ライフサイエンスコーパス: restraint

1 er studies suggesting its function in action restraint.

2 ng effects on acquired behaviors and dietary restraint.

3 scripts in the CeA and in the BLA after body restraint.

4 suggesting that tumorigenesis is subject to restraint.

5 armosets can perform visual tasks under head restraint.

6 ther, while maternally inherited genes favor restraint.

7 erformed awake NHP imaging with minimal head restraint.

8 lvement in incidents involving seclusion and restraint.

9 on groups studied, was modified by cognitive restraint.

10 es evoked by varying stiffness of mechanical restraint.

11 ) technique and cross-linking MS/MS distance restraints.

12 ia devoid of the influence of anesthetics or restraints.

13 energy solutions that also satisfy the given restraints.

14 e restrained by interprotomer ssNMR distance restraints.

15 nder the strong influence of solid-state NMR restraints.

16 spinning data yielded interhelical distance restraints.

17 tered the energy model with the experimental restraints.

18 coat protein was also performed without any restraints.

19 models during phasing by providing accurate restraints.

20 by potential interface residues or symmetry restraints.

21 in the molecular dynamics simulation without restraints.

22 he maximum impose the most stringent angular restraints.

23 osed complex because of geometric and steric restraints.

24 on channels by building models using generic restraints.

25 ons either on its own or complemented by NMR restraints.

26 are assembled using inter-protomer distance restraints.

27 deprivation, radical stress, and nutritional restraints.

28 Does cooperation require deliberate self-restraint?

29 111 quantitative distance and torsion angle restraints (10 per residue) that describe the various le

30 Based on the experimental restraints, a structural model of this heterodimer was d

31 ner drugs in female rats throughout repeated restraint abolished their heightened hypothalamic-pituit

32 ignaling pathway is activated after repeated restraint/acoustic stress exposure in mice prefrontal co

33 the program X-PLOR-NIH based on NMR and SAXS restraints agree remarkably well; even the shapes of the

34 s that are higher than dimer, these distance restraints all have two-fold directional ambiguity, and

35 With injectable chemical restraint alone, spontaneous fluctuations in pupil size

36 ollagen gels and applied uniaxial mechanical restraint along the short or long axis of the fibrin wou

37 We demonstrate that acute restraint and acute forced swim stressors induce differe

38 CR group retained higher degrees of dietary restraint and avoidance of certain foods.After a 2-y int

39 elfare implications associated with physical restraint and demonstrate a method which can be used to

40 FpEF was associated with greater pericardial restraint and heightened ventricular interdependence, re

41 ween those involved/not involved in physical restraint and in physical restraint plus seclusion respe

42 , whereas insufficient sleep reduced dietary restraint and led to weight gain in women.

43 ses in hippocampal CA3 were impacted by both restraint and multimodal stress, multimodal stress alone

44 miR-182-mediated disruption of TGFbeta self-restraint and provide a mechanism to explain the unleash

45 ressive incidents; coercive measures such as restraint and seclusion should only be used as a last re

46 ction) and 'physical control' (e.g. physical restraint and seclusion).

47 tpartum weight retention and improve dietary restraint and self-weighing in study completers.

48 d models of opioid stress-induced analgesia (restraint and warm water swim) were studied in both sexe

49 Information about their involvement in restraint and/or restraint plus seclusion incidents was

50 sing nothing but their simulated profiles as restraints and experimental difference data for individu

51 in facilitated identification of unambiguous restraints and improvement of the quality of the calcula

52 Protein docking supported by evolutionary restraints and machine learning can be used to reliably

53 41 ectodomain monomer, based on NOE distance restraints and residual dipolar couplings, shows that th

54 fferent acute challenges, including novelty, restraint, and FS stress, produced distinct glucocortico

55 rth weight (BW), as a marker of fetal growth restraint, and high birth weight (BW), especially after

56 ssion, their attitudes towards seclusion and restraint, and their emotions.

57 strongest in the lowest tertile of cognitive restraint, and weakest in the highest tertile.Genetic su

58 benzodiazepines, narcotics, use of physical restraints, and exposure to vasopressors and antiepilept

59 practices, such as heavy sedation, physical restraints, and immobility, as well as aging physiology,

60 mulated annealing using NOE-derived distance restraints, and the NMR spectra of a series of designed

61 ss-linkers stabilize the fold by macrocyclic restraints, and they also form an integral part of a sma

62 t molecular dynamics simulations with energy restraints applied simultaneously using a novel methodol

63 F-actin is modeled as a monomer with restraints applied to coarse-grained variables enforced

64 We further argue that futurity and restraint are life history variables, and that Life Hist

65 al structures with minimum readily available restraints are lacking.

66 l and biophysical data containing structural restraints are not available, but one still wants to obt

67 However, such restraints are quickly removed to exert antimicrobial re

68 itively correlated with their endorsement of restraint as a management technique, but not with their

69 l changes in the KcsA channel removes steric restraints at the selectivity filter, thus resulting in

70 secondary structure prediction with perfect restraints (base pair information of known structures).

71 We developed a novel restraint-based method that is capable of reconstructing

72 By subjecting the models generated by our restraint-based strategy to molecular dynamics (MD) simu

73 tects motifs solely on the basis of distance restraints between catalytic residues.

74 r and for obtaining long-range DEER distance restraints between the ASR trimer subunits that were use

75 itio folding using our predicted contacts as restraints but without any force fields can yield correc

76 contact correlation and enforcing a sparsity restraint, but these methods demand for a very large num

77 Voluntary restraints by the food and drinks industry have had litt

78 ork shows how adopting strategies that avoid restraint can minimize a widespread source of stress in

79 s non-contacts and adding them as additional restraints, can increase the reconstruction accuracy by

80 caused by geographic dispersal and extrinsic restraints caused by shifts in reproductive mode associa

81 systematically varied by applying positional restraints, causing the remarkable effect of turning the

82 The restraint consists of myosin IIB- and IIA-dependent proc

83 repulsion, accounting for pairwise distance restraints, construction of homo-multimers, consideratio

84 Together with complementary restraints derived from cross-linking and native MS, we

85 In this study, geometric restraints derived from these experimental data were use

86 Cognitive restraint did not mediate this association (P-Sobel > 0.

87 gnetic relaxation enhancement (PRE) distance restraints, dihedral angle, small-angle X-ray scattering

88 atment and posttreatment levels of cognitive restraint, disinhibition, and hunger and 1-y changes in

89 questionnaire-derived perceptions of dietary restraint, disinhibition, hunger, and control of eating.

90 lated DELLAs, resulting in beneficial growth restraint during stress.

91 These distance restraints enable us to position Psb28 on the cytosolic

92 rect identification of internuclear distance restraints encoded in 3D spectra with automated data ana

93 ue, but not with their actual involvement in restraint episodes.

94 curate structure when using generic geometry restraints, even at a very high diffraction data resolut

95 ons, before acute and repeated loud noise or restraint exposures.

96 rious options, the construction of auxiliary restraints files, the selection of the energy parameters

97 ough an incrementally increasing convergence restraint for corresponding positions.

98 a complex with WDR5 and RbBP5, suggesting a restraint for the architectural arrangement of subunits

99 lity to crystallize or obtain sufficient NMR restraints for large or flexible proteins.

100 rM-NG during transport and afforded distance restraints for modeling the intracellular facing transpo

101 protein complexes, which are in turn used as restraints for modeling the structures of those analytes

102 ) has been an important source of structural restraints for solving structures of oligomeric transmem

103 terpretation and relatively few but reliable restraints for structure calculation.

104 d lanthanide spin label, provided structural restraints for the protein.ligand complex.

105 n restrained simulations satisfying distance restraints from (13)C-(2)H rotational-echo double-resona

106 n of diagonal-compensated protein structural restraints from four-dimensional solid-state NMR spectra

107 prediction protocols tailored to the type of restraints gained by contact predictions.

108 These structural restraints generally confirm the expected binding mode o

109 As expected, accounting for restraints generally improves the rank of near native pr

110 Using restraints generated from both cytb 5 and cyt c, a compl

111 fully solvated SLO model using ENDOR-derived restraints give additional metrical information.

112 s impediment, we have developed a robust NMR restraint guided docking protocol to generate high-quali

113 scribe quantitatively the effects that these restraints have on the free energy landscapes of protein

114 del for a HA/Link module complex using novel restraints identified from NMR spectroscopy of the prote

115 selectivity and suggest that conformational restraints imposed by the amino-acid sequence on the tra

116 ition of NMR RDC (residual dipolar coupling) restraints improves the structure models.

117 l processing is outside awareness, cognitive restraint in a world of plenty is made difficult and pre

118 Restraint in animals is known to cause stress but is use

119 stimulation, indicating the central role of restraint in directed outgrowth.

120 allowing sympathoexcitation to occur without restraint in the setting of increased pressor response.

121 activity for localized membrane cytoskeleton restraint in the syncytial Drosophila embryo.

122 the need for further evidence, we encourage restraint in the widespread use of ECMO until we have a

123 orating NMR measurements as replica-averaged restraints in molecular dynamics simulations, and by val

124 emical shifts as replica-averaged structural restraints in molecular dynamics simulations.

125 s and NMR chemical shifts used as structural restraints in replica-averaged metadynamics simulations.

126 a method of using methyl chemical shifts as restraints in replica-averaged molecular dynamics (MD) s

127 By using the probability scores as restraints in RME, we compared its secondary structure p

128 To predict the variability of the spatial restraints in template-based modeling, we have devised a

129 ransfer measurements, which were not used as restraints in the calculations.

130 he characteristic features of conformational restraint, including improved fluorescence quantum yield

131 to constraint (increases with experience) or restraint (increases with age in the face of declining r

132 M (group 1) and infants with prenatal growth restraint indicated by rapid postnatal catch-up growth (

133 subjects, Null mice showed highly attenuated restraint-induced analgesia, showing a critical role for

134 s comparable across species and is robust to restraint-induced reduction in sensory input.

135 rol male) were seen in swim-induced, but not restraint-induced, analgesia.

136 is closely related to the reliability of the restraint information extracted from a template, and it

137 cattering data as a differentiable energetic restraint into explicit-solvent MD simulations, termed S

138 d t rotameric angles, even though no rotamer restraint is used when deriving the sampled angles.

139 n distribution, the variability of a spatial restraint, is closely related to the reliability of the

140 for 5LO were investigated after undergoing a restraint/isolation paradigm.

141 the present paper, we found that 28 days of restraint/isolation stress worsened tau phosphorylation

142 same: NGF-induced weakening of MII-dependent restraint led to dynamic microtubules entering the actin

143 Stiff mechanical restraint led to formation of an extensive actin cup mat

144 higher robustness against incorrect distance restraints, making it the ideal sampling strategy for th

145 ns encircling the disaggregase constitute a 'restraint mask' that sterically controls the mobility an

146 earch into interventions designed to support restraint may help to protect genetically susceptible in

147 c harnessing of the role of stroma in cancer restraint may hinge on our knowledge of the signaling pr

148 mpatible with the full range of experimental restraints measured by various techniques.

149 matically identify and prioritize additional restraint measurements that allow us to rapidly optimize

150 vered an evolutionarily conserved allosteric restraint mechanism for Nedd4 ligases and demonstrated i

151 This restraint might be because of the poor proliferative cap

152 Cognitive restraint modified the relation between the BMI-GRS and

153 , hours-long light, loud noise, jostling and restraint (multimodal stress) with those of restraint or

154 ttributed to the (i) lessening of the steric restraints near the beta-ionone ring and SB ends of the

155 Restraints obtained by IMS are used to map the surfactan

156 g Rosetta model building guided by structure restraints obtained from magic-angle spinning solid-stat

157 cell type-specific and critical role in the restraint of B-cell homeostatic survival, a role with im

158 t of neutrophils in the dLNs, leading to the restraint of B. anthracis dissemination.

159 Stromal restraint of cancer growth and progression-emerging as a

160 MDM4 inhibition resulted in growth restraint of HCC cell lines both in vitro and in vivo.

161 ntitative BCR signal weakness contributes to restraint of IgE B cell responses.

162 lays important roles in bone homeostasis and restraint of inflammation.

163 Restraint of intracellular signal transduction pathways

164 uses decreased vinculin-dependent actomyosin restraint of microtubule advance.

165 genes to promote further differentiation and restraint of Notch activity.

166 The mechanism of the former is through restraint of SCF(betaTrCP)-dependent destruction of the

167 procedures, almost always involves physical restraint of the animal.

168 apture resulted in a concentration-dependent restraint of the cell activity.

169 fine-tuning of Tregs and their all-important restraint of the immune system.

170 megakaryocytes and platelets both depend on restraint of the intrinsic (or "mitochondrial") apoptosi

171 ere observed, they contributed little to the restraint of the overall fold.

172 on with mass spectrometry generates distance restraints of amino acid pairs in close proximity on the

173 titative detail with the solid-state angular restraints of huntingtin 1-17 obtained in supported plan

174 A 3D structure prediction using evolutionary restraints of nucleotide-nucleotide interactions from di

175 3 dimers define the topological and mobility restraints of the entire assembly.

176 Restraints of the flexibility of the coiled-coil greatly

177 Spatial restraints of the interaction of this segment with the b

178 ults deepen our understanding of the binding restraints of this CC MBS.LZ PKG-Ialpha low-affinity het

179 ncluding a pseudoknot provided the strongest restraint on conformational freedom with the effect bein

180 ymphocytes or asialo GM1-positive cells, the restraint on dormant disseminated metastatic cells was r

181 PP2A activity by okadaic acid (OA) releases restraint on MAPKs and thereby increases MAPK-mediated p

182 In addition, a restraint on T cell activation by CD6 was revealed in pr

183 g a handling tunnel, or cupping mice without restraint on the open hand.

184 the TGFbeta type II receptor gene relieves a restraint on tumorigenesis.

185 -terminal acetylation imposes conformational restraints on N-terminal residues in alphaS, thus predis

186 the tryptophans in WT sybII impose sterical restraints on oligomer packing, thereby maintaining an a

187 human pathogenic fungi, we examine extrinsic restraints on recombination associated with bottlenecks

188 tous fungus Neurospora, we examine intrinsic restraints on recombination associated with mating syste

189 ed in the simulation process except for weak restraints on secondary structure to enable us to finish

190 onary covariation across these ORs to define restraints on structural proximity of residue pairs, whi

191 d in the active site and provides additional restraints on substrate binding.

192 When combined with restraints on the distance and orientation between helix

193 ns and imposing orientational and positional restraints on the other domains.

194 P hydrolysis with and without conformational restraints on the spring helix further supported the imp

195 nists are characterized by apparently strict restraints on their tertiary or quaternary amine and the

196 Mice exposed to hours-long restraint or loud noise were modestly or minimally impai

197 restraint (multimodal stress) with those of restraint or of loud noise alone.

198 s for experimental or bioinformatics-derived restraints or novel structural features to be included,

199 and although mutations of Trp-55 reduce the restraints placed on the requirement for orthosteric ago

200 about their involvement in restraint and/or restraint plus seclusion incidents was gathered for the

201 volved in physical restraint and in physical restraint plus seclusion respectively were detected.

202 patients, larger 1-y increases in cognitive restraint predicted a greater 2-y weight loss in both se

203 ow that the application of a small number of restraints predicted by coevolution analysis can provide

204 Chemical restraint protocols were compared to determine which pro

205 Combined injectable chemical and inhalation restraint provided a steady baseline pupil size througho

206 Using these restraints, pseudocontact shift-based rigid body docking

207 in(1-13)NH2 increased the IPSP amplitudes in restraint rats but not in unrestraint rats, suggesting a

208 selectively reduced anxiety-like behavior in restraint rats in the elevated plus maze.

209 Importantly, in stress-restraint rats, baseline CeA GABAergic responses were el

210 than enthalpies and demonstrate by using the restraint release (RR) approach that the observed entrop

211 ic understanding of pain, but the anesthesia/restraint required to administer electroacupuncture may

212 Acute stress [i.e., 30 min restraint (RES) or 5 min elevated platform exposure] rob

213 forces applied to beads at low stiffness of restraint revealed switching between two states: frictio

214 and fecal pellet production during repeated restraint sessions.

215 oach is that it provides structural distance restraints spanning a range of ca 3-60A while using the

216 stress, this study demonstrates how chronic restraint stress (CRS) modulates gene expression in resp

217 short-term (1 h per day for 7 days) chronic restraint stress (CRS), do not display depressive-like b

218 e mice and in mice with a history of chronic-restraint stress (CRS).

219 dala in response to prolonged 21-day chronic restraint stress (CRS).

220 After administering chronic restraint stress (CRS; 6 hours/day for >/=21 consecutive

221 Rats exposed to prenatal restraint stress (PRS) develop enduring biochemical and

222 r pituitary and/or the amygdala and 2) acute restraint stress activates (internalizes) NK3Rs on surfa

223 These results suggest that restraint stress activates LH orexin neurons, releasing

224 Chronic restraint stress also reduced the CB1 receptor-mediated

225 Neither acute nor chronic intermittent restraint stress altered Gad1 expression in POMC neurons

226 One month of chronic unpredictable restraint stress and inhibition of adult neurogenesis le

227 ompared the effects of chronic unpredictable restraint stress and inhibition of neurogenesis in a rat

228 e anxiety-like response in rats subjected to restraint stress and nonrestraint rats after N/OFQ micro

229 eural, and endocrine habituation to repeated restraint stress and subsequent cognitive flexibility wa

230 lamic stress-sensitive cells, multimodal and restraint stress differ in their activation of brain net

231 Water avoidance and repeat restraint stress each led to visceral hyperalgesia, acco

232 ment in mGlu3-LTD following a single, 20-min restraint stress exposure.

233 sed the function of the HPA axis response to restraint stress following hormone treatments, or after

234 ere randomly assigned to two groups; G1: CS (restraint stress for 12 hours/day) (n = 10), and G2: not

235 nd that a 60-minute MCAO followed by spatial restraint stress for 2 h daily for 2 to 4 weeks from the

236 In STR groups, the animals were subjected to restraint stress for 2.5 hours per day for 30 days.

237 ctively, these results indicate that chronic restraint stress impairs the alpha1-AR LTD by reducing t

238 We found that rats submitted to chronic restraint stress in adulthood display reduced sociabilit

239 Here, we show that acute restraint stress in mice activates lateral hypothalamic

240 neurons of the PVN and plasticity following restraint stress in rats are unknown.

241 Acute restraint stress increased c-Fos (known as a neuronal ac

242 Moreover, chronic restraint stress induces bursting action potentials in L

243 Here we show that chronic restraint stress induces the selective loss of p11 (also

244 The protocol used for restraint stress influenced the immunomodulatory effects

245 An animal model involving restraint stress of pregnant mice suggests that PRS indu

246 ent study, we examined the impact of chronic restraint stress on alpha1-AR-mediated regulation of glu

247 npredictable times over 14 days, followed by restraint stress on day 15) and diminished HPA output se

248 zation (ISH), we assessed the effect of body restraint stress on the gene expression of CRF and N/OFQ

249 Restraint stress or optogenetic C1 neuron (C1) stimulati

250 and decreased tumor burden and metastasis in restraint stress orthotopic models.

251 Chronic unpredictable restraint stress over 4 weeks decreased total hippocampa

252 By contrast, repeated restraint stress produced habituation in HPA responses,

253 portantly, we found that chronic exposure to restraint stress profoundly reduced the magnitude of alp

254 An acute restraint stress session of 30 min significantly increas

255 ng female rats exposed to 1 week of repeated restraint stress show no negative effects on temporal or

256 tients with depression and mice subjected to restraint stress showed elevated PGE2 levels.

257 Restraint stress was applied to pregnant Slc6a4 (+/+) an

258 n physiological reactivity and recovery from restraint stress were then characterized.

259 Therefore, we hypothesized that chronic restraint stress would lead to reduced hippocampal NLGN-

260 verified by body weight gain after repeated restraint stress, and fecal pellet production during rep

261 here a powerful anti-inflammatory effect of restraint stress, mediated by C1 neurons: protection aga

262 sis, we have exposed C57/Bl6 mice to chronic restraint stress, which results in an increase in fatty

263 cerebral artery occlusion (MCAO) and spatial restraint stress.

264 gature-induced periodontitis associated with restraint stress.

265 RT) and a more rapid decay of CORT following restraint stress.

266 ion, is significantly upregulated by chronic restraint stress.

267 HPA output seen following repeated (14 days) restraint-stress exposure are associated with differenti

268 esponses, with habituation to the same acute restraint stressor and sensitization to a novel forced-s

269 rats, via chronic water avoidance or repeat restraint stressors, and investigated whether rifaximin

270 Anisotropic mechanical boundary conditions (restraint, stretch, or tension) could affect the rate of

271 heir MS-based identification yields modeling restraints that allow mapping the location and orientati

272 ing mass spectrometry, we extracted distance restraints that allowed us to model the complexes' molec

273 residues for cross-linking provides distance restraints that are complementary and orthogonal to thos

274 nd with ajmalicine as well as sparse lattice restraints that would hinder adaptations.

275 By tertiles of cognitive restraint, the association between the BMI-GRS and BMI w

276 static pressure known as turgor-and an outer restraint-the polymeric wall that surrounds a cell.

277 e intervention group reported higher dietary restraint through 6 mo postpartum (P = 0.023) and more f

278 nhibit orexin activation throughout repeated restraint to determine if the stress-related impairments

279 , including CYFIP1, acts as a conformational restraint to prevent WASF3 activation.

280 ure from the harmful inertia of sedation and restraints to an animated ICU filled with patients who a

281 and chemical cross-linking MS into modeling restraints to compute the most likely structure of a pro

282 cs (RAM) simulations with NMR chemical shift restraints to determine an ensemble of structures repres

283 Users can also provide distance restraints to guide the AIDA energy minimization.

284 ith recently collected experimental distance restraints, to illustrate the toolkit's capabilities and

285 Rats were trained to initiate periods of restraint up to 8 s in duration, which provided the mech

286 endently associated with delirium onset were restraint use (hazard ratio, 1.87; 95% CI, 1.33-2.63; p

287 sure ulcer and higher unit rates of physical restraint use were not associated with higher Pressure U

288 delirium-free days, vasopressor and physical restraints use, and device removal.

289 al docking, accounting for pairwise distance restraints using penalty terms in the scoring function i

290 ent ad libitum lunch were assessed in 26 low-restraint volunteers by using a within-participant desig

291 Physical restraint was most strongly associated with delirium.

292 nt of right heart congestion and pericardial restraint, was similar in TR and controls (6+/-3 versus

293 carried out with and without chemical shift restraints we describe quantitatively the effects that t

294 Rietveld refinement using geometric restraints were then performed to optimize the positions

295 ement approach wherein membrane and distance restraints were used to generate an initial NMR structur

296 l eating, uncontrolled eating, and cognitive restraint-were measured through the use of a validated q

297 Oriented-sample data yielded orientational restraints, whereas magic-angle spinning data yielded in

298 s exhibited impaired habituation to repeated restraint with subsequent deficits in cognitive flexibil

299 mass spectrometry yielded 17 unique distance restraints within the ECD of the TSHR, its ligand TSH, a

300 ructures using Rosetta with experimental NMR restraints yields more accurate protein NMR structures t