ライフサイエンスコーパス: reticulin

1 rit, splenomegaly, and increased bone marrow reticulin.

2 e lobulated and contained dense, centralized reticulin.

3 typia, absence of biliary epithelia, loss of reticulin, alteration of normal perivenular glutamine sy

4 by bone marrow megakaryocytic proliferation, reticulin and/or collagen fibrosis, and presence of JAK2

5 llelic burden was in patients with increased reticulin deposition.

6 im clinical trials, 10 were reported to have reticulin deposition; reticulin grade was increased in 4

7 onists are reported to increase the risk for reticulin fiber deposition within bone marrow.

8 v) of bFGF(+) MC and the density of collagen/reticulin fibers in silicotic nodules (rho = -0.80, p <

9 associated cells and the density of collagen/reticulin fibers in the hypocellular nodule centers (rho

10 rge, mature nodules, the density of collagen/reticulin fibers was higher, and bFGF(+) MC were found o

11 The V(v) of collagen/reticulin fibers was increased in silicosis and correlat

12 yh9(-/-) mice a much stronger increase in BM reticulin fibers was present after 4 weeks of romiplosti

13 +) MC throughout the loose array of collagen/reticulin fibers.

14 oplasia, and deposition of a fine network of reticulin fibers.

15 ntain abundant pericapillary and parenchymal reticulin fibrils, which were shown by immunohistochemis

16 features such as splenomegaly (P =.004) and reticulin fibrosis (P =.005).

17 elevated leukocyte counts, splenomegaly, and reticulin fibrosis compared with C57Bl/6 mice.

18 sessable responders who started therapy with reticulin fibrosis grade 4 experienced reductions to at

19 ations in myeloid and erythroid lineages and reticulin fibrosis identified a subclinical myeloprolife

20 ence and prognostic relevance of bone marrow reticulin fibrosis in 526 patients with World Health Org

21 tic/megakaryocytic proliferation and lack of reticulin fibrosis in the bone marrow.

22 hematopoiesis resulting in splenomegaly, and reticulin fibrosis in the bone marrow.

23 egakaryocyte polyploidization; and increased reticulin fibrosis of the bone marrow and spleen.

24 se 2 features were inversely proportional to reticulin fibrosis, whereas increases in marrow angiogen

25 four patients (14%) displayed mostly grade 1 reticulin fibrosis, with only 2 cases showing higher-gra

26 s in marrow angiogenesis were independent of reticulin fibrosis.

27 Our results demonstrate that bone marrow reticulin grade at diagnosis represents an independent p

28 de showed significantly greater increases in reticulin grade compared with those allocated to hydroxy

29 In the prospective study, reticulin grade during romiplostim treatment remained wi

30 Reticulin grade often decreased soon after romiplostim d

31 Reticulin grade positively correlated with white blood c

32 were reported to have reticulin deposition; reticulin grade was increased in 4 of 5 patients with bo

33 Reticulin grade was the dominant independent predictor o

34 y, evaluation of bone marrow progenitors and reticulin in nonaffected family members of patients with

35 and produces modest increases in bone marrow reticulin in some ITP patients that decrease when therap

36 topathology including the increase in marrow reticulin is completely and rapidly reversible upon the

37 that those who show substantially increasing reticulin levels are at risk of myelofibrotic transforma

38 Higher reticulin levels at diagnosis were associated with great

39 Elevated reticulin levels at presentation predicted higher rates

40 im-treated rats, a retrospective analysis of reticulin observed in romiplostim ITP clinical trials, a

41 patients who developed increased bone marrow reticulin on anagrelide showed regression of fibrosis wh

42 ary acidic protein-positive) or mesenchymal (reticulin-positive) differentiation.

43 iption factor 6, which, via induction of the reticulin protein Nogo, can lead to the disruption of th

44 ns include thrombosis, increased bone marrow reticulin, rebound worsening of thrombocytopenia upon di

45 , periodic acid-Schiff, Masson trichrome, or reticulin stains.

46 Bone marrow reticulin was observed in 8 patients; marrows were not r