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1 1% intraretinal, 38% subretinal, and 36% sub-retinal pigment epithelium).
2 glia cells, and the basolateral side of the retinal pigment epithelium.
3 hed chromophores and recycling in the nearby retinal pigment epithelium.
4 ar surface ectoderm, lens, neuro-retina, and retinal pigment epithelium.
5 generalized dysfunction at the level of the retinal pigment epithelium.
6 nted when sFlt-1 expression is attenuated in retinal pigment epithelium.
7 and infiltrating myeloid cells but not from retinal pigment epithelium.
8 particularly toxic to photoreceptors and/or retinal pigment epithelium.
9 s </=325 mum or >/=425 mum, and elevation of retinal pigment epithelium.
10 terized by macular atrophy and flecks in the retinal pigment epithelium.
11 etabolite carrier between the retina and the retinal pigment epithelium.
12 al pigmentation consistent with transplanted retinal pigment epithelium.
13 of 11-cis-retinyl esters (11-REs) within the retinal pigment epithelium.
14 hway called the visual cycle in cells of the retinal pigment epithelium.
15 2 in the re-attachment of the retina to the retinal pigment epithelium.
16 ally secreted in exosomes by polarized human retinal pigment epithelium.
17 e physical separation of the retina from the retinal pigment epithelium.
18 n within hyperreflective lesions adherent to retinal pigment epithelium.
19 n early age and peripapillary sparing of the retinal pigment epithelium.
20 posited at the apical and basal sides of the retinal pigment epithelium.
21 e can suppress consumption of glucose by the retinal pigment epithelium.
22 istent with PVR, and reactive changes in the retinal pigment epithelium.
23 on, optic nerve head pallor, and mottling of retinal pigment epithelium.
24 tween the interdigitation zone and an intact retinal pigment epithelium.
25 ning of the cone outer segment closer to the retinal pigment epithelium.
26 in pigment cells, including melanocytes and retinal pigment epithelium.
27 ated retina preparation after removal of the retinal pigmented epithelium.
28 ge, indicative of pathological events in the retinal pigmented epithelium.
29 se was composed of 6 layered components: (1) retinal pigment epithelium, (2) basal laminar deposits,
30 undus photographs were graded for drusen and retinal pigment epithelium abnormalities and were evalua
31 o 17.6% (n = 37) in those 80 years or older, retinal pigment epithelium abnormalities from 4.1% (n =
34 ound the injection site demonstrated diffuse retinal pigment epithelium alterations with dense hard e
35 ion, and position of the CNV relative to the retinal pigment epithelium and Bruch membrane were descr
36 ed to visualize CNV location relative to the retinal pigment epithelium and Bruch's layer and classif
37 location of vitamin A derivatives across the retinal pigment epithelium and Bruch's membrane, 2 tissu
38 thesis that toll-like receptor activation of retinal pigment epithelium and cellular metabolic switch
40 ipofuscin accumulate in the lysosomes of the retinal pigment epithelium and display cytotoxic effects
42 tors then export the lactate as fuel for the retinal pigment epithelium and for neighboring Muller gl
43 lly if multimodal imaging supports an intact retinal pigment epithelium and inner retina but an abnor
44 insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may lim
45 ns in the choriocapillaris in the absence of retinal pigment epithelium and outer retinal abnormaliti
46 cellular adhesion between the retina and the retinal pigment epithelium and prevention of its cellula
50 s were associated with absence of underlying retinal pigment epithelium and were longer (r = -0.62; 9
51 raphy confirmed that these areas had loss of retinal pigmented epithelium and ellipsoids zones, with
52 cal coherence tomography thinning but intact retinal pigment epithelium), and severe (visible bull's-
53 xcavation involving the neurosensory retina, retinal pigment epithelium, and choroid in 4 eyes (44%).
54 e posterior ocular segment (neuronal retina, retinal pigment epithelium, and choroid) of wild-type (W
55 sequential involvement of the outer retina, retinal pigment epithelium, and choroid, as well as freq
56 able degrees of atrophy of the outer retina, retinal pigment epithelium, and choroid, with outer reti
57 extent of structural alterations of the CC, retinal pigment epithelium, and photoreceptors with mult
58 quantitative characteristics of the choroid, retinal pigment epithelium, and retina were compared bet
59 ion, likely by promoting inflammation of the retinal pigment epithelium, and validate TLR2 as a novel
63 beneath the small irregular elevation of the retinal pigment epithelium at the site of the quiescent
64 bited several nummular perifoveal islands of retinal pigment epithelium atrophy and adjacent pale dep
67 appeared as hyperreflective debris above the retinal pigment epithelium band in all 3 eyes, and were
68 data highlight an unrecognised link between retinal pigment epithelium bioenergetic status and tissu
70 hows that fibulin 2 is mainly present in the retinal pigment epithelium, Bruch membrane, choriocapill
72 the distance between the outer border of the retinal pigment epithelium-Bruch's membrane complex, and
73 retinosomes and condensation products in the retinal pigment epithelium by their characteristic local
74 Suppression of glucose consumption in the retinal pigment epithelium can increase the amount of gl
75 d by the analysis of LC/MS data from a human retinal pigment epithelium cell line (ARPE-19) grown on
76 y AMD, including Bruchs membrane thickening, retinal pigment epithelium cell loss, retinal functional
77 ascularization and a decrease in mesenchymal retinal pigment epithelium cells in alphaB-crystallin kn
82 ine, bipolar, horizontal, photoreceptor, and retinal pigment epithelium cells, thus exposing the anat
86 fundus appearance but later develop mottled retinal pigment epithelium change along the arcades, fol
90 nt component 3 and factor B in plasma and in retinal pigment epithelium/choroid/sclera, establishing
92 angles, loss of pigment and thinning of the retinal pigment epithelium, choroidal thinning, undiffer
94 tics of combined hamartoma of the retina and retinal pigment epithelium (CHRRPE) involving the macula
95 f increased autofluorescence as a measure of retinal pigment epithelium damage and lipofuscin accumul
97 ansdifferentiation of the dorsal and ventral retinal pigment epithelium, defective optic cup peripher
98 ccelerated accumulation of lipofuscin in the retinal pigment epithelium, degeneration of the neuroret
99 hydroxychloroquine retinopathy involving the retinal pigment epithelium demonstrated progressive dama
101 on; and stage 5 (3 patients [18%]), complete retinal pigment epithelium disruption and/or loss of the
102 s [29%]), optically empty space with partial retinal pigment epithelium disruption; and stage 5 (3 pa
104 gy revealed malformations in the choroid and retinal pigmented epithelium, early cone photoreceptor c
105 ed by quantitative RT-PCR in the retina, the retinal pigment epithelium, fibroblasts, and whole-blood
106 e fellow eye, hemorrhage, and absence of sub-retinal pigment epithelium fluid at baseline were associ
108 s of fibulin 2 dramatically increased in the retinal pigment epithelium following retinal detachment,
112 oRNA (miRNA)-processing enzyme DICER1 in the retinal pigmented epithelium has been implicated in geog
113 A uptake across the blood-retinal barrier or retinal pigment epithelium have not been identified.
114 , we use human induced pluripotent stem cell-retinal pigment epithelium (hiPSC-RPE) derived from pati
115 hemorrhages in 2 (17%) and 3 (18%); loss of retinal pigment epithelium in 1 (8%) and 4 (24%); and dr
116 id zone and hyperreflectivity underlying the retinal pigment epithelium in 9 eyes (100%), retinal thi
117 monstrate that Mfsd2a is highly expressed in retinal pigment epithelium in embryonic eye, before the
118 LRP3 inflammasome to cause cell death of the retinal pigment epithelium in geographic atrophy, a type
120 f subretinal transplantation of hESC-derived retinal pigment epithelium in nine patients with Stargar
121 ine the incidence of atrophic lesions of the retinal pigment epithelium in patients with Stargardt di
122 caused by abnormalities of photoreceptors or retinal pigment epithelium in the retina leading to prog
123 lindrical melanosomes forming the remains of retinal pigment epithelium indicates that it is a verteb
124 classic features of new intraretinal or sub-retinal pigment epithelium infiltration of lymphoma in t
125 le of Bruch's membrane, the Bruch's membrane-retinal pigment epithelium interface, or both in the pat
127 nct morphologies arranged in layers, forming retinal pigment epithelium, is a synapomorphy of vertebr
129 Progressive geographic atrophy (GA) of the retinal pigment epithelium leads to loss of central visi
130 associated with a significant enlargement of retinal pigment epithelium lesion area (0.282 mm(2)/year
131 Optical coherence tomography revealed a mean retinal pigment epithelium lesion area of 2.6 mm(2), pre
132 tomography parameters (IS/OS alteration and retinal pigment epithelium lesion area) were obtained in
133 gh closely coupled, the results suggest that retinal pigment epithelium loss is more extensive than p
134 inal lamination, neural retinal attenuation, retinal pigment epithelium loss, or hypertrophy was seen
136 visualization of structures posterior to the retinal pigment epithelium, may be a useful tool to moni
137 rmal amount of pigment granules deposited in retinal pigment epithelium microvilli area and an abnorm
138 at the interface between photoreceptors and retinal pigment epithelium microvilli, a region critical
141 gic functions of photoreceptor cells and the retinal pigmented epithelium necessitate precise gene re
142 n no eye of either groups was atrophy of the retinal pigment epithelium observed in the area of treat
143 arget of TLR2 signaling, was detected in the retinal pigment epithelium of human eyes, particularly i
144 point to subnormal lipofuscin levels in the retinal pigment epithelium or, alternatively, limitation
145 ies, including congenital hypertrophy of the retinal pigment epithelium, ora serrata pearl, TCD, cyst
146 inal hyperreflective foci represent cells of retinal pigment epithelium origin that are similar to th
147 ted with acquired vitelliform lesions are of retinal pigment epithelium origin, and the natural cours
148 pment of ischemic infarction of the choroid, retinal pigment epithelium, outer part of the retina and
149 g vortex vein, congenital hypertrophy of the retinal pigment epithelium, pars plana, ora serrata pear
150 usen phenotypes, including the occurrence of retinal pigment epithelium (RPE) abnormalities, choroida
151 opathy that begins around the age of 30 with retinal pigment epithelium (RPE) and Bruch's membrane ch
152 pear as hyperreflective deposits between the retinal pigment epithelium (RPE) and Bruch's membrane on
154 in SD-OCT images in eyes with atrophy of the retinal pigment epithelium (RPE) and compared with histo
155 se cause remains elusive, dysfunction of the retinal pigment epithelium (RPE) and dysregulation of co
156 ter segments is an important function of the retinal pigment epithelium (RPE) and it is essential for
158 Bestrophin1 (BEST1) is expressed in human retinal pigment epithelium (RPE) and mutations in the BE
159 bi-potential progenitor cells from which the retinal pigment epithelium (RPE) and neural retina fates
160 damage in the diseased retina, damage in the retinal pigment epithelium (RPE) and neural retina from
161 including OV specification and formation of retinal pigment epithelium (RPE) and neural retina proge
162 NH surfaces (BMOM, BMOH) and the terminal of retinal pigment epithelium (RPE) and ONH surfaces (RPEM,
163 xudative AMD that manifests with progressive retinal pigment epithelium (RPE) and photoreceptor degen
164 roduced by neighboring epithelial cells, the retinal pigment epithelium (RPE) and podocytes, respecti
166 he interaction between autophagy impaired in retinal pigment epithelium (RPE) and the responses of ma
167 ations in the morphology and function of the retinal pigment epithelium (RPE) are common features sha
168 nner and outer boundaries of the choroid and retinal pigment epithelium (RPE) as well as the inner re
169 outer retinal disruption and atrophy of the retinal pigment epithelium (RPE) associated with ORT on
171 that photoreceptor atrophy can occur without retinal pigment epithelium (RPE) atrophy and that atroph
172 refied choriocapillaris in correspondence of retinal pigment epithelium (RPE) atrophy in 80% (n = 16)
173 est-corrected visual acuity (BCVA), age, and retinal pigment epithelium (RPE) atrophy were recorded a
174 (OS) length, thickness and elevation of the retinal pigment epithelium (RPE) band, grading of the in
176 l and histopathologic evidence suggests that retinal pigment epithelium (RPE) can harbor M tuberculos
177 hannel is localized to the apical aspects of retinal pigment epithelium (RPE) cells and contributes t
178 polar cells, mitochondria, Muller cells, and retinal pigment epithelium (RPE) cells and were visualiz
180 o evaluate the intraretinal migration of the retinal pigment epithelium (RPE) cells in age-related ma
182 h encodes cadherin-3, a protein expressed in retinal pigment epithelium (RPE) cells that may have a k
186 s revealed either no abnormalities or foveal retinal pigment epithelium (RPE) changes in 10 and 9 pat
187 eloping murine eye, melanin synthesis in the retinal pigment epithelium (RPE) coincides with neurogen
188 ound TRPV4 expression in the endothelium and retinal pigment epithelium (RPE) components of the BRB,
189 ed macular degeneration and atypical central retinal pigment epithelium (RPE) defects not attributabl
190 ozygous Adamtsl4(tvrm267) mice exhibit focal retinal pigment epithelium (RPE) defects primarily in th
192 al dystrophy, characterised by extensive sub-retinal pigment epithelium (RPE) deposits, RPE atrophy,
193 fluid (IRF), subretinal fluid (SRF), and sub-retinal pigment epithelium (RPE) fluid and performed man
194 nal fluid (IRF), subretinal fluid (SRF), sub-retinal pigment epithelium (RPE) fluid, and subretinal t
195 d induced pluripotent stem cells to generate retinal pigment epithelium (RPE) from an individual suff
196 eceptors in three-dimensional optic cups and retinal pigment epithelium (RPE) from iPSCs with this co
197 of pathways necessary for photoreceptor and retinal pigment epithelium (RPE) function is critical to
199 lipid profiles specifically localized to the retinal pigment epithelium (RPE) in Abca4 (-/-) Stargard
204 nd lipid-containing deposits external to the retinal pigment epithelium (RPE) is common in the aging
205 interface between the neural retina and the retinal pigment epithelium (RPE) is critical for several
206 tion of lipofuscin bisretinoids (LBs) in the retinal pigment epithelium (RPE) is the alleged cause of
207 < 0.001-0.03) were: hyperreflective foci and retinal pigment epithelium (RPE) layer atrophy or absenc
208 ber layers (P = 0.024) and diffusely thinned retinal pigment epithelium (RPE) layers (P = 0.009) vers
209 s calculated from the SD-OCT and the area of retinal pigment epithelium (RPE) loss from the FAF.
210 The FAF imaging showed well-defined areas of retinal pigment epithelium (RPE) loss that corresponded
211 e damage to mitochondrial DNA (mtDNA) in the retinal pigment epithelium (RPE) may play a key role in
212 ated kinase 1/2 (ERK1/2) is increased in the retinal pigment epithelium (RPE) of age-related macular
213 lel clinical phenotypes were observed in the retinal pigment epithelium (RPE) of individuals with but
214 sponded to outer retinal atrophy with viable retinal pigment epithelium (RPE) on spectral-domain OCT
215 e NLRP3 inflammasome have been implicated in retinal pigment epithelium (RPE) pathology in age-relate
217 s in DPED, estimate of coverage by different retinal pigment epithelium (RPE) phenotypes in the DPED
218 rectly elicit a Wnt/beta-catenin response in retinal pigment epithelium (RPE) progenitors near the op
220 ean (SD) height of 45.3 (36.1) mum above the retinal pigment epithelium (RPE) reference plane that wa
221 absolute measurements of vitreous (VIT) and retinal pigment epithelium (RPE) signal intensities, whi
223 thelial growth factor (VEGF) inhibitors, (2) retinal pigment epithelium (RPE) tear, (3) subretinal he
225 ted to OCT measurement parameters, including retinal pigment epithelium (RPE) thickness, central macu
226 abolite transport is a major function of the retinal pigment epithelium (RPE) to support the neural r
227 tiated, biologically and genetically defined retinal pigment epithelium (RPE) to the diseased human e
229 To conditionally inactivate genes in the retinal pigment epithelium (RPE) transgenic mouse strain
232 rmalities in regions with normally appearing retinal pigment epithelium (RPE) were the loss of the PO
233 lated macular degeneration (AMD) affects the retinal pigment epithelium (RPE), a cell monolayer essen
234 te mechanisms that modulate autophagy in the retinal pigment epithelium (RPE), a key site of insult i
235 t), (3) retinal projection through SHRM onto retinal pigment epithelium (RPE), and (4) masking of cho
236 intensities were lower at the photoreceptor, retinal pigment epithelium (RPE), and choroid layers (st
237 tina, resulting from loss of photoreceptors, retinal pigment epithelium (RPE), and underlying chorioc
238 this reisomerization occurs in the adjacent retinal pigment epithelium (RPE), but because ipRGCs are
239 on was found in the photoreceptor-supporting retinal pigment epithelium (RPE), especially in a zone c
240 h the coordinated terminal maturation of the retinal pigment epithelium (RPE), fenestrated choroid en
241 ty, which was then compared with that of the retinal pigment epithelium (RPE), generating an optical
242 ioretinopathy, congenital hypertrophy of the retinal pigment epithelium (RPE), hemorrhagic RPE detach
243 tinoid-containing lipofuscin pigments in the retinal pigment epithelium (RPE), increased oxidative st
244 n abundant membrane-associate protein in the retinal pigment epithelium (RPE), is a key retinoid isom
245 d by many cell types, including those of the retinal pigment epithelium (RPE), is a regulatory protei
246 of TGF-beta signaling in the entire eye, the retinal pigment epithelium (RPE), or the vascular endoth
247 assic 'fingerprint' lysosomal storage in the retinal pigment epithelium (RPE), replicating the human
248 educe cytotoxic bisretinoid formation in the retinal pigment epithelium (RPE), which is associated wi
249 ciations of ocular and systemic factors with retinal pigment epithelium (RPE)-Bruch's membrane (BM) c
250 all interfering RNA (siRNA) to transfect the retinal pigment epithelium (RPE)-derived cell line ARPE-
252 ia 9.7, P = .001; SE -2.27 D [SD 4.65]), and retinal pigment epithelium (RPE)-related dystrophies (OR
268 e (ELM) and mild transient thickening of the retinal pigment epithelium (RPE)/Bruch's complex (Bc).
269 lammatory IL-1beta was markedly increased in retinal pigment epithelium (RPE)/choroid and positively
270 ntally regulated manner in chicken embryonic retinal pigment epithelium (RPE)/choroid in the absence
271 CT B-scans showed 2 distinct profiles of the retinal pigment epithelium (RPE): a slight RPE detachmen
273 elated macular degeneration characterized by retinal pigmented epithelium (RPE) death; the RPE also e
276 One of the major biological functions of the retinal pigmented epithelium (RPE) is the clearance of s
277 ession, we delivered a wild-type Mfrp to the retinal pigmented epithelium (RPE) of Mfrp (rd6) /Mfrp (
279 neration (AMD) characterized by death of the retinal pigmented epithelium (RPE), causes untreatable b
280 types, photoreceptor cells and the adjacent retinal pigmented epithelium (RPE), reportedly display t
281 alysis revealed predominant up-regulation of retinal pigmented epithelium (RPE)-specific genes associ
285 iber layer, photoreceptor outer segments and retinal pigment epithelium show promise for the diagnost
286 n area >/=196350 mum2) and depigmentation of retinal pigment epithelium (slope of -19.17 for the NEI-
287 decreased levels of CFH led to increased sub-retinal pigmented epithelium (sub-RPE) deposit formation
290 We excluded 5 eyes from analysis (4 had retinal pigment epithelium tears, and 1 had a laser scar
291 hat included the ectopic island of surviving retinal pigment epithelium that had been exposed to vect
292 se enzymatic effect on photoreceptors or the retinal pigment epithelium that is not limited to areas
294 rystal mutant lacks pigmentation also in the retinal pigment epithelium, therefore enabling optical a
295 from the choroidal blood passes through the retinal pigment epithelium to the retina where photorece
296 r displacement of the temporal peripapillary retinal pigment epithelium (tRPE) from its position in c
297 91/266), and 16.9% (45/266) were type 1 (sub-retinal pigment epithelium), type 2 (subretinal), type 3
298 bilateral soft drusen and depigmentation of retinal pigment epithelium was associated with substanti
300 s features, photoreceptor outer segments and retinal pigment epithelium when 23 diabetic eyes with mi
301 calcium-activated chloride channel from the retinal pigment epithelium, where mutations are associat
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