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1 their properties, for example, the rarity of reverse mutations.
2 approach further minimizes the concern over reverse mutations.
4 our graph-based signatures, considering the reverse mutation and by using a refined, more reliable d
5 ns were tested for bacterial mutagenicity in reverse-mutation assays using Salmonella typhimurium fra
6 Interestingly, the diabetes drug metformin reverses mutation-associated alterations on energy metab
8 hod correlates well against the hypothetical reverse mutations, better than comparable methods built
10 otably, the rate of evolution of forward and reverse mutations correlated with the conservation of ea
11 6 +/- 0.7 mV for wild-type HCN1); the charge-reversed mutation E235R shifted activation even more pos
17 sensitivity to zinc while the corresponding reverse mutation in TASK-1, K70E, induced zinc sensitivi
18 vity of the channel to cholesterol whereas a reverse mutation in the corresponding position in Kir2.3
23 neurotensin at the neurolysin site, and the reverse mutations in neurolysin switch hydrolysis to the
24 av1.7 by approximately 300-fold, whereas the reverse mutations in rNav1.4 (N655D/Q657E) and the corre
25 190GD stimulation, whereas the corresponding reverse mutation of Cdc42 (S88D) was able to respond to
26 crosatellites within a fragment, and forward/reverse mutations of repeat length resulting in microsat
27 pproximately 10 times more frequent than the reverse mutation, resulting in an overall mutation press
29 ergy changes due to the corresponding charge-reversing mutations, suggesting that the charges in the
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