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1 Furthermore, kynureninase knockdown in mice restrained 3-HAA, matrix metallopeptidase 2, and resulta
2 s patients were more likely to be physically restrained (86.3% vs 76.7%; p = 0.014) and undergo trach
4 , leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation
5 show that two of these tropomyosin positions restrain actomyosin interactions, whereas in the third p
6 "trap" that elicits an endosiRNA response to restrain acute transposon activity during epigenetic rep
8 facilitates apoptosis and erythropoiesis and restrains adverse proliferation, indicating the therapeu
9 hanced, and these enhanced capabilities were restrained after blocking their Ror2 signaling using sma
12 activation; MaR1 targets Tregs and ILC2s to restrain allergic lung inflammation, suggesting MaR1 as
13 TS1 TN, indicating that additional pathways restrain alloreactive TEM TS1 TN also caused more severe
14 of BRAF deletions reveal the truncated loop restrains alphaC in an active "in" conformation, imparti
15 programs that support Th17 cell identity and restrain alternative Th1 and Treg cell fates in inflamma
18 The early-destroyed cyclins-Cyclins A and B-restrain anaphase-promoting complex/cyclosome (APC/C) fu
21 e conventional microscopes for studying head-restrained animals and head-mounted miniature microscope
26 3 overexpression increases proliferation and restrains apoptosis of wild-type p53-harboring cancer ce
30 nd context-dependent role for neutrophils in restraining autoreactive B cell activation in lupus.
31 ort experimental and theoretical evidence of restrained axial rotation for heteroleptic L2.Ir(I).1,5-
36 Furthermore, rotation of the molecule is restrained because of charge rearrangement induced by th
40 ins unclear if these responses are maximally restrained by age-related changes in cutaneous microvasc
41 equired for mitotic entry, and this event is restrained by an inhibitory phosphorylation of the catal
42 AQP4-specific T-cell responses are normally restrained by central tolerance, which may be relevant t
43 f glycosylation, the conformation of GtfB is restrained by GtfA to bind substrate with unmodified Ser
44 riazapentadienes 10-12, which are sterically restrained by incorporation into six- or seven-membered
45 efficient modeling of the helical structure restrained by interprotomer ssNMR distance restraints.
46 ly attenuated in vivo, suggesting that it is restrained by molecular clutching forces within the spin
47 st-induced apoptosis (negative selection) or restrained by regulatory T (Treg) cells, whose different
49 sulfur battery, its application is seriously restrained by the challenges due to its low sulfur elect
52 urprising given that the evolution of NS5 is restrained by the requirement to maintain function of tw
54 eefxPot, to include a membrane model for NMR-restrained calculations of membrane protein structures i
55 ly expensive and impractical for routine NMR-restrained calculations that start from completely exten
56 at circulating platelets remain quiescent by restraining CalDAG-GEFI/RAP1 signaling and suggest that
57 a critical tumor-suppressing mechanism that restrains cancer progression at premalignant stages, in
59 cells indeed hinder CLL survival in vitro by restraining CD1d-expressing nurse-like cells, a relevant
62 ugh functional studies, miR-126 was found to restrain cell cycle progression, prevent differentiation
63 that Fat1 controls mitochondrial activity to restrain cell growth during the reparative, proliferativ
64 Furthermore, Gab2 knockout in HepG2 cells restrained cell proliferation, migration and tumor growt
67 anics-based system is proposed to physically restrain cells that grow more than their neighbours, buf
70 ulation, functions as a homeostatic brake to restrain cocaine action, and provide novel candidates fo
73 between W104C and A128C in the PhoQ PD that restrains conformational flexibility in alpha-helices 4
74 group of 5hmC and formyl group of 5fC adopt restrained conformations through forming hydrogen bonds
75 moxia or hypercapnia, C1 neuron discharge is restrained continuously by arterial baroreceptors, and C
76 These data establish that mTORC2 activity restrains conventional DC proinflammatory capacity and t
77 a novel MSD algorithm, which we refer to as REstrained CONvergence in multi-specificity design (RECO
78 nhibition of Pol III activity in macrophages restrains cytokine secretion and suppresses phagocytosis
79 Runx3 functions and cytotoxicity; and STAT3 restrained cytotoxic gene expression in CD8(+) T cells r
81 ssion of AK017368 promoted proliferation and restrained differentiation of myoblasts; whereas inhibit
84 ssion GTPase Drp1 and phosphatidic acid that restrains Drp1 activity and shifts the balance toward mi
85 postnatal stages of life and is subsequently restrained during childhood, and its reactivation culmin
90 h2 in favoring regulatory T cell generation, restraining effector T cell differentiation, and potenti
91 l death (RICD) regulates immune responses by restraining effector T cell expansion and limiting nonsp
92 , thereby arresting microfilament growth and restraining elongation to remaining free barbed ends.
93 ates the development of alphabeta T cells by restraining endoplasmic reticulum (ER) stress responses.
94 ially due to adipokine regulatory mechanisms restraining energy-avid adaptive immunity in times of st
95 erimental solid-state NMR data, we performed restrained ensemble dynamics simulations with different
96 es in implicit environments, solid-state NMR restrained ensemble simulations in explicit membranes re
97 eavage activation components (PS2, TACE) and restrained expression of the inhibitory component of the
98 crotaline-induced pulmonary hypertension and restrained extracellular matrix accumulation in PAs in r
102 anding of the mechanisms that facilitate and restrain generalization in humans is therefore needed.
105 ls also decreased tumor vascular density and restrained growth of desmoplastic human lung cancer xeno
109 ulatory T (Tr1) cells play a pivotal role in restraining human T-cell responses toward environmental
110 PAF1 occupies transcriptional enhancers and restrains hyperactivation of a subset of these enhancers
114 tick-derived immunosuppressor sialostatin L restrains IL-9 production by mast cells, whereas degranu
115 c Arg1 abrogated type 2 lung inflammation by restraining ILC2 proliferation and dampening cytokine pr
116 te the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinica
119 e B cells maintain tonic BCR signaling while restraining inappropriate antigen-dependent activation t
120 s cyclin-dependent kinase 8 (CDK8) and CDK19 restrain increased activation of key SE-associated genes
121 ever, the key COX product(s) responsible for restraining indomethacin-mediated STAT6-independent alle
123 ng-time procedure, we found that temporarily restraining infants' articulators impeded their discrimi
125 +) regulatory T (Treg) cells are crucial for restraining inflammation in a variety of autoimmune dise
127 ted an alternative hypothesis, in which Phox restrains inflammation by downregulating caspase-1, ther
128 unogenic SPI-1 components contributes to the restrained inflammatory infection elicited by S. Paratyp
130 tion of the IL2Rbeta chain on CD8(+) T cells restrains inhibitory receptor induction, in particular 2
133 y drugs that either block PGI2 production or restrain IP signaling may augment STAT6-independent path
135 ed the helical IL-23p19 subunit of IL-23 and restrained its IL-12p40 subunit to cooperatively bind th
139 Since the complexity of TC neuron model restrains its hardware implementation in parallel struct
140 nsic regulatory loop through which NF-kappaB restrains its own inflammation-promoting activity and or
141 f the ERK-RSK phosphorylation sites of c-Fos restrains KSHV lytic gene expression and virion producti
143 n-chest animal preparations, the pericardium restrains LV filling when central blood volume increases
147 3a, we found that this enzyme is involved in restraining mast cell responses to acute and chronic sti
148 esent study we have used solid-state NMR and restrained MD simulations to refine structure and topolo
149 consequences, loss of a uSTAT5 program that restrains megakaryocytic differentiation and activation
154 ctivation of BMDCs and monocyte-derived DCs, restrains migration of skin and BMDCs, supports MHC clas
155 a commonly prescribed diabetic medicine can restrain mitochondrial metabolism and tumorigenesis in a
156 otubule-interacting machines on chromosomes, restrain mitotic exit when not attached to spindle micro
158 btained from residual dipolar coupling (RDC)-restrained molecular dynamics (MD) in the presence and a
160 consuming trial-and-error calculations using restrained molecular dynamics (MD) with simulated anneal
161 are performed using simulated annealing with restrained molecular dynamics and an energy function, wh
162 f the transmembrane domain was refined using restrained molecular dynamics simulations in an all-atom
163 ctroscopy in native-like lipid bilayers with restrained molecular dynamics simulations represents a p
165 urbation study by investigating, in the head-restrained monkey, the generation of saccades toward a t
166 port that a small molecule combination could restrain mouse haESCs from diploidization by impeding ex
167 Channel activity was reduced in response to restraining movement within this region by cross-linking
168 duction of D3 in keratinocytes significantly restrains murine BCC tumorigenesis and demonstrate the c
170 erefore, alternatively activated macrophages restrain NK cell activation and effector functions throu
171 cytomegalovirus (MCMV)-encoded protein, m12, restrains NK cell effector function by directly engaging
172 er, also prevents excessive inflammation and restrains NLRP3-inflammasome activation through a poorly
175 xert a differential impact on proactive (the restrain of actions in preparation for stopping) and rea
176 cular mechanism by which the CHK2-BRCA1 axis restrains oncogenic Aurora-A activity during mitosis and
177 er, how the CHK2-BRCA1 tumor suppressor axis restrains oncogenic Aurora-A during mitosis to ensure ka
178 aling event led to the hypothesis that TRAF3 restrains one or both of two known inhibitors of Lck, C-
179 by a combined mechanism that simultaneously restrains ongoing obsolete actions while it facilitates
180 function of growth cone point contacts is to restrain or "clutch" myosin-II-based filamentous actin (
182 that prohibit persons subject to IPV-related restraining orders from possessing firearms and also req
184 lockade of these events is not sufficient to restrain osteoclast formation, inhibit resorption, or st
186 sus macaques: constrained space (CAGE), head-restrained passive locomotion (CHAIR), constrained locom
187 ggest that SUMO modification is essential to restrain pathogenic bacterial entry by limiting cytoskel
189 l AT-rich sequence-binding protein-1 (Satb1) restrains PD-1 expression induced upon T cell activation
190 a key role for the genome organizer Satb1 in restraining PD1 expression and promoting tumor immunity.
191 ur findings demonstrate that stromal lumican restrains PDAC cell growth through mediating cell entry
192 Importantly, cell-intrinsic CD28 expression restrained pDC (and systemic) IFN-I production during in
196 nflammatory responses to atherogenic diet by restraining proinflammatory signaling in endothelial cel
197 (AISC) either through inability of Tregs to restrain proliferation and effector cytokine production
199 a signaling network of interacting pathways restrains proliferation in normal cells and prevents tum
200 port Hippo pathway suppressor functions, and restrain prostate cancer migration, invasion, and anchor
201 ots of activating mutations in residues that restrain Ras dynamics and promote the inactive state.
204 ations affected the ability of Drosophila to restrain rather than tolerate infections and suggested t
205 s (DMH) promoted hypothermia in cold-exposed restrained rats, but attenuated hypothermia in rats chal
206 lular resolution imaging in voluntarily head-restrained rats, we examined the responses of neurons in
210 3beta1 signals through Abl family kinases to restrain Rho GTPase activity, support Hippo pathway supp
212 ricate regulatory mechanisms responsible for restraining RIPK1 from killing are discussed primarily i
213 from chemical probes and/or ribonucleases to restrain RNA secondary structure prediction via the RNAs
214 iption factor Thpok, which in CD4(+) T cells restrains Runx3 functions and cytotoxicity; and STAT3 re
216 pileptic drug therapy, though beneficial for restraining seizures, cannot thwart status epilepticus (
218 relation map is consistent with the ensemble-restrained simulations and reveals a complex network.
222 the anteroventral BST that were necessary to restrain stress-induced HPA activation and passive copin
223 ally, given evidence that endogenous opioids restrain stress-induced LC activation and promote recove
226 negative selection and inhibitory receptors restrain TCR signaling to enforce both central and perip
228 cts in opposition to the BLM DNA helicase to restrain telomere replication and recombination in human
231 ctor differentiation in vivo, they failed to restrain Th2 effector responses that drive allergic inte
232 GI-58 and the LD coating protein perilipin 1 restrain the ability of CGI-58 to activate ATGL under ba
235 B-lymphomas, and that heparanase inhibitors restrain the growth of tumor xenografts produced by lymp
236 icrovascular and cardiac functions maximally restrain the levels of cutaneous vasodilatation and card
238 nsport channel for TRB, which is probably to restrain the precipitation and its distribution pattern
239 ors do not affect bacterial growth, but they restrain the virulence of pathogenic bacterial strains,
240 peptides made insoluble complexes with mRNA, restrained the access of translation factors to mRNA, an
242 Due to the benefit of methyl group, the dyes restrained the formation of aggregates in the solid stat
243 -capping with butterfly shaped phenothiazine restrained the formation of molecular aggregates in the
245 mational transfer that occurs as a result of restraining the DNA within the closed loop of the minici
246 -induced phosphorylation of H2AX and MDC1 by restraining the expansion of these phosphorylation event
248 irment of synaptic structure and function by restraining the expression level of active zone (AZ) and
250 rofound tumour suppressive role in cancer by restraining the growth-promoting function of the transcr
251 response of endothelial cells to TNFalpha by restraining the induced expression of intercellular adhe
254 t MBD1 maintains the multipotency of NSCs by restraining the onset of differentiation genes and that
255 anscription factor is implicated in actively restraining the specification of mesodermal progenitors
257 s of alternative splicing across samples and restrains the applications of the tools from many biolog
259 in in the GPIbalpha binding interface, which restrains the conformational degrees of freedom and the
264 s, suggesting that kinesin-5 acting normally restrains the number of minus end-distal microtubules th
267 witch involving PI3K/AKT/mTOR signaling that restrains the senescence secretory responses to limit th
268 s a low glucose inhibitory domain (LID) that restrains the transactivation domain when glucose catabo
270 cells overcome negative-acting signals that restrain their growth and promote senescence and cell de
272 ing valves represents negative feedback that restrains tissue overgrowth rather than simply reporting
274 y undescribed tumor suppressor in the liver, restraining TNFR1-independent apoptosis in hepatocytes w
277 associated paracrine secretory responses are restrained to preserve tissue homeostasis and prevent ch
279 hen the relevant articulator was selectively restrained to prevent the movements associated with prod
281 ng mitochondrial respiratory capacity, which restrains transit of the RagA-RagC GTPase heterodimer th
282 suppressive activity of splenic MDSCs, which restrained tumor growth through mechanisms involving CD8
284 signaling markedly decreased glycolysis and restrained tumor growth, these signaling and metabolic r
285 ografts mimicked the effects of ESE3/EHF and restrained tumor-initiating and self-renewal properties
287 mandates that the pulmonary alveolar surface restrain unnecessarily harmful inflammatory responses to
291 logical, behavioral and emotional impacts of restrained versus non-restrained injection procedures.
293 mosquito-borne viruses, whose impact can be restrained via mosquito population control programs, for
294 ulting from releasing these conformationally restrained waters to the bulk solvent is likely a major
296 ation of APC(Min/+); Fbw7(DeltaIEC) mice was restrained when Usp28 was inactivated concomitantly.
297 nding, the conformational entropy of LacY is restrained, which leads to a significant decrease in sug
298 ng Xplor-NIH ensemble structure calculations restrained with the RDC and CCR data, we observe collect
299 and contains both phosphorylation sites, is restrained within the central channel of the 14-3-3 dime
300 complex in which all saccharide residues are restrained without undergoing substantial conformational
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