ライフサイエンスコーパス: restart

1 ication stress by promoting replication fork restart.

2 CD2, followed by FAN1 nuclease-mediated fork restart.

3 anded DNA break repair, and replication fork restart.

4 mventing the need for replication repair and restart.

5 of diverse replication forks to replication restart.

6 aberrations as well as defective replication restart.

7 ifferent pathways to promote fork repair and restart.

8 eckpoint activation and faithful replication restart.

9 replication forks to facilitate replication restart.

10 ication forks to promote their stability and restart.

11 t the expense of lesion-skipping replication restart.

12 ame time repressing stalled replication fork restart.

13 g DSB repair and repressing replication fork restart.

14 omologous recombination and replication fork restart.

15 and STN1 depletion has little effect on fork restart.

16 have roles in recombination and replication restart.

17 ystem for replisome assembly and replication restart.

18 , it remodels the fork to promote repair and restart.

19 subsequent factors required for replication restart.

20 ollapsed replication forks, without apparent restart.

21 RAD51-mediated strand invasion supports fork restart.

22 ging agents and defects in fork stability or restart.

23 in vitro based on their roles in replication restart.

24 ompetent conformation primed for replication restart.

25 replication forks to facilitate replication restart.

26 tic link between Rad53 deactivation and fork restart.

27 tivation is a key mechanism controlling fork restart.

28 anding of primosomal assembly in replication restart.

29 to stalled forks to facilitate repriming and restart.

30 of PTEN with Rad51 in promoting stalled fork restart.

31 poly (ADP-ribose) polymerase/RECQ1-regulated restart.

32 ed ART affects outcomes once these drugs are restarted.

33 ork regression when stalled forks need to be restarted.

34 ase progression, when the same treatment was restarted.

35 stroke and mortality in comparison with not restarting.

36 and that RAD52-dependent HR occurs later to restart a subset of blocked or collapsed replication for

37 ntegrity and poising cells for translational restart, a process that has significant clinical implica

38 C(CTF18)) controls the velocity, spacing and restart activity of replication forks in human cells and

39 ired for chromosome stability and cell cycle restart after checkpoint arrest.

40 ) to be specifically required for cell cycle restart after DNA damage in G1.

41 ylation of Rad53 as well as replication fork restart after DNA damage, suggesting a mechanistic link

42 lays a novel role in genome-wide replication restart after hydroxyurea (HU)-induced replication fork

43 of reversed replication fork processing and restart after prolonged genotoxic stress.

44 rates with Mre11 to promote replication fork restart after release from replication blocks, most like

45 ased and the ability of replication forks to restart after replicative stress is restored.

46 ted and optimized using the Random Walk with Restart algorithm in a protein-protein interaction netwo

47 thod by integrating network random walk with restart algorithm, gene set enrichment analysis, and hyp

48 on stress, including slowed replication fork restart, although DNA replication checkpoints are functi

49 interaction likely promotes replication fork restart and gap avoidance.

50 t auxiliary proteins involved in replication restart and in helping to clear a path along the DNA for

51 ays a major role in HDR-mediated replication restart and in suppressing new origin firing.

52 apsed replication forks by facilitating fork restart and limiting inappropriate recombination that co

53 lly associated with fork repair, replication restart and recombination, establishing new forks with t

54 n the FA pathway: promoting replication fork restart and simultaneously limiting the accumulation of

55 ty necessary for its function in replication restart and that its SET domain is essential for recover

56 CtIP cooperates with FANCD2 to promote fork restart and the suppression of new origin firing.

57 shortened, and pipes experience regular flow restarting and draining.

58 Job inputs are persisted across restarts and running jobs can be cancelled where applica

59 apsed by prolonged replication blocks do not restart, and global replication is rescued by new origin

60 th unscheduled replication fork stalling and restart, and suppresses tumorigenesis, at least partiall

61 Blocked forks must somehow be restarted, and the original blockage cleared, in order t

62 o had 2 negative D-dimer results and did not restart anticoagulant therapy, rates of recurrent VTE we

63 icularly important when planning to start or restart anticoagulation after an intracerebral hemorrhag

64 how to bridge; and 6) outline the process of restarting anticoagulation post-procedure.

65 significant difference between the need for restarting antireflux medication between both groups bec

66 Patients were to start or restart antiretroviral therapy if they met predefined cr

67 checkpoint termination and replication fork restart are less well understood.

68 evidence that mechanisms of DNA replication restart are not identical across diverse species and tha

69 Failure to stabilize and restart arrested forks results in fork collapse and geno

70 ve evolved complex mechanisms to process and restart arrested forks through the coordinated action of

71 work points to replication fork reversal and restart as a central mechanism to ensuring high-fidelity

72 eria plays a key role in DNA replication and restart as a loader protein for the recruitment of repli

73 t the lagging-strand polymerase is forced to restart at short intervals.

74 ion, of DNA replication, and for replication restart at stalled forks.

75 tive helicase at oriC and during replication restart at stalled replication forks.

76 he implementation of the L-BFGS algorithm is restarted at every segment.

77 igatran was held 1 to 2 doses before PVI and restarted at the conclusion of the procedure or as soon

78 atients requiring a drug hold, treatment was restarted at the original dose in 73 (92%) patients.

79 g RNA primers, the lagging-strand polymerase restarts at short intervals and produces Okazaki fragmen

80 governed by a short element upstream of the restart AUG, designated "termination upstream ribosomal

81 n two catalysis-based assays, we demonstrate restarting autonomously stalled reactions, enabling accu

82 GreA restarts backtracked RNA polymerase and hence promotes t

83 60% v 30%, P = .001) and were less likely to restart bisphosphonates (5% v 35%, P < .0002).

84 temporary blinatumomab discontinuation; all restarted blinatumomab successfully.

85 By contrast BLM restarted, but did not protect, replication forks in a m

86 A, the pools were normalized and cell growth restarted, but only after SAMHD1 had reappeared.

87 tiple pathways that initiate DNA replication restart by recognizing and remodeling abandoned replicat

88 The dynamic exchange can be restarted by addition of potassium ions that competitive

89 lled replication forks can be stabilized and restarted by homologous recombination (HR), which also r

90 the consequences of replication with a fork restarted by homologous recombination in fission yeast.

91 superior guest 4,4'-dimethylazobenzene, then restarted by irradiation.

92 in BRCA1 mutant cells arise by a replication restart-bypass mechanism terminated by end joining or by

93 structure breaks (broken fork), replication restart can proceed either by homologous recombination o

94 free survival defined as the percent free of restarting CD medical therapy after transplantation is 9

95 rbed DNA replication and protect, repair and restart damaged forks.

96 nce of RTF2 at stalled forks results in fork restart defects, hyperactivation of the DNA damage signa

97 ocks, prioritize genes with random walk with restart, detect enriched subnetworks and test the signif

98 ow-up for >/=3 years after stopping DMT; not restarting DMT for >/=3 months after discontinuation.

99 leted cells exhibited a decreased ability to restart DNA replication following fork stalling in compa

100 here was a decreased ability to subsequently restart DNA synthesis, which is normally dependent upon

101 igin firing while promoting replication fork restart/DNA repair.

102 ng ELL as an essential player for RNA Pol II restart during cellular DNA damage response opens the wa

103 gative Rad53-KD, is sufficient to allow fork restart during recovery.

104 Statins should be restarted early after surgery.

105 r proteins that are required for replication restart following fork replication stalling.

106 causes a decrease in genome-wide replication restart following fork stalling similar to that observed

107 ed by polyubiquitinated PCNA to promote fork restart following replication arrest.

108 The restarted fork is susceptible to further collapse causin

109 cific barrier in fission yeast, leading to a restarted fork within approximately 60 min, which is onl

110 We propose that the error-prone nature of restarted forks contributes to the generation of GCRs an

111 t through the observation that recombination-restarted forks have a considerably high propensity to e

112 Def1 also enhanced transcription restart from TFIIS-induced cleavage in a pol II transcri

113 negative effects in ppGpp degrees cells when restart function priB was knocked out, causing loss of v

114 lude replication fork-stabilization and fork-restart functions.

115 transforming event, such as a mutation, can restart growth of a tiny, growth-restricted metastasis;

116 CSCs in bone, whereas the withdrawal of BMP7 restarted growth of these cells.

117 undetectable size until a transforming event restarts growth.

118 hanisms by which PriC drives DNA replication restart have remained poorly defined due to the limited

119 iscontinuing HC and fewer symptoms when they restarted HC could we conclude that HC may protect women

120 ed SMARCAL1 promotes stalled fork repair and restart; however, unregulated SMARCAL1 contributes to fo

121 dimer test results were negative and was not restarted if results were still negative after 1 month.

122 trial Doppler was performed and transfusions restarted immediately in the case of reversion to abnorm

123 itored setting and their antiplatelet agents restarted immediately.

124 Transcription is known to restart in bulk by telophase, but whether de novo transc

125 ld potentially be used to assist replication restart in conjunction with its strand annealing activit

126 replication and does not support replication restart in vitro.

127 ur when treatment with the MEK inhibitor was restarted in 2 of the patients.

128 Treatment was restarted in 57 of 61 patients with MR, and 55 patients

129 at stalled replication forks are efficiently restarted in a RAD51-dependent process that does not tri

130 re, the nature of the cues required for this restarting in oilseed rape (Brassica napus) seed has bee

131 We demonstrate that CME can be 'restarted' in mitotic cells despite high membrane tensio

132 ive helicase outside oriC during replication restart, independently of DnaA.

133 ce at 18 months (group 1; n=5) and those who restarted insulin within 18 months (group 2; n=9).

134 efore, and 30 minutes after interrupting and restarting intra-aortic balloon pump.

135 rocirculation were unchanged by stopping and restarting intra-aortic balloon pump.

136 that the rate-limiting steps of replication restart involve the synthesis and activation of the new

137 However, replication restart is relatively slow and, therefore, replication t

138 However, its exact role in replication restart is unclear.

139 Surprisingly, in our system fork restart is unnecessary for maintaining cell viability.

140 ew technique in which we stall the motor and restart it after increasing waiting periods, we show tha

141 s entry process at a specific stage and then restart it rapidly with a non-invasive stimulus.

142 This restarted L-BFGS algorithm balances the computational ef

143 The restarted L-BFGS algorithm proposed here is both stable

144 ets discovered by GWAS have the potential to restart largely stalled psychiatric drug development pip

145 hermore, once stopped, such assays cannot be restarted, limiting the dynamic range to two orders of m

146 st to the findings in vitro, the replication restart machinery is involved in vivo in resolving poten

147 on and binding to the lesions, a replication restart mechanism has not been identified.

148 such, bacteria have evolved DNA replication restart mechanisms that function to reload replisomes on

149 away from the oocyte lowers oocyte cGMP and restarts meiosis.

150 The pump can be restarted multiple times simply by re-illumination.

151 Sometimes restarting natalizumab treatment may be the best option

152 After restarting NNRTI-based ART (n = 90), virologic suppressi

153 RFWD3 is necessary for replication fork restart, normal repair kinetics during replication stres

154 sis in patients with atrial fibrillation who restarted OAC showed a decreased HR of 0.258 (95% CI, 0.

155 rmore, it is not clear how recovery and fork restart occur in higher eukaryotes.

156 In contrast, in cells where replicative restart occurred, it was accompanied by extensive reoxyg

157 ions: it binds chromatin and coordinates the restart of aphidicolin (APH)-stalled replication forks i

158 ible pathway that might allow processing and restart of blocked forks, replication fork reversal, inv

159 mplete genome duplication via the repair and restart of blocked replication forks also challenges via

160 ermediates in DNA recombination, repair, and restart of blocked replication.

161 ckout of the gene by CRISPR/Cas9 compromised restart of collapsed forks and led to DNA damage in cell

162 omes, preservation of the genetic integrity, restart of collapsed replication forks and telomere main

163 for accurate repair of damaged chromosomes, restart of collapsed replication forks, and telomere mai

164 SMARCAL1 promotes the repair and restart of damaged replication forks.

165 PriA protein serves as an initiator for the restart of DNA replication on stalled replication forks

166 (dsDNA) junctions or breaks, and promote the restart of DNA replication.

167 observations implicate PrimPol in promoting restart of DNA synthesis downstream of, but closely coup

168 formation, is also required for replication restart of HU-stalled forks, suggesting that RAD51-media

169 e, which sets the stage for the orchestrated restart of life.

170 of the PriA SF2 DNA helicase, which governs restart of prematurely terminated replication processes

171 restart or homologous recombination-mediated restart of replication downstream of the lesion, and byp

172 plication, C-strand fill-in, and genome-wide restart of replication following fork stalling.

173 ns of Metnase in NHEJ repair and accelerated restart of replication forks.

174 ired for subsequent recombination repair and restart of replication forks.

175 merase inappropriately binds to and inhibits restart of reversed replication forks within telomeres,

176 crucial for DNA replication fork repair and restart of stalled forks in human is Metnase (also known

177 onarily conserved physiological response for restart of stalled forks.

178 thway proteins play an important role in the restart of stalled replication and DNA repair in prokary

179 Rad50-Nbs1) complex that plays a role in the restart of stalled replication forks and enhanced resect

180 In conclusion, our data suggest that restart of stalled replication forks and HR repair of co

181 replication, defects in the protection, and restart of stalled replication forks are major causes of

182 gly, the S495A mutant demonstrated increased restart of stalled replication forks compared with wt Me

183 The restart of stalled replication forks is critical for the

184 The protection and efficient restart of stalled replication forks is critical for the

185 pair of double-strand breaks, as well as the restart of stalled replication forks through homologous

186 stress, FANCD2 and BLM cooperate to promote restart of stalled replication forks while suppressing f

187 to suggest that lamin A/C has a role in the restart of stalled replication forks, a prerequisite for

188 ablish Metnase as a key factor that promotes restart of stalled replication forks, and implicate Metn

189 MUS81 plays important cellular roles in the restart of stalled replication forks, the resolution of

190 a capability that could be important for the restart of stalled replication forks.

191 oth DNA double-strand break (DSB) repair and restart of stalled replication forks.

192 telomere replication by promoting efficient restart of stalled replication forks.

193 cation stress and confers a marked defect in restart of stalled replication forks.

194 des inactivation of checkpoint signaling and restart of stalled replication forks.

195 permits initiation of HR-mediated repair and restart of stressed forks.

196 replication stress response by mediating the restart of temporarily stalled replication forks thereby

197 ture rise in the Northern Hemisphere and the restart of the Atlantic meridional overturning circulati

198 n-repair coupling factor Mfd promotes direct restart of the fork after the collision by facilitating

199 Specifically, new roles for BRCA1 in the restart of transcription after UV damage and in preventi

200 venting the arrival of polymerase II and the restart of transcription.

201 trimestrial Doppler follow-up and immediate restart of transfusions in the case of reversion.

202 ed, and resulted in an altered velocity upon restart of translocation downstream of Chi.

203 The ending and restarting of school terms had a major effect in attenua

204 PriA, the initiator of replication restart on collapsed or misassembled replication forks,

205 cularly, we apply downward random walks with restart on the GO directed acyclic graph, along with the

206 ed with 3HP experienced side effects--9 were restarted on 3HP, 18 switched treatment regimens, and 13

207 s [D] in at least 1 eye) during phase 2 were restarted on atropine 0.01% for a further 24 months (pha

208 respectively, who progressed in phase 2 were restarted on atropine 0.01%.

209 Two subjects were restarted on ERT because of poor gene marking and immune

210 orticosteroids could be tapered, stopped, or restarted on the basis of disease activity.

211 There the synthesis of DHFR mRNA restarts on the arrival of RNA polymerase II and CSB and

212 of uncontrolled outbreaks that would require restarting OPV.

213 at Mcm10 may have a role in replication fork restart or DNA repair.

214 he damage and origin-independent replication restart or homologous recombination-mediated restart of

215 her treatment should be augmented, switched, restarted, or discontinued.

216 We hypothesized that restarting oral anticoagulant treatment was associated w

217 ectively) in the recombination-mediated fork restart pathway.

218 echanistic differences among DNA replication restart pathways in diverse bacteria.

219 cG-catalyzed replication fork remodeling and restart pathways in vivo.

220 be overcome by lesion bypass or replication restart pathways, leaving repair for a later time.

221 plication forks in bacterial DNA replication restart pathways.

222 Cells and viruses possess several known 'restart' pathways to overcome lesions during DNA replica

223 Our method involves a random walk with restarts, performed on an initial network with multiple

224 gene set, based on a second random walk with restarts, performed on the above subnetwork.

225 oxynucleotide synthesis and replication fork restart, prevention of double-stranded DNA break formati

226 edication, increased dose, recommendation to restart preventive medication) than in the UC group (58%

227 riC/SSB complex formation in DNA replication restart, PriC variants that cannot bind SSB are non-func

228 binational repair system and the replication restart primosome are also prominent, as are mutations i

229 eplication stalls and forks disassemble, the restart primosome is required to reload the replicative

230 ell-studied Escherichia coli DNA replication restart primosome proteins, suggesting that there might

231 d DNA and protein binding by DNA replication restart primosome proteins, we determined the crystal st

232 taining reversible quiescence so cells could restart proliferation after switching p21 off.

233 ART was restarted promptly.

234 ficiency in helicase activity of replication restart protein PriA leads to a considerable loss of via

235 PriC, a key Escherichia coli DNA replication restart protein, and the single-stranded DNA-binding pro

236 of the replicative helicase and replication restart proteins where head-on and co-directional confli

237 n resumes without the need for any auxiliary restart proteins, at least in vitro.

238 independent of any of the known replication-restart proteins.

239 n, leading to the involvement of replication restart proteins.

240 It is often unnecessary to restart psychiatric medications upon which a patient has

241 k DNA and coordinates subsequent replication restart reactions have remained unclear due to the deart

242 problem is resolved by cellular "replication restart" reactions that recognize the structures of prem

243 ein blocks the first step of DNA replication restart, reloading of the replicative DnaB helicase onto

244 ke, during which metabolism of the embryo is restarted, remain enigmatic.

245 In such circumstances, failure to restart replication could result in incomplete genome du

246 Failure to restart replication forks stalled at genomic regions tha

247 synthesis unless recombination intervenes to restart replication.

248 lled replication forks to promote repair and restart replication.

249 ruitment of RPA and RAD51 to repair DSBs and restart replication.

250 ing support for a DDK role in stabilizing or restarting replication forks under S phase checkpoint co

251 s were defective in resolving stalled forks, restarting replication, and completing chromosome duplic

252 Homologous recombination also stabilizes and restarts replication forks without a DSB.

253 e rescued by homologous recombination, which restarts replication.

254 ng (MeRIP-Seq) data using a Random Walk with Restart (RWR) algorithm and then builds a consensus m6A-

255 lf-organizing map (SOM) and random walk with restart (RWR) algorithms to separate the progenitors fro

256 The analysis, using a random-walk with restart (RWR) method, is adapted to the setting of WES b

257 Then, translation elongation was restarted simultaneously to synchronize the translation.

258 In this case, the inability to restart stalled forks is likely to account for the letha

259 itated by the SCFDia2 complex is critical to restart stalled replication forks during checkpoint reco

260 tly, hSSB1-depleted cells fail to repair and restart stalled replication forks.

261 ynthesizing past DNA lesions and may help to restart stalled replication forks.

262 DNA-binding interface for the BLM complex to restart stalled replication forks.

263 ynthesis during normal replication and/or to restart stalled replication from downstream ssDNA.

264 RAD51 is important for restarting stalled replication forks and for repairing D

265 epair (PRR) pathways play important roles in restarting stalled replication forks and regulating muta

266 These cells were defective for restarting stalled replication forks and repairing break

267 itinated PCNA and plays an important role in restarting stalled replication forks.

268 s suggest that they all share a related stop-restart strategy for RdRp translation.

269 hat a coupled termination-reinitiation (stop-restart) strategy is indeed used.

270 n strand from MRE11-mediated degradation and restarted stressed replication forks in a manner additiv

271 nces of IF2-1 and IF2-2/3 on the replication restart system depending on (p)ppGpp levels, each having

272 sion, and rest before regenerating itself to restart the cycle.

273 It is shown that repeatedly restarting the optimization can drive the stock level do

274 1-induced miR-146a prevents death in mice by restarting the production of type I interferon.

275 ays between doses might be acceptable before restarting the sequence of injections.

276 C2 pollen tubes could frequently recover and restart their speedy elongation, resulting in a repetiti

277 empt can safely re-establish remission after restarting their TKI therapy.

278 of MMR is a practical and safe criterion for restarting therapy in patients with CML with prolonged C

279 apy (eg, to identify a threshold above which restarting therapy should be considered).

280 At the time of restarting therapy, median difference of free light chai

281 apsing patients regained MMR and MR4.5 after restarting therapy.

282 n be mimicked by preventing replication fork restart through depletion of RECQ1 or PARG.

283 ere we show that Rad53 regulates replication restart through the checkpoint-dependent transcriptional

284 a 5'-to-3' polarity and promote replication restart, thus preventing aberrant processing of unresolv

285 Of the 3 patients with recurrence, 2 had restarted TNF-alpha blocker therapy, 1 of whom died.

286 s to S. pombe Rtf2) must be removed for fork restart to be optimal.

287 ven when repaired, if transcription does not restart to reestablish cellular metabolism.

288 reassemble these gene promoters and thus to restart transcription after UV irradiation.

289 Urea injection was stopped and restarted twice.

290 ndonuclease is required for replication fork restart under replication stress elicited by exogenous t

291 t activation during HR-dependent replication restart using a site-specific replication fork-arrest sy

292 ed replication fork stalling, as replication-restart was impaired in both SMI#9-pretreated and RAD6B-

293 o chronic hypoxia, we found that replicative restart was inhibited along with numerous replication fa

294 ction when the intra-aortic balloon pump was restarted was observed in the seven patients whose pulmo

295 s tight regulation: too little inhibits fork restart, whereas too much causes fork degradation.

296 the BLM helicase to promote replication fork restart while suppressing new origin firing.

297 stages) is both necessary and sufficient to restart wing program.

298 nd deactivation that coordinates replication restart with DNA repair.

299 disease progression, which ultimately could restart with similar aggressive behavior.

300 Treatment was restarted with intravenous steroids and immunoglobulins,