ライフサイエンスコーパス: retrograde transport

1 port whereas IFT-A and dynein participate to retrograde transport.

2 orting to signaling endosomes and supporting retrograde transport.

3 a partner in Actr10-dependent mitochondrial retrograde transport.

4 mage signals and virus particles compete for retrograde transport.

5 other by tethering to organelles rather than retrograde transport.

6 d rates of transport, stalling, or increased retrograde transport.

7 chondria, whereas full-length PINK1 promoted retrograde transport.

8 out MTs to stabilize MTs and allow efficient retrograde transport.

9 ynactin thereby inhibiting the initiation of retrograde transport.

10 -ends to receive kinesin-3-delivered EEs for retrograde transport.

11 nent of IFT complex A, which is required for retrograde transport.

12 hypothesized that complex A is required for retrograde transport.

13 ofiles seen in fast and slow anterograde and retrograde transport.

14 her back to the ER by KDEL receptor-mediated retrograde transport.

15 PKC-dependent inhibition of dynein-dependent retrograde transport.

16 together with reductions in FluoroGold (FG) retrograde transport.

17 ion at presynaptic terminals by enhancing AV retrograde transport.

18 rly and sustained changes in anterograde and retrograde transport.

19 aps mediating cytoskeletal attachment during retrograde transport.

20 DSL3 and other factors required for Golgi-ER retrograde transport.

21 eticulum, further implicating this tether in retrograde transport.

22 formation of Kupffer's vesicle and delays in retrograde transport.

23 ade pathway complex), a central component of retrograde transport.

24 bleaching DCVs entering a synaptic bouton by retrograde transport.

25 sferase, an established cargo of intra-Golgi retrograde transport.

26 dosome-localized complex involved in protein retrograde transport.

27 hila motoneuron terminals by anterograde and retrograde transport.

28 early endosomes for clathrin removal during retrograde transport.

29 upregulation of the ARF6 GEF ARNO enhancing retrograde transport.

30 l of various endosomal activities, including retrograde transport.

31 LIP-170), and dynactin-1 (DCTN1) to initiate retrograde transport.

32 the trans-Golgi network and is essential for retrograde transport.

33 early step in Golgi-to-endoplasmic reticulum retrograde transport, affects amyloid precursor protein

34 sicular trafficking was evidenced by delayed retrograde transport after brefeldin A treatment and abn

35 autophagosomes undergo robust unidirectional retrograde transport along axons.

36 here diffusion is slow-is thought to utilize retrograde transport along the microtubule network by th

37 agosomes from the distal axon, for sustained retrograde transport along the midaxon, and for autophag

38 ein gene, App, acts to markedly decrease NGF retrograde transport and cause degeneration of BFCNs.

39 the molecular processes that underlie their retrograde transport and cell transduction.

40 rochemical nature of PT-PUL cells labeled by retrograde transport and found that most are non-GABAerg

41 sicle circulation, which includes long-range retrograde transport and inefficient bidirectional captu

42 f axonal mRNAs is required for efficient PRV retrograde transport and infection of cell bodies.

43 of Dsl1p and Tip20p, is involved in Golgi-ER retrograde transport and it is functionally conserved fr

44 tic insights into how Snapin-DIC coordinates retrograde transport and late endosomal-lysosomal traffi

45 the potential to link Plexin-A receptors to retrograde transport and microtubule function in axonal

46 step in Golgi-to-endoplasmic reticulum (ER) retrograde transport and one of the very first trafficki

47 ing that Strip is a molecular linker between retrograde transport and Rab5 activation.

48 , which require retromer physiologically for retrograde transport and recycling, respectively.

49 tic components by inhibiting dynein-mediated retrograde transport and setting the balance between ant

50 Given that dynactin initiates retrograde transport and that amino acid sequences impli

51 is a large multisubunit complex involved in retrograde transport and the positioning of various orga

52 ese data support a model where Asna1 ensures retrograde transport and, hence, ER and insulin homeosta

53 endosomes to support both endosome-to-Golgi (retrograde transport) and endosome-to-plasma membrane (r

54 ablishment of latency in peripheral ganglia (retrograde transport) and for viral spread in axons to e

55 vents involving their formation, processing, retrograde transport, and somal signaling in sympathetic

56 Although effects on retrograde transport are predicted by the proposed funct

57 virus (AAV) undergoes microtubule-dependent retrograde transport as part of a program of vectorial t

58 s (Ad) capsids undergo microtubule-dependent retrograde transport as part of a program of vectorial t

59 brane-to-trans Golgi network and Golgi-to-ER retrograde transport as well as to ER stress in beta-cel

60 al. reveals a role for p150 in initiation of retrograde transport at synaptic terminals.

61 ed) CAP-Gly domain regulates dynein-mediated retrograde transport at synaptic termini, and this funct

62 dependent of its role in recruiting COPI for retrograde transport, at least of a subset of Golgi-ER c

63 xcess distal DCVs undergo dynactin-dependent retrograde transport back through proximal boutons into

64 GARP with SNAREs are insufficient to promote retrograde transport, because deletion of the C-terminal

65 in protein Coy1 and document its function in retrograde transport between early Golgi compartments.

66 ed interaction partner p31, both involved in retrograde transport between endoplasmic reticulum and G

67 ed in SMA disease conditions, with decreased retrograde transport but no effect on anterograde transp

68 ther support for a vesicle-based process for retrograde transport but raise new questions that need t

69 Increased retrograde transport by BICD2 mutants also was observed

70 fore, Rab7 plays an essential role in axonal retrograde transport by controlling a vesicular compartm

71 interestingly that kinesin-1 is critical for retrograde transport by dynein.

72 Defective retrograde transport by genetic ablation of snapin in mi

73 hat Abeta oligomers compromise BDNF-mediated retrograde transport by impairing endosomal vesicle velo

74 Regulation of normal retrograde transport by Kinesin-1 is independent of dyne

75 It plays a key role in initiating retrograde transport by recruiting and tethering endosom

76 Inhibition of retrograde transport by small molecule inhibitors reduce

77 In mice, the fusion protein underwent retrograde transport by spinal cord motor neurons follow

78 rdered pathway, leading to the initiation of retrograde transport by the motor dynein.

79 Retrograde transport carriers bud from the endosome coat

80 l sorting and fission machineries to produce retrograde transport carriers.

81 Early endosomes undergo retrograde transport (clustering) before their homotypic

82 early endosomes supports their maturation to retrograde transport-competent endosomes.

83 Here, we demonstrate that defective retrograde transport contributes to autophagic stress in

84 gos, and help to explain previously reported retrograde transport defects generated when kinesin-1 is

85 e abnormal axon morphology and mitochondrial retrograde transport defects observed in actr10 mutants

86 d that pk2 knockdown suppresses bbs7-related retrograde transport delay.

87 h, in turn, facilitates the microtubule- and retrograde transport-dependent mutant SOD1 aggregation.

88 ants of kinesin-2 (fla10) showed exclusively retrograde transport events, driven by 7 motors on avera

89 Consistent with this finding, retrograde transport experiments showed that the very lo

90 Many retrograde transport factors were required for efficient

91 t mitochondria that are stranded in axons by retrograde transport failure; a protective process aimed

92 etromer plays an important role in efficient retrograde transport for endosome-to-Golgi retrieval of

93 it is difficult to uncouple the functions of retrograde transport from anterograde, as null mutants i

94 gainst Shiga toxins by specifically blocking retrograde transport from early endosomes to the trans-G

95 In contrast, we provided evidence that retrograde transport from early endosomes to the trans-G

96 he retromer complex is well known to mediate retrograde transport from endosomes to the Golgi.

97 ese findings indicate that GARP orchestrates retrograde transport from endosomes to the TGN by promot

98 esicles might correspond to intermediates in retrograde transport from endosomes to the TGN.

99 retrograde protein (GARP) complex regulates retrograde transport from endosomes to the trans-Golgi n

100 ynein and its partner complex dynactin drive retrograde transport from the distal axon.

101 M4 cells are readily labeled by retrograde transport from the dorsal lateral geniculate

102 le subunits of the retromer, which initiates retrograde transport from the endosome to the trans-Golg

103 with PACS-1, a cytosolic protein, to mediate retrograde transport from the endosomes to the TGN.

104 Also retrograde transport from the endosomes to the trans-Gol

105 nriched in the endoplasmic reticulum (ER) by retrograde transport from the Golgi that is mediated by

106 ell, mediate the early secretory pathway and retrograde transport from the Golgi to the endoplasmic r

107 tivin, the transcription factor, dSmad2, and retrograde transport from the growth cone to the R7 nucl

108 Trafficking of Anc.a did not require retrograde transport from the late endosome to the Golgi

109 Neurobiotin retrograde transport from the spinal cord combined with

110 art et al. with general staining methods and retrograde transport from the spinal cord.

111 h are required for sensory transduction, and retrograde transport genes, which are required to differ

112 tment and excluded from axons by predominant retrograde transport However, on overexpression rab11 wa

113 RV share a conserved mechanism for postentry retrograde transport in axons and provides the foundatio

114 Cytoplasmic dynein mediates retrograde transport in axons, but it is unknown how its

115 of intermediate chains for their subsequent retrograde transport in axons.

116 rt, whereas WT La shows both anterograde and retrograde transport in axons.

117 mpaired organelle transport and particularly retrograde transport in hippocampal neurons.

118 r symptoms, demonstrating the involvement of retrograde transport in inducing alphaS CNS inclusion pa

119 Of note, pharmacological inhibition of retrograde transport in isolated islets and insulinoma c

120 y active type I BMP receptors or by reducing retrograde transport in motor neurons also restored syna

121 Intriguingly, enhancement of retrograde transport in mutant hAPP neurons facilitates

122 serves as a dynein-independent mechanism for retrograde transport in plants.

123 o quantum dots, we selectively analyzed TrkB retrograde transport in response to BDNF stimulation at

124 ation uncouples the roles of anterograde and retrograde transport in SHH signaling, suggesting that a

125 ed DYNC2H1, a cytoplasmic dynein involved in retrograde transport in the cilium.

126 Finally, retrograde transport in the nerve terminal is regulated

127 and molecular function for MAGE-L2-TRIM27 in retrograde transport, including an unappreciated role of

128 Thus imaging selective retrograde transport inhibition led to the discovery of

129 an altered secretome and sensitivity to the retrograde transport inhibitor brefeldin A (BFA) in cell

130 ssential role for +TIPs in the regulation of retrograde transport initiation in the neuron.

131 Liprin-alpha mutants but also an increase in retrograde transport initiation.

132 rade transport is driven by kinesin, whereas retrograde transport is ensured by a specific dynein.

133 Retrograde transport is required to maintain homeostasis

134 Disruption of retrograde transport leads to a variety of neurodegenera

135 Mouse models with defects in the retrograde transport machinery, including the Loa mouse

136 An impairment of axonal retrograde transport may therefore represent one of the

137 neuronal survival/death decisions through a retrograde transport mechanism.

138 first clear evidence of linkage between the retrograde transport mediated by the retromer complex an

139 but not NT-3, to induce internalization and retrograde transport of activated TrkA.

140 The retrograde transport of associated focal adhesion protei

141 Atg1 kinase activity is essential only for retrograde transport of Atg23, while recycling of Atg9 r

142 rrant activation of kinesin to ensure robust retrograde transport of autophagosomes along the axon.

143 iated with reduced anterograde and increased retrograde transport of axonal mitochondria.

144 eady-state BACE1 levels as well as increased retrograde transport of BACE1 in the endocytic pathway,

145 irs BACE1 endocytosis and produces a delayed retrograde transport of BACE1 to the trans-Golgi network

146 and 16, which are two major effectors in the retrograde transport of both exogenous and endogenous ca

147 intracellular journey of AAV by showing that retrograde transport of capsids to the trans-Golgi netwo

148 that disease triggered in muscle can impair retrograde transport of cargo in motoneuron axons, possi

149 Subcellular retrograde transport of cargo receptors from endosomes t

150 eurons in cats and on 80 neurons labelled by retrograde transport of cholera toxin b subunit injected

151 perturbation of retromer, which controls the retrograde transport of CI-M6PR via sorting nexins, incl

152 he cargo-selective elements that mediate the retrograde transport of CI-MPR from endosomes to the TGN

153 vertible fluorescent protein further reveals retrograde transport of CREB2 from distal neurites to th

154 We find that stimulus-induced retrograde transport of different cargos requires the lo

155 P complex is a tethering complex involved in retrograde transport of endosomes to the trans-Golgi app

156 acting as a retrieval signal, which mediates retrograde transport of escaped endoplasmic reticulum (E

157 rojecting to the midbrain were identified by retrograde transport of fluorescent microspheres injecte

158 ons (MNs) and interneurons (INs), labeled by retrograde transport of fluorescent tracers from ventral

159 Retrograde transport of Fluoro-Gold (FG) from the rostra

160 ptic transmission to lumbar motoneurons, (2) retrograde transport of fluororuby anatomical tracer fro

161 n of constitutively active RAB-6.2 drove the retrograde transport of GLR-1 from dendrites back to cel

162 A2) in Golgi enzyme recycling, and show that retrograde transport of Golgi membrane underlies Golgi d

163 the ER occurs only from cis cisternae, that retrograde transport of Golgi resident proteins by COPIb

164 The retrograde transport of gp120 and apoptosis were mediate

165 the tapa-sin-COPI interaction regulates the retrograde transport of immature MHC class I molecules f

166 The microtubule-dependent retrograde transport of injury signals from the lesion s

167 locally at the injury site to facilitate the retrograde transport of injury signals that are required

168 e mechanisms contributing to this process is retrograde transport of injury signals.

169 arily due to maintenance of the constitutive retrograde transport of its components to the ER.

170 of the L-selectin tail blocks AP-1-dependent retrograde transport of L-selectin.

171 n acts as a dynein adaptor that mediates the retrograde transport of late endosomes (LEs) and interac

172 ase mice demonstrates impaired dynein-driven retrograde transport of late endosomes (LEs).

173 immature lysosomes, clustering and impaired retrograde transport of late endosomes along processes,

174 arance of the FRET signal is consistent with retrograde transport of lysosomal cargo back to late end

175 , concomitant with a block in Rab6-dependent retrograde transport of mannose 6-phosphate receptors to

176 t that regulates the retrieval, sorting, and retrograde transport of membrane receptors.

177 -negative bacteria and is thought to mediate retrograde transport of misplaced phospholipids from the

178 We found significantly slower retrograde transport of mitochondria in Ser135Phe, Pro39

179 t, Aplip1 mutation caused a decrease only in retrograde transport of mitochondria, suggesting inhibit

180 pports a previously proposed role of AP-1 in retrograde transport of MPRs from late endosomes to the

181 t, delayed cytoplasmic release from NPCs and retrograde transport of mRNPs was observed.

182 Retrograde transport of multiple Golgi proteins to the E

183 heimer's disease and normal aging may impair retrograde transport of nerve growth factor (NGF) from c

184 veling the exact mechanisms that account for retrograde transport of neurotrophins and their receptor

185 factor deprivation arising from blockade of retrograde transport of neurotrophins may involve simila

186 toplasmic dynein and dynactin participate in retrograde transport of organelles, checkpoint signaling

187 Retrograde transport of other important cargoes, such as

188 rsely, NGF antibody injections decreased the retrograde transport of p-Erk1/2 and p-p38.

189 ripheral target of DRG neurons increased the retrograde transport of p-Erk1/2, p-p38, and pAkt in the

190 he site of nerve injury but is necessary for retrograde transport of p-STAT3 to the cell body.

191 ed intraflagellar Ca(2+) elevations initiate retrograde transport of paused IFT particles to modulate

192 ) has been implicated in the anterograde and retrograde transport of proteins and lipids between the

193 for synapse-to-nucleus signaling by means of retrograde transport of proteins from distal processes.

194 We identified IN via the transsynaptic retrograde transport of pseudorabies virus (PRV) injecte

195 urons in cats by combining the transneuronal retrograde transport of rabies virus from the diaphragm

196 nsporter is a recycling system mediating the retrograde transport of released trehalose.

197 We demonstrate that retrograde transport of retromer is impaired, leading to

198 que retinal ganglion cells were labeled with retrograde transport of rhodamine dextran injected into

199 sed signaling regulates the dynein-dependent retrograde transport of Shiga toxin to the Golgi apparat

200 enerative diseases, highlighting the role of retrograde transport of signaling endosomes for axonal m

201 nuclear transport adaptors in mediating the retrograde transport of signals from synapse to nucleus

202 receptor 1 to ciliary membranes and affects retrograde transport of Smoothened inside cilia.

203 ss I presentation involving the constitutive retrograde transport of soluble proteins to the ER by DC

204 This implies that retrograde transport of target-derived molecules is nece

205 of acidotrophic dyes does not affect axonal retrograde transport of TeNT HC.

206 and verification of projections by means of retrograde transport of the beta subunit of cholera toxi

207 t order afferent projections were defined by retrograde transport of the beta-subunit of cholera toxi

208 I components, general protein secretion, and retrograde transport of the KDEL-containing protein BIP,

209 the first insight into the requirements for retrograde transport of the MLV preintegration complex.

210 of cellular proteins, which appears to favor retrograde transport of the organelles.

211 The transsynaptic retrograde transport of the pseudorabies virus Bartha (P

212 Depletion of GARP subunits also blocks the retrograde transport of the TGN protein, TGN46, and the

213 However, 5C12 blocked the retrograde transport of the toxin into the Golgi and the

214 bly upon Shiga toxin binding facilitates the retrograde transport of the toxin through the secretory

215 alized chambers, we demonstrated that axonal retrograde transport of these vectors was rapid and effi

216 that the double lysine is important for the retrograde transport of tpn from late secretory compartm

217 cone turning and that local translation and retrograde transport of transcription factors mediate ne

218 Neurons exploit local mRNA translation and retrograde transport of transcription factors to regulat

219 The retromer complex mediates retrograde transport of transmembrane cargo from endosom

220 The retrograde transport of Trk-containing endosomes from th

221 on via the TrkA receptor, only NGF activates retrograde transport of TrkA endosomes to support neuron

222 We show that the retrograde transport of TrkB vesicles within striatal de

223 elope glycoprotein (RV-G) enabled the axonal retrograde transport of two distinct subtypes of lentivi

224 act double lysine retrieval signal regulates retrograde transport of unstable MHC I molecules from th

225 ate cell-specific infection and monosynaptic retrograde transport of virus, which strongly labels eve

226 lation must exist for proper anterograde and retrograde transport of vital proteins, little is known

227 glutamatergic inputs to the VTA by combining retrograde transport of wheat germ agglutinin-bound gold

228 These data suggest that HDAC6-dependent retrograde transport on microtubules is used by cells to

229 from aggregated proteins by dynein-dependent retrograde transport on microtubules to the microtubule

230 enes encoding MAGEL2 partners, either in the retrograde transport or in the ubiquitination-deubiquiti

231 Inhibition of local translation and retrograde transport or knockdown of axonal Atf4 mRNA ab

232 all available tools suffer from inefficient retrograde transport or limited clinical potential.

233 ules from axon tips to neuronal cell bodies (retrograde transport) or from cell bodies to axon tips (

234 somes and autophagosomes is coupled to their retrograde transport, our results suggest that extracell

235 (ER) and Golgi complex and is required for a retrograde transport pathway between these organelles.

236 Our data demonstrate that TeNT H(C) uses a retrograde transport pathway shared with p75(NTR), TrkB,

237 tion efficiency and relies on a nonclassical retrograde transport pathway that is independent of the

238 GLR-1 in Caenorhabditis elegans utilizes the retrograde transport pathway to regulate AMPAR synaptic

239 aptic strength by recycling AMPARs along the retrograde transport pathway.

240 irus Vaccinia virus (VACV) exploits cellular retrograde transport pathways to facilitate the wrapping

241 N) from the endosomal system through several retrograde transport pathways to maintain the compositio

242 Cellular retrograde transport pathways traffic cargo from endosom

243 To determine if cellular retrograde transport pathways were required for this wra

244 This work links cellular retrograde transport pathways with morphogenesis of poxv

245 Here, we demonstrate that Snapin-mediated retrograde transport plays a critical role in removing B

246 Retrograde transport, powered by dynein motors, supplies

247 es the foundation for further studies of the retrograde transport process.

248 relate to its proposed role in dynein-based retrograde transport processes.

249 Here, we reveal that dynein-Snapin-mediated retrograde transport regulates BACE1 trafficking in axon

250 However, the mechanisms initiating this retrograde transport remain poorly understood.

251 inesin and dynein motors for anterograde and retrograde transport, respectively.

252 ot in their subsequent progression along the retrograde transport route, which escapes acidification

253 monas dynein mutant cells, which show slower retrograde transport speed.

254 Finally, small molecule inhibitors of retrograde transport strongly suppressed VACV multi-step

255 nal pattern similar to that seen after their retrograde transport, suggesting localization primarily

256 fined partly because the constituents of the retrograde transport system and their interactions have

257 Thus, vaccinia virus makes novel use of the retrograde transport system for formation of the viral w

258 RNAi) mutant, an IFT-A protein essential for retrograde transport, the IFT dynein components are foun

259 ein in the Wobbler mouse strain is active in retrograde transport, thus explaining the viability of t

260 (KSHV/HHV8), exploit microtubule (MT)-based retrograde transport to deliver their genomes to the nuc

261 M) may provide a general mechanism for their retrograde transport to endoplasmic reticulum (ER).

262 orm and subverted subsequent Gb(3)-dependent retrograde transport to Golgi/ER to render cytotoxicity

263 omes cocontribute to these processes through retrograde transport to poles by dynein.

264 nt proteins from capsids invariably preceded retrograde transport to the cell body in sensory ganglia

265 in the nerve terminals, which then underwent retrograde transport to the cell soma, where they fused

266 hromophore were made in MGBv, and, following retrograde transport to the cortical cell bodies, apopto

267 otriaosyl ceramide (Gb(3)), mediates VT1/VT2 retrograde transport to the endoplasmic reticulum (ER) f

268 ing the coatomer protein I complex-dependent retrograde transport to the endoplasmic reticulum (ER).

269 receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).

270 es yeast and fungal cells by endocytosis and retrograde transport to the endoplasmic reticulum (ER).

271 ta strongly suggest that syntaxin 5-mediated retrograde transport to the Golgi apparatus is a broadly

272 STB normally requires MTs and dynein for its retrograde transport to the juxtanuclear Golgi complex a

273 he Vps52/53/54 complex) that is required for retrograde transport to the late Golgi.

274 how that 6-PGDase, like G-6-PDase, undergoes retrograde transport to the microtubule-organizing cente

275 capsid to the cytosol resulted in efficient retrograde transport to the neuronal cell body.

276 iviral vector by peripheral nerve fibers and retrograde transport to the nucleus.

277 ding of virion capsids onto microtubules for retrograde transport to the nucleus.

278 , follows a strict degradation pathway after retrograde transport to the soma.

279 t oxidative stress without a requirement for retrograde transport to the soma.

280 After retrograde transport to the spinal cord following inject

281 ized into vesicular carriers undergoing fast retrograde transport to the spinal cord.

282 oxin into this transcytotic pathway bypasses retrograde transport to the TGN.

283 r multiple protein-sorting events, including retrograde transport to the trans-Golgi network (TGN) an

284 lycolipid receptor, enter cells, and undergo retrograde transport to ultimately reach the cytosol, wh

285 eripheral nervous system neurons and undergo retrograde transport toward the distant cell bodies.

286 e cleared from the bud via actin cable-based retrograde transport toward the mother and that Bni1p fo

287 tated GARP complex, suggesting that impaired retrograde transport uncouples nascent IMVs from the IEV

288 ing and fusion of recycling endosome-derived retrograde transport vesicles to the TGN.

289 GN, but appears to regulate the targeting of retrograde transport vesicles to the TGN.

290 plex into the rat hindpaw and its subsequent retrograde transport via sciatic nerve to DRG.

291 iary tips, suggesting that IFT turnaround or retrograde transport was affected.

292 Retrograde transport was effectively shut down in this m

293 Retrograde transport was evaluated from hypothalamic and

294 ondria, anterograde transport was slower yet retrograde transport was increased.

295 of the SNX5 phox domain (SNX5-PX) influence retrograde transport, we have determined the SNX5-PX str

296 phenotype can be reversed by Snapin-enhanced retrograde transport, which facilitates BACE1 traffickin

297 Lis1 overexpression stimulated retrograde transport, while a Lis1 dynein-binding mutant

298 pletion, phosphodeficient JIP1-S421A rescues retrograde transport, while phosphomimetic JIP1-S421D ab

299 wing release is evident after inhibiting the retrograde transport with the dynactin disruptor mycalol

300 ction in the number of IEVs, thereby linking retrograde transport with the wrapping of IMVs.