known as resistin-like molecule (RELM)-beta, belongs to a novel c

203 Resistin-like molecule (RELM)alpha belongs to a family o

204 Resistin-like molecule alpha (Relm-alpha) is a secreted

205 ulomatous inflammation, increased numbers of resistin-like molecule alpha(+) cells, and enhanced coll

206 so known as found in inflammatory zone 1 and resistin-like molecule alpha, belongs to a novel class o

207 that expressed a smooth muscle cell mitogen, resistin-like molecule alpha, but surprisingly, there wa

208 protein product of the most promising gene, resistin-like molecule alpha, demonstrated a significant

209 Goblet cell numbers and resistin-like molecule beta (RELM-beta) expression were

210 3 production in IL-33-deficient mice impairs resistin-like molecule beta (RELMbeta) expression and eo

211 The secreted goblet cell-derived protein resistin-like molecule beta (RELMbeta) has been implicat

212 Here, we show that resistin-like molecule beta (RELMbeta) is a bactericidal

213 Resistin-like molecule beta (RELMbeta) is a goblet cell-

214 Basal and DSS-induced production of resistin-like molecule beta (RELMbeta) was substantially

215 We previously reported that resistin-like molecule beta (RELMbeta; also known as FIZ

216 ed expression of the antihelminthic proteins resistin-like molecule beta and mucin 5ac.

217 increase in secretion of goblet cell-derived resistin-like molecule beta into the intestinal lumen.

218 Resistin-like molecule beta is important in mucosal defe

219 Moreover, the expression of resistin-like molecule-alpha, a target of IL-13 signalin

220 und in inflammatory zone 1 (FIZZ1/Retnla), a resistin-like molecule.

221 Resistin-like molecules (RELMs) are highly expressed fol

222 istin, and its closely related homologs, the resistin-like molecules (RELMs) have been implicated in

223 ore, HIF2alpha induced the expression of the resistin-like molecules alpha and beta (RELMalpha and be

224 Although adipocyte-derived murine resistin links insulin resistance to obesity, the role o

225 Plasma tumor necrosis factor-alpha, resistin, macrophage chemoattractant protein-1, and adip

226 Thus, human resistin may link insulin resistance to inflammatory dis

227 log deleted on chromosome ten) expression by resistin may mediate the inhibitory effects.

228 Our results suggest that human resistin may play an important contributory role in enha

229 Thus, like many other adipocytokines, resistin may possess a dual role in contributing to meta

230 e tissue, including leptin, adiponectin, and resistin, may influence osteoarthritis though direct joi

231 Our findings suggest that resistin-mediated inhibition of insulin signaling and eN

232 In LPS-induced acute lung injury, humanized resistin mice demonstrated enhanced production of proinf

233 , experiments were performed using humanized resistin mice that exclusively express human resistin (h

234 Remarkably, unlike native resistin, monomeric C26A resistin had no effect on basal

235 To investigate the role of human resistin on glucose homeostasis in inflammatory states,

236 rent studies appear to re-affirm the role of resistin on glucose homeostasis in rodent systems, we ar

237 The effects of central resistin on glucose production as well as hepatic expres

238 t we believe to be a novel site of action of resistin on GP and inflammation and suggest that hypotha

239 TEN is involved in the inhibitory effects of resistin on insulin signaling and eNOS activation in end

240 The effect of resistin on primary OA osteoblasts was determined by ana

241 The infusion of either resistin or an active cysteine mutant in the third cereb

242 3), lower serum IL-(P = 0.0022), lower serum resistin (P = 0.0043), lower serum OVA-specific IgE (P =

243 atin (P = 0.06), adiponectin (P = 0.55), and resistin (P = 0.98) showed no association with the HOMA-

244 is study, our goal was to determine if human resistin plays a role in regulating the uptake of athero

245 lin resistance to obesity, the role of human resistin, predominantly expressed in mononuclear cells a

246 Resistin promotes both inflammation and insulin resistan

247 Here, we investigated whether central resistin promotes insulin resistance through the impairm

248 Additionally, central resistin promotes the activation of the serine kinases J

249 We also found evidence for a QTL influencing resistin protein levels (LOD score 5.3) on chromosome 14

250 However, the resistin receptor and the molecular mechanisms mediating

251 rallel high-throughput robotic processing of resistin related disease cohorts.

252 NP rs13144478 with NDST4 gene expression and resistin-related disease.

253 Marked variation in resistin release and the neutrophil secretome profile we

254 newly defined family of proteins, including resistin, Relm-beta, and Relm-gamma.

255 ogenic factor (HIMF) is a member of the FIZZ/resistin/RELM family of proteins that we have shown to h

256 n muscle, and these changes were reversed by resistin replacement.

257 A high resistin response was triggered exclusively by SpeB-nega

258 centrations of TNF-alpha, IL-6, adiponectin, resistin, retinol binding protein-4, or intraabdominal f

259 ha, IL-6, high-molecular-weight adiponectin, resistin, retinol binding protein-4, or intraabdominal o

260 was positively associated with expression of resistin (RETN) and negatively associated with expressio

261 Unlike expression of Retn in mouse, human resistin (RETN) is expressed primarily in macrophages.

262 chromosome 19p13 affecting the abundance of resistin (RETN) mRNA in the omental adipose tissue of ba

263 Rhox5-regulated genes are insulin 2 (Ins2), resistin (Retn), and adiponectin (Adipoq), all of which

264 In addition, the resistin-rising allele of the TYW3/CRYZ SNP rs3931020, b

265 he interplay between adiponectin, FGF21, and resistin signaling pathways during the onset of insulin

266 eukin-8, monocyte chemoattractant protein-1, resistin, soluble interleukin-1 receptor I, soluble inte

267 alysis showed the expression of galectin-12, resistin, SREBP-1, and stearoyl-CoA desaturase mRNAs in

268 The resistin standard addition curve was constructed from se

269 Leptin and resistin stimulated GH-release, a response that was bloc

270 Circulating resistin stimulates endogenous glucose production (GP).

271 ted that levels of the adipokines leptin and resistin, the inflammatory marker myeloperoxidase (MPO),

272 n resistance onset orchestrated by a central resistin-TLR4 pathway that impairs adiponectin signaling

273 rkedly diminished the ability of circulating resistin to enhance GP.

274 In addition to the ability of resistin to sensitize neutrophils to LPS stimulation, hu

275 ime, to our knowledge, the direct binding of resistin to Toll-like receptor (TLR) 4 receptors in the

276 Resistin-treated human articular chondrocytes increased

277 Resistin treatment also decreased plasma adiponectin lev

278 Central resistin treatment inhibited insulin-dependent phosphory

279 transcription inhibitor actinomycin D after resistin treatment or with the NF-kappaB inhibitor IKK-N

280 d in Retn(+/-) and Retn(-/-) adipocytes, but resistin treatment rescued LPL responsiveness to GIP.

281 with the NF-kappaB inhibitor IKK-NBD before resistin treatment.

282 s binding to PTEN promoter were increased by resistin treatment.

283 Overexpression of resistin using adenoviral vector in neonatal rat ventric

284 Here, we show that recombinant human resistin was able to protect the heat-labile enzymes cit

285 A ketamine-induced decrease in resistin was also observed; because resistin is a potent

286 Central infusion of resistin was associated with neuronal activation in the

287 In 3T3-L1 cells, resistin was demonstrated to be a key mediator of GIP st

288 Resistin was detected in the GCF of all patients.

289 Resistin was found to promote epithelial-mesenchymal tra

290 The serum concentration of resistin was higher in overweight/obese OA patients, com

291 Resistin was initially defined based on its insulin resi

292 rage, TGF-beta was elevated (P = 0.0052) and resistin was lower (P = 0.0052) in patients compared wit

293 Although resistin was recently found to modulate insulin resistan

294 elevated resistin levels or serum from which resistin was removed via antibody-immunoprecipitation.

295 Plasma resistin was significantly higher in patients with septi

296 Another RELM family member, human resistin, was also bactericidal, suggesting that bacteri

297 Increased circulating concentrations of resistin were associated with incident heart failure, ev

298 nsity lipoprotein-cholesterol (LDL-CHL), and resistin were higher in the raspberry group.

299 PYY, ghrelin, and resistin were significantly elevated in cases and fell d

300 The roles of endogenous and recombinant resistin were subsequently reversed, using rhRES as the

301 , adipokines (i.e., leptin, adiponectin, and resistin) were undetectable or found at very low levels