ライフサイエンスコーパス: response regulator

1 rgfA results in premature truncation of the response regulator.

2 d NreC has been characterized as its cognate response regulator.

3 A is a sensor kinase/phosphatase for CpxR, a response regulator.

4 The JmjC protein Mina is an important immune response regulator.

5 n indicates a role in repression by the SalR response regulator.

6 ne pentaphosphate (ppGpp) alarmone/stringent response regulator.

7 transfers its phosphoryl group to a cognate response regulator.

8 er from its sensor kinase domain to the AtsT response regulator.

9 ze the hydrolytic dephosphorylation of their response regulator.

10 ng sensor histidine kinase and a cytoplasmic response regulator.

11 through transcription inhibition of the RcsB response regulator.

12 pe systems that employ a sensor kinase and a response regulator.

13 sensor histidine kinase (HK) and an effector response regulator.

14 y named the protein RsrR for Redox sensitive response Regulator.

15 y, thereby regulating the levels of the CheY response regulator.

16 f XBP1u mRNA to spliced XBP1 (XBP1s), an UPR response regulator.

17 ctive state of receiver domains of bacterial response regulators.

18 s a knotless red/far-red phytochrome and two response regulators.

19 to an uncharacterized family of DNA-binding response regulators.

20 lects the transcriptional activity of type-B response regulators.

21 ation and phosphotransfer from HnoK to three response regulators.

22 s the functional capabilities of DNA-binding response regulators.

23 se to cytokinin being mediated by the type-B response regulators.

24 the core genome, some of which encode orphan response regulators.

25 s and similar mechanisms of action for these response regulators.

26 dies and by analogy with other two-component response regulators.

27 comprise histidine kinases and their cognate response regulators.

28 esis, transport/binding, and transcriptional/response regulators.

29 ve concentration exceeds that of all soluble response regulators.

30 all molecule scaffold that targets bacterial response regulators.

31 se activity and mutants involving the type B response regulators.

32 rv0431 be named "vesiculogenesis and immune response regulator."

33 copper-sensing transcription factor, copper response regulator 1 (CRR1), dramatically reduces the co

34 n of a CML-interacting partner, PRR2 (PSEUDO-RESPONSE REGULATOR 2), a plant specific transcription fa

35 GLK2 and the related gene ARABIDOPSIS PSEUDO RESPONSE REGULATOR 2-LIKE (SlAPRR2-LIKE) to establish th

36 ows partial identity to maize gene BT068773 (RESPONSE REGULATOR 6).

37 repressor that binds the promoter of Pseudo Response Regulator 7 (PRR7) at a conserved binding site.

38 Here, we show that PSEUDO-RESPONSE REGULATOR 7 (PRR7), a central component of the

39 or through the morning-expressed gene PSEUDO-RESPONSE REGULATOR 7 (PRR7), and we identify that prr7 m

40 Finally, we identified the cognate response regulator (A1S_0236) for GacS and confirmed the

41 DELLA proteins, negative GA response regulators, act as positive factors for ovule i

42 Type-B response regulators, acting as transcriptional activator

43 We have previously showed that the RcsB response regulator activates expression of the cupD gene

44 The ResD response regulator activates transcription of diverse ge

45 eus VraR, a vancomycin-resistance-associated response regulator, activates a cell-wall-stress stimulo

46 The dominant theory on the mechanism of response regulators activation in two-component bacteria

47 between the sabA promoter region and ArsR, a response regulator affecting sabA expression.

48 expression of one CK receptor (AHK4) and one response regulator (AHP6).

49 e-virulence factors, and through its cognate response regulator AlgB.

50 losis genes Rv0844c/Rv0845 encoding the NarL response regulator and NarS histidine kinase are hypothe

51 relevance to NO metabolism and that the ResD response regulator and NsrR coordinately regulate transc

52 or two-component system mutants, the cognate response regulator and sensor kinase genes clustered tig

53 r two SARPs, a CRP family regulator, an iron response regulator and that for LexA.

54 e questions, we studied the Escherichia coli response regulator and transcription factor RcsB, which

55 rate that RpoE is a key cell envelope stress response regulator and, similar to E. coli, RpoE may hav

56 nges in the DNA arising from the presence of response regulators and coinducer molecules binding to C

57 via several experimental approaches that the response regulators and coinducers act synergistically o

58 identify the amino acid interactions between response regulators and histidine kinases and the specif

59 those determinants might vary for different response regulators and phosphodonors are largely unknow

60 of using DNA binding domains from bacterial response regulators and their cognate binding elements i

61 CST system in H. ducreyi is CpxRA; CpxR is a response regulator, and CpxA is a sensor kinase.

62 FimY does not appear to function as a response regulator, and its activity can be lost by mimi

63 Hemin binding proteins, secretion systems, response regulators, and genes for invasion and cell att

64 e ability to act as a phosphodonor for their response regulators, and in many cases the ability to ca

65 harboring the domains of sensor kinases and response regulators, and thus, are thought to autophosph

66 n Arabidopsis (Arabidopsis thaliana), type-B response regulators (ARABIDOPSIS RESPONSE REGULATORS [AR

67 We found that only three response regulators, ArcA, CpxR, and RcsB, produce stron

68 ion and was dependent on either the nitrogen response regulators AreA and AtfA or the iron response r

69 lade of the CK-responsive type-A Arabidopsis response regulator (ARR) genes increases in buds followi

70 characterized the growth-promoting cytokinin response regulator ARR1, and the wood development genes

71 network initiated by the type-B ARABIDOPSIS RESPONSE REGULATORs (ARRs) that mediate the cytokinin pr

72 is regulated by action of type-B Arabidopsis response regulators (ARRs).

73 tionally antagonistic classes of Arabidopsis response regulators (ARRs): type B ARRs (response activa

74 na), type-B response regulators (ARABIDOPSIS RESPONSE REGULATORS [ARRs]) form three subfamilies based

75 nsistent with the role of type-B Arabidopsis response regulators as primary mediators of cytokinin-re

76 Previous studies indicated that the response regulators, as well as various coinducers (effe

77 GATA4 activation depends on the DNA damage response regulators ATM and ATR, but not on p53 or p16(I

78 in AtsR, and we also identify the cytosolic response regulator AtsT (BCAM0381) as a key component of

79 e, comprehensive kinetic characterization of response regulator autophosphorylation is limited to Che

80 Although response regulator autophosphorylation is physiologicall

81 of phosphate flux from a histidine kinase to response regulators based on targeting by eukaryotic pro

82 an overrepresentation of type-B Arabidopsis response regulator binding elements, consistent with the

83 The unfolded protein response regulator binding immunoglobulin protein/78-kDa

84 ication was completely dependent on the OmpR response regulator, but did not require known OmpR-regul

85 proprietary ligand Phos-tag to separate the response regulator BvgA from its phosphorylated counterp

86 and transferring the phosphoryl group to the response regulator BvgA.

87 In contrast, inactivating the CpxR response regulator by mutating the phosphorylation site

88 robust, constitutive activation of the QseB response regulator by the noncognate polymyxin resistanc

89 ting of the CprK sensor kinase and an orphan response regulator (CD3320; CprR).

90 An activated form of the response regulator CheY destabilizes the parallel arrang

91 the gain of the pathway at the level of the response regulator CheY increases with overall chemotaxi

92 rotation is determined by the intracellular response regulator CheY, which when phosphorylated (CheY

93 Binding of the chemotaxis response regulator CheY-P promotes switching between rot

94 ns to phosphorylate the flagellar rotational response regulator, CheY, and modulate the flagellar rot

95 in the steady-state level of the chemotaxis response regulator, CheY-P, by adjusting the number of F

96 c, a process controlled by the two-component response regulator CiaR and requiring Sia uptake by the

97 on the protein level, we found that the PmrA response regulator contributes to qseB transcription in

98 sis factors, including chaperones and stress-response regulators, controlled the response to carfilzo

99 In Streptococcus mutans, the global response regulator CovR plays an important role in biofi

100 The response regulator CpdR couples phosphorylation events i

101 l phosphate-dependent phosphorylation of the response regulator CpxR and (ii) acetyl coenzyme A-depen

102 The response regulator CpxR appears to function as a positiv

103 embrane histidine kinase CpxA, the cytosolic response regulator CpxR, and the periplasmic auxiliary f

104 ls of CpxA, which activates virF through the response regulator CpxR.

105 ponse owing to buildup of the phosphorylated response regulator (CpxR approximately P) that occurs in

106 rothelial cells, and we demonstrate that the response regulator (CpxR)-sensor kinase (CpxA) two-compo

107 The response regulator CsrR repressed expression of Ape1, wh

108 activation and deactivation of the essential response regulator CtrA.

109 the degradation of an essential DNA-binding response regulator, CtrA, by the ClpXP protease.

110 Deletion of the cpxR transcriptional response regulator derepresses hlyA expression, leading

111 In contrast, deletion of the rpoS stress response regulator did not affect in vivo survival.

112 Our data challenge the notion that response regulator dimers primarily form between two pho

113 the kinases PleC and DivJ and their cognate response regulator DivK.

114 on or in the presence of bacterial stringent response regulators DksA and ppGpp.

115 and likely other plants that display common response regulator DNA-binding specificities.

116 The molecular basis for formation of stable response regulator-DNA complexes that precede the assemb

117 Our results show that the response regulator domain of FrzE is a negative regulato

118 This indicates that the response regulator domain of FrzE is required for the in

119 lation of FrzZ; this inhibition required the response regulator domain of FrzE.

120 ted an intramolecular phosphotransfer to the response regulator domain that resulted in c-di-GMP degr

121 domain, followed by an autokinase domain, a response regulator domain, and a C-terminal c-di-GMP pho

122 ost exclusively to their covalently attached response regulator domain, whose effective concentration

123 by phosphotransfer to an Asp residue of the response regulator DosR.

124 me receptors or activate overlapping sets of response regulators downstream.

125 ested by a histidine kinase (receptor) and a response regulator (effector).

126 carboxypeptidase encoded by pbpX, the orphan response regulator encoded by degU, and the highly abund

127 nsional protein structures predicted for the response regulators encoded by cop and czc operons showe

128 ssion between the two strains, a GntR-family response regulator encoding gene (LMOf2365_0414), design

129 ylation kinetics of 21 variants of the model response regulator Escherichia coli CheY that contained

130 The response regulator, Escherichia coli CheY, allostericall

131 a dual-hairpin substrate for the RNA binding-response regulator, EutV.

132 ve conditions under which PleC, CckA and its response regulators exhibit bistable behavior, thus prov

133 of dosR, which encodes the immediate hypoxic response regulator, failed to adapt to low-oxygen stress

134 bers of the TIMING OF CAB1 EXPRESSION/PSEUDO RESPONSE REGULATOR family of core-clock genes in the aft

135 by the adaptor protein RssB, a member of the response regulator family.

136 consisting of the sensor kinase FlgS and the response regulator FlgR.

137 rithm's performance on histidine kinases and response regulators from bacterial two-component signali

138 fimZ is homologous to response regulators from other two-component regulatory

139 ously, we showed that phosphorylation of the response regulator FrzZ correlates with reversal frequen

140 phosphotransfer from the kinase FrzE to the response regulator FrzZ is required, it is unknown how p

141 ight into how the anti-adaptors perturb RssB response regulator function and activation.

142 est that CheY2, despite resembling a typical response regulator, functions distinctively from most ot

143 izes a complex between 14-3-3 and the stress response regulator GCN1, inducing GCN1 turnover and neur

144 rameshift mutation that inactivates the etaR response regulator gene, while M7 is a wild-type reverta

145 d ZmCCT, a homologue of the rice photoperiod response regulator Ghd7, as the most important gene affe

146 ock function in Arabidopsis thaliana: PSEUDO-RESPONSE REGULATORs, GIGANTEA, and the evening complex g

147 esponse regulators AreA and AtfA or the iron response regulator HapX.

148 alk between a sensor kinase and a noncognate response regulator has been previously demonstrated, the

149 Histidine kinases and response regulators have an intrinsic modularity that se

150 ctivation and new roles for unphosphorylated response regulators have been identified.

151 , PGC-1alpha requires the central heat shock response regulator heat shock factor protein 1 (HSF1) to

152 ated monomers and raise the possibility that response regulator heterodimers containing one phosphory

153 Two of these response regulators, HnoB and HnoD, regulate cyclic-di-G

154 Here we investigate the essential orphan response regulator HP1043, a member of the OmpR/PhoB sub

155 rately knocked out each two-component system response regulator in MP1 and performed competitions aga

156 ression of cfcR, encoding the only GGDEF/EAL response regulator in Pseudomonas putida, is transcripti

157 nes, thereby implicating a role for the DevR response regulator in the regulation of nitrate metaboli

158 However, the role of the third response regulator in the signaling network, HnoC, has n

159 nt system CovS/CovR, which is the major acid response regulator in this organism, is required for sur

160 tems in RNA molecules, and kinases and their response regulators in signal-transduction systems.

161 -binding domain (DBD) of only one of the two response regulators in the complex.

162 ith VirG and Escherichia coli UhpA, and NarL response regulators indicated compatibility of these bac

163 These are all response regulators involved in signal transduction.

164 nsiveness of ftrA is dependent upon the iron response regulator Irr.

165 dobacteriacae as it contains a putative iron response regulator (Irr) but does not possess a copy of

166 iron directly, the rhizobia employ the iron response regulator (Irr) to monitor and respond to the s

167 nd gel shift assays determined that the AirR response regulator is a direct positive regulator of the

168 ng on how sensory information carried by the response regulator is best utilized by the motor, we ide

169 (TCSs), dephosphorylation of phosphorylated response regulators is essential for resetting the activ

170 aponicum transcriptional regulator Irr (iron response regulator) is a key regulator of the iron homeo

171 present structures of DNA complexed with the response regulator KdpE, a member of the OmpR/PhoB famil

172 show that deletion of the gene encoding the response regulator, LiaR (a member of the LiaFSR system

173 at low cell density, the sigma 54-dependent response regulator LuxO is active and regulates the two

174 The quorum-sensing response regulator LuxO represses type VI secretion gene

175 phorylation and inhibition of the downstream response regulator LuxO.

176 Francisella contains only three response regulators, making it an ideal system to study.

177 ts have elevated activities for three stress response regulators, MarA, SoxS, and Rob, and we suggest

178 ily, the calcineurin-independent, osmostress response regulator NFAT5.

179 evidence that, in the receiver domain of the response regulator nitrogen regulatory protein C (NtrC(R

180 sparent testa glabra2 and HAIKU1 and defense response regulators non-expressor of pathogenesis relate

181 nuclear translocation of the anti-oxidative response regulator, Nrf2.

182 e the free energy landscape of the bacterial response regulator NtrC by combining computation and nuc

183 n in a global activator (gacA), encoding the response regulator of a two-component regulatory system.

184 vation of a gene (mesR) encoding a predicted response regulator of a two-component signal transductio

185 The AccR response regulator of Azoarcus sp. CIB controls succinat

186 that mutation of the ciaR gene, encoding the response regulator of the CiaRH two-component system in

187 High expression of PcrZ depends on PrrA, the response regulator of the PrrB/PrrA two-component system

188 red the expression and activity of DegU, the response regulator of the two-component DegS-DegU circui

189 FgrM, which is also a response regulator of the two-component His-Asp phosphor

190 The Agrobacterium tumefaciens VirG response regulator of the VirA/VirG two-component system

191 RcsB, the response regulator of this signaling system, is a pleiot

192 Especially, response regulators of two component systems (TCSs), the

193 that FimZ belongs to the family of bacterial response regulators of two-component systems.

194 We also show that the response regulator OmpR, which had previously been hypot

195 gnificantly activated by the cellular stress response regulator, p53.

196 re we describe WigK/WigR, a histidine kinase/response regulator pair that enables Vibrio cholerae, th

197 virulence regulator Mga (mga), the peroxide response regulator PerR (perR), and the RofA-like regula

198 The peroxide stress response regulator PerR coordinates the oxidative-stress

199 We characterized autophosphorylation of the response regulator PhoB, known to dimerize upon phosphor

200 The response regulator PhoP and its cognate sensor kinase Ph

201 that is triggered by phosphorylation of the response regulator PhyR.

202 involving the anti-sigma factor NepR and the response regulator PhyR.

203 actor NepR, which is itself regulated by the response regulator PhyR.

204 g protein, with one of the Chp system output response regulators PilG.

205 We also show that the GlnR response regulator plays a very different role in M. tub

206 st likely functions via the putative cognate response regulator PlrR.

207 The orphan response regulator PmrA is essential for the intramacrop

208 aptor complex includes CpdR, a single-domain response regulator; PopA, a cdG-binding protein; and Rcd

209 Drugs that target the response regulator portion of two-component systems repr

210 TCS) comprising sensor histidine kinases and response regulator proteins are among the most important

211 In two-component signal transduction, response regulator proteins contain the catalytic machin

212 Response regulator proteins within two-component signal

213 n between histidine kinases and their output response regulator proteins, and thus are a good target

214 ther increased in response to nitrite by the response regulator proteins, NarL and NarP.

215 of signaling phosphates to the CheY and CheB response regulator proteins.

216 predict pairing of the histidine kinase and response-regulator proteins forming TCSs.

217 Pseudo response regulators (PRRs) comprise a five-member family

218 PSEUDO-RESPONSE REGULATORs (PRRs) play overlapping and distinct

219 ess-induced degradation of YfgM relieves the response regulator RcsB and thereby permits cellular pro

220 SypE contains a central response regulator receiver domain flanked by putative k

221 hitectures except for the loss of C-terminal response regulator receiver domains in the streptophyte

222 ine/aspartate phosphorelays of two-component response regulators, recent work in Mycobacterium tuberc

223 Most activated response regulators regulate transcription by binding ti

224 The DNA-binding response regulator RegX3 is normally activated by phosph

225 s that impinge on actin cytoskeleton and its response regulators remain largely unknown.

226 a key Pseudomonas aeruginosa transcriptional response regulator required for virulence.

227 scnR, which encode the histidine kinase and response regulator, respectively, of a two-component sys

228 ucture of the N-terminal domain of QseB, the response regulator responsible for biofilm formation.

229 that depletion or overproduction of the AirR response regulator resulted in a corresponding decrease

230 /far-red photoreceptor, RfpA, as well as two response regulators (RfpB and RfpC), one of which is a D

231 ing the sensor histidine kinase RgfC and the response regulator RgfA mediate GBS binding to extracell

232 Here, we show that the response regulator RpaA serves as the master regulator o

233 The response regulator RpaB (regulator of phycobilisome asso

234 Expression of the general stress response regulator RpoS and formation of biofilm communi

235 receptor histidine kinase (HK) and a partner response regulator (RR) and control important prokaryoti

236 (P4) of CheA and transfers it to the cognate response regulator (RR) CheY, which is docked by the P2

237 oding sequences of histidine kinase (HK) and response regulator (RR) components were codon-optimized

238 tion factor CtrA via an interaction with the response regulator (RR) DivK.

239 Phosphorylation of the response regulator (RR) PhoB has been found to be depend

240 followed by phosphoryl transfer to a cognate response regulator (RR) protein, which may affect gene e

241 otransfers reversibly to two separate output response regulator (RR) proteins.

242 histidine kinase (HK) that phosphorylates a response regulator (RR), modulating its activity in resp

243 his study, EpsW, an orphan and single-domain response regulator (RR), was identified as a potential D

244 r between a sensor kinase (SK) and a cognate response regulator (RR).

245 ific, with one sensor talking to its cognate response regulator (RR).

246 Two-component systems [sensor kinase/response regulator (RR)] are major tools used by microor

247 ] and a cognate, intracellular effector [the response regulator (RR)].

248 , transferring information toward downstream response regulators (RR).

249 study on the histidine kinase HK853 and its response regulator RR468 from Thermotoga maritima, here

250 bacitracin and nisin, respectively, the two response regulators (RRs) bind their target promoters, P

251 The OmpR/PhoB family of response regulators (RRs) is the largest class of two-co

252 hotransfer proteins and different classes of response regulators (RRs).

253 ent activation of two classes of Arabidopsis response regulators (RRs): the type-B RR (RRB) transcrip

254 , the mechanism for dephosphorylation of the response regulator SaeR has not been identified.

255 regulators, some of which are single-domain response regulators (SD-RRs) such as CheY.

256 Here, we identified the single-domain response regulator (SDRR) SdrG and seven histidine kinas

257 In C. crescentus the CtrA response regulator serves as the master regulator of cel

258 direct repression of three cytokinin A-type response regulators show its role in balancing meristem

259 phorelays comprised of histidine kinases and response regulators, some of which are single-domain res

260 art by the phosphorylated form of the master response regulator Spo0A (Spo0A approximately P).

261 s largely governed by a circuit in which the response regulator Spo0A turns on the gene for the anti-

262 n by accelerating the phosphorylation of the response regulator Spo0A.

263 sively transferred via relay proteins to the response regulator Spo0A.

264 ulation protein NT-NtrC, and the sporulation response regulator Spo0F.

265 atase that dephosphorylates the intermediate response regulator Spo0F.

266 the central phosphotransferase, ChpT, to its response regulator substrate, CtrA, and provide evidence

267 ylation level or the DNA-binding activity of response regulators such as Spo0F, involved in sporulati

268 The sulfur response regulator, SurR, is among a handful of known re

269 kinase RscS, which functions upstream of the response regulator SypG to regulate transcription of the

270 One such regulator, the NtrC-like response regulator SypG, controls biofilm formation and

271 The histidine kinase/response regulator system YehU/YehT of Escherichia coli

272 as direct inhibition of the master nutrient response regulator target of rapamycin complex 1 (TORC1)

273 ation site domain and the binding domain for response regulator target proteins.

274 rylation of HnoC induces dissociation of the response regulator tetramer and detachment of subunits f

275 Inactivation of narP, encoding a response regulator that activates napABC transcription i

276 KdpE is a response regulator that activates the transcription of h

277 n is also controlled by SypE, a multi-domain response regulator that consists of a central regulatory

278 e, while pull-down assays identified BfmR, a response regulator that is the master controller of biof

279 st motile bacteria possess at least one CheY response regulator that is typically dedicated to the co

280 iurnal growth, but mutants defective for the response regulator that mediates transcriptional rhythms

281 A recent study reported that Rrp1, a response regulator that synthesizes cyclic diguanylate (

282 lates reversal frequency through a localized response regulator that targets cell polarity regulators

283 LiaR is the response regulator that, upon phosphorylation, binds in

284 at these findings extend to a large group of response regulators that act as transcription factors.

285 -binding proteins are thought to be stimulus-response regulators that bind to signaling phospholipids

286 eptors with sensor-kinase domains to control response regulators that function as transcription facto

287 These mutants allowed the response regulator to act in the absence of phosphorylat

288 ing of a sensor kinase and a transcriptional response regulator to detect environmental signals and m

289 horylation-mediated dimerization allows many response regulators to bind to tandem DNA-binding sites

290 histidine kinase (TolRSK) and an independent response regulator (TolRRR).

291 or kinase (usually a membrane protein) and a response regulator (usually a DNA binding protein).

292 he hybrid sensor kinase BarA and its cognate response regulator UvrY, members of the two-component si

293 conserved aspartic acid (Asp53) of the LytR response regulator was shown to be the target of phospho

294 kinase and directing flux to the cotargeted response regulator, was significantly more robust to var

295 These signalling complexes phosphorylate a response regulator which in turn governs flagellar motor

296 ms consist of pairs of histidine kinases and response regulators, which mediate adaptive responses to

297 on CSP binding, ComD phosphorylates the ComE response-regulator, which then activates transcription o

298 says demonstrated specificity of the 2AI for response regulators, while computational docking provide

299 led a role for PAX4, GATA, and the ER stress response regulators XBP1 and ATF6.

300 Chemotaxis response regulator Y (CheY), a 129-amino acid bacterial