ライフサイエンスコーパス: retrotransposon

1 families, except for the highly-abundant roo retrotransposon.

2 ells but affecting a different repertoire of retrotransposons.

3 esis of MIWI2 piRNAs, and de-represses LINE1 retrotransposons.

4 hich is conserved among retroviruses and LTR-retrotransposons.

5 mposition that can lead to the activation of retrotransposons.

6 d harbors features characteristic of non-LTR retrotransposons.

7 iately cotranscribed with their flanking LTR retrotransposons.

8 rate through conserved mechanisms to contain retrotransposons.

9 nal retrocopies flanked by discontinuous LTR retrotransposons.

10 rnal deletions of large long terminal repeat retrotransposons.

11 ag protein of all orthoretroviruses and some retrotransposons.

12 lasticity, was "domesticated" from Ty3/Gypsy retrotransposons.

13 NA, three-quarters of which are derived from retrotransposons.

14 er-reporter gene constructs with and without retrotransposons.

15 es, papillomaviruses, hepatitis B virus, and retrotransposons.

16 n, and may silence abundant A-genome-derived retrotransposons.

17 the OAS-RNase L system in the restriction of retrotransposons.

18 ate immune response against retroviruses and retrotransposons.

19 ion as a suppressor of structurally distinct retrotransposons.

20 enable primates to respond to newly emerged retrotransposons.

21 tion strategies used by long terminal repeat retrotransposons.

22 ilencing, imprinting, and the suppression of retrotransposons.

23 ed high rates of sequence diversification in retrotransposons.

24 ots") on foreign genomes such as viruses and retrotransposons.

25 stage embryos, including MERVL and ERVL-MaLR retrotransposons.

26 pe 1 (HIV-1) and the mobility of LTR/non-LTR retrotransposons.

27 rotransposons with three out of ten examined retrotransposons (1a11, lambda-olt 2-1 and xretpos(L)) b

28 ed from many of the 4000 copies of ERV-9 LTR retrotransposons acted by a similar cis mechanism to mod

29 es (Piwi) proteins are known for suppressing retrotransposon activation in the mammalian germline.

30 Retrotransposon activation is generally assumed to be a

31 e beginning of development and indicate that retrotransposon activation is integral to the developmen

32 regulation of mRNA export during stress via retrotransposon activation.

33 LINE retrotransposons actively shape mammalian genomes.

34 zebrafish models, we show that p53 restricts retrotransposon activity and genetically interacts with

35 d among all retroviruses and even some yeast retrotransposons, although the reason for this conservat

36 ribution of long interspersed element (LINE) retrotransposon and their potential to mediate NAHR.

37 nts revealed widespread induction of Class I retrotransposons and activation of cytoplasmic DNA viral

38 as well as epigenetic changes, especially in retrotransposons and heterochromatin, although the mecha

39 However, many LTR retrotransposons and imprinted genes are impervious to s

40 y which DNA methylation is maintained at LTR retrotransposons and imprinted genes during developmenta

41 ion for achieving metal selectivity in human retrotransposons and metalloregulatory proteins.

42 AID / APOBEC hotspots have a large impact on retrotransposons and non-mammalian viruses while having

43 ecific classes of long terminal repeat (LTR) retrotransposons and organize into large loci (>50 kbp)

44 ppeared to target long terminal repeat (LTR) retrotransposons and other unrelated genes.

45 A regulatory network mediated by piRNAs with retrotransposons and pseudogenes as regulatory sequences

46 CCR4-NOT also assembles HOODs at retrotransposons and regulated genes containing cryptic

47 Dbr1 is also involved in the propagation of retrotransposons and retroviruses, although the precise

48 is composed of highly repetitive centromeric retrotransposons and satellite repeats that are highly v

49 omplex to tandem repeat sequences, including retrotransposons and telomeres.

50 se of other researchers have made clear that retrotransposons and the genomic plasticity they permit

51 tantly, we also identify putative autonomous retrotransposons and very recent transpositions of a TRI

52 eteriously mutating invading retroviruses or retrotransposons and, in the case of AID, changing antib

53 et1 was strongly bound to the SET1 mRNA, Ty1 retrotransposons, and noncoding RNAs from the ribosomal

54 a unique target to specifically inhibit LTR-retrotransposons, and tRF-targeting is a potentially hig

55 posons transfer horizontally more often than retrotransposons, and unveil phylogenetic relatedness an

56 the human-specific subfamily of LINE-1 (L1) retrotransposon are highly polymorphic across individual

57 Retrotransposons are "copy-and-paste" insertional mutage

58 LINE-1 (L1) retrotransposons are a noted source of genetic diversity

59 Retrotransposons are a pervasive class of mobile element

60 Long terminal repeat (LTR) retrotransposons are an abundant class of genomic parasi

61 L1 retrotransposons are an abundant class of transposable e

62 This way, retrotransposons are divided into young, potentially mob

63 Retrotransposons are eukaryotic mobile genetic elements

64 LINE-1 retrotransposons are fast-evolving mobile genetic entiti

65 LTR retrotransposons are mobile elements that are able, like

66 LINE-1 (L1) retrotransposons are mobile genetic elements whose exten

67 Retrotransposons are mobile genetic elements, and their

68 Long interspersed nuclear element-1 (L1) retrotransposons are mobile repetitive elements that are

69 LTR retrotransposons are repetitive DNA elements comprising

70 CTAA and CGG motifs in these retrotransposons are the likely candidates for the downr

71 Retrotransposons are the main component of plant genomes

72 All three retrotransposons are transcribed by RNA polymerase II.

73 In Schizosaccharomyces pombe the Tf2 LTR retrotransposons are transcriptionally silenced and are

74 We identified L1 retrotransposons as the primary targets of PLZF.

75 ost of the deletions and duplications had Ty retrotransposons at their breakpoints.

76 ical bird lineages exclusively share a novel retrotransposon, AviRTE, resulting from horizontal trans

77 RVs), also called long terminal repeat (LTR) retrotransposons, begins with transcription by RNA polym

78 es by mutation, with somatic reactivation of retrotransposons being one such mutational process.

79 ied Copia25 in Coffea canephora, a new plant retrotransposon belonging to the Ty1-Copia superfamily.

80 e myeloid leukemia cells to evade sensing of retrotransposons by innate immune receptors.

81 Expression of the L1 retrotransposon can damage the genome through insertiona

82 members of the L1 (LINE-1) clade of non-LTR retrotransposons can be deleterious, the L1 clade has re

83 Here, we applied mouse retrotransposon capture sequencing (mRC-seq) and whole-g

84 Here, we performed single-cell retrotransposon capture sequencing (RC-seq) on individua

85 mammalian endogenous retrovirus-related ERVL retrotransposon class on gene expression in the germline

86 pansion limits the activity of newly emerged retrotransposon classes, and this is followed by mutatio

87 Long interspersed element-1s (L1) are mobile retrotransposons comprising 17% of the human genome.

88 y population of chromosomally integrated LTR retrotransposons consisting of pairwise recombination pr

89 Retrotransposons constitute a major source of genetic va

90 Retrotransposons containing long terminal repeats (LTRs)

91 region of Arabidopsis thaliana COPIA78/ONSEN retrotransposons contains heat-responsive elements (HREs

92 RNA molecules into the human genome by LINE retrotransposons, contributing to the approximately 50%

93 ycomb protein EZH2 and RNA made from B2 SINE retrotransposons controls stress-responsive genes in mou

94 However, potentially active retrotransposon copies evade this initial wave, likely m

95 e positions and the degradation level of LTR retrotransposons copies.

96 retrotransposons than DNA transposons and as retrotransposon copy number in both rice and maize genom

97 nH3 are colonized by the centromere-specific retrotransposon CR2 at a rate that would result in centr

98 However, the identity of KZNF genes battling retrotransposons currently active in the human genome, s

99 The retrotransposon-derived enzyme TGIRT exhibits more slipp

100 imprinted retrotransposon-like 1 (Rtl1) is a retrotransposon-derived gene that has evolved a function

101 We demonstrate that retrotransposon-derived transcripts act as decoys for mi

102 ate, with particular emphasis on nuclear and retrotransposon-derived transcripts.

103 y LINE1 (long interspersed nuclear element1) retrotransposon-derived].

104 The retrotransposon DIRS-1 is the most abundant retroelement

105 A cassette from Drosophila retrotransposon Dme1_chrX_2630566, a candidate for utili

106 Retrotransposons dominate the chromosomal landscape in m

107 In mammals, L1 retrotransposons drive retroposition, but the elements r

108 other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromov

109 NA methylation with particular enrichment at retrotransposon elements associated with their transcrip

110 The present work describes a retrotransposon-encoded restriction protein derived from

111 Here we report that certain classes of retrotransposons ensure transgenerational inheritance by

112 illion years ago when the L1PA3-subfamily of retrotransposons escaped ZNF93's restriction through the

113 Furthermore, retrotransposons, especially lambda-olt 2-1, are enriche

114 rt interspersed nuclear elements (SINEs) are retrotransposons evolutionarily derived from endogenous

115 L1 retrotransposons express proteins (ORF1p and ORF2p) that

116 n has been shown, the mechanisms controlling retrotransposon expression in early embryos are still no

117 n early embryos and the proper regulation of retrotransposon expression is essential for normal devel

118 genomic approach to address whether specific retrotransposon families play a direct role in chromatin

119 apidly evolved to repress these two distinct retrotransposon families shortly after they began to spr

120 dy, and long-term amplification of a few LTR retrotransposon families.

121 Both types are found within a single retrotransposon family and it is assumed that the old me

122 indicates Arc originated from the Ty3/Gypsy retrotransposon family and was "domesticated" in higher

123 ied transposition bursts of a heat-activated retrotransposon family in Arabidopsis We recorded a high

124 rized an antisense (AS) promoter in mouse L1 retrotransposons for the first time, oriented antiparall

125 tly transposes in P. patens, being the first retrotransposon from a vascular plant reported to transp

126 We identified three bursts of retrotransposons from 20 million years ago (Mya) and a g

127 has been used to mine potentially active L1 retrotransposons from the reference genome sequences of

128 nding may represent the birth of an emerging retrotransposon gene that can adopt various fates, as it

129 mbination of gene-disruption platforms (Tnt1 retrotransposons, hairpin RNA-interference constructs, a

130 We also showed L1 retrotransposons have a more significant impact on the o

131 Long interspersed element 1 (LINE-1 or L1) retrotransposons have generated one-third of the human g

132 family designated "Tyba" and by centromeric retrotransposons (i.e., CRRh) occurring as genome-wide i

133 al, we identify that the insertion of an LTR-retrotransposon in its 11(th) intron results in a consid

134 he ms2 mutant has acquired a terminal-repeat retrotransposon in miniature (TRIM) element in its promo

135 reas the presence of LINE in P2 or gypsy LTR retrotransposon in P3 reduced expression of the reporter

136 ntrast with the LINE in P2 and the gypsy LTR retrotransposon in P3 which act as silencers.

137 Tf1, a long-terminal repeat retrotransposon in Schizosaccharomyces pombe, integrates

138 resent the only currently active, autonomous retrotransposon in the human genome, and they make major

139 LINE-1 (or L1) is an autonomous non-LTR retrotransposon in the human genome, comprising 17% of i

140 for silencing the developmentally regulated retrotransposon in Xenopus laevis.

141 HT-TREBS to study DNA methylation changes at retrotransposons in a locus-specific manner in multiple

142 L1) and mouse intracisternal A-type particle retrotransposons in cultured human cells.

143 the DNA methylation pattern of 4799 IAP LTR retrotransposons in embryonic stem, somatic and Neuro2A

144 ed programs for identifying LTRs and non-LTR retrotransposons in eukaryotic genome sequences.

145 aintaining the genome stability by silencing retrotransposons in germline tissues- where piRNAs were

146 refully annotated, full-length Sirevirus LTR retrotransposons in maize, we show that their silencing

147 Terminal repeat retrotransposons in miniature (TRIMs) are a unique group

148 Their impact on retrotransposons in non-coding regions shed light on imp

149 and genomic studies of long terminal repeat retrotransposons in other genomes.

150 ions, we also found patterns of unrestrained retrotransposons in p53-driven mouse and human cancers.

151 Given the established role of L1 retrotransposons in shaping mammalian genomes, it become

152 were primarily associated with the LTR/Gypsy retrotransposons in the heterochromatin flanking the cen

153 acute stress can regulate the expression of retrotransposons in the rat hippocampus via an epigeneti

154 ng model for studying the propagation of LTR retrotransposons in these genomes.

155 by long interspersed element-1 (LINE-1; L1) retrotransposon, in PDAC.

156 he insertion of Sal-T1, a 4863-bp Copia-like retrotransposon, in the 5' untranslated region.

157 ys a key role in limiting the propagation of retrotransposons including Long Interspersed Element-1 (

158 periments revealed that activation of LINE-1 retrotransposons increases the expression of IFNbeta and

159 nt involvement of TREX1 in preventing the L1 retrotransposon-induced DNA damage response.

160 R2 non-LTR retrotransposons insert at a specific site in the 28S rR

161 we identify the mutation in this strain as a retrotransposon insertion in the Clcc1 gene, which encod

162 Using a positional cloning strategy and a retrotransposon insertion line, we identify two novel al

163 lop legume genetics resources, > 21 700 Tnt1 retrotransposon insertion lines have been generated.

164 We also identify a copia-like retrotransposon insertion polymorphism in the R2R3 myb-l

165 nd HONE1 do not have a HeLa cell-specific L1 retrotransposon insertion, suggesting that these three H

166 s, L1s) are responsible for over one million retrotransposon insertions and 8000 processed pseudogene

167 Retrotransposon insertions are associated with a diverse

168 q, a computational framework that identifies retrotransposon insertions from sequencing data, to whol

169 jor source of genetic variation, and somatic retrotransposon insertions have been reported in cancer.

170 The effect of retrotransposon insertions in four rice promoter regions

171 ation of conservation patterns of these four retrotransposon insertions in several rice accessions im

172 e exome data and discovered 35 novel somatic retrotransposon insertions into exonic regions, includin

173 e screenings for phylogenetically diagnostic retrotransposon insertions involving the representatives

174 ment across tumor types suggest that somatic retrotransposon insertions may represent an important cl

175 Many somatic retrotransposon insertions occur in known cancer genes.

176 germline polymorphisms, we find 810 somatic retrotransposon insertions primarily in lung squamous, h

177 nce long interspersed element-1 (LINE-1, L1) retrotransposon insertions selectively in the human geno

178 s of 250 families, including complex indels, retrotransposon insertions, and interchromosomal events.

179 Rice genome harbors genes and promoters with retrotransposon insertions.

180 of rearrangements, copy-number changes, and retrotransposon insertions.

181 imate genomes have been modified by waves of retrotransposon insertions.

182 d data sets, a large proportion of which are retrotransposon insertions.

183 he disease is the spontaneous insertion of a retrotransposon into the 3' untranslated region (3'UTR)

184 entas and that protein encoded by the LINE-1 retrotransposon is upregulated in hypomethylated trophec

185 Inactivation of retrotransposons is accompanied by the emergence of cent

186 In Drosophila, a group of retrotransposons is mobilized exclusively to telomeres i

187 Uncontrolled propagation of retrotransposons is potentially detrimental to host geno

188 escribe the propensity for a gibbon-specific retrotransposon (LAVA) to insert into chromosome segrega

189 The paternally expressed imprinted retrotransposon-like 1 (Rtl1) is a retrotransposon-deriv

190 ing overexpression of proximal microRNAs and retrotransposon-like 1 (Rtl1) were associated with HCC.

191 few fragments presented high homologies with retrotransposon-like sequences.

192 The retrotransposon LINE-1 (long interspersed element 1, L1)

193 We now implicate retrotransposons LINE-1 (L1), activated during epigeneti

194 zation (e.g. the clustering of telomeres and retrotransposon long terminal repeats (LTRs)) were obser

195 r between DNMT1 and DNMT3a/3b in suppressing retrotransposon long terminal repeats and long intersper

196 Analyzing the long terminal repeat-retrotransposon (LTR-RT) type of TE, we estimated their

197 Long terminal repeat retrotransposons (LTR-RTs) are prevalent in plant genome

198 e duplication and dispersed duplications via retrotransposons may have played pivotal roles in the ex

199 methylation reprogramming genes and in LINE1 retrotransposons may play important roles in downstream

200 er, these results suggest a role for ORF0 in retrotransposon-mediated diversity.

201 To establish a retrotransposon-mediated mouse model with regulatable an

202 umbers of NLRs were greatly increased by LTR-retrotransposon-mediated retroduplication.

203 ngle-stranded DNA and to inhibit viruses and retrotransposons, mediates this RNA editing.

204 The amplification of athila LTR-retrotransposons, members of the gypsy superfamily, led

205 RNA pathway is thought to target the bulk of retrotransposon methylation.

206 ish models, we found that diverse classes of retrotransposons migrate to the germ plasm, a specialize

207 lly interfere with reverse transcription and retrotransposon mobility.

208 In humans, retrotransposon mobilization is mediated primarily by pr

209 s operate at multiple levels to restrict Tf2 retrotransposon mobilization.

210 this large-scale, comprehensive analysis of retrotransposon movement across tumor types suggest that

211 Furthermore, we show that retrotransposon mRNAs are derepressed in Tex19.1(-/-) pl

212 (SIV), murine leukemia virus (MLV), and the retrotransposon MusD.

213 ssion of the transcriptome that includes Tf2 retrotransposons, noncoding RNAs, and regulators of deve

214 The Ty1 retrotransposon of Saccharomyces cerevisiae belongs to t

215 The Ty1 retrotransposon of the yeast Saccharomyces cerevisiae in

216 throblasts, lncRNAs transcribed from the LTR retrotransposons of ERV-9 human endogenous retrovirus ac

217 Retrotransposons often carry long terminal repeats (LTRs

218 The effect of retrotransposons on gene regulation correlated with the

219 These TSIs were derived from genic, retrotransposon, or telomere sequences and were not dele

220 In the mouse, long terminal repeat (LTR)-retrotransposons, or endogenous retroviruses (ERV), acco

221 how that post-translational regulation of L1 retrotransposons plays a key role in maintaining trans-g

222 The significant accordance of retrotransposon presence/absence patterns and flanking n

223 Fungal LTR retrotransposons prevent mutagenic insertions through di

224 e transcriptional program with innovation at retrotransposon promoters, and establish a basis for ani

225 sites demonstrated significant overlap with retrotransposons, providing evidence for the long-standi

226 repressive histone modifications to silence retrotransposons, rather than DNA methylation as in diff

227 A new study provides evidence that LINE-1 retrotransposons regulate chromatin dynamics and are ess

228 Differences in microRNA genes and retrotransposon regulation could partly explain an incre

229 Retrotransposon regulation is also highly diverse, and t

230 DNA hypomethylation of a LINE retrotransposon related to rice Karma, in the intron of

231 satellite repeat (Ss1) and several Ty3/gypsy retrotransposon-related repeats (Ss166, Ss51, and Ss68).

232 In contrast, the Ty3/gypsy retrotransposon-related repeats are either clustered spa

233 aimondii centromeric repeats originated from retrotransposon-related sequences.

234 LINE-1 (L1) retrotransposons represent approximately one sixth of th

235 PP2A complex, demonstrating a role of URI in retrotransposon repression, a key function previously de

236 nic stem cells, transcriptional silencing of retrotransposons requires KAP1 (also known as TRIM28) an

237 To our knowledge, this is the first Gag-like retrotransposon restriction factor described in the lite

238 long interspersed nuclear elements (LINE-1) retrotransposons, resulting in increased LINE-1 mRNA.

239 an RNA intermediate in a process mediated by retrotransposons (retroposition).

240 tive chromatin states separated by extensive retrotransposon-rich regions that are associated with ab

241 Retrotransposons (RTs) can rapidly increase in copy numb

242 Here we show that most retrotransposon sequences are modified by default de nov

243 and in vivo functional analyses reveal that retrotransposon sequences in the 3' UTR of mRNAs are tar

244 ll-specific lncRNAs by piRNAs is mediated by retrotransposon sequences.

245 Pnldc1 mutant mice exhibit disrupted LINE1 retrotransposon silencing and defect in spermiogenesis.

246 is reduced capacity for long terminal repeat retrotransposon silencing and removal in A. alpina co-oc

247 Thus, RNA interference through gene and retrotransposon silencing previously encountered in Aply

248 ing RNA) ribonucleoproteins (piRNPs) enforce retrotransposon silencing, a function critical for prese

249 l regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, and X-chr

250 n modifications necessary for retroviral and retrotransposon silencing.

251 racting RNA (piRNA) pathway is essential for retrotransposon silencing.

252 Likewise, vertebrate retrotransposons similarly migrated to the germ plasm in

253 e consists of repetitive elements, including retrotransposons, some of which are transcribed after fe

254 he DUX4 and DUX homeodomains correlates with retrotransposon specificity.

255 We recently identified a retrotransposon, Steamer, that is highly expressed and a

256 evolutionary scenarios received considerable retrotransposon support, leaving us with a network of af

257 to limit this risk by expressing a cohort of retrotransposon-suppressing genome-defence genes whose s

258 ndem repeat-Alu (SINE-VNTR-Alu), subfamily-E retrotransposon (SVA-E) inserted into CASP8 intron 8.

259 the widespread occurrence and importance of retrotransposons, systematic studies to reveal the exten

260 plicing and are evolutionary predecessors of retrotransposon, telomerase, and retroviral RTs as well

261 We sequenced 1 million insertions of retrotransposon Tf1 in the genome of Schizosaccharomyces

262 show that insertion of the fission yeast LTR retrotransposon Tf1 is guided by the DNA binding protein

263 TE-lincRNAs were more often derived from retrotransposons than DNA transposons and as retrotransp

264 In fact, we have identified a retrotransposon that is highly transcribed in roots and

265 a unique group of small long terminal repeat retrotransposons that are difficult to identify.

266 elements, or SINEs, are an abundant class of retrotransposons that are transcribed by RNA polymerase

267 Alu elements are retrotransposons that frequently form new exons during p

268 oxymethylation as well as by the activity of retrotransposons that may alter genomic stability.

269 rapid amplification of long terminal repeat retrotransposons that occurred 38 million years ago in

270 LINEs and SINEs are retrotransposons; that is, they transpose via an RNA int

271 cluding germline genes and several mammalian retrotransposons, then drives pathogenesis.

272 Together, these data support the retrotransposon theory of aging, which hypothesizes that

273 we show that the tobacco (Nicotiana tabacum) retrotransposon Tnt1 efficiently transposes in P. patens

274 Thus, our data demonstrate the Tnt1 retrotransposon to be a powerful system that can be used

275 epresents a fitness strategy adopted by some retrotransposons to ensure transgenerational propagation

276 , and this is followed by mutations in these retrotransposons to evade repression, a cycle of events

277 Mobilization of retrotransposons to new genomic locations is a significa

278 SINE is a class of retrotransposon transcribed by RNA polymerase III (Pol I

279 , the host eventually finds a way to repress retrotransposon transcription and prevent further insert

280 not only controls the accumulation of Gypsy retrotransposon transcripts but also regulates the splic

281 In order to succeed, retrotransposon transcripts must identify the subset of

282 hat the primordial germline is a hideout for retrotransposon transcripts, providing early access to f

283 ermediate products of Tn7 and retroviral and retrotransposon transposition, and may hint at a common

284 Unlike other long terminal repeat retrotransposons, TRIMs are enriched in or near genes; t

285 Here we synthetically optimize the retrotransposon Ty1 to enable in vivo generation of muta

286 similar to that of Saccharomyces cerevisiae retrotransposons Ty1 and Ty3, which assemble virus-like

287 exameric lengths found in the unique XDP SVA retrotransposon using luciferase reporter constructs.

288 fusion points between the mRNAs and the LTR retrotransposons, we identified shared short similar seq

289 which endogenous Long Interspersed Element-1 retrotransposons were a major source.

290 BEL/Pao-like long-terminal repeat (LTR) retrotransposons were annotated from the highly adaptabl

291 ociated with centromere, 45S rDNA, knob, and retrotransposons were found among groups, revealing glob

292 The majority of these elements derive from retrotransposons, which expand throughout the genome thr

293 inately driven by Gypsy long terminal repeat retrotransposons, which extended the low-recombining per

294 es, they may be involved in the silencing of retrotransposons, which in brain have critical roles in

295 primarily by proteins encoded by LINE-1 (L1) retrotransposons, which mobilize in pluripotent cells ea

296 nce searches and PCR analyses show that this retrotransposon with LTRs (Long Terminal Repeats) is wid

297 , we observe a dynamic expression pattern of retrotransposons with three out of ten examined retrotra

298 ense insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within an intron of TAF1 This unique ins

299 f ASAR6 map to the antisense strand of an L1 retrotransposon within ASAR6 RNA, deletion or inversion

300 The proliferation of retrotransposons within a genome can contribute to incre