ライフサイエンスコーパス: retain

1 on criteria, such as toxicity, 36 drugs were retained.

2 models, whatever the significance threshold retained.

3 ype allele is most commonly, but not always, retained.

4 -Ciocalteau- and Fe-reducing capacities were retained.

5 e in which multiple substates are apparently retained.

6 h of the inferred connectivity is eventually retained.

7 All extravascular fragments except one were retained.

8 From 24 compounds, irradiated CSP retained 23 volatile compounds, while thermally treated

9 ation using the TRBO-sgRNA constructs, which retained 5' nucleotide overhangs.

10 a reversible capacity of 1340 mAh g(-1) and retains 590 mAh g(-1) after 100 cycles.

11 We retained 61 of 70 studies for review, representing 27 co

12 75%, 50%, and 25% 2D BSH reserve, premolars retained 67-68%, 39-41%, and 15-17% 3D BA-RSA, respectiv

13 rigerated condition over a period of 45 days retains 96.4% glucose response current.

14 hocholine (DMPC) and POPC/POPS 3:1 liposomes retain a bilayer macroscopic phase even at the highest p

15 d categorical language by modality, but they retain a binary distinction.

16 h allele-specific expression show that iPSCs retain a donor-specific gene expression pattern.

17 ntify that a subset of breast/ovarian tumors retain a normal allele, which is associated with decreas

18 type, in which lysis occurs while the cells retain a rod shape, revertant alleles with second-site s

19 R60Q) significantly reduced DNA binding, but retained a preference for the 5caC modified E-box.

20 esence of partially reprogrammed cells which retained a typical gene expression profile of mesendoder

21 early as day 3 post-transduction while still retaining a CM gene expression profile.

22 ydrophobic sidechains of a canonical D-site, retaining a significant degree of disorder in its ERK2-b

23 data vanishes, the profile-based calculation retains a strong correlation with the experimental measu

24 Metastatic tumors retained abnormal SHH signaling like tumor xenografts.

25 disc-well ultramicroelectrodes (UMEs), which retain access to stripping information but are less susc

26 roteins were washed off with 3 M NaCl, while retaining AChE bound to Hupresin.

27 generated by natural flow mimicry, and were retained across periods of heightened drought.

28 derived from the fact that membrane proteins retain activity in detergent extracts) that phospholipid

29 etric change of the assemblies could be well-retained after the stimulus was removed.

30 compared to untreated tumors, the tracer was retained after treatment due to a larger reduction in th

31 t of ependymal layer cells (ELCs) were label-retaining after a 140-day chase period.

32 showed that these MOFs could encapsulate and retain AITC molecules within their pores under low (30-3

33 med in the UK which include ingredients that retain all three structural components of the grain, and

34 nition at A2BAR, with the (S)-16b enantiomer retaining all the affinity (Ki = 15.1 nM), as predicted

35 Likewise, it retained almost complete activity at a concentration ran

36 Thus, human NSCs retain an intrinsic human rate of maturation, despite im

37 n a multivariate analysis, the monotypic PCs retained an independent prediction for PFS/OS, whereas t

38 and these Argentine-breeding swallows might retain ancestral patterns, breeding in Argentina but ret

39 de any active learning in their teaching may retain and more effectively educate far more students th

40 with high enzymatic activity and ability to retain and protect SOD1 under physiological conditions.

41 tential branch-point region differed between retained and constitutive introns.

42 o pass through the chip whereas the other is retained and subsequently recovered.

43 hese dosage forms, in particular, are poorly retained and traditional gels typically have little cont

44 ations accompany increased unspliced (intron-retained) and decreased spliced mRNA of IFNG and TBX21 b

45 pose a framework of how eDNA is transported, retained, and resuspended in stream systems.

46 Conclusion Gadoteridol was far less retained, and the entire detected gadolinium was intact

47 The fabricated DURA-Z coating retains antifouling property after 90 d of immersion in

48 rubicin-induced neutropenia and anemia while retaining antitumor efficacy.

49 oevolved in ancient repeat proteins and were retained as a functional pair due to their utility for s

50 he C-terminal region of FUS is sufficient to retain ASOs in cellular foci.

51 The unadjusted risk ratio (RR) of being retained at 12 months with HIV-1 RNA <50 copies/ml was 1

52 the cell's transcription pattern is largely retained at a low level through mitosis, whereas the amp

53 90.3%]) were significantly more likely to be retained at the end of the taper compared with clonidine

54 The transmembrane VRK2A isoform is retained at the NE by association with A-type lamins.

55 bitor resistant mutants hyperproduce L1, but retain aztreonam/inhibitor susceptibility because aztreo

56 Additionally, low-dose RCEM islets retained better morphology (confirmed with scanning elec

57 ighly effective, with the best compound (6p) retaining better efficacy against a broad panel of known

58 Fragments of Ef-Tu retain binding capabilities to host proteins.

59 alent antibodies of defined composition with retained bioactivity.

60 ) in which a cyanobacterium was engulfed and retained by a eukaryotic cell, although early steps in p

61 8)F]-FDG) is commonly used in PET/CT that is retained by metabolically active inflammatory cells in g

62 r stress or during ageing are preferentially retained by the mother cell, in part through tethering t

63 interacts with and edits the 3UTR of nuclear-retained Cat2 transcribed nuclear RNA (Ctn RNA).

64 BrdU label-retaining cells, a key characteristic of epithelial stem

65 The use of CG models which retain chemical specificity translates into a direct pat

66 erminal Pro-B-Type Natriuretic Peptide) were retained (chi(2), 62.2; P<0.0001).

67 s geological history, leading to water being retained close to its surface, and thus creating conditi

68 Genes with fewer retained CNSs show lower overall expression, although th

69 turation is not required for establishing or retaining cocaine-CPP.

70 in vitro mouse brain slice preparation that retains connectivity across the extended circadian syste

71 at the level of the township hospital would retain correct management close to current levels at 37%

72 ), can automatically adjust MIM operation to retain detector sensitivity when mobile phase changes.

73 Finally, reciprocally retained duplicates are often subject to dosage balance

74 lasma membrane and dorsal ruffles, but it is retained during collapse of ruffles to form macropinosom

75 idbrain floor plate progenitors (mFPPs) that retain efficient DA neurogenic potential over multiple p

76 onth after birth is readily acquired but not retained efficiently in peripheral tissues of neonatal r

77 og) to Uox with the HSA binding capacity and retained enzyme activity.

78 the evolution of substrate specificity from retained enzymes.

79 This model retains essential features of human neocortical developm

80 he recent adult validation cohort, the model retained excellent performance as in the original study.

81 In2, which binds with a KD of 120nM and also retains excellent state selectivity.

82 endent nuclear export of C9ORF72 transcripts retaining expanded hexanucleotide repeats and reveal a n

83 vealed defective IL-2 and TNF production yet retained expression of IFN-gamma and regulatory T cell-r

84 CDDO-DFPA exposed DCs retained expression of surface ligands and capacity for

85 ly ablated Tcf1 long isoforms in mice, while retaining expression of Tcf1 short isoforms.

86 ilament compaction and bundling, whilst also retaining extensibility to ensure flexibility of the ker

87 r treatment, especially in women who wish to retain fertility.

88 ls, and both high- and low-fidelity variants retained fitness during coinfection with the wild-type v

89 h models lead to reduced turnaround time and retain flexibility for integrating different specimen ty

90 ressed in most cases of B-ALL and is usually retained following CD19 loss.

91 w that "memory" of anomeric configuration is retained following gas-phase glycosidic bond fragmentati

92 n bias in the functional categories of genes retained following WGD, the difference in gene loss rate

93 ported gains in parental knowledge that were retained for 7 months.

94 galE2 alleles in meningococcal isolates was retained for all serogroups except serogroup E which has

95 sed with FASD (age range, 0-16.4 years) were retained for data extraction.

96 We tested whether these relationships are retained for major agricultural legumes and nonlegumes.

97 report a case of folded bandage contact lens retained for six and a half years in the upper subtarsal

98 echniques used for removal, and follow-up of retained fragments.

99 The immobilized SrtA was proved to retain full enzymatic activity for peptide-to-peptide li

100 nt mutations in Avr2 (e.g. Avr2(R45H) ), but retain full virulence.

101 On gentle agitation, the SCI retained full activity for >140 days at 45 degrees C and

102 ation, and a mutant expressing this mutation retained full hemolytic activity.

103 ng affinities, with three candidate peptides retaining full cardiovascular activities for potential t

104 We found that apelin-36(L28A) retains full metabolic activity, but is 100-fold impaire

105 Cysteine mutants retain function and stability for double electron-electr

106 ubtilis encodes the first EF-P ortholog that retains function in the absence of modification.

107 that the more ancestral FtsZ2 and FtsZA have retained functional attributes of their common FtsZ ance

108 ivation markers, suggesting that these cells retain functionality.

109 Reciprocally retained gene families exhibit stronger sequence diverge

110 is a general characteristic of reciprocally retained genes.

111 ith a high-fat diet, Ocy-PPARgamma(-/-) mice retain glycemic control, with increased browning of the

112 was optimized to subnanomolar potency while retaining good physical druglike properties.

113 ved survival in a mouse model of aGVHD while retaining graft-versus-leukemia effects, unveiling a nov

114 The tumor cells retain high-quality intact RNA suitable for single-cell

115 ational entropy for these residues, but they retained high preferences for octane omega-hydroxylation

116 is characterized by large fluctuations while retaining high sensitivity to external varying stimuli.

117 molten salts CaCl2 -MgCl2 -NaCl, which still retains high CaSiO3 solubility, and a supporting electro

118 We show that gAHB retains high levels of genetic diversity after evolution

119 At follow-up, the CR group retained higher degrees of dietary restraint and avoidan

120 tolerance is Ag specific, and tolerant mice retain immune competence to respond to unrelated Ags.

121 The Exorh (rod opsin) gene has been retained in 56 genomes.

122 esembling latency in which viral genomes are retained in a low number of neurons, viral gene expressi

123 modeling results, nutrients seem efficiently retained in actively feeding Noctiluca for reproduction

124 Canonical, PLZF-expressing NK cells were retained in asymptomatic carriers of GATA2 mutation.

125 also showed that CD1a and CD1d proteins were retained in early and late endosomal compartments, respe

126 oaded with a hydrophobic fluorescent dye are retained in local neural tissue for up to 5 days and tha

127 sociated with wind speed, both of which were retained in models as a significant predictor more often

128 show that colour plasticity has been largely retained in most species in the genus, but behavioural p

129 Immune responses were retained in TFR patients off-therapy, suggesting the res

130 both inflammatory and resident monocytes are retained in the bone marrow vasculature, representing an

131 ly, we found that the AR cistrome is largely retained in the CRPC stage.

132 bind more strongly to R2TP, with one mutant retained in the cytoplasm in an R2TP-dependent manner.

133 Moreover, the d-peptide is retained in the cytosol of cells for several days, where

134 reby the ancestral F6H activity is partially retained in the derived SbCYP82D2.

135 ned 13 disease-causing DAT mutants that were retained in the endoplasmic reticulum when heterologousl

136 Approximately 60% of the phosphorus retained in the filter media was recovered in the top 0-

137 e experiment, three times as much (15) N was retained in the O and A soil layers when N was derived f

138 t mouse lines, with FAdE expression/activity retained in the postnatal 20alphaHSD-positive postnatal

139 -EME transfers of target analytes, which are retained in the sample, and the resulting salt-free samp

140 It has been shown to hinder phagocytosis, is retained in tumors, and aids in cellular penetration.

141 lution by removing projection artifact while retaining in-situ flow signal from real blood vessels in

142 techniques to determine which brain regions retain information during WM.

143 as the HML-2 group of HERV-K elements, still retain intact open reading frames and the capacity to pr

144 , tumors displaying TMPRSS2-ERG fusions that retained interstitial genes were less likely to be assoc

145 and NDRG1 and other ETS family genes, which retained interstitial TMPRSS2/ERG sequences.

146 aP) xenografts express high levels of AR and retain intratumoral androgen concentrations similar to t

147 raconserved Element (UCE) that is within the retained intron and overlaps the alternative exon.

148 We also found that retained introns, high in GC content, served as substrat

149 with the PepQ folding intermediate and help retain it deep within the GroEL cavity, resulting in red

150 ding the conserved Ndc1 encircle the SPB and retain it within the NE.

151 t of a strain of ASFV that has been shown to retain its ability to cause disease in swine, efficientl

152 More impressively, the developed aerogel can retain its underwater superoleophobicity even after 30 d

153 In contrast to many natural AMPs, D-RR4 retained its activity under challenging physiological co

154 ity and cool insolation, the planet may have retained its atmosphere despite the greater luminosity (

155 NKA incorporated into the LCP retained its ATP-hydrolysing activity for 7 days, while

156 microwave roasting (1.1kW, 6min) effectively retained its low starch digestibility similar to its nat

157 ing to generation of ICOVIR-15K-cBiTE, which retained its oncolytic properties in vitro cBiTE express

158 encing (WGS) confirmed that the A. gambiae Y retained its original sequence content in the A. arabien

159 e, tantalum flows like a viscous fluid while retaining its crystal lattice and remaining a strong and

160 roll on, budding off more disciplines, while retaining its own identity.

161 utilized rhesus CD4 more efficiently, while retaining its resistance to antibodies and sera from inf

162 When bound to the merozoite surface, C1-INH retains its ability to complex with and inhibit C1s, MAS

163 d C2A domain of Synaptotagmin-I protein that retains its ability to preferentially bind to apoptotic

164 apelin-36 at activating the APJ receptor but retains its ability to significantly lower blood glucose

165 first demonstration that home-cooked garlic retains its antioxidant activity, and, at the same time,

166 ssing, mature HMR, which begins from Lys-58, retains its biochemical properties in phytochrome signal

167 dermis and that the skin-penetrating aptamer retains its biologically active conformational structure

168 ver, because the central element essentially retains its eight valence electrons.

169 formation of assemblies in which the protein retains its native-like structure, which subsequently co

170 t can only be ubiquitinated in cells when AR retains LBD suggesting a role for AR C-terminus in E2/E3

171 amander (Salamandra salamandra), was able to retain learned spatial information after a period of bru

172 rrhage (n = 7), endophthalmitis (n = 6), and retained lens material (n = 4).

173 are not yet curative, because most patients retain leukemic stem cells (LSC) and their progenitors i

174 ells form long-term expanding organoids that retain liver tissue function and genetic stability.

175 and 47% other dissolved solids removed while retaining majority of the pigment ( approximately 98%) i

176 trates that these HCMV-specific immune cells retain many important functions and help to prevent dele

177 patic microtissues, unlike 2D cell cultures, retain many of the in-vivo-like functionalities even aft

178 ring MPs, it can be extremely challenging to retain membrane localization capability while changing o

179 mmune system have been considered capable of retaining memory for infectious challenges.

180 nciple, they are infinitely deformable while retaining metallic conductivity.

181 We also show that Tubifex worms retain microplastics for longer than they retain other p

182 mature Red Blood Cells of some RTT patients retain mitochondria.

183 icating that the almost fully folded protein retains molten globule characteristics with severe NMR l

184 Placentas retained monoallelic allele-specific gene expression of

185 These protons would retain most of the kinetic energy of the neutrons, while

186 rier is known as a 'size cutoff' slit, which retains nanoparticles or proteins larger than 6-8 nm in

187 To test if BoNT/C1 ad retains neuron-specific targeting without concomitant to

188 r stability than that of Ru/C (95 % vs. 81 % retained OER activity) and Pt/C (92 % vs. 78 % retained

189 s consistent with many T4SS substrates being retained on the phagosomal membrane adjacent to the pole

190 rom the surface of the infected cells but is retained on the surface of cells that have been depleted

191 eloped a highly humanized variant of C8 that retains opsonophagocytic activity in murine and human ma

192 tained OER activity) and Pt/C (92 % vs. 78 % retained ORR activity after 10 h running) in alkaline el

193 ms retain microplastics for longer than they retain other particulate components of the ingested sedi

194 ain typically dominated each species and was retained over time (for >70% of species).

195 ent in at least 1 kidney by 12 weeks and 39% retained parts of both kidneys.

196 ses incorporating two of the stalk mutations retained pathogenicity in vivo.

197 tly, PDX-derived ellipsoids in microchambers retained patterns of drug responsiveness and resistance

198 essed well, were predominantly monomeric and retained peptide specificity.

199 h undergoes plus-end-directed movement while retaining physiological cargo interactions in the tail.

200 terone secretion, activation of NCC helps to retain potassium by increasing electroneutral NaCl reabs

201 ave synthesized novel amide derivatives that retain potency and have much improved solubility.

202 rate that two compounds (1, 3, at 20 mug/mL) retain potent activity in vivo, significantly reducing t

203 ld stronger affinity than wild-type HVEM and retained potent inhibitory activity that reduced T-cell

204 Analogues 9 and 16 were nonhemolytic and retained potent P. aeruginosa-specific antimicrobial act

205 d plasma-protein binding were improved while retaining potent anti-pseudomonal activity in vitro and

206 Furthermore, histopathologic findings may retain prognostic relevance when a genetic diagnosis is

207 es, only TP53 mutations (HR, 6.2; P < .0001) retained prognostic impact for overall survival (OS), wh

208 , A2AR-deficient, terminally mature NK cells retained proliferative capacity and exhibited heightened

209 enotype associated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, di

210 a oscillations at the stimulation site while retaining propagating waves of gamma oscillations in the

211 stability, live-attenuated CDV vaccines can retain residual virulence in highly susceptible species.

212 and PCA3 can avert unnecessary biopsy while retaining robust sensitivity for detecting aggressive pr

213 Here, we examined whether FDCs retain self-antigens and the impact of this process in a

214 We found that FDCs took up and retained self-immune complexes composed of ribonucleotid

215 le analyses (the 37 patients' last episodes) retained Sequential Organ-Failure Assessment score great

216 , convergent to the avian furculum, and they retain shoulder girdle plesiomorphies of mammaliaforms a

217 -dose steroids (odds ratio = 5.05; P = 0.01) retained significance in multivariable analysis.

218 ion for PFS/OS, whereas the pPCs/BMPCs ratio retained significance only for PFS.

219 The samples retained significant anti-oxidant and anti-genotoxic pot

220 y on the ninth day after the expiry date and retained significant inhibitory effects against colon ca

221 exhibiting improved statistical power while retaining similar, and reliable type I errors.

222 The resulting TRAIL-Trimer not only retains similar bioactivity and receptor binding kinetic

223 herefore possible that present-day organisms retain some record of the primordial fluid in which the

224 ups of cells from a single germ layer and to retain spatial information, dorsal and ventral ectoderm

225 es, it can be used to guide the selection of retained sPCA components.

226 l ventral antigen 1 (Nova1(-4)) and intron 2-retained SRSF6 (SRSF6(+intron 2)) transcripts in CRC tis

227 ved by regenerative therapy in IBDs may have retained stability over 5 years.

228 te increasingly specific subphenotypes while retaining statistical power to detect genetic associatio

229 istory of genetic epidemiology and argue for retaining statistical testing as an important part of th

230 conditions, CSC form 3D spheres (SPH), which retain stem-like tumour-initiating features.

231 ntriguing tool to provide or deliver cues to retain stemness, direct differentiation, promote reprogr

232 The retained structural integrity and the mechanism of water

233 reveals that these individuals unexpectedly retain substantial vision in daylight.

234 ne, which provides an effective mechanism to retain substrate proteins with high affinity while also

235 ne integration via the Sec translocon, while retaining sufficient chemical and structural detail to c

236 The retained sulfadiazine was eluted using 180muL of methano

237 he closely related DNA photolyases, but they retain the ability to bind nucleotides such as ATP.

238 ferative cells express stem cell markers and retain the ability to differentiate down multiple cell l

239 ghly plastic self-renewing cancer cells that retain the ability to expand ex vivo as tumourspheres, i

240 espite these defects, C9orf72 synapses still retain the ability to express presynaptic homeostatic pl

241 ional stabilization, whereas ICM cells still retain the ability to regenerate TE up to the early blas

242 can be propagated indefinitely in vitro, yet retain the capacity to become fully differentiated when

243 Moreover, LIF-independent iOCT4 ES cells retain the capacity to differentiate in vitro and in viv

244 The RBCNPs retain the complex biological functions of natural cell

245 Our findings suggest that GTP caps retain the filament helical structure and hydrolysis tri

246 Around 20-30% retain the full syndrome as young adults, and about 50%

247 d time-of-flight neutron diffraction data to retain the P213 space group, though with a cubic lattice

248 e components (ratio 1:1) as wall material to retain the PC and preserve their antioxidant activity wa

249 cannot make the subunits ATP6 and ATP8, but retain the PTP.

250 Haptic memory in particular can retain the sensation of the interaction between the huma

251 no longer induce significant VLP release but retained the ability to be incorporated as a passenger i

252 Cultured LECs retained the ability to differentiate into gamma-crystal

253 ransiently to prevent acute recoil, but have retained the capability to inhibit neointimal proliferat

254 lit, and that the earliest avemetatarsalians retained the crocodylian-like ankle morphology and hindl

255 The abnormal particles retained the D13 scaffold protein of immature virions, w

256 at not all evolutionary lineages of ECM have retained the genetic potential to produce extracellular

257 Overall, 17 of 20 BrM retained the PAM50 subtype of the primary BrCa.

258 a 20 wt % application rate almost completely retained the pathogenic E. coli in the subsurface, sugge

259 The tomato-paste purified TCMPs retained the resistance to gastrointestinal digestion an

260 and crystallography, the engineered monomer retained the same overall structure of native TGF-beta m

261 Remarkably, all 33 metabolites retained the tricyclic ring structure common to tricycli

262 oth water vapor and oxygen is the key factor retaining the activated state of the TiO2 powder for a t

263 es (MCR-ALS), to circumvent this issue while retaining the advantages of multivariate analysis.

264 mplete (i.e. per-fragment) likelihood, while retaining the computational efficiently of the compatibi

265 enesis that also accumulated viral membranes retaining the D13 scaffold.

266 -preventive probiotic strains may benefit by retaining the escherichelin biosynthetic capacity of the

267 MRN acts as a processivity factor for Exo1, retaining the exonuclease on DNA for long-range resectio

268 ast, mutants lacking the TAD alpha-helix but retaining the most distal C-terminal residues exhibited

269 ally demethylate expressed gene bodies while retaining the role of MeCP2 in chromatin organization.

270 ligand-binding domain of the receptor while retaining the transmembrane and tyrosine kinase domains.

271 n is released, the integrin-bound talin head retains the ability to inhibit actin assembly.

272 portantly, TET1ALT lacks the CXXC domain but retains the catalytic domain.

273 The extended 150-loop of the H15 HA retains the conserved conformation as in H7 and H10 HAs.

274 The film retains the photoconductive and photoluminescent propert

275 {Cu(II)24[(S,S)-hismox]12(OH2)3}.178H2O (2), retains the polar space group of 1 and is ferroelectric

276 These cells naturally retain their bond distribution asymmetry after division

277 em cells survive consecutive involutions and retain their identity throughout adult life.

278 Moreover, our studies show that SCs retain their plasticity to myelinate and remodel myelin

279 t naturally occurring magnetic particles can retain their primary magnetic recording over billions of

280 The lines thus derived faithfully retained their parental cystic and spiky morphologies an

281 enum-like organoids and ileum-like organoids retained their regional identity, demonstrating that reg

282 tracool dwarf star TRAPPIST-1 are capable of retaining their atmospheres.

283 biomedical applications are contingent upon retaining their optical properties in an aqueous environ

284 most imbibed into the shale rock matrix and retained there for the long term.

285 into the shale rock by capillary forces and retained there indefinitely.

286 How it retains these associations to guide future behavior is l

287 to induce cardiac injury and remodeling, and retain this memory on adoptive transfer.

288 We retained three components (50% of total variation) which

289 nd woodchuck hepatitis virus), and an intron-retaining transcript encoded by the cellular NXF1 gene.

290 ociated with lower protein levels and intron-retaining transcripts that escape nonsense-mediated deca

291 RNA polymerase II specifically at the intron retained under hypoxia.

292 combinations, so that the epilepsy observed retained universality with respect to genetic background

293 The ELP's reversible phase behavior is retained upon myristoylation and can be tuned to span a

294 ime-varying confounding, with nonrespondents retained via proxy assessments.

295 of cases with noninfectious endophthalmitis retained vision within 10 letters of the pre-endophthalm

296 nic visit and at 18 mo postpartum.The median retained weight of women was 0.90 kg (IQR: -1.40, 3.25)

297 degenerate high signal characteristics were retained when conjugated to a large protein, indicating

298 Mdm2 is often overexpressed in tumors that retain wild-type TP53 but may affect therapeutic respons

299 d ART group, and the unadjusted RR for being retained with HIV-1 RNA <1,000 copies was 1.18 (95% CI:

300 ry hydrogen bonding, and while they are both retained within the in vivo environment of an Escherichi