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1 ) could be bound by vitamin D receptor (VDR)/retinoid X receptor.
2 and involves direct interaction with RAR and retinoid X receptor.
3 and was dependent upon dimerization with the retinoid X receptor.
4 ein modification and heterodimerization with retinoid X receptor.
5 tor, and their obligate heterodimer partner, retinoid X receptor.
6 LXRs or their heterodimerizing partner, the retinoid X receptor.
7 overexpression of its heterodimeric partner, retinoid X receptor.
8 e PLA2g2a promoter as a heterodimer with the retinoid X receptor.
9 RA signaling were partially mediated by the retinoid X receptor.
10 elements and for heterodimerization with the retinoid X receptors.
11 embers of retinoic acid receptors (RARs) and retinoid X receptors.
12 mined the neuronally directed effects of the retinoid X receptor agonist bexarotene in an aggressive
13 and a panel of retinoid acid receptor (RAR)/retinoid X receptor agonist treatments suggested that RA
14 We investigated the effects of bexarotene (a retinoid X receptor agonist), CD1530 (a retinoic acid re
19 port that Nuclear receptor-related 1 (Nurr1):Retinoid X receptor alpha (RXRalpha) activation has a do
20 three closely related human NRs--HNF4alpha, retinoid X receptor alpha (RXRalpha) and COUPTF2--reveal
21 way that strongly inhibits the expression of retinoid X receptor alpha (RXRalpha) and suppresses the
23 tor activated receptor-gamma (PPARgamma) and retinoid X receptor alpha (RXRalpha) complex was found t
26 sactivation of BSEP and SHP promoters by FXR/retinoid X receptor alpha (RXRalpha) in HepG2 cells.
28 r partner to class II nuclear receptors, the retinoid X receptor alpha (RXRalpha) plays a vital physi
29 93T, it was possible to demonstrate that the retinoid X receptor alpha (RXRalpha) plus its ligand can
30 epatocyte nuclear factor 4alpha (HNF4alpha), retinoid X receptor alpha (RXRalpha) plus peroxisome pro
31 ediated by hepatocyte nuclear factor 4alpha, retinoid X receptor alpha (RXRalpha) plus peroxisome pro
32 tocyte nuclear factor 4alpha (HNF4alpha) and retinoid X receptor alpha (RXRalpha) plus peroxisome pro
33 ptors hepatocyte nuclear factor 4 (HNF4) and retinoid X receptor alpha (RXRalpha) plus peroxisome pro
34 s predicted to interact efficiently with VDR-retinoid X receptor alpha (RXRalpha) was identified in s
35 pharmacologically perturbed the activity of retinoid X receptor alpha (RXRalpha), a key hub within t
38 ctive homodimers to active heterodimers with retinoid X receptor alpha (RXRalpha), and phosphorylatio
39 depends on vitamin A signals mediated by the retinoid X receptor alpha (RXRalpha), as the systemic mu
41 interact in an agonist-dependent manner with retinoid X receptor alpha (RXRalpha), suggesting that th
42 Pbeta), forkhead box protein A2 (FOXA2), and retinoid X receptor alpha (RXRalpha), were markedly decr
43 ln275, Arg316 and Arg371 in nuclear receptor retinoid X receptor alpha (RXRalpha), where berberine co
44 xisome proliferator-activated receptor alpha-retinoid X receptor alpha (RXRalpha), with which PGC-1be
48 onstitutive androstane receptor (CAR, NR1I3)/retinoid X receptor alpha (RXRalpha, NR2B1) heterodimer
49 mation weight matrix for vitamin D3 receptor/retinoid X receptor alpha (VDR/RXRalpha) binding sites w
54 X receptor (FXR) via a direct binding of FXR/retinoid X receptor alpha heterodimers to a highly conse
56 d to this site as a monomer, because neither retinoid X receptor alpha nor retinoid X receptor beta a
57 Ralpha, induced the recruitment of PPARalpha:retinoid x receptor alpha, but not PPARgamma coactivator
58 stored the DNA binding activity of PPARalpha/retinoid X receptor alpha, induced mRNA levels of PPARal
59 itation studies confirmed the recruitment of retinoid X receptor alpha, PPARalpha, and PGC1alpha on t
63 istent with this suggestion, it appears that retinoid X receptor alpha/farnesoid X receptor alpha and
67 r expression of vitamin D receptor (VDR) and retinoid X receptor-alpha (RXR) has not been investigate
71 ing protein-alpha (Cebpalpha), Cebpbeta, and retinoid x receptor-alpha (Rxralpha) compared with untre
72 how here that keratinocytic nuclear receptor retinoid X receptor-alpha (RXRalpha) regulates mouse ker
74 brate drugs were abrogated in the absence of retinoid X receptor-alpha (RXRalpha), a molecule known t
75 n availability as hepatic nuclear PPARgamma, retinoid X receptor-alpha (RXRalpha), and PPARgamma/RXRa
81 specific target genes.The vitamin D receptor/retinoid X receptor-alpha heterodimer (VDRRXRalpha) regu
85 pha, but were decreased in mice deficient in retinoid X receptor-alpha, the major heterodimerization
86 receptor 4 and the ligand-binding domains of retinoid X receptor and retinoic acid receptor by observ
87 ith a selective PPARgamma antagonist or with retinoid X receptor and retinoic acid receptor ligands p
88 clear receptors that heterodimerize with the retinoid X receptor and then modulate at the transcripti
89 ediated by preferential interactions between retinoid X receptors and CYP4F promoter elements in epid
90 inoic acid receptors (retinoic acid receptor/retinoid X receptor) and glucocorticoid receptors are re
91 Sult2A1 chromatin to recruit VDR, RXR-alpha (retinoid X receptor) and PXR in mice injected with D(3)
92 lets, also in vitro translated PPARgamma and retinoid X receptor, and chromatin immunoprecipitation a
94 by nuclear receptors retinoic acid receptor, retinoid X receptor, and thyroid hormone receptor and in
95 ic identity were linked to RUNX2, C/EBPbeta, retinoid X receptor, and vitamin D receptor binding site
96 th retinoic acid receptor, does not activate retinoid-X receptor, and is not a substrate for CYP26s,
97 unctional expression cloning approach, a gag-retinoid X receptor beta (gag-RXRbeta) fusion protein wa
98 ecause neither retinoid X receptor alpha nor retinoid X receptor beta antibody supershifted the prote
99 nscription factors PPARalpha, PPARdelta, and retinoid X receptor beta; and (c) liver development asso
100 , all found in the MHC class III region; and retinoid X receptor, beta (RXRB),which resides in the MH
102 21 gene transcription was mediated by an FXR/retinoid X receptor binding site in the 5'-flanking regi
103 ites identified two vitamin D receptor (VDR)/retinoid X receptor binding sites in the 1-kb promoter r
104 s 1,25(OH)(2)D(3) induces rapid VDR and RXR (retinoid X receptor) binding to the Cyp24a1 gene in both
105 adipocyte differentiation favored PPARgamma, retinoid X receptor, C/EBPalpha, and C/EBPbeta binding s
106 peroxisome proliferator-activated receptor, retinoid X receptor, CCAAT/enhancer binding protein, and
109 er and show that binding of the liganded VDR.retinoid X receptor directly impacts both the distal and
110 f Fgf15 by vitamin A is mediated through the retinoid X receptor/farnesoid X receptor heterodimer and
111 imal promoter recruit retinoic acid receptor/retinoid X receptor from a distal RARE to form an enhanc
114 ormone receptor siRNA library, we identified retinoid X receptor gamma (RXRgamma) instead as being in
115 receptors, retinoic acid receptor alpha and retinoid X receptor gamma, were up-regulated in response
117 a direct transcriptional target for the LXR/retinoid X receptor heterodimer and that the ability of
118 forms a complex with the vitamin D receptor.retinoid X receptor heterodimer in electrophoresis mobil
119 (NRs), especially the liver X receptor (LXR)/retinoid X receptor heterodimer, as an important event i
122 TRAP220 interacted predominantly with the TR.retinoid X receptor heterodimeric pair in a ligand-depen
123 id not exhibit any defects in DNA binding or retinoid X receptor heterodimerization and was transcrip
125 oic acid can activate retinoic acid receptor/retinoid X receptor heterodimers but not retinoid X rece
126 aling did not involve reduced binding of LXR/retinoid X receptor heterodimers to target gene promoter
127 hormone receptor (TR) homodimers, but not TR-retinoid X receptor heterodimers, to thyroid hormone res
128 s of the LXRbeta homodimer and LXRalpha:RXR (retinoid X receptor) heterodimers explains differences i
130 tor/retinoid X receptor heterodimers but not retinoid X receptor homodimers in reporter cell assays.
131 signaling through heterodimerization with a retinoid X receptor homologue Ultraspiracle (USP), the o
133 association of the ligand-binding domain of retinoid X receptor in the presence and absence of 9-cis
134 )2D3-independent interaction between VDR and retinoid X receptors in primary keratinocytes, indicatin
137 al proliferator-activated receptor-gamma and retinoid X receptor inhibit expression of CYP3a13 at the
138 bition of IL-1beta-dependent genes by active retinoid X receptors involves antagonism of NF-kappaB si
139 We observe the formation of homodimers of retinoid X receptor ligand binding domain upon addition
140 of alpha-synuclein toxicity and suggest that retinoid X receptor ligands with appropriate pharmacolog
141 peroxisome proliferator-activated receptor, retinoid X receptor, liver X receptor, and activating pr
143 udes the binding of the liver X receptor and retinoid X receptor (LXR/RXR) heterodimer to the DR-4 el
144 miferana ultraspiracle (CfUSP), Mus musculus retinoid X receptor (MmRXR) to either GAL4 DNA binding d
145 of matrix metalloproteases, liver X receptor/retinoid X receptor, nuclear factor erythroid 2-related
146 etic ligand for the nuclear hormone receptor retinoid X receptor, on the expression of matrix metallo
147 inoic acid, a retinoic acid receptor-, and a retinoid X receptor pan-agonist were unable to induce NA
148 how that expression of genes involved in the retinoid X receptor pathway are decreased with ageing in
153 13 promoter shows putative binding sites for retinoid X receptor, pregnane X receptor, and estrogen r
154 ), through binding to retinoic acid receptor-retinoid X receptor (RAR-RXR) heterodimers bound at RA r
156 perfamily including retinoic acid receptors, retinoid X receptors (RAR and RXR, respectively), and pe
157 tg2 promoter and show that the element binds retinoid X receptor/RAR heterodimers in vitro, is occupi
158 on in response to 9-cis-RA as evident by the retinoid X receptor response element-luciferase assays.
160 and migration, lower retinol, and abolished retinoid X receptor/retinoid A receptor transcriptional
161 ds bound to the ligand binding domain of the retinoid X receptor reveal key structural aspects that e
163 ither BADGE nor BPA activated or antagonized retinoid "X" receptor (RXR) or PPARgamma in transient tr
165 thalenyl]-1-propenyl ) benzoic acid) and RAR/retinoid X receptor (RXR) agonist (9-cis-RA) promote exp
166 ious data demonstrate that bexarotene (Bex), retinoid X receptor (RXR) agonist, reduces soluble and i
171 served enrichment for liver X receptor (LXR)/retinoid X receptor (RXR) and farnesoid X receptor/RXR n
173 r that can form a heterodimeric complex with retinoid X receptor (RXR) and initiate transcription of
174 hormone receptor, which heterodimerizes with retinoid X receptor (RXR) and regulates transcription of
175 g protein (C/EBP), HNF3, and heterodimers of retinoid X receptor (RXR) and retinoic acid receptor (RA
177 ale gastropods, because of the activation of retinoid X receptor (RXR) at very low environmental conc
178 10R slightly but significantly decreased FXR/retinoid X receptor (RXR) binding affinity but enhanced
180 As a promiscuous dimerization partner the retinoid X receptor (RXR) can contribute to signaling by
182 oth VDREs bound the vitamin D receptor (VDR)-retinoid X receptor (RXR) complex and drove reporter gen
184 eracts with retinoic acid receptor (RAR) and retinoid X receptor (RXR) constitutively, but hormone bi
185 hat competed with a normally functioning VDR-retinoid X receptor (RXR) dimer for binding to the vitam
186 Ligands that activate the nuclear receptor retinoid X receptor (RXR) display potent anticarcinogeni
187 or, a transcriptional corepressor) from a TR*retinoid X receptor (RXR) heterodimer bound to a DR+4 th
188 multiprotein complex that assembles on a TR.retinoid X receptor (RXR) heterodimer in HeLa nuclear ex
189 ferator activated receptor-alpha (PPARalpha)/retinoid X receptor (RXR) heterodimer promotes transcrip
190 5(OH)(2)D(3)) via a vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two
191 These response elements directly bind FXR/retinoid X receptor (RXR) heterodimers and confer the ac
197 anisms underlying the anti-cancer effects of retinoid X receptor (RXR) ligand (rexinoid) therapy are
199 ed receptor gamma (PPARgamma) interacts with retinoid X receptor (RXR) on PPAR response elements (PPR
200 tion was achieved through the binding of PXR-retinoid X receptor (RXR) or CAR-RXR heterodimers to dir
203 orphan receptors and, in particular, of the retinoid X receptor (RXR) positioned nuclear receptors a
207 itamin D receptor (VDR) FokI AA genotype and retinoid X receptor (RXR) rs7861779 TT genotype were ass
209 sed here expressed all RA receptor (RAR) and retinoid X receptor (RXR) subtypes (as detected by North
210 mechanisms that may cause aberrations in the retinoid X receptor (RXR) subunits, RXR-alpha and RXR-be
211 binding of retinoic acid receptor (RAR) and retinoid X receptor (RXR) to a dominant site in enhancer
213 (FXR), which binds as a heterodimer with the retinoid X receptor (RXR) to the FXR response element (F
214 g a co-activator of the LCPUFA-sensing PPARG-retinoid X receptor (RXR) transcription complex, may inf
216 a functional heterodimer between EcR and the retinoid X receptor (RXR) upon application of the chemic
217 (NRs) function as obligate heterodimers with retinoid X receptor (RXR), allowing integration of ligan
218 receptors (PPARs) form heterodimers with the retinoid X receptor (RXR), and PPAR-gamma has been inten
220 iption factors retinoic acid receptor (RAR), retinoid X receptor (RXR), and Sp-1 exhibited >2-fold in
221 a (PPARgamma) and its heterodimeric partner, retinoid X receptor (RXR), are effective agents for the
223 by activating the retinoic acid receptor and retinoid X receptor (RXR), indirectly influencing RXR he
224 ndrostane receptor, pregnane X receptor, and retinoid X receptor (RXR), modulate acetaminophen (APAP)
225 r hormone receptors that heterodimerize with retinoid X receptor (RXR), such as thyroid receptors, pe
227 imers and heterodimers with PPARgamma or the retinoid X receptor (RXR), thereby competing with PPARga
229 selective ablation of the nuclear receptors retinoid X receptor (RXR)-alpha and RXR-beta in mouse ep
230 f hepatocyte nuclear factor (HNF)-1alpha and retinoid X receptor (RXR)-alpha to investigate whether a
231 am promoter-transcription factor (COUP-TF1), retinoid X receptor (RXR)-gamma, thyroid hormone recepto
232 s controlled by the transcription regulation retinoid X receptor (RXR)-liver X receptor (LXR) system.
234 tes fundamental biological processes through retinoid X receptor (RXR)-mediated gene expression, mole
235 However, when used in combination with a retinoid X receptor (RXR)-selective ligand, tazarotene c
248 PCR analyses showed increased PPAR mRNA and retinoid X receptor (RXR)alpha mRNA expression after exp
253 soforms of retinoic acid receptors (RAR) and retinoid X receptors (RXR) with the exception of RXRgamm
256 id receptors (RAR-alpha, -beta, -gamma), and retinoid X receptors (RXR-alpha, -beta, -gamma) was perf
257 ion of retinoic acid receptor (RAR-beta) and retinoid X receptors (RXR-beta, -gamma) was significantl
259 tor-activated receptor gamma (PPARgamma) and retinoid-X receptor (RXR) ligands on AIB3(+/-)/PyMT cell
261 ranscription factor II (ARP-1/COUP-TFII) and retinoid X receptor (RXRalpha) as the protein factors th
263 totic effect was associated with loss of the retinoid X receptor (RXRalpha) protein in the adenocarci
266 ic acid receptors (RARs) heterodimerize with retinoid X receptors (RXRs) and bind to RA response elem
269 iferator-activated receptors (PPARs) and the retinoid X receptors (RXRs) are ligand-activated transcr
275 sms underlying neuritogenesis, we found that retinoid X receptors (RXRs) control neuritogenesis.
279 t activation of liver X receptors (LXRs) and retinoid X receptors (RXRs) inhibits apoptotic responses
280 rodimeric binding partners of PPARgamma, the retinoid X receptors (RXRs), showed additive enhancement
288 vious studies of the retinoid, bexarotene, a retinoid X receptor-specific ligand, have indicated that
289 e expression of known retinoic acid receptor/retinoid X receptor target genes, whereas GW0742 did not
290 lly targeted by bexarotene, a ligand for the retinoid X receptor that forms heterodimers with Nurr1.
291 factors are the retinoic acid receptor, the retinoid X receptor, the hepatocyte nuclear factor 4alph
292 monstrated specific binding of PPARgamma and retinoid X receptor to the human and mouse pdx-1 x PPREs
293 omoted binding of the vitamin D receptor and retinoid X receptor to the promoters of osteoblastic tar
298 inoid receptors (retinoic acid receptors and retinoid X receptors), which are nuclear transcription f
300 specific nuclear retinoic-acid receptors and retinoid-X receptors, which are encoded by separate gene
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