ライフサイエンスコーパス: retinol-binding protein

1 llular LBPs such as serum albumin and plasma retinol binding protein.

2 yx in a manner similar to retinol binding in retinol-binding protein.

3 ne tetramer of TTR can bind two molecules of retinol-binding protein.

4 bundant substrate: retinol bound to cellular retinol-binding protein.

5 Here we show that mouse and human SAAs are retinol binding proteins.

6 it upon ligand binding by mammalian cellular retinol-binding proteins.

7 hibitor families, as well as fatty acid- and retinol-binding proteins.

8 The cellular retinol-binding protein 1 (CRBP1) and the retinoic acid

9 orage, and metabolism of retinoids, cellular retinol-binding protein 1 (CRBP1) is essential for traff

10 A receptor beta2 (RARbeta2) and the cellular retinol-binding protein 1 (CRBP1).

11 in, and desmin, and negatively with cellular retinol-binding protein 1 and matrix metalloproteinase 2

12 on, retinol-related genes such as CRABP2 and retinol-binding protein 1 were overexpressed in WT, and

13 eased markers of dedifferentiation, cellular retinol-binding protein 1, and matrix metalloproteinase

14 enger RNA (mRNA) levels of LRAT and cellular retinol binding protein-1.

15 regulating RA-responsive genes like cellular retinol-binding protein-1.

16 uced by immunization with interphotoreceptor retinol-binding protein 1177-1191 peptide were treated b

17 Vitamin A bound to retinol binding protein 4 (RBP4) constitutes the major t

18 are located near the transthyretin (TTR) and retinol binding protein 4 (RBP4) genes which encode majo

19 Retinol binding protein 4 (RBP4) is a serum protein that

20 lective increase in plasma and intra-adipose retinol binding protein 4 (RBP4) that preceded obesity.

21 sed in the vascular endothelial cells, while retinol binding protein 4 (rbp4) was expressed in the yo

22 L-HDLs showed a reduced content of lipocalin retinol binding protein 4 and apolipoprotein M and in th

23 stance have been found; a notable example is retinol binding protein 4.

24 erations in the vitamin A-transport proteins retinol-binding protein 4 (RBP4) and prealbumin.

25 investigate the mechanisms by which elevated retinol-binding protein 4 (RBP4) causes insulin resistan

26 The increase of apo-/holo-retinol-binding protein 4 (RBP4) concentrations has been

27 Elevated levels of serum retinol-binding protein 4 (RBP4) contribute to insulin r

28 onsiderable evidence that both retinoids and retinol-binding protein 4 (RBP4) contribute to the devel

29 Retinol-binding protein 4 (RBP4) has been implicated as

30 Antagonists of retinol-binding protein 4 (RBP4) impede ocular uptake of

31 Serum retinol-binding protein 4 (RBP4) is the sole specific tr

32 Serum retinol-binding protein 4 (RBP4) is the sole specific vi

33 in (TTR) is a critical determinant of plasma retinol-binding protein 4 (RBP4) levels.

34 Retinol-binding protein 4 (RBP4) may play an important r

35 Retinol-binding protein 4 (RBP4) transports retinol from

36 bition of the retinol-induced interaction of retinol-binding protein 4 (RBP4) with transthyretin (TTR

37 onizing the retinol-dependent interaction of retinol-binding protein 4 (RBP4) with transthyretin in t

38 Serum levels of retinol-binding protein 4 (RBP4), a protein secreted by

39 To examine whether serum retinol-binding protein 4 (RBP4), an endogenous TTR liga

40 Retinol-binding protein 4 (RBP4), the sole retinol trans

41 Similarly, serum levels of retinol-binding protein 4 and retinoids were significant

42 adipocytokines (interleukin-6, adiponectin, retinol-binding protein 4) or soluble intercellular adhe

43 variate analysis) determinant of circulating retinol-binding protein 4, a reliable proxy for retinol

44 e show, using DNA arrays, that expression of retinol binding protein-4 (RBP4) is elevated in adipose

45 s of TNF-alpha, IL-6, adiponectin, resistin, retinol binding protein-4, or intraabdominal fat volume.

46 high-molecular-weight adiponectin, resistin, retinol binding protein-4, or intraabdominal obesity, su

47 Retinol-binding protein-4 (RBP4) is an emerging candidat

48 factor B, haptoglobin, transthyretin, plasma retinol binding protein, albumin, and hemopexin.

49 our serum proteins-carcinoembryonic antigen, retinol binding protein, alpha1-antitrypsin, and squamou

50 the fatty acid binding proteins and cellular retinol binding protein also are down-regulated in the a

51 Cellular retinol binding protein and cellular retinoic acid bindi

52 bin concentration or serum concentrations of retinol-binding protein and prealbumin.

53 usly quantifying iron (ferritin), vitamin A (retinol-binding protein), and inflammation (C-reactive p

54 fetoprotein, apolipoproteins, transthyretin, retinol binding protein, and transferrin.

55 -reactive protein, alpha1-acid glycoprotein, retinol binding protein, and transthyretin.

56 n and serum concentrations of beta-carotene, retinol-binding protein, and prealbumin.

57 between tetrameric transthyretin, thyroxine, retinol-binding protein, and retinol.

58 m constitutive hepatic proteins (prealbumin, retinol-binding protein, and transferrin) increased with

59 enases (RoDH), which recognize holo-cellular retinol-binding protein as substrate, had been cloned, e

60 ions with both unbound and CRBP(I) (cellular retinol-binding protein)-bound retinal, but apo-CRBP(I)

61 The metabolism of retinol-binding protein-bound all-trans-retinol, and alb

62 Km of approximately 0.7 microM, and cellular retinol-binding protein-bound retinal, with a Km of appr

63 esponse tests work on the principle that apo-retinol-binding protein builds up in the liver as liver

64 y using high-pressure liquid chromatography, retinol-binding protein by using ELISA, and alanine amin

65 The genes encoding serum retinol binding protein, cellular retinol binding protei

66 and serum amyloid-A and an increase in serum retinol-binding protein compared with placebo (p < .05).

67 nd provided with retinol or with the retinol/retinol-binding protein complex.

68 the transport of thyroxine and the vitamin A-retinol-binding protein complex.

69 serum RBP to an intracellular acceptor, the retinol-binding protein CRBP-I.

70 We showed earlier that cellular retinol-binding protein (CRBP) expression is downregulat

71 toward retinoids in the presence of cellular retinol-binding protein (CRBP) type I or cellular retina

72 e lipid-binding protein (KLBP), the cellular retinol-binding protein (CRBP), and the cellular retinoi

73 ic-acid-binding protein (CRABP) and cellular retinol-binding protein (CRBP), as well as their relatio

74 RA biosynthesis pathway consists of cellular retinol-binding protein (Crbp), retinol dehydrogenase (D

75 The physiologic role(s) of cellular retinol-binding protein (CRBP)-III, an intracellular ret

76 xploration of a beta-sheet protein, cellular retinol-binding protein (CRBP).

77 ses (RDHs), access retinol bound to cellular retinol-binding protein (CRBP).

78 mbrane by an intracellular homolog, cellular retinol-binding protein (CRBP).

79 Two cytoplasmic retinol-binding proteins, CRBP and CRBP II, and two cyto

80 ow that Rald is present in rodent fat, binds retinol-binding proteins (CRBP1, RBP4), inhibits adipoge

81 ol), and proximal renal tubular dysfunction (retinol-binding protein/creatinine ratio >2.93mug/mmol a

82 n causes distal bowel aganglionosis in serum retinol-binding-protein-deficient (Rbp4(-/-)) mice.

83 Ratios of serum retinol to retinol-binding protein did not deviate from 1.0, which

84 ein II (CRBP II) is a member of the cellular retinol-binding protein family, which is expressed prima

85 Unliganded cellular retinol-binding protein has no effect on RoDH activity.

86 tamin A is transported in the blood bound to retinol-binding protein (holo-RBP), and its target cells

87 We crossed mice overexpressing human retinol-binding protein (hRBP) under the muscle creatine

88 ding serum retinol binding protein, cellular retinol binding protein I and cellular retinol binding p

89 Cellular retinol-binding protein I (CRBP I) and cellular retinol-

90 cyl chloromethyl ketone (AcDCMK) or cellular retinol-binding protein I (CRBP) diminished the generati

91 The levels of cellular retinol binding protein-I mRNA expression are not correl

92 Downregulation of the cellular retinol-binding protein-I (CRBP-I) occurs in breast and

93 e structure and dynamics of rat apo-cellular retinol binding protein II (apo-CRBP II) in solution has

94 protein cavity, we redesigned human cellular retinol binding protein II (hCRBPII) to fully encapsulat

95 cid increases the mRNA level of the cellular retinol binding protein II and the rate of retinol uptak

96 lular retinol binding protein I and cellular retinol binding protein II have been disrupted by homolo

97 inol-binding protein I (CRBP I) and cellular retinol-binding protein II (CRBP II) are closely homolog

98 Cellular retinol-binding protein II (CRBP II) is a member of the

99 Cellular retinol-binding protein II (CRBPII), a cytosolic retinoi

100 e and backbone dynamics of rat holo cellular retinol-binding protein II (holo-CRBP II) in solution ha

101 fter CM-RE uptake, the levels of retinol and retinol-binding protein in serum, and retinoid levels in

102 mechanism for the uptake of retinol bound to retinol-binding protein in the small intestine of suckli

103 We have identified an intracellular retinol-binding protein in these tissues.

104 s (ferritin, serum transferrin receptor, and retinol binding protein) in settings of prevalent inflam

105 d missense mutations in RBP4, encoding serum retinol binding protein, in three families with eye malf

106 is transported to and taken up by the eye by retinol-binding protein-independent and retinoic acid-re

107 the ability of M-TTR to form a complex with retinol binding protein, indicate that M-TTR forms a ter

108 me oxygenase-1 (HO-1) and interphotoreceptor retinol binding protein (IRBP) were determined 1 to 2 da

109 heme oxygenase (HO)-1 and interphotoreceptor retinol binding protein (IRBP).

110 nder control of the human interphotoreceptor retinol-binding protein (IRBP) promoter.

111 5 ng/mL or 32 pmol/L), vitamin A deficiency (retinol-binding protein <14.7 mug/mL or 0.70 mumol/L) an

112 Hemoglobin, ferritin, retinol binding protein, malaria, and anthropometric mea

113 luded height for age at 10 weeks, vitamin D, retinol binding protein, maternal education, household i

114 le transferrin receptor or vitamin A status (retinol-binding protein or retinol)] and >/=1 biomarker

115 ons as the high-affinity receptor for plasma retinol binding protein (RBP) and mediates cellular upta

116 The interaction of HPR with retinol binding protein (RBP) and transthyretin was stud

117 Retinol binding protein (RBP) concentrations were determ

118 transports vitamin A from its blood carrier retinol binding protein (RBP) into cells, and it also fu

119 Urinary total protein, albumin, retinol binding protein (RBP), alpha-1-microglobulin, Ig

120 Plasma retinol, vitamin E, retinol binding protein (RBP), and C-reactive protein (C

121 s transported in the blood as a complex with retinol binding protein (RBP), but the molecular mechani

122 Serum retinol is transported by retinol binding protein (RBP), which has one high-affini

123 ments of retinol, retinyl palmitate (RP), or retinol binding protein (RBP).

124 ular-weight proteins beta2-microglobulin and retinol binding protein (RBP)], although other measures

125 Retinol circulates in blood bound to retinol-binding protein (RBP) and is transported into ce

126 reported previously that mice lacking plasma retinol-binding protein (RBP) are phenotypically normal

127 Binding of the natural ligands thyroxine or retinol-binding protein (RBP) by Ser52Pro variant TTR st

128 Finally, by knocking out the retinol-binding protein (RBP) gene in the MCK-L0 backgro

129 The molten globule state of human serum retinol-binding protein (RBP) has been postulated previo

130 Mice lacking retinol-binding protein (RBP) have low circulating retin

131 ate uptake of retinol from its blood carrier retinol-binding protein (RBP) into cells and to function

132 Retinol-binding protein (RBP) is often used in populatio

133 Retinol-binding protein (RBP) is the sole specific carri

134 Retinol-binding protein (RBP) is the sole specific trans

135 Retinol-binding protein (RBP) was chosen as a surrogate

136 s, respectively: serum retinol, 90% and 78%; retinol-binding protein (RBP), 40% and 91%; retinol/RBP

137 aditional RDR test, could be circumvented if retinol-binding protein (RBP), a more stable marker of V

138 oss of CMOI function studies in mice lacking retinol-binding protein (RBP), an established model of e

139 Retinol-binding protein (RBP), an extracellular retinol

140 inol is transported around the body bound to retinol-binding protein (RBP), is transferred across the

141 Plasma retinol-binding protein (RBP), the principal carrier of

142 Dams lacking both LRAT and retinol-binding protein (RBP), the sole specific carrier

143 inol is transported in a 1-to-1 complex with retinol-binding protein (RBP).

144 transthyretin-associated transport protein, retinol-binding protein (RBP).

145 retinol and its specific transport protein, retinol-binding protein (RBP).

146 e target cells as all-trans-retinol bound to retinol-binding protein (RBP).

147 e basal surface of the cultured RPE by serum retinol-binding protein (RBP).

148 min A, retinol, circulates in blood bound to retinol-binding protein (RBP).

149 min A, retinol, circulates in blood bound to retinol-binding protein (RBP).

150 ular stores and circulates in blood bound to retinol-binding protein (RBP).

151 molecule metabolically interacting with TTR [retinol-binding protein (RBP)], for possible association

152 on retinyl esters (CM-REs), retinol bound to retinol-binding protein (RBP-ROH), and total retinol wer

153 revents inhibition by the cytosolic cellular retinol-binding protein (RBP1).

154 f mice with a pNO(2)Phe(43) mutant of murine retinol-binding protein (RBP4) also elicited a high tite

155 and secreted into circulation bound to serum retinol-binding protein (RBP4).

156 The Stra6 protein binds the serum retinol-binding protein, RBP4, and acts in conjunction w

157 of the lipophilic vitamin is mediated by the retinol-binding protein, RBP4.

158 Here we examined the role of zebrafish retinol binding protein receptor 2 (Rbpr2) for RBP4-reti

159 Our aim was to elucidate the role of the retinol-binding protein receptor STRA6, mediating cellul

160 ascade, suppressed CRBP-I/RARalpha (cellular retinol-binding protein/retinoic acid receptor alpha) ex

161 entify SAAs as a family of microbe-inducible retinol binding proteins, reveal a unique protein archit

162 media did not result from increased retinol-retinol-binding protein secretion but was dependent on t

163 least one retinoid binding protein (cellular retinol binding protein) serves as a retinoid concentrat

164 beta-Lg is a lipocalin, like plasma retinol-binding protein, so that ligand association was

165 However, the addition of retinol binding proteins stimulates 11-cis-retinol forma

166 retinoid-binding protein (IRBP) or cellular retinol-binding protein, suggesting that peropsin plays

167 Study of adipocyte retinol-binding protein synthesis and secretion indicate

168 binding protein (CRBP)-III, an intracellular retinol-binding protein that is expressed solely in hear

169 nstitutive serum protein levels (prealbumin, retinol binding protein, transferrin) and decreased seru

170 riptionally up-regulated by RA, the cellular retinol binding protein type I (CRBPI) and the RA recept

171 sts in a bound form, complexed with cellular retinol binding protein type I (holo-CRBP).

172 by the enterocyte is complexed with cellular retinol-binding protein type 2 and the complex serves as

173 Here we show that cellular retinol-binding protein type I (CRBP-I), a small cytosol

174 etinol oxidation in the presence of cellular retinol-binding protein type I (CRBPI) than human micros

175 Cellular retinol-binding protein type I (CrbpI), encoded by Rpb1,

176 esence of a 10-fold molar excess of cellular retinol-binding protein type I, which is believed to seq

177 9cRA)-inducible enhancer of the rat cellular retinol-binding protein type II gene (CRBP II) was shown

178 ulation (3-4-fold) in the level of cytosolic retinol-binding protein type III (CRBPIII) in adipose ti

179 All-trans-retinol bound to cellular retinol-binding protein (type I) exhibits a similar Ki v

180 vitamin A, i.e., retinol bound with cellular retinol binding-protein, type I.

181 -binding protein, type I (CrbpI), encoded by retinol-binding protein, type 1 (Rbp1), is a chaperone o

182 Rdh10 behaves similarly to cellular retinol-binding protein, type 1, which also localizes to

183 ate available physiologically, holo-cellular retinol-binding protein, type I (CRBP).

184 Cellular retinol-binding protein, type I (CRBP-I) and type II (CR

185 Cellular retinol-binding protein, type I (CrbpI), encoded by reti

186 Our data also establish that cellular retinol-binding protein, type II (CRBPII), which is expr

187 ntified a novel FABP family member, cellular retinol-binding protein, type III.

188 Cellular retinol-binding proteins types I and II (CRBP-I and CRBP

189 friendly approaches are hemoglobin (anemia), retinol-binding protein (vitamin A), and iron (transferr

190 At least 70 genes control retinol-binding protein, vitamin A, and L-thyroxine leve

191 toichiometry of three interacting molecules, retinol-binding protein, vitamin A, and L-thyroxine, not

192 amer and binds the hormone thyroxine and the retinol-binding protein-vitamin A complex.

193 A possible role for C8 gamma as a retinol binding protein was also investigated.

194 Because RBP4 is a retinol-binding protein, we investigated whether these e

195 reception in mice, animals mutated in plasma retinol binding protein were placed on a vitamin A-free

196 es either in plasma TTR or in CSF and plasma retinol-binding protein were detected.

197 therefore represents a novel class of small retinol-binding protein, which appears to be confined to