ライフサイエンスコーパス: retinoic acid receptor alpha

1 ticoid receptor (GR), androgen receptor, and retinoic acid receptor alpha.

2 pression of the fusion protein promyelocytic-retinoic acid receptor alpha.

3 receptors such as the androgen receptor and retinoic acid receptor alpha.

4 s in a fusion protein comprising PML and the retinoic acid receptor alpha.

5 s (LCL) were treated with AM580, a synthetic retinoic acid receptor-alpha agonist that upregulates CD

6 ed fusion transcription factor proteins (PML-retinoic acid receptor alpha and AML1-ETO), but it is al

7 The retinoic acid receptor alpha and bone morphogenetic prot

8 ntly demonstrated for promyelocytic leukemia-retinoic acid receptor alpha and breakpoint cluster regi

9 ed FoxP3+ T cells is mediated by the nuclear retinoic acid receptor alpha and involves T cell activat

10 , increased cellular levels of ubiquitinated retinoic acid receptor alpha and markedly reduced chymot

11 PP1c specifically interacts with VDR but not retinoic acid receptor alpha and retinoid X receptor alp

12 The levels of the retinoid receptors, retinoic acid receptor alpha and retinoid X receptor gam

13 demonstrated that PKC delta associated with retinoic acid receptor-alpha and was present in an RA-in

14 rated that hADA3 directly binds to the 9-cis retinoic acid receptors alpha and beta, and functions as

15 a role for the TFs estrogen receptor alpha, retinoic acid receptors alpha and gamma in breast cancer

16 ex containing E26 transformation-specific 1, retinoic acid receptor alpha, and HATs (p300 and p300/cA

17 thyroid receptor alpha, vitamin D receptor, retinoic acid receptor alpha, and retinoid X receptor al

18 Both retinoic acid receptor (alpha, beta, gamma) and AP-1 (c-

19 The retinoic acid receptors alpha, beta and gamma (RARalpha,

20 model of the inactive conformation of human retinoic acid receptor-alpha by using information derive

21 ved residues within the docking motif of the retinoic acid receptor alpha cause defects in dimerizati

22 Expression profiling of a retinoic acid receptor alpha coactivator protein, P/CAF,

23 TGF-beta2 and IGFBP-3 expression through an retinoic acid receptor-alpha-dependent pathway, and the

24 A dominant-negative form of the retinoic acid receptor alpha (DNhRARalpha) was expressed

25 in CD8(+) T cells using a dominant negative retinoic acid receptor alpha (dnRARalpha) established th

26 me proliferator-activated receptor alpha and retinoic acid receptor alpha, enabling a mild and leaky

27 ta, only in PML-RARA (promyelocytic leukemia-retinoic acid receptor alpha)-expressing cells.

28 Cytokines both potentiate retinoic acid receptor alpha expression and enhance its

29 I/RARalpha (cellular retinol-binding protein/retinoic acid receptor alpha) expression, and led to apo

30 esence of factors that interfere with proper retinoic acid receptor alpha function.

31 n, initially discovered as a part of the PML/retinoic acid receptor alpha fusion protein, has been fo

32 promyelocytic leukemia protein (PML) and PML-retinoic acid receptor alpha fusion protein.

33 translocation t(15;17), which generates PML-retinoic acid receptor alpha fusion proteins (PML-RARalp

34 NuMA-retinoic acid receptor alpha fusion proteins have been d

35 The PML gene is fused to the retinoic acid receptor alpha gene (RAR alpha) in the acu

36 e promyelocytic leukemia gene (PML) with the retinoic acid receptor alpha gene (RAR alpha).

37 ith chromosomal translocations involving the retinoic acid receptor alpha gene (RARA) and the PML gen

38 ivator of transcription protein 5B, with the retinoic acid receptor alpha gene are commonly associate

39 RARA (retinoic acid receptor alpha) haploinsufficiency is an i

40 ds of the ligand binding domain of the human retinoic acid receptor alpha (hRAR alpha).

41 DNA-binding transcriptional factor fused to retinoic acid receptor alpha in acute promyelocytic leuk

42 LZF was identified by its translocation with retinoic acid receptor alpha in t(11;17) acute promyeloc

43 leukemia zinc finger) is fused to RARalpha (retinoic acid receptor alpha) in a subset of acute promy

44 and exposure to retinoic acid (signaling via retinoic acid receptor alpha) increased alpha4beta7 expr

45 An antagonist of retinoic acid receptor-alpha, LG100629, abrogated the in

46 Here, we show that retinoic acid receptor alpha not only links retinoic aci

47 ly bound PXR as a heterodimer with the 9-cis retinoic acid receptor alpha (NR2B1).

48 Nuclear mitotic apparatus protein-retinoic acid receptor alpha (NuMA-RARalpha) is the four

49 e progressive multifocal leukoencephalopathy/retinoic acid receptor alpha oncoprotein, in combination

50 proteins, promyelocytic leukemia zinc finger-retinoic acid receptor alpha (PLZF-RARalpha) and RARalph

51 proteins, promyelocytic leukemia zinc finger-retinoic acid receptor alpha (PLZF-RARalpha) and RARalph

52 the expression of the promyelocytic leukemia-retinoic acid receptor alpha (PML-RAR-alpha) oncoprotein

53 tion that creates the promyelocytic leukemia-retinoic acid receptor alpha (PML-RARA) fusion oncogene.

54 es the fusion protein promyelocytic leukemia-retinoic acid receptor alpha (PML-RARA) in nearly all ca

55 evealed that IL-3 and promyelocytic leukemia-retinoic acid receptor alpha (PML-RARalpha) combined to

56 ytes expressing human promyelocytic leukemia-retinoic acid receptor alpha (PML-RARalpha) fusion gene,

57 ons produce a promyelocytic leukemia protein-retinoic acid receptor alpha (PML-RARalpha) fusion gene.

58 c leukemia specific promyelocytic locus gene-retinoic acid receptor alpha (PML-RARalpha) fusion prote

59 tic leukemia (APL), a promyelocytic leukemia-retinoic acid receptor alpha (PML-RARalpha) fusion prote

60 carrying leukemogenic promyelocytic leukemia-retinoic acid receptor alpha (PML-RARalpha) fusion prote

61 Expression of the PML-retinoic acid receptor alpha (PML-RARalpha) fusion prote

62 t all cases of APL, a promyelocytic leukemia-retinoic acid receptor alpha (PML-RARalpha) fusion prote

63 (APL) and the role of promyelocytic leukemia-retinoic acid receptor alpha (PML-RARalpha) in establish

64 ic cells that express promyelocytic leukemia-retinoic acid receptor alpha (PML-RARalpha) or are at th

65 The promyelocytic leukemia-retinoic acid receptor alpha (PML-RARalpha) protein of a

66 he fusion oncoprotein promyelocytic leukemia-retinoic acid receptor alpha (PML-RARalpha).

67 a (APL) cells express promyelocytic leukemia/retinoic acid receptor alpha (PML/RARalpha) fusion prote

68 e by fusing the human promyelocytic leukemia-retinoic acid receptor-alpha (PML-RARA) oncogene to teta

69 expression of promyelocytic leukemia protein retinoic acid receptor-alpha (PML-RARalpha) fusion prote

70 We also demonstrate that the PML retinoic acid receptor-alpha (PML-RARalpha) oncofusion p

71 ssociation of promyelocytic leukemia protein-retinoic acid receptor-alpha (PML-RARalpha) with corepre

72 igenetic landscape of promyelocytic leukemia/retinoic acid receptor-alpha (PML-RARalpha)-associated a

73 on (PCR) negative for promyelocytic leukemia/retinoic acid receptor-alpha (PML/RARalpha) after liposo

74 APL-associated aberrant fusion proteins (PML-retinoic acid receptor alpha [PML-RAR alpha] or PLZF-RAR

75 The promyelocytic leukemia retinoic acid receptor alpha (PMLRARalpha) chimeric prot

76 is blocked by its dominant-negative form PML-retinoic acid receptor alpha (PMLRARalpha).

77 Expression of a bcr-3 isoform of retinoic acid receptor alpha-promyelocytic leukemia (RAR

78 c acid leads to degradation of promyelocytic-retinoic acid receptor alpha protein and disappearance o

79 significant consequences in stabilizing the retinoic acid receptor alpha protein levels that are nec

80 the recovery of the retinoid-induced loss of retinoic acid receptor alpha protein pools.

81 LiCl on proteasome-dependent degradation of retinoic acid receptor alpha proteins.

82 osomal translocations that generate chimeric retinoic acid receptor-alpha proteins (x-RARalpha fusion

83 PRKAR1A (R1A)-retinoic acid receptor-alpha (R1A-RARalpha) is the sixth

84 ed with chromosomal translocations involving retinoic acid receptor alpha (RAR alpha) and its fusion

85 e expression of promyelocytic leukemia (PML)/retinoic acid receptor alpha (RAR alpha) and RAR alpha/P

86 ceptor characterization of a novel series of retinoic acid receptor alpha (RAR alpha) antagonists, 1-

87 mal translocations, invariably involving the retinoic acid receptor alpha (RAR alpha) gene fused to o

88 The PML gene is fused to the retinoic acid receptor alpha (RAR alpha) gene in t(15;17

89 n fuses the PML gene on chromosome 15 to the retinoic acid receptor alpha (RAR alpha) gene on chromos

90 acid (RA)-induced maturation mediated by the retinoic acid receptor alpha (RAR alpha) has been implic

91 cytic leukemia (PML) protein is fused to the retinoic acid receptor alpha (RAR).

92 el-like zinc finger protein, is fused to the retinoic acid receptor-alpha (RAR alpha) gene, yielding

93 Retinoic acid receptor-alpha (RAR alpha) is a known estr

94 armacokinetics of TAC-101, a novel synthetic retinoic acid receptor-alpha (RAR-alpha) selective retin

95 L-60R mutant cells, which harbor a defective retinoic acid receptor-alpha (RAR-alpha), ATRA is unable

96 Retinoic-acid receptor-alpha (RAR-alpha) and peroxisome

97 ranslocation, which results in fusion of the retinoic acid receptor alpha (RARA) gene to another gene

98 etic risk factor for these conditions is the retinoic acid receptor alpha (RARA) locus, which is invo

99 ar phosphoprotein nucleophosmin (NPM) to the retinoic acid receptor alpha (RARA).

100 l translocation t(15;17) that fuses PML with retinoic acid receptor alpha (RARA).

101 of the APL-associated fusion oncoprotein PML/retinoic acid receptor alpha (RARA).

102 adation and decreased CAK phosphorylation of retinoic acid receptor alpha (RARa).

103 Knockdown of Kif7, and retinoic acid receptors alpha (Rara), beta (Rarb), and g

104 hrough overexpression of a dominant negative retinoic acid receptor alpha (RARalpha) (dnRARalpha mice

105 n gel mobility shift assays, heterodimers of retinoic acid receptor alpha (RARalpha) and retinoid X r

106 dependent manners, which is mediated through retinoic acid receptor alpha (RARalpha) and retinoid X r

107 Here, we show that UTX interacts with the retinoic acid receptor alpha (RARalpha) and that this in

108 munoprecipitation (ChIP) assays, the nuclear retinoic acid receptor alpha (RARalpha) associated with

109 ed by inducing expression of APL-related PML-retinoic acid receptor alpha (RARalpha) chimeric protein

110 Estradiol-mediated enhancement of retinoic acid receptor alpha (RARalpha) expression in th

111 with a switch to CAK hypophosphorylation of retinoic acid receptor alpha (RARalpha) from CAK hyperph

112 sable for spermatogenesis, and disruption of retinoic acid receptor alpha (RARalpha) function resulte

113 ukemic blast of fusion proteins in which the retinoic acid receptor alpha (RARalpha) fuses to distinc

114 translocation, involves a fusion between the retinoic acid receptor alpha (RARalpha) gene and a previ

115 The PML gene is fused to the retinoic acid receptor alpha (RARalpha) gene in chromoso

116 control of apoptosis, which is fused to the retinoic acid receptor alpha (RARalpha) gene in the vast

117 omosomal translocations always involving the retinoic acid receptor alpha (RARalpha) gene on chromoso

118 omosomal translocations always involving the Retinoic Acid Receptor alpha (RARalpha) gene on chromoso

119 omosomal translocations always involving the retinoic acid receptor alpha (RARalpha) gene on chromoso

120 anslocation that fuses the PML gene with the retinoic acid receptor alpha (RARalpha) gene.

121 RARalpha, in which the PML gene fuses to the retinoic acid receptor alpha (RARalpha) gene.

122 romyelocytic leukemia zinc finger (PLZF) and retinoic acid receptor alpha (RARalpha) genes.

123 through its fusion to the gene encoding the retinoic acid receptor alpha (RARalpha) in acute promyel

124 PML fuses with retinoic acid receptor alpha (RARalpha) in the t(15;17)

125 tinoic acid (ATRA) and other agonists of the retinoic acid receptor alpha (RARalpha) inhibit the form

126 Retinoic acid receptor alpha (RARalpha) is a transcripti

127 Retinoic acid receptor alpha (RARalpha) is the target of

128 cal chromosomal translocations involving the retinoic acid receptor alpha (RARalpha) locus on chromos

129 eukemia gene (PML) on chromosome 15 with the retinoic acid receptor alpha (RARalpha) on chromosome 17

130 a crucial role in leukemogenesis by the PML-retinoic acid receptor alpha (RARalpha) oncoprotein, an

131 ML) nuclear bodies (NBs) mediated by the PML-retinoic acid receptor alpha (RARalpha) oncoprotein.

132 n of C/EBPepsilon expression was through the retinoic acid receptor alpha (RARalpha) pathway.

133 It was found that steady-state retinoic acid receptor alpha (RARalpha) protein levels w

134 PML-retinoic acid receptor alpha (RARalpha) regulated adapto

135 The regulation of retinoic acid receptor alpha (RARalpha) signal transduct

136 expression of a dominant-negative mutant of retinoic acid receptor alpha (RARalpha) specifically to

137 Retinoic acid receptor alpha (RARalpha) transactivates t

138 The retinoic acid receptor alpha (RARalpha) was recruited by

139 Retinoic acid receptor alpha (RARalpha) was the critical

140 Fusion proteins of retinoic acid receptor alpha (RARalpha) with promyelocyt

141 er) transcriptional repressor, when fused to retinoic acid receptor alpha (RARalpha), causes a refrac

142 15,17) product, promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha), have clinical r

143 rans retinoic acid, an activating ligand for retinoic acid receptor alpha (RARalpha), is used to trea

144 es the genes for nucleophosmin (NPM) and the retinoic acid receptor alpha (RARalpha).

145 EPRO cell line harboring a dominant-negative retinoic acid receptor alpha (RARalpha).

146 press aberrant fusion proteins involving the retinoic acid receptor alpha (RARalpha).

147 sed approach to isolating NRs by cloning the retinoic acid receptor-alpha (RARalpha) gene from the ge

148 Translocations of the retinoic acid receptor-alpha (RARalpha) locus with the p

149 a was reduced by pharmacological blockade of retinoic acid receptor-alpha (RARalpha) signaling, indic

150 elective retinoids revealed that ligands for retinoic acid receptor-alpha (RARalpha), including atRA,

151 hesized that specific activation of a single retinoic acid receptor-alpha (RARalpha), without direct

152 omosomal translocations always involving the Retinoic Acid Receptor(alpha) (RARalpha) gene on chromos

153 We demonstrated that the retinoic acid receptor alpha/retinoic X receptor alpha h

154 other nuclear receptors [vitamin D receptor, retinoic acid receptor alpha, retinoid X receptor alpha,

155 e to negative for the promyelocytic leukemia/retinoic acid receptor-alpha transcript by the completio

156 development of transgenic mouse models, some retinoic acid receptor alpha translocation fusion protei

157 Stimulation of the Sox9 and HoxA1 genes by retinoic acid receptor-alpha was found to require both D