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1 nctions (HJs), identifying SLX1-SLX4 as a HJ resolvase.
2 es x res recombination promoted by wild-type resolvase.
3 proach for identifying a eukaryotic Holliday resolvase.
4 and regulation in recombination by wild-type resolvase.
5 sed to be an example of a eukaryotic nuclear resolvase.
6 of double Holliday junctions (HJs) by an HJ resolvase.
7 donuclease Mus81-Eme1 is a Holliday junction resolvase.
8 ers, required the meiosis-specific MutLgamma resolvase.
9 ed that it functions as a Holliday structure resolvase.
10 for the broad substrate specificity of phage resolvase.
11 ke structures in cells lacking Mus81-Eme1 HJ resolvase.
12 ted tet gene flanked by targets for the TnpR resolvase.
13 avages characteristic of a Holliday junction resolvase.
14 interface that abolish activity of wild-type resolvase.
15 1 from humans and fission yeast encodes a HJ resolvase.
16 expression of a bacterial Holliday junction resolvase.
17 ystal structure of the canarypox virus (CPV) resolvase.
18 tes DNA repair in strains lacking the RuvABC resolvase.
19 obstacle may interfere with the binding of a resolvase.
20 expression of a bacterial Holliday junction resolvase.
21 s evaluated from the degree of inhibition of resolvase.
22 are subunits of a nuclear Holliday junction resolvase.
23 sis to investigate such residues in the RusA resolvase.
24 binding and catalysis by a Holliday junction resolvase.
25 n established as a major cellular quadruplex resolvase.
26 dimers in the synaptic complex of gammadelta resolvase.
27 t to a regulatory sequence recognized by Tn3 resolvase.
28 ing protein Brc1 and Mus81 Holliday junction resolvase.
29 SOS induction, and RuvABC Holliday-junction resolvase.
30 nformation of the DNA junction when bound by resolvase.
31 fferent functions of the viral and bacterial resolvases.
32 transposases and RuvC-like Holliday junction resolvases.
33 opological selectivity as Tn3 and gammadelta resolvases.
34 new type of substrate for Holliday junction resolvases.
35 pite a lack of sequence homology between the resolvases.
36 mmetry, a feature more akin to cellular RuvC resolvases.
37 sing shared by prokaryotic and eukaryotic HJ resolvases.
38 tructure-selective endonucleases known as HJ resolvases.
39 that encode putative Holliday junction (HJ) resolvases.
40 /RecBCD is compared to that of the RecU/RuvC resolvases.
44 associated with AU rich elements) (RHAU) (G4 resolvase 1), Bloom helicase (BLM), and Werner helicase
45 to the putative resolution site for the ParA resolvase, a potential hot spot for those transposons.
49 This mechanism stands in contrast to classic resolvase activities that use a structure-specific endon
50 ain of Ydc2 resulted in the complete loss of resolvase activity and impaired significantly the bindin
51 recombinant YDC2 exhibits Holliday junction resolvase activity and is, therefore, a functional S.pom
52 helicase shown to have G-quadruplex (G4)-RNA resolvase activity and the major source of G4-DNA resolv
53 on analyses, we found that Holliday junction resolvase activity associated tightly and co-eluted with
54 preferences for Mg(2+) versus Mn(2+) Optimal resolvase activity is maintained with 5 mum Mn(2+) and 1
56 provide evidence that the Holliday junction resolvase activity of Ydc2 is required for mtDNA transmi
58 etramolecular G4-DNA into single strands (G4-resolvase activity) has been observed only in recombinan
59 to linear duplexes as would be expected of a resolvase activity, the artificial cruciforms were degra
65 has been proposed to be a Holliday junction resolvase and has now been found to be responsible for n
69 extensively redesigned and highly convergent resolvase and invertase populations in the context of en
70 al intriguing structural differences between resolvase and RuvC, and a model of the CPV resolvase.Hol
71 ike a canonical, RuvC-like Holliday junction resolvase and support a novel model in which Mlh1-Mlh3 i
73 using the resII-resIII synapse formed by Tn3 resolvase and the LER synapse formed by phage Mu transpo
75 that a specific synaptic structure formed by resolvase and the res accessory sequences permits Cre to
77 ecombinase family, which includes transposon resolvases and DNA invertases, in that they utilize two
78 at its Atu2523 gene encodes a protelomerase (resolvase) and that the purified enzyme can generate the
80 s are a collection of putative transposases, resolvases, and integrases, suggesting an evolution invo
81 to the second gene of IS1535 (annotated as "resolvase," apparently due to a weak short recombinase m
82 irus, bacterial, and fungal mitochondrial HJ resolvases are consistent with their predicted evolution
84 The model also explains why the poxvirus resolvases are more promiscuous than RuvC, cleaving a va
89 f resolvase-mediated cleavage and effects on resolvase binding and synapsis, providing insight into t
90 ve D70N variant of the Escherichia coli RusA resolvase bound to a duplex DNA substrate that reveals c
91 nvestigated the stability of synapses of Tn3 resolvase-bound res recombination sites, in plasmids con
92 we propose that pairing interactions between resolvase-bound res sites are in a state of rapid flux,
93 nsight into how a Holliday junction-specific resolvase can evolve into a debranching endonuclease tai
94 scopy that purified T4 gp49 endonuclease VII resolvase can release DNA compression in vitro in prohea
95 gment, and pht operon, encoding a transposon resolvase, catabolism of protocatechuate (3,4-dihydroxyb
98 n vector containing a codon optimized serine resolvase CinH recombinase (CinH) and its recognition si
100 deletion by blocking Holliday junction (HJ) resolvase cleavage activity, but whether TRF2 also modul
103 he RAD51C-XRCC3-associated Holliday junction resolvase complex associates with crossovers and may pla
104 characterized, but an atomic structure of a resolvase complex with a Holliday junction remained elus
107 structure of a eukaryotic Holliday junction resolvase confirms a distant evolutionary relationship t
108 of the site-specific recombinase gammadelta resolvase covalently linked through Ser10 to two cleaved
109 SOS-deficient (lexA3) and Holliday junction resolvase-deficient (ruvC) cells were very sensitive to
114 tive complex, the catalytic domains from two resolvase dimers form a central core, while the DNA bind
115 s an architectural role that is taken by two resolvase dimers in models of the Tn3/gammadelta synapse
117 stly, we describe possible roles for the A22 resolvase DNA-branch nuclease activity in DNA replicatio
118 alent metals dictate the conformation of FPV resolvase-DNA complexes and subsequent DNA cleavage.
122 role of the vaccinia virus Holliday junction resolvase during an infection, we constructed two recomb
125 ce charge potential of the Holliday junction resolvases endo VII, RuvC, Ydc2, Hjc and RecU, despite h
126 clude hydroxyl radicals, KMnO4, the junction resolvases endonuclease VII and RuvC, and RuvC activatio
127 , topoisomerase action and Holliday junction resolvases, ensure that all SCIs are removed before they
130 m similar to that shown by the prototypic HJ resolvase, Escherichia coli RuvC protein, but it is uncl
131 insights into how archaeal Holliday junction resolvases evolved to incise 5' flap substrates and how
133 utants of the serine recombinase, gammadelta resolvase, form a simplified recombinogenic synaptic com
135 e determined the crystal structure of a RuvC resolvase from bacteriophage bIL67 to help identify feat
138 (also known as SpCce1), a Holliday junction resolvase from the fission yeast Schizosaccharomyces pom
139 d Holliday junction cleaving (Hjc) family of resolvases from the moderately thermophilic archaeon Met
141 he site-specific DNA recombinase, gammadelta resolvase, from Escherichia coli catalyzes recombination
143 we present the crystal structure of human HJ resolvase GEN1 complexed with DNA at 3.0 A resolution.
146 a defective H-19B prophage encoding the TnpR resolvase gene downstream of the phage PR promoter and a
148 transcriptional fusions of genomic DNA to a resolvase gene was ingested by five healthy adult volunt
150 k repair, and in ruvC, the Holliday junction resolvase gene, were synthetically lethal with dnaB107,
153 mutant; and (3) expression of a bacterial HJ resolvase has no suppressive effect on mus81 meiotic phe
163 n resolvase and RuvC, and a model of the CPV resolvase.Holliday junction complex provides insights in
164 that Rap can function as a Holliday junction resolvase in addition to eliminating other branched stru
169 that Mus81/Mms4 is not the major meiotic HJ resolvase in S. cerevisiae: (1) MUS81/MMS4 is required t
170 les for the vaccinia virus Holliday junction resolvase in the replication and processing of viral DNA
172 ed from each mutant strain by supplying ParA resolvase in trans, yielding a strain in which a long se
173 interest to further characterize a poxvirus resolvase in view of the low sequence similarity with Ru
175 studies reveal potential roles for these HJ resolvases in repair after DNA damage and during meiosis
176 ites for site-specific recombination by Tn21 resolvase, in buffers that contained either EDTA or CaCl
177 structural elements of RuvC, a bacterial HJ resolvase, in uncharacterized open reading frames from p
178 ites for site-specific recombination by Tn21 resolvase; inhibition of recombination would indicate th
180 striction endonucleases, DNA-repair enzymes, resolvases, intron splicing factors and transcription fa
182 activated catalytic domain derived from the resolvase/invertase family of serine recombinases and a
184 activated catalytic domains derived from the resolvase/invertase family of serine recombinases fused
189 e phiC31 encodes an integrase related to the resolvase/invertases and is evolutionarily and mechanist
191 different group, are similar in size to the resolvase/invertases but have the DNA binding domain N-t
192 The well studied serine recombinases, the resolvase/invertases, bring two recombination sites toge
193 e three structural groups represented by the resolvase/invertases, the large serine recombinases and
195 and the resT gene, which encodes a telomere resolvase involved in resolution of the replicated telom
196 mbinational repair, but since a classic RecG resolvase is absent from H. pylori, deployment of the Re
198 on is required for viral replication, so the resolvase is an attractive target for small molecule inh
201 specificity: the branch migration-associated resolvase is highly specific for Holliday junctions, whe
204 r nuclease, the Mus81-Eme1 Holliday junction resolvase, is required to generate crossovers accompanyi
205 tion, our study revealed a Holliday junction resolvase-like activity in the liver that cleaved T-shap
207 a tetrameric synaptic complex of gammadelta resolvase linked to two cleaved DNA strands had suggeste
209 To provide a platform for understanding resolvase mechanism and designing inhibitors, we have de
210 iesters result in abolition or inhibition of resolvase-mediated cleavage and effects on resolvase bin
211 However, after infection of these cells, resolvase-mediated excision of the dal gene resulted in
212 oxP sites in several distinct ways, and that resolvase-mediated intertwining of the accessory sequenc
216 ynapse is assembled by sequential binding of resolvase monomers to site I followed by interaction of
218 eriophage S-PM2, which is similar to the DNA resolvase of bacteriophage T4 and is encoded adjacent to
219 factors on the activity and structure of the resolvase of fowlpox virus, which provides a tractable m
228 that evolutionary loss of the H. pylori RecG resolvase provides an "antirepair" pathway allowing for
235 n recently identified as a Holliday junction resolvase, results in increased sensitivity of the cells
236 s, bacterial transposases, Holliday junction resolvases, retroviral integrases and many other enzymes
237 Likewise, expression of the bacterial HJ resolvase RusA partially rescues the defects of nse6Delt
242 tructural homology with the Escherichia coli resolvase RuvC but Ydc2 contains a small triple helical
244 Type II R-M systems, the nuclease nucT and resolvase ruvC reduced integration length whereas the he
245 , showing that, like the Escherichia coli HJ resolvase RuvC, it binds specifically to HJs and resolve
250 is thaliana has two putative homologs of the resolvase (structure-specific endonuclease): GEN1/Yen1.
251 Comparisons of the four known tetrameric resolvase structures show that the subunits interact thr
252 half-site that is not covalently linked to a resolvase subunit dissociates rapidly from the synapse,
254 prior formation of a synapse, comprising 12 resolvase subunits and two recombination sites (res).
257 ssembling the topologically well defined Tn3 resolvase synapse, it is possible to determine whether t
259 Cleavage of the cruciform by the junction resolvase T4 endonuclease VII is independent of PARP-1,
262 n a synapse of two sites, held together by a resolvase tetramer; cleavage at one site stimulates clea
264 oduction of modified substrate cassettes for resolvase that can be positively and negatively selected
266 iochemical studies show that SLX-MUS is a HJ resolvase that coordinates the active sites of two disti
267 resolution, forms a synaptic intermediate of resolvase that is covalently linked to two cleaved DNAs,
268 y employing a portal-bound Holliday junction resolvase that trims and releases these DNA roadblocks t
269 of the site-specific recombinase, gammadelta resolvase, that form activated tetramers have been deter
270 time assays, showing that, as with vaccinia resolvase, the fowlpox enzyme could cleave a wide array
271 ng up to six res recombination sites for Tn3 resolvase to analyse looping interactions (synapsis) in
272 No mutations strongly inhibited binding of resolvase to site I, but several caused conspicuous chan
273 eed RecA recombinase and a Holliday junction resolvase to survive rapid growth, but SOS induction, al
274 utations at the interface that either enable resolvase to synapse two copies of site I or inhibit syn
275 rgeted an Escherichia coli Holliday junction resolvase to the nuclei of fission yeast recombination-d
278 These findings provide a tractable poxvirus resolvase usable for the development of small molecule i
280 We have analysed the in vitro properties of resolvase variants with 'activating' mutations, which ca
283 ells infected with vA22-HA revealed that the resolvase was expressed after the onset of DNA replicati
286 east CCE1 gene, encoding a Holliday junction resolvase, was introduced into cells carrying partially
287 nique active site structure observed for CPV resolvase, we have carried out a series of experiments t
288 ages catalysed by the serine recombinase Tn3 resolvase, we made modified recombination sites with a s
289 joining by the site-specific recombinase Tn3 resolvase, we mutated conserved polar or charged residue
291 in the RuvC family of Holliday junction (HJ) resolvases, which have a key role in homologous recombin
292 li radiation and UV sensitive C paradigm for resolvases, which involves resolving HJs by symmetricall
293 precleavage synaptic tetramer of gammadelta resolvase, whose structure is not known, may be formed b
294 r than the 150 domains detected with the Tn3 resolvase, wild-type cells measured over a 10 min time s
295 cible transcription, we constructed a set of resolvases with cellular half-lives ranging from less th
297 d properties of eukaryotic Holliday junction resolvases, with intriguing connections to DNA replicati
298 Schizosaccharomyces pombe Holliday junction resolvase Ydc2 revealed significant structural homology
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