ライフサイエンスコーパス: reversal learning

1 avioral flexibility after negative feedback (reversal learning).

2 signals conveying reward contingency (object reversal learning).

3 r BLA (or SHAM) on visual discrimination and reversal learning.

4 with OFC, may be differentially involved in reversal learning.

5 r errors during initial acquisition and also reversal learning.

6 ulsivity, compulsivity, motivation, and rule-reversal learning.

7 r example, with a negative affective bias in reversal learning.

8 ic, integrity being important for successful reversal learning.

9 the cognitive processes underlying impaired reversal learning.

10 ve learning, shifts of attentional sets, and reversal learning.

11 ial caudate nucleus on serial discrimination reversal learning.

12 OFC and medial caudate in the regulation of reversal learning.

13 e OFC and VLPFC in the performance of serial reversal learning.

14 lofen and muscimol, on place acquisition and reversal learning.

15 f inactivation, which concomitantly impaired reversal learning.

16 ontrol over visual object representations in reversal learning.

17 learning tasks, namely serial and concurrent reversal learning.

18 ns, but impairs performance on tasks such as reversal learning.

19 ing, and reward-based tasks like gambling or reversal learning.

20 ate poor decision making and are impaired in reversal learning.

21 ctions that differentiate different forms of reversal learning.

22 injection prevented its beneficial effect on reversal learning.

23 of the amygdala in rhesus monkeys on object reversal learning.

24 C) has long been associated with deficits in reversal learning.

25 odor cup contained a cereal reinforcement in reversal learning.

26 rats, failed to change cue preference during reversal learning.

27 ncoding in basolateral amygdala (ABL) during reversal learning.

28 ns, while ABL lesions alone had no effect on reversal learning.

29 k with higher-order structure, probabilistic reversal learning.

30 ible stimulus-reward learning, namely object reversal learning.

31 on a task that distinguishes imitation from reversal learning.

32 perated monkeys were also impaired on object reversal learning.

33 romedial frontal damage selectively impaired reversal learning.

34 ad 4 days FR20 testing vs. inactivity before reversal learning.

35 ized differences to a transitional period of reversal learning.

36 s during different phases of acquisition and reversal learning.

37 caine-exposed rabbits during acquisition and reversal learning.

38 blink conditioning during discrimination and reversal learning.

39 conditions were examined: place learning and reversal learning.

40 ed to play a permissive role in this form of reversal learning.

41 tially to processes such as set-shifting and reversal learning.

42 make distinct contributions to probabilistic reversal learning.

43 show no deficits in spatial reference memory reversal learning.

44 n these animals, which also show deficits in reversal learning.

45 ptors alter anxiety, social interaction, and reversal learning.

46 ve deficits in hippocampal-dependent spatial reversal learning.

47 but volume of neither region correlated with reversal learning.

48 nal shift abilities and impairment of serial reversal learning.

49 ponse to changes in reward is discrimination reversal learning.

50 rd-based decision-making task: probabilistic reversal-learning.

51 y impaired spatial memory retrieval and new (reversal) learning.

52 of long-term memory, disrupted retention of reversal learning 24 h later in saline-, but not METH-,

53 ronic intermittent cold (CIC) stress impairs reversal learning, a form of cognitive flexibility media

54 gnaling in the orbitofrontal cortex (OFC) in reversal learning, a form of cognitive flexibility that

55 The results revealed that during reversal learning, a network including anterior cingulat

56 ) and amygdala are thought to participate in reversal learning, a process in which cue-outcome associ

57 amygdala yield severe impairments on object reversal learning, a task that assesses the ability to s

58 observed maintenance of prefrontal-dependent reversal learning ability.

59 also impaired in object, but not in spatial, reversal learning, although there were no differences in

60 on on dorsomedial striatal ACh output during reversal learning and a resting condition.

61 g task, which yields dissociable measures of reversal learning and attentional set-shifting, function

62 Whilst both models led to deficits in reversal learning and extra-dimensional set-shifting, th

63 medial prefrontal cortex, which also mediate reversal learning and extra-dimensional set-shifting.

64 tasks in the battery: object discrimination reversal learning and instrumental extinction.

65 They showed a similar trend on reversal learning and memory trials, but were not differ

66 tly more trials and committed more errors on reversal learning and multidimensional discriminations,

67 al Arg inhibition also retarded instrumental reversal learning and potentiated responding for reward-

68 cognitive control of adaptive behavior using reversal learning and reinforcer devaluation paradigms.

69 Similar trends were seen on reversal learning and reversal probe trials.

70 imals were then tested on a cross-maze-based reversal learning and set-shifting task, after which the

71 Rdx gene knockout impairs reversal learning and short-term memory, and Rdx phospho

72 as 11 and 13 do not critically contribute to reversal learning and that adjacent damage to OFC subfie

73 The highest dose of CRF (20 ng) facilitated reversal learning and the lowest dose (2 ng) improved ED

74 of strategy set shifting to facilitation of reversal learning and this was most prominent in a subpo

75 er ethanol-induced changes in OFC-dependent (reversal learning) and mPFC-dependent (set-shifting) beh

76 CRF impaired intradimensional set shifting, reversal learning, and extradimensional set shifting (ED

77 ory, attentional-set formation and shifting, reversal learning, and response inhibition are compared

78 vity was recorded during stable performance, reversal learning, and strategy switching.

79 xcitotoxic amygdala lesions performed object reversal learning as quickly as controls.

80 mice did display a selective enhancement in reversal learning, as measured using Morris water-maze a

81 Chlordiazepoxide interfered with reversal learning at doses that had no effect on the per

82 barbital-exposed rats were also assessed for reversal learning at weaning.

83 The first assay tests reversal learning, attentional set formation and shiftin

84 n the level of training subjects received in reversal learning, being far greater in the latter.

85 at the disconnection severely impairs serial reversal learning but leaves concurrent reversal learnin

86 Morphine and dizocilpine also impaired reversal learning but only at doses that also affected p

87 polamine (0.3 mg/kg) impaired both place and reversal learning but this was less pronounced in isolat

88 acquisition of spatial learning, as well as reversal learning, but are not necessary for the retriev

89 te fear memory formation as well as improved reversal learning, but do not display alterations in hip

90 These data suggest reversal learning, but not attention set-shifting, is tr

91 xposed female rabbits during acquisition and reversal learning, but only during reversal learning in

92 interneurons in orbitofrontal cortex during reversal learning by recording single unit activity from

93 tations in inferotemporal cortex (IT) during reversal learning by studying the effect, in macaque mon

94 of nicotine and varenicline on probabilistic reversal learning choice behavior.

95 icide ideators showed impaired probabilistic reversal learning compared to both nonsuicidal depressed

96 rial reversal learning but leaves concurrent reversal learning completely intact.

97 During mirror-reversal learning, correct movement initiation (feedforw

98 Moreover, prediction errors associated with reversal learning correlated with striatal activation.

99 tor responses to spatial locations) and hot (reversal learning, decision-making under risk, and stimu

100 er ketamine also corrects the stress-induced reversal learning deficit, and if JAK2/STAT3 signaling i

101 or to testing rescued the CIC stress-induced reversal learning deficit.

102 ng in the OFC rescued the CIC stress-induced reversal learning deficit.

103 eurons was critical to the expression of the reversal-learning deficit in the cocaine-treated rats.

104 The reversal learning deficits are particularly noticeable,

105 These outcomes indicate that odor reversal learning deficits in rats with bilateral MD les

106 l cortex (OFC) has long been associated with reversal learning deficits in several species.

107 howed that LSN2463359 selectively attenuated reversal learning deficits in the MAM but not acute PCP

108 Reversal learning deficits were no longer present when m

109 Reversal learning deficits were revealed as greater numb

110 his framework to explain classic findings in reversal learning, delayed alternation, extinction, and

111 rced behaviors more slowly, have deficits in reversal learning demonstrating behavioral inflexibility

112 ility--a form of affective shifting known as reversal learning--depends on orbitofrontal cortex.

113 ional and extra-dimensional set-shifting and reversal learning digging paradigm.

114 showed that behavioral flexibility during a reversal learning discrimination task was reduced in alc

115 sual differences in clock speed, deficits in reversal learning, distortions in temporal memory, and l

116 During reversal learning, dorsal anterior cingulate inactivatio

117 yl-Daspartate (NMDA) receptor antagonist, on reversal learning during development.

118 ociated with impairments in learning but not reversal learning (executive component).

119 kg, but not 0.03 mg/kg, selectively impaired reversal learning (Experiments 1 and 3).

120 ge-related differences in discrimination and reversal learning for olfactory and visual stimuli in 6-

121 amined the neural mechanisms associated with reversal learning for outcomes versus motor responses.

122 cant decline in spatial reference memory and reversal learning from both young and middle-aged mice.

123 ed (COC) animals showed specific deficits in reversal learning; furthermore, spontaneous LFP oscillat

124 Reversal learning has been extensively studied across sp

125 Reversal learning has been studied as the process of lea

126 Research in reversal learning has mainly focused on the functional r

127 erstanding the neural substrates involved in reversal learning has provoked a great deal of interest

128 Deficits in reversal learning have been seen after manipulations of

129 Studies of visual discrimination reversal learning have revealed striking neurochemical d

130 While J.S. showed no reversal learning impairment, he presented with severe d

131 These findings suggest that reversal learning impairments in patients with developme

132 Pf inactivation selectively impaired reversal learning in a dose-dependent manner.

133 tion of the odor discrimination but impaired reversal learning in a dose-dependent manner.

134 inge-type ethanol regimen exhibited impaired reversal learning in a modified Barnes maze, indicative

135 We found that moderate stress enhanced late reversal learning in a mouse touchscreen-based choice ta

136 BQCA also restored discrimination reversal learning in a transgenic mouse model of Alzheim

137 textual fear conditioning and serial spatial reversal learning in a water maze, which were associated

138 striatal involvement in the negative bias in reversal learning in depression.

139 esent study examines the anatomical bases of reversal learning in humans.

140 ition and reversal learning, but only during reversal learning in male rabbits.

141 Arc into the shell impaired consolidation of reversal learning in METH-, but not saline-, pretreated

142 y showed that decreasing MD activity impairs reversal learning in mice.

143 on in a breakpoint assay and did not promote reversal learning in MK-801-treated mice.

144 of serotonin are shown by contrast to affect reversal learning in monkeys and human volunteers and me

145 of these neurotransmitters in probabilistic reversal learning in nearly 700 individuals as a functio

146 ing the lateral orbitofrontal cortex, during reversal learning in OCD patients and their clinically u

147 ce that associative encoding increments with reversal learning in OFC suggests that the original asso

148 l documented impairments on various forms of reversal learning in rodents, monkeys, and humans.

149 triatal function by infusion of AP5 impaired reversal learning in saline-, but not METH-, pretreated

150 manner in which these regions may facilitate reversal learning in situations involving reward uncerta

151 ent theories disagree on whether OFC directs reversal learning in the amygdala.

152 iations suggests their importance in outcome reversal learning in the face of interference.

153 TgF344-AD rats had impaired reversal learning in the Morris water maze compared to t

154 20 healthy participants during probabilistic reversal learning, in a placebo-controlled design.

155 s norvegicus) Pf supports flexibility during reversal learning, in part, by modifying dorsomedial str

156 -making processes, assessed by probabilistic reversal learning, in rats before and after they were ex

157 ofrontal cortex (OFC) - a region involved in reversal learning- in rats performing an odor learning a

158 irments in cognitive flexibility and spatial reversal learning, including impaired extinction during

159 However, despite the fact that reversal learning is associated with striatal response i

160 ings, suggests that Pb-induced impairment of reversal learning is due to a deficiency in learning the

161 pulsive disorder and schizophrenia, in which reversal learning is impaired, and which are primarily t

162 Spatial reversal learning is more sensitive to NMDA-receptor ant

163 Reversal learning is often studied as a form of flexible

164 However, reversal learning is often studied in animals that have

165 We propose that reversal learning is supported by complex interactions b

166 tes that one type of behavioral flexibility, reversal learning, is dependent upon proper numbers of G

167 ted contingency changes, as occurs in serial reversal learning, is likely to trigger the development

168 While MD hypofunction impaired reversal learning, it did not affect the ability to lear

169 On reversal learning, knockout mice showed no significant e

170 w that fear extinction, an important form of reversal learning, leads to a dramatic genome-wide redis

171 After extensive training in reversal learning, marmosets received an excitotoxic les

172 y, but is no longer, associated with reward; reversal learning, measuring the rate and extent of swit

173 ed drug-free 24 h after OFC inactivation and reversal learning, memory for the newly learned continge

174 Accordingly, neither VOR phase-reversal learning nor locomotion was impaired following

175 d AMG make different contributions to object reversal learning not highlighted previously.

176 hmt1(+/-) mice in the Visual Discrimination &Reversal learning, object-location Paired-Associates lea

177 Serial reversal learning of 2-choice discriminations was contra

178 al anterior cingulate on the acquisition and reversal learning of a 4-choice odor discrimination.

179 .) or saline in utero during acquisition and reversal learning of a discriminative avoidance response

180 inactivation in rats on the acquisition and reversal learning of different discrimination tasks: 2-

181 The cognitive flexibility required for reversal learning of previously acquired behavioral habi

182 implicate a critical contribution to object reversal learning of structures nearby the amygdala, per

183 Recently, we have developed a model of phase-reversal learning of the vestibulo-ocular reflex, a well

184 mbic-infralimbic areas in intramodal shifts (reversal learning), one group of rats was tested on a pl

185 st, stress was not found to adversely affect reversal learning or dendritic morphology in the lateral

186 ehavioral flexibility, as measured by object reversal learning, or emotion regulation, as assessed by

187 ional magnetic resonance imaging and a novel reversal learning paradigm, the present study examined t

188 h the acquisition of new information using a reversal learning paradigm.

189 he marmoset VLPFC in performance of a serial reversal learning paradigm.

190 abstinence (72 hrs), CIE mice showed reduced reversal learning performance as compared to controls.

191 mirrored that of a hyperbolic function, with reversal learning performance being poorest in either mo

192 like receptor PET measurements is related to reversal-learning performance and sensitivity to positiv

193 ayesian approach we find that variability in reversal-learning performance attributable to different

194 dopamine transporter (DAT) availability and reversal-learning performance were measured before and a

195 d reinforcement learning, like probabilistic reversal learning (PRL), but the neural bases for those

196 ical for acquisition of new memories and for reversal learning, processes that are thought to be cruc

197 nd entorhinal cortex increased after spatial reversal learning relative to an asymptotic performance

198 BLA lesions, conversely, showed facilitated reversal learning relative to SHAM and OFC groups.

199 dependent pairwise visual discrimination and reversal learning, relative to air-exposed controls.

200 Given that reversal learning requires an intact OFC, these findings

201 attentional set-shifting and discrimination reversal learning, respectively.

202 ated with deficits in imitation learning and reversal learning, respectively.

203 ) and made fewer perseverative errors during reversal learning (REV).

204 control rats were compared in discrimination reversal learning set (DRLS) and olfactory discriminatio

205 earning set (ODLS), olfactory discrimination reversal learning set (DRLS), and open field activity.

206 -accuracy tradeoff and offline gains, mirror-reversal learning shares common features with other skil

207 Plaur mice have impaired reversal learning, similar to deficits observed in patie

208 In serial reversal learning, subjects learn to respond differentia

209 cortically to other structures implicated in reversal learning, such as the medial caudate nucleus.

210 to inbred C57BL/6J mice and impaired spatial-reversal learning, suggesting a significant contribution

211 K/STAT signaling pathway in the OFC impaired reversal learning, suggesting that basal IL-6 and JAK/ST

212 ice were able to learn, but were impaired in reversal learning, suggesting that these mice present co

213 ers and nonsmokers completed a probabilistic reversal learning task during acquisition of functional

214 processing was assessed with a probabilistic reversal learning task during event-related functional M

215 nonhuman primate performing a feature-based reversal learning task evaluating performance using Baye

216 hment-based learning using the probabilistic reversal learning task in 65 individuals age 60 and olde

217 The subjects performed a reversal learning task in which they first had to learn

218 d obese participants performed an appetitive reversal learning task in which they had to learn and mo

219 de, and a greater difficulty in performing a reversal learning task relative to baseline performance.

220 RDMP can robustly perform the probabilistic reversal learning task via dynamic adjustment of learnin

221 6 years) were examined using a probabilistic reversal learning task while simultaneous functional mag

222 MRI to compare the hemodynamic response to a reversal learning task with mixed reward- and punishment

223 Additionally, in a spatial reversal learning task, 2CKO mice failed to improve thei

224 ion disrupted performance on a serial object reversal learning task, although aspiration lesions of t

225 ngage dorsomedial striatum during a response-reversal learning task, as their performance is insensit

226 In the reversal learning task, the n-3 fatty acid-deficient rat

227 Using a reversal learning task, we found that amygdala blood oxy

228 keys engaged in a deterministic three-choice reversal learning task, we found that changes in GPe dis

229 d longer latency to find the platform in the reversal learning task.

230 nd punishment-based learning task, such as a reversal learning task.

231 e (cognitive flexibility) in a probabilistic reversal learning task.

232 MG lesions that had been tested on an object reversal learning task.

233 as well as with normal controls on a simple reversal learning task.

234 3-choice, but not 2-choice, olfactory serial reversal learning task.

235 were related to anticipatory strategies in a reversal learning task.

236 and stochastic versions of a two-arm bandit reversal learning task.

237 subregions in the context of an instrumental reversal learning task.

238 erformance on a probabilistic two-arm bandit reversal learning task.

239 After 3-5 weeks, rats were trained on the reversal-learning task and in situ hybridization for Arc

240 man subjects doing an emotion-related visual reversal-learning task in which choice of the correct st

241 , myelin staining, and a novel three-choice, reversal-learning task to identify early behavioral mark

242 a novel three-choice spatial acquisition and reversal-learning task with probabilistic reinforcement.

243 eously acquired fMRI, during a probabilistic reversal-learning task, to offer evidence of temporally

244 nd performance in a frontal-cortex-dependent reversal-learning task.

245 orsal to ventral striatal involvement in the reversal-learning task.

246 ght to determine whether this may be because reversal learning tasks conventionally used to study beh

247 We tested two visual object reversal learning tasks, namely serial and concurrent re

248 " manner, a function thought to be tested by reversal learning tasks.

249 ced animals have decision-making deficits in reversal-learning tasks and more complex 'gambling' vari

250 spectively, impairs flexible responding in a reversal learning test, suggesting that these neurochemi

251 , OFC lesions displayed significantly slower reversal learning than SHAM and BLA rats across sessions

252 with low brain DHA have a deficit in spatial reversal learning that could be related to changes in do

253 Because 5-HT facilitates reversal learning, the present results suggest that stre

254 During initial task acquisition and initial reversal learning, there was a remarkable change in the

255 sic responses both during discrimination and reversal learning to decisions and rewards, and the stre

256 n of the NAc shell and core on probabilistic reversal learning using an operant task wherein a "corre

257 rons, whose activity we could link to normal reversal learning using pharmacogenetics.

258 st examination of age-related differences in reversal learning using the same paradigm for odors and

259 that although the OFC is indeed critical for reversal learning, ventrolateral prefrontal cortex (VLPF

260 ected mice exhibited cognitive deficits in a reversal learning version of the Morris water maze.

261 Reversal learning was assessed in all animals reaching c

262 he completion of extensive operant training, reversal learning was assessed.

263 gence of learning-dependent asymmetry during reversal learning was associated with decreased function

264 approximately 30% above basal levels) during reversal learning was blocked by Pf inactivation, which

265 The deficit in reversal learning was comparable for odors and objects.

266 VOR phase-reversal learning was singularly impaired in these anima

267 implementation of anticipatory strategies in reversal learning, we first studied, in 20 healthy indiv

268 amine the contribution of areas 11 and 13 to reversal learning, we tested monkeys with selective dama

269 and simultaneous discrimination learning and reversal learning were demonstrated.

270 not impair learning, and no changes in FR20 reversal learning were detected in sham vs. ischemic rat

271 Six weeks later place learning and reversal learning were determined using the Morris water

272 The results showed that place learning, and reversal learning were enhanced in isolation reared rats

273 s in acquisition, recall, perseveration, and reversal learning were evident 1 month after CUS.

274 between stimulus-reward associations (i.e., reversal learning) when reinforcement is predictable.

275 ic, and anterior cingulate) on probabilistic reversal learning wherein "correct" versus "incorrect" r

276 the integration of negative feedback during reversal learning, whilst orbitofrontal 5-hydroxytryptam

277 This sparing of reversal learning will be discussed in relation to defic

278 at dose we examined the faster feature-based reversal learning with Guanfacine with single-subject co

279 The +/rl mice showed a selective deficit in reversal learning, with a pattern of errors that suggest