ライフサイエンスコーパス: restitution

1 t p40(phox) expression is necessary for this restitution.

2 e in E-cadherin membrane localization during restitution.

3 cure does not lead to complete immunological restitution.

4 immune tolerance, inflammation or epithelial restitution.

5 ion but have a controversial role in gastric restitution.

6 role of calcium effectors in CXCL12-mediated restitution.

7 ung inflammation, PC clearance, and complete restitution.

8 mation in the heart, in addition to steep CV restitution.

9 activation delay near PVs that flattens APD restitution.

10 reflect the maximum slope of ventricular APD restitution.

11 abbit ventricle, possibly via effects on APD restitution.

12 stored connexin 43 expression and intestinal restitution.

13 IFN-gamma) release and inadequate intestinal restitution.

14 terrupted enterocyte migration, and impaired restitution.

15 rbB-1 and ERK1/2 activation and in intrinsic restitution.

16 characteristics of action potential duration restitution.

17 mechanisms of intrinsic and rHB-EGF-induced restitution.

18 K/Akt, and MEK/ERK are involved in intrinsic restitution.

19 manifested by a steep slope of cellular APD restitution.

20 h intracellular Ca2+ cycling rather than APD restitution.

21 F-stimulated intestinal epithelial monolayer restitution.

22 rier function and are involved in epithelial restitution.

23 mobilization during gastric epithelial cell restitution.

24 epithelia, concomitant with enhanced barrier restitution.

25 s necessary for efficient gastric epithelial restitution.

26 senger that also promotes gastric epithelial restitution.

27 zation of immune cells to promote epithelial restitution.

28 m than control mice, with reduced epithelial restitution.

29 (2+) sparks, Ca(2+) blinks, and Ca(2+) spark restitution.

30 collective sheet migration during epithelial restitution.

31 role for E-cadherin in intestinal epithelial restitution.

32 ficantly enhances cell proliferation and IEC restitution.

33 growth factor important for epithelial cell restitution.

34 ier integrity of polarized epithelium during restitution.

35 ation was more prevalent in patients with CV restitution (17 of 23 vs. 2 of 8; p = 0.03) and immediat

36 isopropyl) amiloride or 25 mum HOE694) slows restitution 72-83% in wild-type or NHE1(-/-) mice.

37 f intestinal function after injury occurs by restitution, a complex process with a poorly understood

38 otential catheters to define left atrial APD restitution, activation latency, and AF incidence from p

39 ational repair provides accurate chromosomal restitution after double-strand break (DSB) induction.

40 actor (TFF) peptides are pivotal for gastric restitution after surface epithelial damage, but TFF cel

41 lammatory responses and promoting epithelial restitution and barrier recovery.

42 In general, steep action potential duration restitution and broad conduction velocity restitution pr

43 morphology, action potential duration (APD) restitution and conduction velocity (CV) restitution cur

44 rly in relation to action potential duration restitution and conduction velocity restitution properti

45 itional factors, such as conduction velocity restitution and ectopic beats, promote spatially discord

46 heterogeneity index and maximal slope of CV restitution and estimated the effects of short-term memo

47 m, and these processes are indispensable for restitution and function after severe radiation-induced

48 rier and is modulated by conduction velocity restitution and gap junctional conductance.

49 d a critical role for E-cadherin in in vitro restitution and in vivo wound repair.

50 ury was associated with decreased intestinal restitution and increased alpha 3- and beta 1-integrin e

51 The first mechanism is based on steep CV restitution and is associated with small tau and stable

52 However, human left atrial APD restitution and its relationship to AF have not been stu

53 ity of APD indicates that factors other than restitution and memory are also important in determining

54 wave dynamics, and both are important in APD restitution and memory in these models.

55 genetically equivalent to a second division restitution and produce diploid gametes that are highly

56 ons are involved in mechanisms of epithelial restitution and production of pro-inflammatory mediators

57 enterocyte apoptosis and reduced enterocyte restitution and proliferation after mucosal injury compa

58 Imagining hand movements could stimulate restitution and redistribution of brain activity, which

59 tigated the role of conduction velocity (CV) restitution and short-term memory in the organization an

60 In addition, for steep CV restitution and sufficiently large tau, we observed form

61 ly enhances model intestinal epithelial cell restitution and that FPR localized along actin filaments

62 1, is essential for mouse gastric epithelial restitution and that TFFs activate epithelial repair via

63 male meiotic cytokinesis leading to meiotic restitution and the production of diploid (2n) pollen gr

64 The role of HB-EGF in intestinal restitution and the underlying intracellular signaling p

65 sociated with competing contribution from CV restitution and tissue spatial heterogeneity, increasing

66 arge tau) and is characterized by shallow CV restitution and unstable behavior of nodal lines.

67 Restitution and vectorial ion transport effects of PSTI

68 quency had steeper action potential duration restitution and was more susceptible to pacing-induced C

69 stitution, effective refractory period (ERP) restitution, and conduction velocity (CV) restitution.Te

70 lnerability, action potential duration (APD) restitution, and conduction velocity were measured.

71 ch domain plays an active role in epithelial restitution, and represents a potential novel therapeuti

72 abilizing mucin gels, stimulating epithelial restitution, and restraining the associated inflammation

73 rties; cellular factors promoting growth and restitution; and vascular, neural, and inflammatory fact

74 Action potential duration restitution (APDR) and conduction velocity restitution (

75 apamin can flatten action potential duration restitution (APDR) curve and can reduce ventricular fibr

76 produced steepened action potential duration restitution (APDR) curves as well as augmented membrane

77 iation and subsequent Ca(2+) spark amplitude restitution arose from 1), the extent to which the regen

78 the mucosa from injury by promoting cellular restitution as well as inhibiting gastric acid secretion

79 treatment significantly inhibited intestinal restitution, as measured by impaired IEC-6 cell migratio

80 Proliferation and restitution assays in the presence of recombinant wild-t

81 latency that enables engagement of steep APD restitution at rapid rates.

82 During restitution, both CXCL12 and TGF-beta1 tightened the mon

83 -derived cell line to determine whether TSC2 restitution brings about the cell type from which AML ar

84 Conduction restitution, but not fractionated electrograms, may thus

85 decreased permeability, and enhanced barrier restitution by 2 +/- 0.5-fold.

86 SUMO1 restitution by adeno-associated-virus-mediated gene deli

87 ng revealed that isoproterenol steepened APD restitution by increased L-type calcium current and decr

88 is essential for early intestinal epithelial restitution by increasing the expression of cell divisio

89 n proliferation ([3H]-thymidine uptake), and restitution (cell-wounding migration) were assessed usin

90 analyzing the effects of conduction velocity restitution, cellular dynamics, electrotonic coupling, a

91 beneficial remodeling of both conduction and restitution characteristics of the posterior left atrium

92 akup resistance, contact time reduction, and restitution coefficient increase.

93 derive a We(-.25) dependence of the lateral restitution coefficient.

94 APD restitution, conduction velocities, and anisotropy were

95 TG hearts without significant changes in APD restitution, conduction velocity, or the anisotropy rati

96 The large differences in theta' and APD restitution contrasted with minor differences in maximum

97 4 mA, wash 1.1 +/- 0.2 mA) and flattened the restitution curve (n = 6) derived from optically mapped

98 potential is not due to a steepening of the restitution curve (not present in our model), but rather

99 e maximum slope of action potential duration restitution curve and converted sustained to nonsustaine

100 etylcholine also reduced the slope of the AP restitution curve and suppressed AP alternans (n = 6).

101 pears when the magnitude of the slope of the restitution curve exceeds one, known as the restitution

102 increased VFT and flattened the slope of APD restitution curve in this isolated rabbit heart preparat

103 ion, we found that the slopes of the dynamic restitution curve S(dyn) were also statistically similar

104 The restitution curve was shifted upwards and became less st

105 slope of the action potential duration (APD) restitution curve, by reducing the propensity of APD alt

106 prediction of alternans is to construct the restitution curve, which is the nonlinear functional rel

107 ly, it has been proposed that the slope of a restitution curve, which relates the duration of the act

108 threshold (VFT) and flattens the electrical restitution curve.

109 PD) restitution and conduction velocity (CV) restitution curves in these patients.

110 ng may contribute to differences between APD restitution curves measured by S1S2 versus dynamic pacin

111 duces experimental action potential duration restitution curves obtained by either dynamic or S1S2 pa

112 of the L-type Ca2+ current I(Ca,L) steepened restitution curves of action potential duration and cond

113 Using a standard S(1)-S(2) protocol, restitution curves of local activation time and activati

114 restitution portrait, which combines several restitution curves simultaneously, is associated with th

115 rough S1-S2 APD and conduction velocity (CV) restitution curves with different S1 cycle lengths.

116 RA were identified, with Fork- and Eye-type restitution curves, based on RA persistence or disappear

117 odation and the slopes of different types of restitution curves, Sdyn and S12, measured at varying BC

118 atrial APD and ERP and flattened APD and ERP restitution curves.

119 n restitution (APDR) and conduction velocity restitution (CVR) curves were generated and analyzed, an

120 (DI), currently used protocols to determine restitution do not use sequential changes in DI.

121 On the other hand, the slope of CV restitution does not change the regions of alternans in

122 r crypt cells to resist apoptosis and ensure restitution during a potentially lethal insult, but reta

123 IL-22-binding protein suppressed goblet cell restitution during the recovery phase of a dextran sulfa

124 ts are repaired by the process of intestinal restitution, during which enterocytes migrate from healt

125 ts are repaired by the process of intestinal restitution, during which enterocytes migrate from healt

126 Standard restitution, effective refractory period (ERP) and VF th

127 quantified on AP profile, AP duration (APD) restitution, effective refractory period (ERP) restituti

128 refractoriness barriers, conduction velocity restitution, etc.

129 In spayed mice treated with TP, restitution experiments with progesterone and estrogen n

130 ErbB4 promotes intestinal cell survival and restitution following injury or inflammation.

131 reased proliferation and impaired liver mass restitution following partial hepatectomy (PH).

132 lambda' restitution gradient better correlated with alternans ma

133 alternans magnitude than either APD or theta restitution gradient.

134 odeling suggest that piles of confined, high-restitution grains, subject to low-amplitude vibration,

135 Patients with broad CV restitution had larger atria (p = 0.03) and were more li

136 response of action potential duration (APD) restitution has a slope >1.

137 Although restitution has been hypothesized to determine action po

138 However, this restitution hypothesis was derived under the assumption

139 restitution curve exceeds one, known as the restitution hypothesis.

140 recedes AF initiation, whereas absence of CV restitution identifies inability to induce AF.

141 ction potential duration and conduction time restitution in a dose-dependent fashion, effects that we

142 with ulcerative colitis and promote mucosal restitution in animal models of colitis.

143 tinal epithelial cells, promoting epithelial restitution in fibronectin-rich tissue and proliferation

144 ffect on the intrinsically defective gastric restitution in NHE2(-/-) mice or TFF2(-/-) mice.

145 The action of topical rat TFF3 to accelerate restitution in TFF2(-/-) mice was inhibited by AMD3100 (

146 nt reduction in intrinsic and HB-EGF-induced restitution in vitro.

147 rHB-EGF enhances restitution in vivo and in vitro in a PI3K/Akt- and MEK/

148 hat are essential to gastric epithelial cell restitution in vivo.

149 We hypothesized that rate-dependent changes (restitution) in action potential duration (APD) and acti

150 suppresses inflammation and promotes tissue restitution, in part, by promoting alternative macrophag

151 Steep APD restitution is a common pathway for AF initiation by iso

152 Epithelial restitution is an essential process that is required to

153 ening at short cycle length; (2) steep Pcell restitution is attributable to slow recovery of I(NaL);

154 sights into the development of NEC, in which restitution is impaired.

155 the pathogenesis of NEC, in which intestinal restitution is impaired.

156 ositive coefficient of DI(n-1) indicate that restitution is important in determining APD during VF, w

157 ting system of automixis with first-division restitution is the result of feedback mechanisms to cont

158 Although restitution is used to predict APD during sequential cha

159 ions, intracellular Ca(2)(+) transients, and restitution kinetics, and tested for AF vulnerability.

160 velocity (CV; P<0.01 versus WKY), steeper CV restitution kinetics, greater collagen deposition, highe

161 d the transcripts for fibrosis, flattened CV restitution kinetics, reduced action potential duration

162 However, steep CV restitution leads to more complicated dynamical behavior

163 nism of DEEPs relates to conduction velocity restitution magnified by zigzag conduction within scar c

164 Unreduced gametes produced by first division restitution mechanisms comprise complete sets of nonsist

165 However, the visual restitution might be impeded because of preceded deposit

166 Consistent with restitution, motogenic concentrations of HBD2 and CCL20

167 The AP duration and activation restitution (n = 11 patients) were flat at 109 beats/min

168 eness, which may participate in the impaired restitution observed in experimental NEC.

169 Hence, timely restitution of a genetic deficiency or, alternatively, t

170 on removal of dysfunctional mitochondria and restitution of a healthy mitochondrial population.

171 sized that abnormal TWA is linked with steep restitution of action potential duration (APD) and that

172 Restitution of action potential duration (APD) is though

173 Restitution of action potential duration and conduction

174 Vm factors include electrical restitution of action potential duration and conduction

175 Neonatal restitution of beta-hexosaminidase in mutant mice by gen

176 KN93, decreased DCW frequency and normalized restitution of Ca(2+) release in VF myocytes.

177 We conclude that restitution of Ca2+ sparks depends on local refilling of

178 vestigate indirectly this issue by exploring restitution of Ca2+ sparks.

179 ing the moment-closure approach to study the restitution of Ca2+-induced Ca2+ release during simulate

180 Restitution of CD59 activity in joints of CD59a(-/-) mic

181 2 response are both associated with impaired restitution of cellular polarity.

182 The restitution of depolarization-induced Ca(2+) transients,

183 elial IL-10 signaling in the maintenance and restitution of epithelial barrier and of the temporal re

184 se thresholds was termed the "penumbra," and restitution of flow above the functional threshold was a

185 ed the disease-associated microbiome, with a restitution of health-compatible species.

186 s in eradication of the microbial threat and restitution of homeostasis.

187 Restitution of injured mucosa involves the recruitment o

188 We further investigated whether restitution of interleukin (IL)-23 enhances PP cell IL-1

189 Restitution of intestinal epithelial barrier damage invo

190 verexpressing NSCs resulted in a significant restitution of motor function.

191 a significant, substantial and long-lasting restitution of motor function.

192 expression of mucus-associated molecules and restitution of mucus-producing goblet cells.

193 on of optimal motor neuron function requires restitution of multiple dysregulated cellular pathways.

194 ivision across remaining lobes, resulting in restitution of organ mass but with permanent alteration

195 Unexpectedly, we found that virtually full restitution of the AD1 sequence is required to reinstate

196 nflammatory bowel disease (IBD), compromised restitution of the epithelial barrier contributes to dis

197 Restitution of the TM-protein C pathway is an appealing

198 regression of the established neuropathy and restitution of the typical characteristics of the islets

199 Physiological properties of cells such as restitutions of refractoriness and of conduction velocit

200 en T-wave alternans (TWA) and rate-response (restitution) of repolarization in subjects with and with

201 heir interplay with conduction velocity (CV) restitution on alternans formation using numerical simul

202 Here, alpha quantifies the dependence of APD restitution on pacing history and tau characterizes APD

203 In controls, no intervention steepened APD restitution or initiated AF.

204 ane voltage (V(m)) attributable to steep APD restitution or to calcium (Ca) cycling.

205 dependent slowing in conduction velocity (CV restitution) or local slowing evidenced by signal fracti

206 Cardiac muscle restitution, or true regeneration, is an unmet need in t

207 ctor in patients with broad but not steep CV restitution (p < 0.01).

208 as slow as 100 to 120 bpm, unrelated to APD restitution (P>0.10).

209 l dispersion of refractoriness by modulating restitution parameters can have an antifibrillatory effe

210 ging to antimicrobial defense and epithelial restitution pathways that showed a similar pattern of ep

211 heta') rather than DI, provided novel lambda restitution plots of lambda' against lambda'0, which sum

212 ction of the action potential duration (APD) restitution portrait allows visualization of multiple as

213 tion, the maximum slope S12, measured in the restitution portrait at the lowest BCL, predicts the ons

214 demonstrate that the slopes measured in the restitution portrait correlate with the onset of alterna

215 conclusion, the results demonstrate that the restitution portrait is a powerful technique to investig

216 e in this study was to determine whether the restitution portrait is correlated with the onset of alt

217 For the first time, we obtained the restitution portrait of isolated rabbit and guinea pig c

218 It was recently shown that the restitution portrait, which combines several restitution

219 cts of cardiac dynamics measured through the restitution portrait.

220 dividual slopes Sdyn and S12 measured in the restitution portrait.

221 of the L-type calcium current, ICa-L, in the restitution portrait.

222 We constructed two-dimensional restitution portraits for the epicardial surface of the

223 a(2+)-frequency relations, and extrasystolic restitution/post-extrasystolic potentiation.

224 n-dependent slowing of atrial conduction (CV restitution) precedes AF initiation, whereas absence of

225 re, a better understanding of the epithelial restitution process has potential for improving the deve

226 on restitution and broad conduction velocity restitution promote dispersion of refractoriness in resp

227 These restitution properties also promote spatially discordant

228 Action potential duration (APD) restitution properties and repolarization alternans are

229 The effect of the restitution properties of cardiac tissue on the outcome

230 trait is a powerful technique to investigate restitution properties of periodically paced cardiac myo

231 mal number of filaments, wave fragmentation, restitution properties, and whether dominant waves are a

232 ties under steady pacing at different rates, restitution properties, block of particular channels, an

233 o reproduce nanoscopic measurements of spark restitution properties.

234 duration restitution and conduction velocity restitution properties.

235 -induced decoupling of tissue with different restitution properties.

236 lated responses to epithelial cell migration/restitution rather than proliferation during wound closu

237 3 hours of reperfusion and was attributed to restitution rather than proliferation.

238 pranolol flattened action potential duration restitution, reduced wavebreaks and converted ventricula

239 Restitution relationship obtained during sequential chan

240 being short or long; and linear, to compare restitution relationship obtained during sequential chan

241 Epithelial restitution requires active cell migration, a process de

242 During oscillatory DIs, restitution showed bimodal trajectory similar to hystere

243 AC produced AF in 5 patients; in all, an APD restitution slope >1 caused extreme APD oscillations aft

244 We hypothesized that an APD restitution slope >1 near PVs explains the initiation of

245 In patients with paroxysmal AF, maximum APD restitution slope >1 near the PVs enables single PACs to

246 BS hearts having any RV segment with maximal restitution slope >1 was 3.86 versus controls.

247 er 829 +/- 473 days, TWA (p = 0.02), but not restitution slope >1, predicted ventricular arrhythmias

248 0.7 +/- 0.2; p < 0.001); no patient had APD restitution slope >1.

249 s 24+/-14 ms; P<0.05), steepened maximum APD restitution slope (0.8+/-0.7 versus 1.7+/-0.5 versus 1.1

250 e in conduction inhomogeneity, flattening of restitution slope and decreased duration of induced AF,

251 Both combinations flattened APD restitution slope and prevented APD alternans, similar t

252 AP model, which reproduced flattening of APD restitution slope and prevention of APD/Ca(i) transient

253 ar calcium (Ca2+i) cycling in regulating APD restitution slope and repolarization (APD) alternans in

254 nd there was no relationship between maximum restitution slope and TWA magnitude.

255 regions with steep action potential duration restitution slope and unstable Ca(i) dynamics.

256 cy (86+/-27 ms; P=0.002) so that maximum APD restitution slope did not steepen (1.0+/-0.5; P=NS), and

257 ication of subcellular calcium alternans and restitution slope during cycle-length ramping alternans

258 dynamic rapid pacing method, the maximum APD restitution slope exceeded 1 by both methods, but was mo

259 +/- 12%) subjects did not differ in APD(90) restitution slope maxima (1.2 +/- 0.6 vs. 1.3 +/- 0.6, r

260 BAPTA-AM or BAPTA failed to flatten APD restitution slope to <1 by either method.

261 Thapsigargin and ryanodine flattened APD restitution slope to <1 when measured by the dynamic met

262 In paroxysmal AF, maximum left atrial APD restitution slope was 1.5 +/- 0.4; and 12 of 13 patients

263 rred at diastolic intervals at which the APD restitution slope was significantly <1 and was abolished

264 cycling and is not reliably predicted by APD restitution slope when Ca2+i cycling is suppressed.

265 abilities in membrane voltage (ie, steep APD restitution slope) and intracellular Ca (Cai) cycling dy

266 ution of three different slopes (the dynamic restitution slope, S(dyn)(RP), and two local S1-S2 slope

267 0.01), which prolonged DI and flattened APD restitution (slope 0.7 +/- 0.2; p < 0.001); no patient h

268 y modulating APD and APD/conduction velocity restitution slopes in atrial tissue with I(K,ACh-c).

269 APD and changing APD and conduction velocity restitution slopes, thereby altering the probability of

270 were constructed to determine local maximal restitution slopes.

271 ynamic processes is a key step in developing restitution-targeted therapies.

272 P) restitution, and conduction velocity (CV) restitution.Temporal and spatial vulnerabilities of atri

273 or adaptive eye movements; and visual field restitution therapies, in which vision in the damaged fi

274 These results suggest CXCL12 regulates restitution through calcium-activated Pyk2 localized to

275 tion in enhancing intestinal epithelial cell restitution through PI3K-dependent activation of Rac1 an

276 ligand CXCL12 enhances intestinal epithelial restitution through reorganization of the actin cytoskel

277 sis-induced changes in atrial conduction and restitution to decrease AF.

278 tionary sentences with payments of fines and restitution to the government for urologists who coopera

279 by Medicare or Medicaid, and paid fines and restitution to the government.

280 We explored restitution using a new pacing protocol to change DI seq

281 tivation, whereas rapid pacing steepened APD restitution via increased cardiac inward potassium recti

282 newborn rats by hypoxia/gavage feedings, and restitution was determined by assessing bromodeoxyuridin

283 duced in Swiss-Webster or IFN(-/-) mice, and restitution was determined in the presence of the gap ju

284 and functional recovery of the intestine by restitution was evaluated in vivo.

285 When APD restitution was measured by either the standard extrasti

286 Activation time restitution was measured using the time from the pacing

287 ys occurred at diastolic intervals where APD restitution was not steep (p < 0.001), and there was no

288 Restitution was plotted as APD of progressively early PA

289 In vivo restitution was preceded by activation of Akt and extrac

290 The maximum slope of restitution was reduced from 1.17 +/- 0.14 to 0.60 +/- 0

291 model of NEC, we determined that intestinal restitution was significantly impaired compared with con

292 The maximum slope of the CV restitution was steeper (18.16+/-3.34 m/s(2)) and tau wa

293 he base of the left ventricle, not where APD restitution was steepest.

294 e epithelium and directly measure epithelial restitution, we evaluated whether TFFs and NHE isoforms

295 Three patterns of CV restitution were observed: 1) broad (gradual CT prolonga

296 s, and self-renewal ability for survival and restitution were reduced in the isolated intestinal epit

297 dispersion (Delta APD and Delta slope of APD restitution) were both increased in LQT2 compared to LMC

298 Furthermore, rat TFF3 did not rescue restitution when NHE2 was inhibited [TFF2(-/-) mice +HOE

299 s produces comprehensive regional functional restitution, which in turn drives improvement in global

300 the slope of action potential duration (APD) restitution while simultaneously protecting the heart ag