ライフサイエンスコーパス: reverse remodeling

1 ion asynchrony, and LV end-systolic volume ("reverse remodeling").

2 ties characteristic of severe heart failure (reverse remodeling).

3 nths and associated with interval 3-month LV reverse remodeling.

4 l scar, and these changes predict subsequent reverse remodeling.

5 paced ECG, anticipate higher probability of reverse remodeling.

6 avefront fusion, were positive predictors of reverse remodeling.

7 eft ventricular ejection fraction and led to reverse remodeling.

8 gree of decrease in MVO2, and the rate of LV reverse remodeling.

9 one to make a decision in the prediction of reverse remodeling.

10 continuous flow assist devices on dystrophin reverse remodeling.

11 rt function by neuroendocrine modulation and reverse remodeling.

12 tion to the left (p < 0.01), compatible with reverse remodeling.

13 tor underlying several important features of reverse remodeling.

14 ved LV ejection fraction, consistent with LV reverse remodeling.

15 esult in a higher degree of left ventricular reverse remodeling.

16 used in patients with HF, leading to partial reverse remodeling.

17 myocardial infarction is associated with LV reverse remodeling.

18 sized that late repair will not result in LV reverse remodeling.

19 w-up than patients with discordant or lesser reverse remodeling.

20 h favorable left ventricular and left atrial reverse remodeling.

21 n that have been referred to collectively as reverse remodeling.

22 unctional recovery of scarred myocardium and reverse remodeling.

23 ng, and metabolic genes were associated with reverse-remodeling.

24 er potential for myocardial recovery through reverse remodeling, a potential that is further enhanced

25 ith LBBB, 212 (40%) with complete left-sided reverse remodeling (above-median change in both LAV and

26 th LAV and LVESV), 115 (22%) with discordant reverse remodeling (above-median change in only LAV or L

27 f factors that are associated with favorable reverse remodeling after cardiac resynchronization-defib

28 pful in selecting patients likely to undergo reverse remodeling after CRT and predicts clinical outco

29 long-term follow-up, responders demonstrated reverse remodeling after CRT with a significant reductio

30 tructural abnormalities of the myocardium or reverse remodeling after LVAD support.

31 HR provides a unique therapeutic approach to reverse remodeling after MI.

32 ces in HF or death risk and in the degree of reverse remodeling among comorbidity groups.

33 l motion delay (SPWMD) would predict greater reverse remodeling and an improved clinical response in

34 hat LBBB and QRS prolongation are markers of reverse remodeling and clinical benefit with CRT in mild

35 vanced heart failure symptoms and/or adverse reverse remodeling and CRT implanted >6 months underwent

36 ng (<97%), with reduced CRT efficacy by less reverse remodeling and higher risk of HF/death and VTA.

37 on therapy results in atrial and ventricular reverse remodeling and improved hemodynamics.

38 with pre-existing LV dysfunction demonstrate reverse remodeling and improved LV ejection fraction aft

39 eft ventricular assist device (LVAD) exhibit reverse remodeling and in some cases recover from heart

40 Elevated GDF-15 correlates with lack of reverse remodeling and increased mortality after TAVR an

41 een serial measurements of functional MR and reverse remodeling and outcomes in patients undergoing C

42 ing cardioprotection and PDE5Is also promote reverse remodeling and reduce myocardial apoptosis, fibr

43 erate systolic and diastolic performance, to reverse remodeling and restore electric stability and me

44 RS prolongation, and LVEF >30%, CRT produced reverse remodeling and similar clinical benefit compared

45 ay act to limit atrophy and apoptosis during reverse remodeling and to promote repair and regeneratio

46 on and vascular remodeling that have led to "reverse-remodeling" and regenerative strategies as novel

47 AR blockers reduced left ventricular volume (reverse remodeling) and restored beta-agonist response i

48 improved left ventricular function, induced reverse remodeling, and decreased scar size.

49 s the biology of cardiac remodeling, cardiac reverse remodeling, and myocardial recovery with the int

50 This treatment initiates LV reverse remodeling, and provides clinical improvement du

51 this pathway may thus serve as an attractive reverse remodeling approach.

52 2 phenomena and that myocardial recovery and reverse remodeling are not synonymous.

53 (provided to LV and right ventricle [RV]) to reverse remodeling are not understood.

54 t improve, and the electric requirements for reverse remodeling are unclear.

55 loading and normalized biochemical milieu to reverse remodeling are unknown.

56 t ventricular function, and left ventricular reverse remodeling as their counterparts.

57 Reverse remodeling associated with CRT-D therapy was sug

58 Structural and functional reverse remodeling associated with LVADs continues to in

59 resulted in major structural and functional reverse remodeling at 1 year, with the greatest changes

60 this analysis was to determine the extent of reverse remodeling at 12 months after successful percuta

61 significant differences in left ventricular reverse remodeling at 2 years.

62 lic volume [ESV; P<0.01]), but shunt closure reversed remodeling at 3 months, with end-diastolic volu

63 6 months indicates a break point after which reverse remodeling becomes significantly less pronounced

64 nly LAV or LVESV), and 206 (38%) with lesser reverse remodeling (below-median LAV and LVESV change).

65 Furthermore, NFLG patients experienced less reverse remodeling but the same symptomatic benefit.

66 reasingly consider therapies that facilitate reverse remodeling by directly targeting the heart itsel

67 AP regression and reverse remodeling can be detected accurately by MRI 6 m

68 mbined assessment of factors associated with reverse remodeling can be used for improved selection of

69 ove functional capacity and left ventricular reverse remodeling compared with CABG alone.

70 k for HF and death in patients with complete reverse remodeling compared with discordant reverse remo

71 cts of left ventricular assist device (LVAD) reverse remodeling could be independent of hemodynamic f

72 echocardiographic score for prediction of LV reverse remodeling (defined as >/=15% reduction in the L

73 However, reverse remodeling does not always equate with clinical

74 Clinical implications of complete left-sided reverse remodeling due to cardiac resynchronization ther

75 th the use of the ECG accurately predicts LV reverse remodeling during cardiac resynchronization ther

76 ohormonal factors underlying other facets of reverse remodeling during LVAD support.

77 play a role in the pathophysiology of HF and reverse remodeling during mechanical support.

78 CRT exerts pronounced reverse remodeling effects on the left atrium that indep

79 sets of patients whose hearts have undergone reverse remodeling either spontaneously or after medical

80 ned with pharmacological therapy to maximize reverse remodeling, followed by the beta2 adrenergic ago

81 ection fraction < or =35%) for predictors of reverse remodeling (> or =10% reduction in end-systolic

82 Patients with complete left-sided reverse remodeling had a significantly lower rate of HF

83 D patients with LBBB and complete left-sided reverse remodeling had a significantly lower risk of HF

84 Reverse remodeling has been identified as the primary me

85 ve worsening of cardiac function, slowing or reversing remodeling has only recently become a goal of

86 with discordant reverse remodeling or lesser reverse remodeling (hazard ratio: 0.66 per each group; 9

87 could improve cardiac performance and induce reverse remodeling in a model of established HF, the spo

88 ction improvement precedes right ventricular reverse remodeling in clinical responders to CRT.

89 ew York Heart Association class and promotes reverse remodeling in CRT nonresponders.

90 of this study was to identify the extent of reverse remodeling in our kidney transplant population a

91 f the molecular basis of factors influencing reverse remodeling in patients with heart failure.

92 perties can be harnessed to both prevent and reverse remodeling in the ischemically injured ventricle

93 >20% of CRT-D patients exhibited discordant reverse remodeling in the left ventricle and the left at

94 When beta-blockers produce reverse-remodeling in idiopathic dilated cardiomyopathy,

95 REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunc

96 sfunction, outcomes in the REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunc

97 ization Therapy], REVERSE [Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunc

98 Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunc

99 , completely restores function and partially reverses remodeling, including normalization of the hype

100 Thus, reverse remodeling is associated with a specific pattern

101 (LV) reverse remodeling with CRT or whether reverse remodeling is modified by the cause of heart fai

102 We hypothesized that reverse remodeling is predicted by the left bundle branc

103 tudy was to further test the hypothesis that reverse-remodeling is associated with favorable changes

104 Spironolactone induced reverse remodeling (left ventricular mass index declined

105 sy (EMB) results to predict left ventricular reverse remodeling (LVRR) in individuals with recent-ons

106 Reverse remodeling may be attributable to a reversal of

107 Our results suggest that reverse remodeling may involve selective, rather than gl

108 improved functional capacity and evidence of reverse remodeling; more recently, CRT has been associat

109 mprove functional capacity, left ventricular reverse remodeling, MR severity, and B-type natriuretic

110 Patients with reverse remodeling (n = 211, 42%) had a lesser extent (p

111 le range, 0%-1% vs 0%-4%) than those without reverse remodeling (n = 296, 58%) (P < .001 in pairwise

112 LV reverse remodeling (n=161; 48%) was associated with pre-

113 in the pathogenesis of heart failure and in reverse remodeling observed with mechanical support.

114 ersus 61.9+/-6.8%; P<0.01), and right atrial reverse remodeling occurred (pPVR versus mPVR, 15.2+/-3.

115 her QRS scores for LV scar predicted reduced reverse remodeling (odds ratio [confidence interval]=0.4

116 activation time predicted increased odds of reverse remodeling (odds ratio [confidence interval]=1.3

117 heart failure (HF) can result in beneficial reverse remodeling of myocardial structure and function.

118 of neurohormonal environment in determining reverse remodeling of the beta-adrenergic pathway.

119 f coronary atherosclerosis is accompanied by reverse remodeling of the EEM, resulting in no change in

120 ft ventricular assist devices (LVADs) induce reverse remodeling of the failing heart except for the e

121 ht guide future studies of unloading-induced reverse remodeling of the failing human heart.

122 and mass and reduce mitral regurgitation by reverse remodeling of the failing ventricle.

123 r, and genomic research that accompanies the reverse remodeling of the human heart in response to a l

124 In the MADIT-CRT study, favorable reverse remodeling of the left atrium with CRT-D therapy

125 py have been recently demonstrated to induce reverse remodeling of the left ventricle and may improve

126 ular dyssynchrony who respond to CRT without reverse remodeling of the LV.

127 In AS patients after AVR, reverse remodeling of the supranormal systolic function

128 PVA polymer injection resulted in acute reverse remodeling of the ventricle with papillary muscl

129 T, we found a remarkable and almost complete reverse remodeling of these structures despite persisten

130 art failure symptomatology and in some cases reversed remodeling of the cardiac dysfunction.

131 r hypertrophy is a major contributor to the "reverse remodeling" of the heart after LVAD implantation

132 eometry, the pathological mechanisms of the "reverse remodeling" of the heart are unknown.

133 However, the effect of reverse remodeling on APD during cardiac resynchronizati

134 and predictive value of complete left-sided reverse remodeling on heart failure (HF) and death event

135 >130 ms, the test characteristics to predict reverse remodeling or a clinical response were inadequat

136 The previous findings that SPWMD predicts reverse remodeling or clinical improvement with CRT were

137 reverse remodeling compared with discordant reverse remodeling or lesser reverse remodeling (hazard

138 te of HF or death than those with discordant reverse remodeling or lesser reverse remodeling (p < 0.0

139 o significant difference in left ventricular reverse remodeling or survival at 12 months between pati

140 between-group difference in left ventricular reverse remodeling or survival at 2 years.

141 al symptoms and significant left ventricular reverse remodeling over 12 months.

142 with discordant reverse remodeling or lesser reverse remodeling (p < 0.001).

143 nts in clinical composite response (P=0.02), reverse remodeling parameters, and time to death or firs

144 >/=0.1% ectopic beats had significantly less reverse remodeling (percent reduction in LVESV 31 +/- 15

145 Predicted probability of reverse remodeling ranged from <20% for patients with ad

146 achieved left ventricular ejection fraction reverse-remodeling response defined as improvement by >/

147 The profound reverse remodeling routinely associated with left ventri

148 between acute hemodynamic response (AHR) and reverse remodeling (RR) in cardiac resynchronization the

149 LV reverse remodeling (RR) was defined as an increase in LV

150 associated with spontaneous left ventricular reverse remodeling (S-LVRR) among mildly symptomatic hea

151 ased over time as the LV became smaller, and reverse remodeling slowed.

152 Significant right heart structural reverse remodeling takes place immediately after PVR, fo

153 re MR before CRT experienced relatively more reverse remodeling than patients with lesser degrees of

154 use of the terms "myocardial recovery" and "reverse remodeling" to describe the reversal of various

155 dysfunction enrolled in the MADIT-CRT trial, reverse remodeling was associated with a significant red

156 Reverse remodeling was defined as a decrease in left ven

157 Reverse remodeling was defined as reduction in LV end sy

158 Reverse remodeling was measured as reductions in atrial

159 Left ventricular reverse remodeling was more common in patients with nong

160 LV reverse remodeling was observed in DCM -MWHE and in ICM

161 ile or continuous devices; the degree of the reverse remodeling was similar in both ventricles, altho

162 Moreover, the potential role of ACT in reverse remodeling was studied in detail.

163 echniques, the only independent predictor of reverse remodeling was the presence of simultaneous none

164 The independent predictors of reverse remodeling were infarct size (odds ratio, 0.98;

165 Predictors of reverse remodeling were nonischemic etiology, female sex

166 trial electrical and anatomic remodeling and reverse remodeling were studied in a canine model of chr

167 3 measurements in functional MR demonstrates reverse remodeling when MR severity is reduced to either

168 cardiographic score allowed prediction of LV reverse remodeling with a sensitivity of 84% and a speci

169 heart failure exhibit left ventricular (LV) reverse remodeling with CRT or whether reverse remodelin

170 Treatment with an aim to halt or reverse remodeling with mainly two classes of medication

171 Reverse remodeling with reduced systolic wall stress and

172 cular pacing alone, indicating no systematic reverse remodeling with right ventricular pacing.

173 recurrent mitral regurgitation, and improved reverse remodeling without adverse effect on left ventri