ライフサイエンスコーパス: resurgent

1 s achieved through vaccination, pertussis is resurgent.

2 d here for the 2013-2014 influenza season of resurgent A(H1N1)pdm09 and late-season type B activity.

3 pes and hormone therapy failures result from resurgent activity of androgen receptor (AR) and the upr

4 dual channels gave openings corresponding to resurgent and conventional transient current.

5 ons revealed enhanced tetrodotoxin-sensitive resurgent and persistent current amplitudes in large, bu

6 ons, and similarly we found an inhibition of resurgent and persistent current by cannabidiol.

7 by wild-type Nav1.6 as well as the aberrant resurgent and persistent current generated by Nav1.6 mut

8 ith prolonged Na(V) open times and increased resurgent and persistent current in native DRG neurons.

9 Correspondingly, resurgent and persistent Na(+) currents were reduced and

10 subunit specifically at the heminode reduced resurgent and persistent Na(+) currents, whereas K(+) ch

11 oms following oxaliplatin, and that enhanced resurgent and persistent sodium currents may provide a g

12 Pertussis is resurgent, and many cases are occurring in vaccinated ch

13 Additionally, transient, resurgent, and persistent sodium current components show

14 treatment of autoimmune disease has led to a resurgent appreciation of B cells as powerful regulators

15 control animal) is helping to dissect a now resurgent area of immunology.

16 ated animals (16 +/- 25, P = 0.037), and the resurgent B cells were primarily of a naive phenotype.

17 of diseases such as PCP that coincides with resurgent CD4 T cells, a phenomenon known as immune reco

18 In med cells, the resurgent component of beta-PMTX-modified sodium current

19 range of conditions, sodium currents with a resurgent component promote and accelerate firing.

20 found that P10-P14 Purkinje cells exhibited resurgent current (ranging from -3.6 to -15.4 pA/pF in 1

21 pen-channel blocking protein responsible for resurgent current acts as a natural antagonist of lidoca

22 inherited spinocerebellar ataxias, controls resurgent current and repetitive firing in Purkinje neur

23 channel inactivation rate, thereby reducing resurgent current and repetitive spiking.

24 pplication of alkaline phosphatase abolished resurgent current and significantly slowed inactivation

25 ical, molecular and structural mechanisms of resurgent current and their relation to the normal funct

26 Resurgent current appears to depend primarily on NaV1.6

27 ptide, can block open Na channels and induce resurgent current as channels unblock upon repolarizatio

28 ion, and conventional inactivation regulates resurgent current by controlling the extent of open-chan

29 The generation of resurgent current depends on a factor in the Na(+) chann

30 resurgent Na(+) and K(+) currents, Kv3.1b's resurgent current does not originate from recovery of ch

31 Na channels that generate resurgent current express an intracellular endogenous op

32 erlying molecular components contributing to resurgent current have not been fully identified.

33 current clamp to investigate the role of the resurgent current in action potential formation.

34 ent current in wild-type neurons and induced resurgent current in med neurons.

35 rom five species have the capacity to induce resurgent current in mouse hippocampal neurons, which la

36 beta-PMTX increased resurgent current in wild-type neurons and induced resur

37 We observed a correlation between resurgent current inhibition and a drug-mediated increas

38 without Na(V)1.6 lack resurgent current, but resurgent current is absent from many other Na(V)1.6-exp

39 es more rapidly than in wild-type cells, and resurgent current is nearly abolished.

40 Emerging research suggests that resurgent current is preferentially increased in a varie

41 ctions on voltage-gated sodium channels, and resurgent current may be a promising therapeutic target

42 inactivation, leading to the hypothesis that resurgent current may facilitate high-frequency firing.

43 Neurons with resurgent current may therefore be less susceptible to u

44 The macroscopic voltage dependence of resurgent current raises the question of whether the blo

45 Here we report a novel TTX-resistant (TTX-R) resurgent current recorded from rat DRG neurons.

46 Resurgent current results from unbinding of a blocking p

47 n endogenous particle whose unbinding allows resurgent current to flow.

48 With 50 mM sodium as a charge carrier, the resurgent current was on average approximately 120 pA.

49 missense mutation in Scn8a, steady-state and resurgent current were also reduced, with altered voltag

50 e electrophysiological phenotypes: a loss of resurgent current, a reduction of persistent current, a

51 Thus, the presence or absence of resurgent current, and of persistent sodium current, app

52 the necessity of this subunit in generating resurgent current, as well as its influence on Na channe

53 urrent; Purkinje cells without Na(V)1.6 lack resurgent current, but resurgent current is absent from

54 Trypsin and chymotrypsin each removed resurgent current, consistent with established roles for

55 of block, beta4(154-167) fully reconstituted resurgent current, whereas scrambled or point-mutated pe

56 d endogenous block, beta4(154-167) generated resurgent current.

57 etics of NaV1.6 appear well adapted to carry resurgent current.

58 e Na(V)1.6 subunit may lead to production of resurgent current.

59 ent current, and step repolarizations evoked resurgent current.

60 ation at -40 mV, coinciding with the rise of resurgent current.

61 ystems, however, Na(V)beta4 fails to produce resurgent current.

62 rst blocking protein that is responsible for resurgent current.

63 At -40 mV, this "resurgent" current peaked in 8 msec and decayed with a t

64 nnels in Purkinje cells produce an unusual, "resurgent" current when the cells are repolarized to int

65 sodium channels of Purkinje neurons produce "resurgent" current with repolarization, which results fr

66 ation from positive potentials, producing a "resurgent" current.

67 ated in part by a voltage-gated Na(+) (NaV) 'resurgent' current, which allows renewed Na(+) influx du

68 tions elicit slower channel reopening, or a 'resurgent' current.

69 ed proexcitatory increases in persistent and resurgent currents and rightward shifts in inactivation

70 Our results indicate that resurgent currents are associated with multiple channelo

71 Therefore, persistent and resurgent currents are likely to determine whether a mut

72 The TTX-R resurgent currents are similar to classic TTX-S resurgen

73 Resurgent currents arise after relief of ultra-fast open

74 ntial firing in nociceptive neurons and that resurgent currents associated with the Nav1.5 mutation c

75 Computer simulations indicated that resurgent currents associated with the Nav1.7 mutation c

76 Inward resurgent currents at strongly negative potentials, howe

77 itions and that enhancement of both types of resurgent currents by inflammatory mediators could contr

78 nsient current amplitude, demonstrating that resurgent currents can be selectively targeted.

79 We propose that these slow TTX-R resurgent currents contribute to the membrane excitabili

80 Additionally, in control gradients, peak resurgent currents decreased linearly with driving force

81 n mutation L955 (DeltaL955) fails to produce resurgent currents despite enhanced persistent currents,

82 However, the TTX-R resurgent currents exhibit much slower kinetics, occur a

83 damide and cannabidiol on peak transient and resurgent currents from wild-type and mutant channels.

84 Tetrodotoxin-sensitive (TTX-S) resurgent currents have been described in many different

85 en observed to mediate unique persistent and resurgent currents in cerebellar Purkinje cells.

86 We also show that both TTX-S and TTX-R resurgent currents in DRG neurons are enhanced by inflam

87 These results suggest that slow TTX-R resurgent currents in DRG neurons are mediated by Nav1.8

88 urgent currents are similar to classic TTX-S resurgent currents in many respects, but not all.

89 Reduced fast inactivation without increased resurgent currents induces symptoms of IEM, not PEPD, in

90 As such, enhancement of resurgent currents may constitute a pathological mechani

91 that selective attenuation of PEPD-enhanced resurgent currents might contribute to this therapeutic

92 trast, IEM mutations, whenever tested, leave resurgent currents unchanged.

93 d the voltage dependence of block, such that resurgent currents were evoked even after conditioning a

94 The amplitudes of the transient and resurgent currents were highly correlated across patches

95 In reverse gradients, outward resurgent currents were tiny or absent, suggesting that

96 h mutations in Nav1.6 dramatically increased resurgent currents while mutations in Nav1.1 did not.

97 nje cells isolated from embryonic chick have resurgent currents with kinetics and amplitudes indistin

98 gent currents, anandamide strongly inhibited resurgent currents with minimal effects on the peak tran

99 ge-clamp that R185H variant channels enhance resurgent currents within dorsal root ganglion neurons a

100 ugh carbamazepine did not selectively target resurgent currents, anandamide strongly inhibited resurg

101 As with TTX-S resurgent currents, they are activated by membrane repol

102 disease-causing mutations lead to increased resurgent currents, unusual sodium currents that have no

103 r insight into the potential mechanism(s) of resurgent currents, we examined whether these inhibitors

104 pen-state inactivation) and did not increase resurgent currents, which have been suggested to contrib

105 PEPD mutations also increase resurgent currents, which involve the voltage-dependent

106 that enhanced SI is accompanied by impaired resurgent currents, which suggests that SI may interfere

107 SI in order to investigate their effects on resurgent currents.

108 , the non-NaV1.6 subunits can produce robust resurgent currents.

109 hitherto been considered a prerequisite for resurgent currents.

110 rated by the same mechanism underlying TTX-S resurgent currents.

111 v1.6 is the major contributor to these TTX-S resurgent currents.

112 the three drugs on Navbeta4 peptide-mediated resurgent currents.

113 andamide, exhibit differential inhibition of resurgent currents.

114 raised global awareness of the potential for resurgent disease in countries with long-standing immuni

115 sidence within the caldera migrated from one resurgent dome to the other between August 1992 and Augu

116 per square second) centered on the uplifting resurgent dome.

117 remote areas, and we were able to confirm a resurgent epidemic in heterosexual networks in urban are

118 we aimed to find out the extent to which the resurgent epidemic is the result of newly introduced str

119 that the global scenario is characterized by resurgent epidemics, their number increasing with increa

120 major contributions to peak, persistent, and resurgent forms of sodium current and to sustained actio

121 ctive about GPe Na+ channels was a prominent resurgent gating mode.

122 a+ channel models with and without prominent resurgent gating suggested that resurgence was critical

123 ossessing Nav1.6 Na+ channels with prominent resurgent gating.

124 Resurgent HCV replication was temporally associated with

125 The resurgent HIV epidemic amongst MSM in the Netherlands is

126 ged in Scn1b (beta1) null CGNs; however, the resurgent I(Na), thought to underlie high-frequency firi

127 ly prolonged action potentials and inhibited resurgent IK tails from guinea-pig isolated ventricular

128 c amongst men who have sex with men (MSM) is resurgent in many countries despite the widespread use o

129 mporary ectoparasite on humans and currently resurgent in many developed countries.

130 to play a major role as a potentially lethal resurgent infectious disease.

131 to respond effectively to the challenges of resurgent infectious diseases, such as tuberculosis, and

132 living species, chimaeroids are the focus of resurgent interest as potential archives of genomic data

133 Resurgent interest in antiviral drugs for the treatment

134 The last 10 years have seen a resurgent interest in cardiac intermediary metabolism an

135 ies target metabolic enzymes, and there is a resurgent interest in developing new cancer drugs that i

136 However, resurgent interest in technologies aimed at enabling pro

137 l and structural data on these proteins, the resurgent interest in Type IV enzymes as tools for epige

138 .1b channels solve this problem by producing resurgent K(+) currents during repolarization, thus ensu

139 r nuclear neurons both have Na currents with resurgent kinetics.

140 ogenous open-channel blocker responsible for resurgent kinetics.

141 Voltage-gated sodium channels with "resurgent" kinetics are specialized for high-frequency f

142 However, mosquito-borne diseases are now resurgent, largely because of the insecticide resistance

143 unbinds at negative potentials, generating a resurgent Na current and permitting rapid firing.

144 Repetitive firing is facilitated by resurgent Na current, which flows upon repolarization as

145 lidocaine-like compounds affect neurons with resurgent Na current.

146 hannel block that approximates physiological resurgent Na current.

147 ayer II neurons by increasing persistent and resurgent Na currents and disrupting channel inactivatio

148 Unlike previously described resurgent Na(+) and K(+) currents, Kv3.1b's resurgent cu

149 calyx terminal revealed the expression of a resurgent Na(+) current (I(NaR)), the amplitude of which

150 Following its initial discovery, resurgent Na(+) current has been found in nearly 20 type

151 Resurgent Na(+) current results from a distinctive form

152 ry Na(+) channel subunit thought to underlie resurgent Na(+) current.

153 the unique electrical properties of Kv3 and resurgent Na+ channels are coordinated to limit accumula

154 e FGF14b N-terminus is a potent regulator of resurgent NaV current in cerebellar Purkinje neurons.

155 , including improved planning for the annual resurgent outbreak, augmented by simple central nationwi

156 ns in Kisii Central and Gucha led to typical resurgent outbreaks whereas exceptional rainfall in Nand

157 Our findings suggest these resurgent parasite populations are highly clonal and tha

158 Identifying the source of resurgent parasites is paramount to a strategic, success

159 ed pronounced slow inactivation (60%-70%) of resurgent, persistent, and transient components of sodiu

160 A resurgent Republican Party will mount a sustained challe

161 e upstroke of action potential, we show that resurgent sodium current flows at the peak of afterhyper

162 Resurgent sodium current is an atypical near threshold c

163 activate resurgent sodium current, and thus, resurgent sodium current likely contributes to the forma

164 Grieco and colleagues present evidence that resurgent sodium current results from a novel form of in

165 mV following brief, large depolarizations, a resurgent sodium current rises and decays in parallel wi

166 ter the gating of sodium channels to produce resurgent sodium current, an unusual form of gating in w

167 ramps was reduced to approximately 30%, and resurgent sodium current, an unusual transient current e

168 is similar to voltage patterns that activate resurgent sodium current, and thus, resurgent sodium cur

169 n and unbinds upon repolarization, producing resurgent sodium current.

170 in a functional blocking element and produce resurgent sodium current.

171 Resurgent sodium currents (I(NaR)) are atypical currents

172 c protrusion with loss of planarity, reduced resurgent sodium currents and abnormal glutamatergic neu

173 cent data suggest that, in some CNS neurons, resurgent sodium currents contribute to production of hi

174 Resurgent sodium currents contribute to the regeneration

175 all substantially increased the amplitude of resurgent sodium currents in an optimized adult rat-deri

176 plitudes of whole-cell peak, persistent, and resurgent sodium currents in Purkinje neurons were reduc

177 d that cannabidiol can preferentially target resurgent sodium currents over peak transient currents g

178 a4 peptide in the pipette solution to induce resurgent sodium currents.

179 abilized inactivation of Nav1.7 and enhanced resurgent sodium currents.

180 ng recovery from inactivation, generating a "resurgent" sodium current that flows immediately followi

181 e "persistent" sodium current and a dynamic "resurgent" sodium current, which promotes rapid firing b

182 during repolarization, carrying an unusual "resurgent" sodium current.

183 r acute infection correlates with subsequent resurgent virus replication and development of neurologi

184 ne high-expression HLA-DPB1 allele predicted resurgent virus-specific T-cell immunity and viral contr

185 te from the response at stimulus onset, is a resurgent visual representation that seems as selective

186 gh modeling efforts; these presumably became resurgent with inexpensive and powerful computing tools.