ライフサイエンスコーパス: reveal that

1 The regional analysis revealed that 28 regions were differentially methylated

2 PCR screening of ETEC isolates revealed that 8.6% (n = 13) of "CF negative" (n = 152) a

3 Our analyses reveal that a conserved diacidic motif (Asp-Glu) in thes

4 Tests in CA1 hippocampal pyramidal cells reveal that a slow AHP is reduced by blocking different

5 s and density functional theory calculations reveal that a stepwise transfer mechanism is dominant in

6 High-throughput sequencing revealed that a 22 nt miRNA with 3G ('22-3G') comprised

7 ing) and flow cytometry (BrdU incorporation) revealed that a discrete proportion of infiltrating T ce

8 in vitro growth in three C. jejuni strains, revealing that a large part of its genome is dedicated t

9 Integrative data analysis reveals that a total of 37 genes in 24 transcription uni

10 Genetic assays revealed that Abl allows growth factors and Semaphorin/P

11 -kinase combined with computational modeling reveals that active Rho-kinase diffuses to growing other

12 d with structural elucidation of metabolites revealed that acylsugar assembly is not conserved betwee

13 Our results revealed that after the exposure of synthesized aerosol

14 RT-qPCR data revealed that AgNPs induced greater changes in gene expr

15 Mutational studies reveal that all the five residues in the conserved seque

16 Analysis revealed that all animals exhibited mucosal antigen-spec

17 We revealed that altering T-cell receptor stimulation influ

18 This comprehensive study revealed that although most ASD participants performed a

19 Moreover, multivariate decoding analyses revealed that amisulpride changed the whole-brain connec

20 Chiral analysis of the reaction products reveals that AmISY reduces C7 to generate the opposite s

21 A path analysis among sensitized children revealed that among all features of severe atopy, only e

22 These structures reveal that an unusual monodentate Zn(2+) coordination m

23 basis for the TIGIT/nectin-2 interaction and revealed that an "aromatic key" of nectin-2 is critical

24 RT and three with viremia suppressed on ART) revealed that an average of 7% of proviruses (range: 2-1

25 This study reveals that appropriate water stress could increase cap

26 RNA sequencing and qRT-PCR revealed that arginine biosynthesis genes (argR, argB, a

27 X-ray photoelectron spectroscopy reveals that, at pH </= 3.5, a significant fraction of t

28 pitation and NNMT promoter luciferase assays revealed that AURKA's effects on NNMT were caused by PAX

29 Enzyme kinetic analysis revealed that BA inhibited tyrosinase activity non-compe

30 coenzyme A and an X-ray cocrystal structure reveals that binding is biased toward occupation of the

31 rphogenetic Protein (BMP) signaling pathway, revealing that BMP signaling inactivation causes exhaust

32 Calculations further reveal that both intermolecular water nucleophilic attac

33 Our results revealed that both forms of self-organization enhanced t

34 Specificity tests reveal that BR scrambles fluorescent analogues of common

35 Time-lapse imaging reveals that branching events are synchronized across di

36 Here we reveal that BRG1, the essential ATPase subunit of the SW

37 of mice during an inhibitory avoidance task revealed that CaMKII activity during, but not after, tra

38 Further analyses revealed that categorical labels such as amusement bette

39 Gene set variation analysis revealed that CD40L-responsive genes in immature dendrit

40 Phasor analysis revealed that Cdc42 is active at all Golgi cisternae and

41 Analysis of these cells revealed that CDK4/6 inhibition failed to induce cell-cy

42 Temporal expression analyses revealed that CDX4 was expressed exclusively within defi

43 Traction force microscopy (TFM) revealed that cells produced the greatest tractions at t

44 (1)H chemical shifts up to 11.8 ppm revealed that certain chemisorbed CO2 species are engage

45 r genes except CBL-CIPK converter genes, and revealed that CFKs act as the main CS conversion system

46 p of a Mediator-RNA polymerase II holoenzyme reveals that changes in the structure of Med14 facilitat

47 lyzed catecholamine release from PC12 cells, revealing that charge neutralization of 5RK promotes spo

48 The structure revealed that ciA-C2 partially occupies the SV2-binding

49 In-depth characterization revealed that circCCDC66 exerts its function via regulat

50 Sequence-based analyses revealed that clone SA possesses a unique CPS locus with

51 Gene expression analysis revealed that CML36 and ACA8 are co-expressed mainly in

52 Taken together, these data reveal that cocaine-evoked synaptic plasticity in PL-mPF

53 These methods reveal that conformational switches modulate normal and

54 f brain transcriptomes during the transition reveals that corazonin, a neuropeptide homologous to the

55 ing and protein interaction network analysis reveal that CPH1 functions as a hub linking key motor an

56 The studies revealed that Cu(100) and (111) have surface adlattices

57 l inhibition in vascular smooth muscle cells reveal that cytochrome b5 reductase 3 expression and act

58 o IL-2, or by addition of IL-12 to cultures, revealing that cytokine signaling could restore the acqu

59 evelopmental Cell, Roh-Johnson et al. (2017) reveal that cytoplasmic transfer from macrophages to mel

60 We revealed that DC3000 significantly alters the expression

61 This structure revealed that DddY contains a cap domain and a catalytic

62 We reveal that defective ATM-mediated DNA repair is a conse

63 fluorescence in situ hybridization analysis revealed that denitrifying anaerobic methane oxidation (

64 Lineage-tracing analysis revealed that descendants of Sfrp5-expressing cells at E

65 itive to inactivation of adult-born neurons, revealing that developmentally defined sets of neurons m

66 nalysis of the immune response via cytokines revealed that dexamethasone was important for shifting t

67 nd speaker information in neural activations revealed that different time intervals jointly encode th

68 8 T cells transferred into antigen-free mice revealed that differentiation to memory cells was couple

69 1 binding assay using radiolabeled verinurad revealed that distinct URAT1 inhibitors benzbromarone, s

70 UV-Vis spectrophotometry reveals that DNA films with surface densities up to 0.03

71 Recent studies revealed that Docs of groups 3 and 6 are recruited to th

72 e analysis of pancreatic islet bioenergetics reveals that Drp1 does not control insulin secretion via

73 Here, we reveal that dynein-Snapin-mediated retrograde transport

74 Mechanistically, single-particle tracking revealed that E2 treatment selectively reduced the dwell

75 ingle-cell transcriptional profiling at E9.5 reveals that endocrine-committed cells are molecularly d

76 ate our enhancer identification pipeline and reveal that enhancers transcribed in breast cancer cells

77 ening a collection of clinical EPEC isolates revealed that espW is present in 52% of the tested strai

78 studies examining downstream Cav1.2 targets revealed that extinction recruited calcium/calmodulin (C

79 Crystal structure analysis revealed that FePYR1 recognizes and binds ABA by the com

80 Genetic sexing revealed that fish with undifferentiated gonads were all

81 endent measurements of membrane vesiculation revealed that fission became spontaneous as steric press

82 The results of three complementary analyses revealed that fMRI response patterns were similar across

83 CV-infected patients and 15 healthy controls revealed that frequencies of class-switched memory B cel

84 Theoretical calculations revealed that from the thermodynamic point of view hydro

85 In vitro studies revealed that FTY720 also attenuated 6-OHDA- or rotenone

86 .1(+) TCR-H-2D(b)-GAP5040-48 ternary complex revealed that germline-encoded complementarity-determini

87 ysis of The Cancer Genome Atlas AML data set reveals that GLI3 expression is silenced in most AML pat

88 Tissue microarray analysis revealed that >98% of ovarian cancers express the prolac

89 Here, a single cell cloning revealed that HepAD38 cells, a widely-used HBV-inducible

90 uclear magnetic resonance structural studies reveal that Hi1a comprises two homologous inhibitor cyst

91 Combination of FUT1 and B3GALT5 revealed that high expression of both genes had poorer R

92 mples from two groups of patients, our study revealed that higher levels of gamma-OHPdG are strongly

93 Simulations revealed that highly localized dispersal and small total

94 Structure-guided mutagenesis reveals that His175, Arg186, Thr276 and Tyr278 contribut

95 Genome-wide correlation studies have revealed that histone activation marks and repression ma

96 Model results revealed that hospital performance metrics for mortality

97 Unconditional LGM revealed that HRQOL was improved over time.

98 Our work reveals that hydrodynamics can profoundly affect how bac

99 Additionally, targeted expression studies reveal that hydrotropism depends on the ABA signalling k

100 Comparison of exomic diversity reveals that: (i) both new and low-frequency variants ar

101 Transcriptional and epigenomic profiling revealed that IFE and HF tumor-initiating cells possess

102 Mechanistic analyses reveal that IFN-gamma induces CD70 expression in T cells

103 tic PCa, histological and molecular analyses revealed that IL-1beta is highly expressed in cancer cel

104 Thus, our results reveal that in addition to being used as a valuable tool

105 Our results reveal that in mammals, for which heart rate is a key de

106 experimental and predicted drug release data revealed that in addition to surface area, other factors

107 Field experiments revealed that in protected salt marshes experiencing a s

108 nctional validation of this transporter gene revealed that in vitro SLC16A5-silencing altered cellula

109 Multivariate pattern analyses revealed that, in production, interlocutor identity was

110 Furthermore, it reveals that, in the human brain, even general purpose a

111 agnitudes in the context of a numerical task revealing that infants can discriminate number when exte

112 Previous studies revealed that INPP5E, the inositol polyphosphate-5-phosp

113 ies using RNAi-rescue systems in human cells revealed that intact PIN domain and Zinc finger motifs i

114 Adoptive transfer experiments revealed that intrahepatically differentiated Treg cells

115 estral reconstruction of transmission events reveals that intraspecific PLVA transmission has occurre

116 g in ER-stressed cells lacking these factors revealed that Ire1-mediated cleavage of ER-associated mR

117 unctional analysis of the R390Q substitution revealed that it did not affect the ability of beta-tubu

118 of the top candidate splicing factor, Ptbp1, revealed that it is a critical barrier for the acquisiti

119 Both analyses revealed that ITNs did not significantly protect against

120 before and 1 year after ivacaftor treatment revealed that ivacaftor decreased airway mucous plugging

121 ChIP-seq studies revealed that KDM5i resulted in the broadening of existi

122 Pharmacological study revealed that lamellipodia formation mediated by arp2/3

123 Psychophysiological interaction analysis revealed that levodopa increased effective connectivity

124 Moreover, the modeling results reveal that light-based interventions may be therapeutic

125 Genome-wide transcriptome analysis reveals that lipid biosynthetic enzymes are among the do

126 mples obtained during carotid endarterectomy revealed that local miR-100 expression was inversely cor

127 Stage-specific gene deletion in trophoblasts reveals that loss of both GATA genes, but not either alo

128 Moreover, the model reveals that lower rates of axon degeneration and more r

129 atin immunoprecipitation-sequencing analysis reveals that LSD1 binding sites overlap significantly wi

130 Further analysis of intronic polyadenylation revealed that LTR/Gypsy and LTR/Copia were two major tra

131 These studies clearly reveal that LumC13-ALK5 form a stable complex.

132 Transcript quantification revealed that Lys12 was highly and rapidly induced durin

133 ing of m(6)A coupled with ribosome profiling reveals that m(6)A promotes the translation of c-MYC, BC

134 ntegrative systems biology approach, we also revealed that M2 polarization and cholesterol efflux do

135 Collectively, these data reveal that mammalian RNAs can harbor a 5' end modificat

136 d distance mapping between sugar and protein revealed that Manalpha(1-2)Manalpha(1-2)ManalphaOMe is b

137 ctrometry analysis of polar metabolites also revealed that many compounds were highly sequestered amo

138 We now reveal that mature domains harbor their own independent

139 t, mcrA overexpressing, and parental strains reveal that mcrA regulates at least ten SM gene clusters

140 Cell-specific transcriptional profiling revealed that microglia selectively enhanced CCL2 expres

141 Altogether, our data reveal that miR-155 collaborates with FLT3-ITD to promot

142 Analyses of potential miR-1 targets revealed that miR-1 directly regulates the 3'UTR of the

143 Validation revealed that miR-181b-5p, miR-21-5p, miR-195-5p, miR-13

144 This research reveals that mitochondria are a bona fide target of Coxi

145 Finally, it reveals that mitogen-activated protein kinase interactin

146 a), Tnf, and Nos2 Additionally, RNA analysis revealed that MK2 signaling regulated chemokines CCL3 an

147 Additionally, a structure-function analysis revealed that MLO homooligomerization, mediated by the a

148 Endocytosis analysis revealed that MOFs are internalized by active transport

149 d metrological analysis of captured PMPs and revealed that more than 95% of PMPs were smaller than 30

150 unoprecipitation and in vitro binding assays revealed that mortalin facilitates PP1alpha-mediated MEK

151 contemporary cohort of patients on dialysis revealed that mortality from acute myocardial infarction

152 A Cox-regression analysis revealed that mortality was much higher in patients rece

153 to the inferior colliculus (IC) of the mouse revealed that most of the subcortical descending project

154 d in silico analysis of the GmSACPD-C enzyme revealed that most of these mutations were localized nea

155 Surprisingly, our analyses revealed that most p53-bound enhancers are located withi

156 Our results further reveal that MSH is important to maintain the reduced sta

157 Dating estimates reveal that myrmecoid clades are separated by substantia

158 Gene silencing revealed that NaJAZi functions as a flower-specific jasm

159 nning electron microscopy of zebrafish cones revealed that nearly 100 mitochondria cluster at the api

160 ous recordings of neurons in singing finches reveal that neural correlations increase across the circ

161 We reveal that neuronal function and integrity decline rapi

162 Our data reveal that Nicotiana benthamiana incorporates two diffe

163 ments and mass spectrometry analyses further reveal that nitric oxide binds to the reduced [2Fe-2S] c

164 These results reveal that NLRC4 and NLRP3, which normally form distinc

165 These data reveal that NSGS mice support the development of CMML an

166 A recent study revealed that null mutations in ACC2, encoding a plastid

167 g specific uptake and/or efflux transporters revealed that OATP1B1, OATP1B3, and OATP1A2, either alon

168 nd multi-angle light scattering experiments, revealed that ObgE is a monomer in solution, regardless

169 These findings reveal that p16 participates in radiosensitization throu

170 nts based on global gene expression profiles revealed that participants with significantly higher ser

171 rium to those of close saprophytic relatives reveals that pathogenicity is associated with remarkable

172 Kaplan-Meier analysis revealed that patients on hemodialysis with a denser clo

173 In vitro activation revealed that patients with CVID behaved heterogeneously

174 Multiphoton imaging revealed that paxillin-deficient neurons migrate approxi

175 These findings reveal that PDGFRalpha+ cells perform diverse roles in C

176 Protein structural analysis revealed that Phe10Leu mutation may decrease the structu

177 We reveal that phosphite and hypophosphite specificity resu

178 Intracellular metabolic profiling revealed that PknG is necessary for efficient metabolic

179 o define the temporal requirements for Glut1 reveal that pre-symptomatic, AAV9-mediated repletion of

180 vo MRI assessments of non-heme cellular iron revealed that preclinical prostate tumor models could be

181 Detailed study of the mechanism revealed that PRMT1 regulates PPARgamma gene expression

182 ugh these waters via Grotthuss shuttling and reveal that proton binding to the extracellular side of

183 Live-cell imaging reveals that Rab8a is first recruited to the plasma memb

184 Altogether, this study reveals that raspberry polyphenols may present a dietary

185 Surprisingly, the results reveal that ReS2 lateral heterojunctions to WS2 produce

186 The structural data reveal that Rtt103 interacts with phospho-Thr4 in a mann

187 ome-wide predictions and confocal microscopy reveal that rust fungi might have evolved multiple effec

188 ng BLM calibrations show good agreement, but reveal that selection of analytical window can impact wh

189 enocarcinoma (PDAC) and our genomic analysis revealed that SERPINB2 is frequently deleted in PDAC.

190 The structure of PawS1 revealed that SFTI-1 and the albumin are independently f

191 We revealed that Skp2 regulates CRPC through Twist-mediated

192 Functional studies revealed that SLC25A46 may play an important role in mit

193 cape mutant viruses with the wild-type virus revealed that some escape mutants possessing an amino ac

194 modeling of 25 missense mutations of CYP11B1 revealed that specific modifications in the heme-binding

195 iochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2

196 A gene ontology analysis reveals that stress response processes are significantly

197 Here, we reveal that sucrose cue exposure recruited a more excita

198 Morphologic analysis revealed that sweat ducts were blocked by hyperkeratotic

199 RAGE signaling in cell and animal models has revealed that targeting RAGE impairs inflammation and pr

200 These studies reveal that TAX1BP1 drives a specialized form of autopha

201 ells from untreated HIV-infected individuals revealed that TFR cells harbored the highest concentrati

202 Our results reveal that the band-edge carrier lifetime increases whe

203 Here, we reveal that the breast epithelial clock is regulated by

204 Furthermore, nanotensile tests reveal that the ceramic-based papers with 0.5 wt% GO sho

205 e cubanes are redox-active, and calculations reveal that the Co ions behave as the reservoir for elec

206 g photoactivated localization microscopy, we reveal that the contact area of single ER-PM junctions i

207 The simulations reveal that the evolutionary dynamics can be collapsed o

208 Hyperbolic law measurements reveal that the higher coercive field is due to domain w

209 Our results reveal that the new microneedle sensor holds considerabl

210 Sub-cellular investigations reveal that the plasma membrane cell fate regulator, SCR

211 elomerase activity in vitro NMR studies also reveal that the pseudoknot does not form in the context

212 The structures reveal that the S531L mutation imparts subtle if any str

213 The studies reveal that the stability of hairpin-monomer complexes i

214 Our analyses reveal that the strain curves associated with the distor

215 density functional theory (DFT) calculations reveal that the surface electron-rich nitrogen simultane

216 We reveal that the underlying mechanism of this intriguing

217 These results reveal that the use of this electrochemical bio-sensor m

218 ormed alternating current voltammetry, which revealed that the 2-methylimidazolate ligand is responsi

219 putational investigation of the alpha-epimer revealed that the 4'-OMe imparts a conformational bias t

220 These studies revealed that the agent inhibited pERK1/2 phosphorylatio

221 ed by inhibitor and antibody-blocking assays revealed that the arthropod HSP70-like molecule contribu

222 e and hydrophobic 2' sugar modifications and revealed that the C-terminal region of FUS is sufficient

223 We revealed that the central retinal lesions either do not

224 In vitro and cell-based assays revealed that the CNAbeta1-containing holoenzyme, CNbeta

225 The obtained results revealed that the designed model can accurately determin

226 Genetic analysis has revealed that the dual specificity protein kinase DYRK1A

227 Two-hybrid analysis revealed that the dynamins are part of the cell division

228 Whole-cell recordings in L2/3 of awake mice revealed that the E/I ratio systematically declines with

229 Our analysis revealed that the E4 34K protein of HAdV-C5 contains a r

230 Our findings from mice and humans revealed that the effects of smoking on risk for IBD dep

231 characterization of the L. major phosphatase revealed that the enzyme is redox sensitive.

232 es of MalA' in complex with three substrates revealed that the enzyme represents a new class of zinc-

233 mRNA profiling by microarray analysis revealed that the expression of PTPRZ1 and Wnt8a, two co

234 Average nucleotide and amino acid identities revealed that the four Ca.

235 A review of the drivers of extinction risk revealed that the heaviest vertebrates are most threaten

236 nd water stressed plants of Carrizo citrange revealed that the hormone depletion was linked to the up

237 Whole cell recordings revealed that the isoflurane-activated background potass

238 Fluorescence quenching measurements revealed that the l-tryptophan interacted with anthocyan

239 The nSSR analysis revealed that the majority (79%) of tea accessions colle

240 ments combined with ellipsoid packing models revealed that the mechanosensitivity of chromosomes was

241 This approach revealed that the metastatic transition is accompanied b

242 In functional interaction studies, we revealed that the miR-144-3p target, PTEN, colocalized w

243 impact of the individual redesigned segments revealed that the most significant effects were conferre

244 omplementation of RM1 with a genomic library revealed that the mutation occurred in a gene designated

245 ates and bearing different anionic ligands X revealed that the nature of anion influences the reactiv

246 d4 Analysis of embryonic and adult fly heart revealed that the Nedd4 protein regulates heart developm

247 These studies revealed that the novel GC/rGO-Nf@Ag6 sensor electrode c

248 l transcripts (CNTs) (novelty score >/= 70%) revealed that the PNTs are both highly conserved across

249 Affinity enrichment mass spectrometry revealed that the primary ciliogenesis regulator, RILPL1

250 The structures revealed that the RVR and RR variants primarily recogniz

251 Moreover, fate-mapping experiments revealed that the timing of SOX2 expression did not para

252 that resemble a spinning top on a tripod and revealed that the two XB co-crystals are isomorphous, wi

253 and Fourier transform infrared spectroscopy, revealing that the enhanced sensing performance originat

254 istant regions to digestion were identified, revealing that the in vitro protocol constitutes a good

255 This review reveals that the bulk of the work in the field is relati

256 Furthermore, our study reveals that the electron-hole wavefunction overlaps in

257 Our analysis reveals that the frequency of MSI events is highly varia

258 The structure reveals that the glycan fills up a surface groove of the

259 Our analysis reveals that the importance of spreaders is fixed by the

260 Structure-function analysis reveals that the intrinsically low activity of Ubc15 lar

261 Analytical ultracentrifugation analysis reveals that the maturation complex is composed of four

262 Evolving work reveals that the MBC compartment in mice and humans cons

263 It reveals that the nanostructured material with plasmonic

264 Modeling reveals that the pool of maternal Vg1 enables rapid sign

265 e structure of a QuiC1 enzyme from P. putida reveals that the protein is a fusion of two distinct mod

266 unts for the high current responses and also reveals that the SECM images of 100 nm diameter Si3N4 na

267 studies of many different histone chaperones reveal that there are few commonalities in their folds.

268 At both time points the genome-wide mapping reveals that there is significant co-occupancy of Nanog

269 MKN45/5FU cells in the stomach of nude mice revealed that these cells had a high potential to metast

270 Our analyses revealed that these different characteristics show stron

271 Molecular dynamics simulations revealed that these ligands adopt distinct binding poses

272 ter deactivation than their WT counterparts, revealing that these substitutions impair gating through

273 periments on subjects with only rod function reveals that these individuals unexpectedly retain subst

274 PFM hysteresis loops for the bubble domains reveal that they undergo an irreversible phase transitio

275 A recent survey of the member programs revealed that they provide an impressive variety of prog

276 (1)H NMR and neutron scattering experiments reveal that this macroscopic response of the gels result

277 Regression analyses revealed that this combination of factors significantly

278 Selective inhibition of individual ligands revealed that this signal does not require canonical lig

279 Our data reveal that tissue and stage-specific expression of anky

280 erologous expression of TmELO genes in yeast revealed that TmELO1 and TmELO2 function to synthesize l

281 Overall, RNA sequencing analysis revealed that transcriptomes during early cardiomyocyte

282 RT-qPCR analysis revealed that TrkC-miR2 is significantly up-regulated (

283 Here we reveal that TRV120027, a beta-arrestin-1-biased agonist

284 Our results reveal that tuning the interface structure, distribution

285 Gas phase analyses revealed that two were complete denitrifiers, which geno

286 Proteomic analysis reveals that two proteases belonging to the calpain fami

287 Ms, in fusion with an N-terminal GFP domain, revealed that type A CBMs possess the ability to recogni

288 Structural and biochemical analyses revealed that UbVs specifically inhibited the activity o

289 genome-wide analysis of S. cerevisiae, which reveals that under favourable growth conditions mRNAs co

290 Transcriptome analysis revealed that various phytohormone (auxin and salicylic

291 Neuropharmacological experiments further reveal that vCA1 GLP-1R activation reduces food intake a

292 ing mechanism, a gene expression time course revealed that VE-cadherin and FLK1 were upregulated in a

293 The proteomic analysis revealed that vitellogenin is only detected in female go

294 Here, we reveal that voltage clamp is completely ineffective for

295 The findings revealed that WMRP displayed excellent antihypertensive

296 egulators of synapse formation, and our data reveal that Wnt5a inhibits glutamatergic synapses formed

297 ilitated by photochemical radical generation reveal that Y731 changes conformation on the ns-mus time

298 Surprisingly, genetic screening reveals that yeast FTase can modify sequences longer tha

299 lantation assays using Zfp521-deficient mice revealed that ZFP521 regulates HSC self-renewal and diff

300 Our results reveal that ZIKV evolved to acquire a spontaneous mutati