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1 tions of melioidosis that are geographically restricted.
2 ose in bulk water and that their mobility is restricted.
3 teins, including IFITM1, IFITM2, and IFITM3, restrict a broad range of viruses.
4 E-mediated hypovolemia and shock required VE-restricted ABL1 expression.
5 ir ablation effectively modifies dynamics on restricted ablation.
6 h rainfall (rain-on-snow) can cause 'icing', restricting access to forage, resulting in starvation, l
7                                     Thus, GR restricts actions of its own coregulator via CDK9-mediat
8 h the device, finding it easy to use without restricting activities or causing anxiety.
9    We demonstrate that Env-specific HLA-B*14-restricted activity is substantially more efficacious th
10         Therefore, this system allows for LC-restricted Ag presentation to T cells.
11  the diversity of protease- and IgG subclass-restricted AHAs and their potential as immunological mar
12                              These complexes restrict AMPAR dendritic mobility, leading to the intrac
13  tissue, which normally becomes increasingly restricted and anisotropic in the brain during childhood
14                 Engrafted cells were myeloid-restricted and matched the immunophenotype, morphology,
15                This analysis revealed highly restricted and mutually exclusive tissue distributions,
16  of the mTEC transcriptome, including tissue-restricted antigen expression.
17 ne activation in the tumour microenvironment restricts antitumour immunity.
18 scFvFITC:sFasL induced potent target antigen-restricted apoptosis in a panel of cancer lines and in p
19  to the transient calcium pulses observed in restricted areas in the forming dendritic arbor.
20 ermline, and, through TAS3-derived ta-siRNA, restricted ARF3 expression to the medio domain of ovule
21 n pregnancy and lactation, which were growth restricted at birth.
22  mouse embryo, possibly in part by spatially restricting atypical protein kinase C, a negative regula
23 oliferation of leaf support tissues, and for restricting auricle expansion at the midrib.
24  (aAPC)-based system, we isolated human CD1c-restricted autoreactive T cells and characterized them a
25  based on machine learning - methods such as Restricted Boltzmann Machines (RBM) or Support Vector Ma
26 tion genes by using a variety of approaches (restricted branch/branch-site models and unrestricted br
27 y as chains transition to a conformationally restricted bridged state.
28 nscription of the paternal genome was highly restricted but unexpectedly included genes encoding puta
29 onal CD8 T cell responses that were entirely restricted by MHC II or the nonclassical MHC I molecule,
30 ion of cell motility studies though is often restricted by the applied approaches such as 2D conventi
31 us (CMV) can elicit a CD8(+) T cell response restricted by the human MHC-Ib molecule human leukocyte
32 al NF-kappaB and PI3K signaling pathways are restricted by the M-ILK deficiency.
33 e transformations with slow kinetics largely restricted by the nucleation and growth of a new phase.
34 iving from improved grain quality traits are restricted by weather variability and markedly affected
35                                       Muscle-restricted Cas9 expression enables direct editing of the
36                     In contrast, cytoplasmic-restricted CASZ1 staining or low nuclear CASZ1 staining
37 tion in a membrane-bound state is crucial to restrict caveolae dynamics in cells.
38 validation, we were able to identify a MHCII-restricted CD4 T cell epitope, corresponding to amino ac
39 lopodia-inducing Cdc42, we generated myeloid-restricted Cdc42 knock-out mice.
40 ndicates that multiple levels of specificity restrict CDI toxin delivery and activity to the same bac
41  with reduced breadth and magnitude of MHC-B-restricted cellular immune responses in HIV-infected ind
42 -HT3 -expressing nerve fibers terminate in a restricted central-lateral portion of the nucleus of the
43 ith highly preorganized and conformationally restricted chiral cavities of [2]rotaxanes to achieve en
44                     BRD2 therefore creates a restricted chromatin environment surrounding DSBs which
45 mming of multipotent lymphoid progenitors by restricting chromatin accessibility at B cell enhancers
46                               Thus, XLalphas restricts clathrin-mediated endocytosis and plays a crit
47 ntrate therapeutics within a unique, cardiac-restricted compartment to allow sustained drug penetrati
48 provided a means to promote their skills and restrict competition.
49 when participants were assessed under sodium-restricted conditions, physiological stimulation of aldo
50  to severe metabolic diseases, while calorie-restricted (CR) diets can improve health and extend life
51 permuted blocks to 6 months of a 25% calorie restricted (CR) or standard diet (SD).
52 nalyzed using multivariable Cox modeling and restricted cubic spline function.
53                                   We applied restricted cubic spline models to evaluate the dose-resp
54                                Risk-adjusted restricted cubic splines modeled the probability of each
55        Multivariate logistic regression with restricted cubic splines was utilized to examine the ass
56 hape of this relationship was examined using restricted cubic splines.
57 ifferentiate, thymocytes encounter spatially restricted cues critical for differentiation and selecti
58 s, including ThCTL that mediate MHC class II-restricted cytotoxicity.
59                                         LSEC-restricted deletion of Gata4 caused transformation of di
60                            Here we show that restricting dietary yeast during Drosophila development
61 r other nonrelated fish to avoid unnecessary restricted diets.
62                     Some of the cases showed restricted diffusion (43%) and hemorrhage (9%).
63 lied to many other systemic as well as liver-restricted disorders which are difficult to study by ger
64                                              Restricted diversity induced by a typical American diet
65                                      The MPN-restricted driver mutations, including those in JAK2, ca
66 mat differs across cities, but most programs restrict driving once or twice a week during weekdays.
67 ity following cochlear implantation has been restricted due to incompatibility between established ne
68 for developmental toxicity have been largely restricted due to the limited molecular data available f
69 rity in areas where Colinus virginianus were restricted during times of thermal extremes (range overl
70 shift) mutations in SAMD9 rescued the growth-restricting effects of mutant SAMD9 proteins in bone mar
71 llus cells, we identified hundreds of tissue-restricted enhancers that require the transcription fact
72 e essential for iron acquisition in the iron-restricted environment of the host, such as in subcutane
73        Therefore, we set out to map H2-IA(b)-restricted epitopes along the PVM proteome.
74 are defined by DNA methylation patterns that restrict expression of viral latency genes.
75  RNA with MyoD-regulated and skeletal muscle-restricted expression that promotes the activation of th
76           We discovered that imposing a time-restricted feeding (TRF) regimen in which all caloric in
77      Maternal folate deficiency is linked to restricted fetal growth, however the underlying mechanis
78                                              Restricting FISH analysis to the 10% of DLBCL patients w
79 es for cargo transport and thereby spatially restrict focus formation to the perinucleus.
80 ther: EI cells) compare ILDs separately over restricted frequency ranges which are not consistent wit
81 re efficacious than the subdominant HLA-B*14-restricted Gag response.
82 chromatin by multiple neural bHLH factors to restrict gene expression in specific neuronal lineages.
83 t Rift System, high genetic exclusivity, and restricted gene flow among mountain ranges.
84 lations of this species is associated with a restricted gene flow.
85 which Neto2 phosphorylation at Ser-409 helps restrict GluK1 targeting to the synapse.
86 A-DQ2, suggesting the involvement of HLA-DQ2-restricted gluten-specific CD4(+) T cells.
87 rentiation into cardiomyocytes; in contrast, restricting Hdac3 to the nuclear periphery rescues myoge
88  state responsible for highly penetrant male-restricted hepatic carcinogenesis.
89 cine vectors expressing a single MHC class I-restricted high-avidity epitope provided strong, T cell-
90 fically recognize IgG subclass- and protease-restricted hinge neoepitopes.
91 c activity of the protein and its ability to restrict HIV-1, and correlates with increased propensity
92 en proteins, of which A3D, A3F, A3G, and A3H restrict HIV-1.
93  clones recognizing the identical HLA-B*2705-restricted HIV-1 epitope KK10 (KRWIILGLNK).
94             These results imply that SERINC5 restricts HIV-1 fusion at a step prior to small pore for
95 tions in which ectopically expressed SERINC5 restricts HIV-1 infectivity and is antagonized by Nef an
96 er, the molecular mechanism by which SERINC5 restricts HIV-1 particle infectivity is still unclear.
97  CD4(+) T-cell therapy using an MHC class II-restricted, HLA-DPB1*0401-restricted TCR that recognized
98 h is closely related to Toxoplasma but has a restricted host range and uses different effector protei
99                 SCORE-IT (Spot Sign Score in Restricting ICH Growth) is a preplanned prospective obse
100 cytes, in tissue-specific regulation of CD1d-restricted immunity and further suggest that alterations
101 omain A isoform (FnEDA), which is relatively restricted in distribution to sites of tissue injury.
102 ich combines peroxidase-catalyzed, spatially restricted in situ protein biotinylation with RNA-protei
103                 The UFRs were more spatially restricted in the brain than lower-frequency HFOs.
104 as observed across most tests, likely due to restricted inclusion of non-CP-CRE to assess the specifi
105 d pinning down of the guard cell ends, which restricts increase of stomatal complex length during ope
106                                              Restricted infection in SLOs by Delta5G also suggests th
107 ght how this work is exposing the previously restricted intracellular space to the potential of thera
108 nteresting new gene (RING)-type E3s, thereby restricting it to homologous to E6AP C-terminus (HECT) a
109 ular analysis shows that ERG binds to SMAD3, restricting its access to DNA.
110 organ size control and cancer prevention via restricting its downstream effector, Yes-associated prot
111 , but the poor analytical sensitivity of LFA restricts its application.
112 sirable noise detected simultaneously, which restricts its uses under weak signal yet strong noise co
113 ts: (1) a TCR specific for the hematopoietic-restricted, leukemia-associated minor H antigen, HA-1; (
114 r a cohort of stage-specific oligodendrocyte-restricted lncRNAs, including a conserved chromatin-asso
115  and antioxidant activity were recorded with restricted losses of 29%, 8%, 12%, 12% (DPPH) and 9% (FR
116           Medial prefrontal connections were restricted mainly to a ventromedial strip located in the
117  contribute to specificity, but in a context-restricted manner.
118 y a large set (649) of novel, evolutionarily restricted miRNAs.
119 s phenomenon is uncommon in tetrapods, being restricted mostly to parrots and marine turtles.
120 n, virus replication and lytic infection and restricts murine CMV replication in vivo.
121 o reduce the computing cost and perform less restricted mutual exclusivity analysis, we developed an
122                                    These may restrict Mycobacterium tuberculosis (Mtb) growth, or pro
123 models, acute administration of peripherally restricted NaV1.7 inhibitors can only produce analgesia
124 ndosome- and lysosome-localized protein that restricts numerous virus infections.
125 as either "brain penetrant" or "peripherally restricted" on the basis of the experimental mouse brain
126 d that the benefits of crowdsourcing are not restricted only to harnessing the time, labor, and funds
127 s can be used to illuminate either spatially restricted or large brain volumes.
128                                           We restricted our analysis to 34 countries that reported mo
129  of dilated cardiomyopathy driven by cardiac restricted overexpression of TNF (tumor necrosis factor;
130 red TCA cycle flux is a central mechanism of restricted oxidative capacity in this disorder.
131 reveal key virulence factors that respond to restricted oxygen availability and specific transporters
132 activating mutations in either the leukocyte-restricted p110delta catalytic (PIK3CD) subunit or the u
133 AVs) pose a major, unresolved challenge that restricts patient enrollment in gene therapy clinical tr
134                          This classification restricts patients presenting with clinical criteria cha
135                                     Policies restricting peanuts from home, served in schools, or hav
136 this, we predicted HLA class I- and class II-restricted peptides from rDEN2Delta30 and used them in a
137 emic medical centers (AMCs) enacted policies restricting pharmaceutical representative sales visits t
138 a complex molecular network that defines and restricts pluripotent developmental potential in culture
139  is essential to induce broad protection and restrict pneumococcal colonization.
140 e and determining Okazaki fragment length by restricting Pol delta progression.
141 tions in genes MLO2, MLO6 and MLO12 not only restrict powdery mildew colonization, but also affect in
142 nstrate that selective Lgr5(+) cell ablation restricts primary tumour growth, but does not result in
143 , indicating that it counteracts a spatially restricted pro-death signal.
144              Thus, therapeutics and vaccines restricting production of afucosylated, IgG1 RNNIg durin
145 ment and growth is proposed to rely on layer-restricted progenitor cells.
146 well as undifferentiated stem cells and more restricted progenitors.
147 ested that this urinary testing algorithm to restrict prostate biopsy has greater potential cost-bene
148 heir secretory granules, including mast cell-restricted proteases such as tryptase.
149 myosin-binding protein C (cMyC) is a cardiac-restricted protein that is more abundant than cardiac tr
150 onizes stress-induced activation of dHSCs by restricting protein translation and levels of reactive o
151                             Monosynaptically restricted rabies virus facilitates the anatomical inves
152 actions between high dam density and species restricted ranges.
153 terized by social communication deficits and restricted, repetitive patterns of behavior.
154 served arms of cell-autonomous immunity that restrict replication of intracellular pathogens.
155 n vitro assays showed that IFIH1 effectively restricts replication of human respiratory syncytial vir
156               UNC-3, which is not regionally restricted, requires region-specific cofactors in the fo
157                       A subdominant HLA-B*14-restricted response targets Gag (DRYFKTLRA, HLA-B*14-DA9
158 Celiac disease is characterized by HLA-DQ2/8-restricted responses of CD4+ T cells to cereal gluten pr
159 expressed in intestinal epithelial cells and restricts rotavirus infection.
160 s regulated salesperson gifts to physicians, restricted salesperson access to facilities, and incorpo
161 del was used to identify transiting and area-restricted search (ARS) behaviours, believed to indicate
162 rgic axo-axonic and some CCK interneurons in restricted septo-temporal CA3 segments.
163  probably involved in the glycosylation of a restricted set of mitochondrial targets.
164 sciplines differentiate into sciences with a restricted set of paradigms, examples, and techniques, d
165                                    The sperm-restricted single-pass transmembrane protein HAP2-GCS1 h
166 veyed, which might be unachievable for range-restricted species occurring at relatively few sites.
167                                        Cubic-restricted splines and multivariable log-Poisson regress
168 genesis in which position-dependent, lineage-restricted stem cells undergo cell mixing in order to co
169 re separately maintained by distinct lineage-restricted stem cells.
170 ohort but with a reduced risk of ROP among a restricted subcohort of P-VLBW infants.
171 e explained by faltering limited to a growth-restricted subgroup of children.
172                         In chronically sleep restricted subjects, low slow-wave sleep intensity over
173 between clustered binding sites in spatially restricted subnuclear regions, suggesting that topologic
174 oteins, and the activation of CD1a- and CD1d-restricted T cells were sensitively inhibited by benzo[a
175 ll corpse-associated antigens to MHC class I-restricted T cells, a property that was associated with
176 oreceptor to promote function of the class I-restricted TCR in CD4(+) T cells; (3) an inducible caspa
177 ng an MHC class II-restricted, HLA-DPB1*0401-restricted TCR that recognized the cancer germline antig
178 anchored PKA holoenzyme action are much more restricted than originally anticipated.
179             Vaccine designers have sought to restrict the conformation of the HIV-1 Env trimer to its
180 l brain, earmuff (erm) uniquely functions to restrict the developmental potential of intermediate neu
181  embryonic carcinoma (EC) cells are shown to restrict the expression of murine leukemia virus genomes
182 d the cytoskeleton, especially microtubules, restrict the lateral mobility of AtHIR1 at the plasma me
183 y and pharmacology showed that HCN1 channels restrict the rate of exocytosis from a subset of cortica
184 ll line the dynamic events that activate and restrict the spatial activity of the ZRS.
185 at the immunosensor surface that efficiently restricted the electron transfer of redox probe Fe(CN)6(
186  kinase C-mediated phosphorylation of LLGL1, restricting the accumulation of AJCs to the basolateral-
187                                           By restricting the analysis to data involving two adjacent
188 f all the other strategies was questioned by restricting the analysis to high-quality trials.
189 -VLBW subcohort also may reflect biases from restricting the cohort to prematurity, because prematuri
190  can be effectively harnessed by elaborately restricting the drying of colloidal suspension using a f
191 ify a suitable model to underpin regulations restricting the marketing of unhealthy foods to children
192 plement such metareasoning approximations by restricting the range of behaviors and states considered
193 porous shells continued to act as regulators restricting the release of oxygen from CaO2 cores.
194  bleaching in STED/RESOLFT nanoscopy through restricting the scanning to subdiffraction-sized regions
195 hat confines caveolae to the cell surface by restricting the scission and subsequent endocytosis of t
196  Several sensitivity analyses were performed restricting the study population by patient demographic
197 e in melanoma patients and whether adenosine restricts the efficacy of clinically approved targeted t
198 eport that, in naive mouse ESCs (mESCs), p53 restricts the expression of the de novo DNA methyltransf
199 s the comparator has several limitations and restricts the full interpretation of biomarker performan
200 ered under a microscope, which substantially restricts the range of behaviors that can be studied.
201 o differentiation of gametes, and the second restricts the regulatory influence of new insertions tow
202 rance to steric hindrance of these couplings restricts the synthetic availability of more substituted
203 st price of DAAs has led many governments to restrict their reimbursement.
204 lated both developmentally and functionally, restricting their utility.
205 an unusual compact and stable structure that restricts their motions.
206  MSCs toward a proinflammatory phenotype and restricts their survival and reparative effects in a mec
207 nger alcohol exposure (7 d x 2.5 g/kg, i.p.) restricted these increases to the dorsal striatum, and t
208 tains DNAse hypersensitive sites active at a restricted time window during retinal development.
209                          Because of its more restricted tissue expression profile, we have therefore
210 7,000 to $7,884), and was robust in analyses restricted to 6-month survivors.
211                      This improvement seemed restricted to a group of responders that included 40% of
212 f richness with farming in nasal samples was restricted to a high gradient of farm exposure, that is,
213 , and in Northern Ireland the species is now restricted to a single population in Peatlands Park, Co.
214 o modify neurons within the visual system is restricted to a so-called critical period that, for cats
215 ixed chain, not all the isopeptide bonds are restricted to a specific lysine of ubiquitin, resulting
216 east, but in A. gossypii, this system is not restricted to a specific nuclear cycle stage, possibly a
217 The active CNV mutation shower appears to be restricted to a transient perizygotic period.
218           Excess mortality was predominantly restricted to admissions between 1100 h and 1500 h (pint
219  is a robust positive association, but it is restricted to adult women in high-income countries.
220 and pregnancy loss in a sensitivity analysis restricted to artemisinin exposures during the embryo se
221                        Drebrin expression is restricted to basal epithelial cells in benign human pro
222 vals (24/35, 69%), all clinical studies were restricted to biomarker-positive patients (enriched).
223 tant target sites of anthelmintics have been restricted to Caenorhabditis elegans because they have f
224  proliferation within the HSC compartment is restricted to CD41-expressing cells that function with s
225 ue to spatial tumor heterogeneity, they were restricted to clones that were anatomically distant from
226  process start-up, catalyst design should be restricted to Co NPs larger than 5.3 nm.
227 43 pathological signature of sporadic ALS is restricted to cortical areas as well as to subcortical n
228            Access to palatable food was then restricted to daily operant self-administration sessions
229      Herpes simplex virus (HSV) infection is restricted to epithelial cells and neurons and is contro
230 olyunsaturated fatty acids (FAs), 18:5 being restricted to galactolipids.
231 val and longer development time of GA nymphs restricted to glucose-containing food.
232        As the mechanism of action of ABMA is restricted to host-endosomal compartments, it reduces ce
233                                  As mice are restricted to infection at the level of DPP4, the MERS-C
234 he involvement of STN in reactive control is restricted to its ventromedial portion, further implicat
235 O2, this phenomenon does not seem to be only restricted to large industrialized areas anymore.
236                 Placental structures are not restricted to mammals but also emerged in some other ver
237   Importantly, this group of Nups is largely restricted to members of the inner and outer NPC rings,
238 esults were reinforced when the analysis was restricted to municipalities with more than 5 radon Spea
239 ental system where putative RVB correlations restricted to nearest neighbours are observed, and poses
240 tic healthy tissues or if L1 mobilization is restricted to neuronal precursor cells (NPCs) in the hum
241 DNA formed during mitotic recombination were restricted to one locus.
242 n developed, but their activity is generally restricted to one or a few classes of chemicals, and the
243 not a rare event, that it is not necessarily restricted to one or a few genes only, and that it can b
244 permatocytes, these cytoskeletal changes are restricted to one pole.
245 fection is that the virus spread is normally restricted to only a small fraction of cells on the corn
246  impacts is spatially limited and temporally restricted to only the most recent events.
247 mproving de novo enzymes since it is largely restricted to optimization of chemical positioning in th
248 on suggested immunomodulation, which was not restricted to parasite-specific responses.
249                   This beneficial effect was restricted to participants with S. aureus infection.
250 th status than SAVR, but this difference was restricted to patients treated via transfemoral access (
251                       Whether this effect is restricted to patients with low baseline vitamin D statu
252 I death among women in comparison to men was restricted to patients with MI-CAD.
253                        When the analysis was restricted to person-years with exposure to PM2.5 of les
254 II on both the pre-F and post-F proteins, is restricted to prophylaxis in neonates at high risk of se
255                        As this enzyme is not restricted to pyoverdine-producing bacteria, its catalys
256           Calcium release in HF myocytes was restricted to regions proximal to the sarcolemma.
257                         Failure to branch is restricted to regions where YAP activity is removed.
258 saber-toothed cats [1-3], and they have been restricted to short fragments of mitochondrial DNA.
259  of these models in some cases, they are not restricted to signaling errors in the prediction of valu
260 c transformations used by chemists are often restricted to simple functional-group interconversions.
261 s accurately: species' surveys are typically restricted to small geographic areas, are conducted over
262 n small changes in the network structure are restricted to some local communities.
263 t has the simplest sample preparation but is restricted to surface structures.
264 demonstrate that TCR-CAR redirection was not restricted to T cells.
265 l-molecule modulators of V-ATPase either are restricted to targeting one membranous subunit of V-ATPa
266 s was reported, and aversive sensations were restricted to the affected limb.
267 ssed human Arf6 GTPase, PSD3 localization is restricted to the brain, particularly the prefrontal cor
268 ntigenicity upon CD4 engagement appear to be restricted to the coreceptor site.
269      The Mitf-positive melanoblasts were not restricted to the dorsolateral pathway as in birds and m
270                        This mechanism is not restricted to the eye, as similar results were observed
271 t effect, the overall survival benefit being restricted to the hyperfractionated group (HR 0.83, 0.74
272 tory bulbs to the hindbrain, while vglut3 is restricted to the hypothalamus and hindbrain.
273 centromere during meiotic prophase II but is restricted to the inner centromere at metaphase II.
274                    The expression of DUO1 is restricted to the male germline and is first detected sh
275                    This protective effect is restricted to the molecular interaction of IL-17A and/or
276 l accommodation inside living plant cells is restricted to the nitrogen-fixing root nodule symbiosis.
277 mitochondrial network in Miro1(-/-) MEFs was restricted to the perinuclear area, with few mitochondri
278     In order to develop novel kappa agonists restricted to the periphery, a diastereo- and enantiosel
279        Unlike solutes, these proteins remain restricted to the phloem-pole pericycle.
280 insically a wave phenomenon and are thus not restricted to the realm of quantum mechanics.
281 bias in the pointing task, and either a bias restricted to the smaller numbers (left side) or no sign
282                                   Kv 3.1b is restricted to the soma, the primary neurite and the axon
283 on, however GPCR X-ray structures are mostly restricted to their inactive inhibitor-bound state.
284 ical localization of Par3, which is normally restricted to tight junctions, is sufficient to alter ap
285 omeostasis and that these DDR2 functions are restricted to TMJ fibrocartilage and not seen in the hya
286 how that constitutive NIK expression that is restricted to Tregs via a Cre-inducible transgene causes
287 demonstrated that CD25 expression is largely restricted to tumor-infiltrating Treg cells in mice and
288 trated that the significance of ASS1 was not restricted to UHCA, but also encompassed certain hemorrh
289  planta and that the role of the T6SS is not restricted to virulence.
290 genously expressed tumor target antigens and restricted trafficking of CAR T cells to and impaired lo
291 ll types as well as temporally and spatially restricted trajectories of radial glia maturation and ne
292                                       Ndfip1 restricts Treg cell metabolism and IL-4 production via d
293 ral vasodilation, unwanted side effects, and restricted use in pediatric patients.
294 rent national vector control policy in India restricts use of residual insecticide sprays to domestic
295 an extended visitation model compared with a restricted visitation model on the occurrence of deliriu
296                           In comparison with restricted visitation model patients, extended visitatio
297 minutes (interquartile range, 97.7-162.0) in restricted visitation model to 245 minutes (interquartil
298 espite increasing interest in goal-directed, restricted-volume fluid administration for major surgery
299 in identifying protein cross-links using non-restricted whole proteome databases.
300  These findings do not support policies that restrict women's access to abortion on the basis that ab

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