ライフサイエンスコーパス: retention signal

1 uclear speckles (dots) by means of a speckle-retention signal.

2 and the presence of an endoplasmic reticulum retention signal.

3 a probable cytoplasmic endoplasmic reticulum retention signal.

4 uence that is ended with SSEL, a putative ER retention signal.

5 sterase active site and the COOH-terminal ER retention signal.

6 studies, and with proteins bearing the KDEL retention signal.

7 her secreted proteins containing a KDEL-like retention signal.

8 domains, the latter of which functions as a retention signal.

9 l-derived factor 1 (CXCL-12) as an important retention signal.

10 al STEL sequence, which is an inefficient ER retention signal.

11 a two amino acid endoplasmic reticulum (ER) retention signal.

12 in the cytoplasm or nucleus with appropriate retention signals.

13 and contains no known endoplasmic reticulum retention signals.

14 tein with separable nuclear localization and retention signals.

15 while four also appear to possess cell wall retention signals.

16 otein were also found to act as transferable retention signals.

17 to screen for agents that modify CXCR4-SDF1 retention signals.

18 aining the dominance of positive residues as retention signals.

19 assays, suggesting the existence of specific retention signals.

20 er demand for specific growth factors and/or retention signals.

21 ogether with the unique combination of an ER-retention signal, a target sequence for SPCs in the reac

22 We developed a method based on dual retention signals adapted from G-protein-coupled GABA-B

23 rved arginine-based motif functions as an ER retention signal and a lumenal leucine motif is required

24 a recombinant reporter consisting of a Golgi retention signal and a protease cleavage sequence fused

25 The ATA27 protein is predicted to have an ER retention signal and an acidic isoelectric point, sugges

26 mera that contained a C-terminal dilysine ER retention signal and entered the recycling pathway.

27 e balance between membrane translocation and retention signals and also allows the presence of negati

28 tants lacking either the retrieval or static retention signals and by an assay for prevacuolar compar

29 udy the kinetics of p30 and to delineate its retention signals and their function in virus replicatio

30 de a rough endoplasmic reticulum (rER)/Golgi retention signal, and it has been suggested that ORF3a i

31 lity that the domain acts as a cell membrane retention signal, and it supports the hypothesis that T2

32 We envision applicability of the retention signal approach for the study of a variety of

33 ino acid residues within this ER pore-region retention signal are also critical for high-affinity bin

34 ctive site, the CRP binding site, and the ER retention signal are functionally distinct.

35 a and the release by Arl2/3 in addition to a retention signal are the determinants for cargo sorting

36 nal sequences and endoplasmic reticulum (ER) retention signals are known to play central roles in tar

37 sphorylation and the presence of putative ER retention signals are required for the PKA-mediated incr

38 loop, masking an endoplasmic reticulum (ER) retention signal as the dominant mechanism for Ca(V)1/Ca

39 the presence of a conserved S. cerevisiae ER retention signal at its C terminus, was confirmed by sub

40 Interestingly M-Vpu bearing an ER retention signal at the C terminus localizes similarly t

41 mic reticulum (ER) via the addition of an ER retention signal at the carboxyl terminus of UL20p force

42 gi exit information, not exposure of cryptic retention signals, because several deletion mutants accu

43 Furthermore, this "retention signal" causing susceptibility to DRN is lost

44 ituting this sequence with KDEL, a robust ER retention signal, concentrated COX-2 in the ER where it

45 This speckle-retention signal contains a domain that interacts with a

46 Addition of a retention signal could inhibit the ciliary localization

47 ntraceptors, which are endoplasmic reticulum retention signal-coupled VEGF receptors, significantly s

48 OBEC-1 with characteristics of a cytoplasmic retention signal (CRS) or a nuclear export signal (NES).

49 ized property of hA3G is a novel cytoplasmic retention signal (CRS) that is necessary and sufficient

50 ich map to a recently identified cytoplasmic retention signal (CRS).

51 signal akin to the cytoplasmic targeting and retention signal CTRS found in Mason-Pfizer monkey virus

52 DeltaE19, an E19 mutant lacking the ER-retention signal, delays maturation of class I molecules

53 heir cytoplasmic N-terminal tails with an ER retention signal derived from the cytoplasmic domain of

54 function of TGD, whereas addition of the ER retention signal did not alter its function.

55 Proteins without a retention signal (e.g., green fluorescent protein-glycos

56 between export signals on the I-II loop and retention signals elsewhere.

57 f the NR1 C-terminal serine 897 (masks an ER retention signal), followed by a PKC-dependent phosphory

58 by bone marrow stromal cells provides a key retention signal for neutrophils in the bone marrow thro

59 with its major receptor CXCR4 provides a key retention signal for neutrophils in the bone marrow.

60 smic tail and containing a carboxyl-terminal retention signal for the endoplasmic reticulum (ER).

61 ely charged domain can act as a localization retention signal for the focal compartmentalization of m

62 and, M4 of NR1, are necessary for masking ER retention signals found in M3.

63 ation S363A in the phosphorylation-dependent retention signal generated a V2 receptor that was recycl

64 lutamic and aspartic acid with a putative ER retention signal (HDEL) at the C terminus.

65 restricted to the ER by their COOH-terminal retention signals (HIEL and HTEL).

66 reminiscent of an endoplasmic reticulum (ER) retention signal; however, Spn4.1 and neuroserpin have d

67 e findings identify netrin-1 as a macrophage retention signal in adipose tissue during obesity that p

68 terminal coiled-coil alpha helices masks the retention signal in GB1, allowing the plasma membrane ex

69 e we report the identification of a novel ER retention signal in the alternatively spliced C-terminal

70 and GBR2 masks an endoplasmic reticulum (ER) retention signal in the cytoplasmic region of GBR1 and f

71 in C-terminal truncation and loss of the ER retention signal in the mutant protein.

72 ontain a dominant endoplasmic reticulum (ER) retention signal in their pore region, preventing surfac

73 ymphocyte mobilization by suppressing CXCL12 retention signals in BM, which, in turn, increases the a

74 charges, which can act as partial subsurface retention signals in certain peptide contexts, lipoprote

75 presence of novel endoplasmic reticulum (ER) retention signals in SUR1 and KIR6.2; incompletely assem

76 These findings identify novel Golgi retention signals in the beta and delta subunit loops th

77 nactivation of similar endoplasmic reticulum-retention signals in the cystic fibrosis transmembrane c

78 uence specificity of C-terminal tetrapeptide retention signals in trypanosomes is analyzed and found

79 Removal of beta4 retention signal increases its surface expression that m

80 The neutrophil retention signal induced by WHIM truncation mutations is

81 Cis-inhibition is compromised when an ER retention signal is added to Serrate, or when the levels

82 terminus of the NR2B subunit show that an ER retention signal is also present in the NR2B subunit.

83 al microscopic imaging indicated that the ER retention signal is likely present within the C-terminal

84 g cells with brefeldin A or by fusing the ER retention signal KDEL to S1P obviates the SCAP requireme

85 th or without the endoplasmic reticulum (ER) retention signal (KDEL), using either a plasmid (p3S5-HA

86 NF ("RTDL"), which resemble the canonical ER retention signal ("KDEL"), to study MANF regulation in n

87 gen-1, and contains an endoplasmic reticulum retention signal, KDEL.

88 Having an inefficient ER retention signal leads to sluggish Golgi to ER transit o

89 two ER localization signals, an independent retention signal located between residues 60 and 88 of i

90 uppressor mutations in a putative dibasic ER retention signal, located within the cytoplasmic C termi

91 nd a likely C-terminal endoplasmic reticulum retention signal (Lys-Lys-Glu-Gln).

92 e to promote lymph node egress by overcoming retention signals mediated by CCR7 and additional G alph

93 rboring either an endoplasmic reticulum (ER) retention signal (NCT-ER) or a trans-Golgi network (TGN)

94 ) was fused to an endoplasmic reticulum (ER) retention signal (NefKKXX).

95 The ER retention signal of GBR1 is not part of the core coiled-

96 on is required to inactivate the adjacent ER retention signal of GBR1.

97 Replacement of the endoplasmic reticulum retention signal of gp96 with the Fc portion of murine I

98 localized by attachment to the NH2-terminal retention signal of N-acetylglucosaminyltransferase I (N

99 ignal for nuclear export or as a cytoplasmic retention signal of PTEN.

100 hese data demonstrate that the Golgi complex retention signal of the ORF7b protein resides solely wit

101 xpression in concert with other described ER retention signals of FcepsilonRI-alpha.

102 Although the nuclear localization and retention signals of pUL34 overlap the domain required f

103 In assembled complexes, ER retention signals on the individual subunits must be ove

104 the cytosol or the ER using ER-targeting and retention signal peptides.

105 1 cassette has been identified as a major ER retention signal present in NR1 subunits, and the surfac

106 l insertion of the remaining TMDs, redundant retention signals present in any pair of TMD retain IP3R

107 n of HIF-2alpha may overcome the bone marrow retention signal provided by stromal-derived CXCL12, the

108 d from cells, whereas scFv with an ER or TGN retention signal remained primarily within targeted intr

109 pertussis toxin to overcome Galphai-mediated retention signals restores lymphocyte egress.

110 clude a potential endoplasmic reticulum (ER) retention signal, RGR, which when mutated to LGL (HERG(D

111 nels requires that the endoplasmic reticulum-retention signal, RKR, present in both SUR1 and Kir6.2,

112 We identified an ER retention signal (RRR) in the C1 cassette of NR1, which

113 e carboxyl tail indicated that a cytoplasmic retention signal(s) was located between residues 316 and

114 bunits fail to mature because of an "RXR" ER retention signal specific to the 1b N terminus of the hu

115 We demonstrate that, even when LN retention signals such as CC chemokine receptor 7 (CCR7)

116 ld type TMEM97, but not TMEM97 missing an ER-retention signal suggesting that TMEM97 contributes to c

117 e CAV1 P158 protein contains a functional ER-retention signal that inhibits ER exit and caveolae form

118 s of FV Gag contains a cytoplasmic targeting/retention signal that is responsible for targeting assem

119 for the RRD repeat as a ribonucleic nuclear retention signal that is sufficient to retain an otherwi

120 n addition to cytosolic and transmembrane ER retention signals, the FcepsilonRI alpha-chain signal pe

121 tor can serve as a selective plasma membrane retention signal, thereby modulating the availability of

122 etween the TGN and PVC by antagonizing a TGN retention signal (TLS2) and facilitating the function of

123 tion, we added an endoplasmic reticulum (ER) retention signal to TGD and, separately, deleted the sec

124 Moreover, snoRNAs lacking specific CB retention signals traffic through CBs en route to nucleo

125 ion can only be understood in the context of retention signals transduced by CCR7.

126 vestigation revealed that mutation of the ER retention signal was able to partially restore surface e

127 The retention signal was dominant, autonomous, and transfera

128 scFv without a retention signal was secreted from cells, whereas scFv w

129 truncated eroA, missing the putative HEEL ER-retention signal was unable to complement as well as the

130 Lys-Asp-Glu-Leu (KDEL) endoplasmic reticulum retention signal were linked at the N and C terminus of

131 reticulum (ER) or trans-Golgi network (TGN) retention signals, were constructed.

132 ubunits contained nuclear export and nuclear retention signals, whereas p54nrb was continuously expor

133 ation within a region called the cytoplasmic retention signal, which also contains a nuclear export s

134 rminal 104 amino acids is to mask the RGR ER retention signal, which becomes exposed when mutations t

135 a trans-Golgi enzyme by replacing its Golgi retention signal with that of alpha-2,6-sialyltransferas

136 icates that p48 contains a bipartite nuclear retention signal within its amino-terminal DNA-binding d