ライフサイエンスコーパス: reversion

1 ide insight into the biology of pathogenesis reversion.

2 are also affected by light-independent dark reversion.

3 -expression of PTEN resulted in a phenotypic reversion.

4 s activity of FT is needed to prevent floral reversion.

5 confirms causality through mutant phenotype reversion.

6 tistic significance was used to confirm this reversion.

7 might increase or decrease the likelihood of reversion.

8 exhibits increased robustness to phenotypic reversion.

9 lts, much TK expression could be ascribed to reversion.

10 pon removal dramatically accelerates thermal reversion.

11 quent active tuberculosis disease and of QFT reversion.

12 Notch signaling, which promotes neuron-to-NB reversion.

13 ion with visible light accelerates the shape reversion.

14 diate restart of transfusions in the case of reversion.

15 say, which exhibits frequent conversions and reversions.

16 nity to study the dynamics of CTL escape and reversion after transmission in the light of shared and

17 ltiple independent reversions indicated that reversion-allele frequency in metastatic sites is an imp

18 uding two patients with multiple independent reversion alleles.

19 t light qualities by regulation of phyB dark reversion, allowing plants to adapt growth and developme

20 consequence, we observe both a lower rate of reversion and a lower probability that reversion to sens

21 environmental conditions to facilitate bond reversion and dynamic property change in bulk materials.

22 1 GPC, we hope to minimize the likelihood of reversion and enhance safety in a second-generation Cand

23 nd F427I thus may minimize the likelihood of reversion and enhance safety in a second-generation Cand

24 Thus, the relative barriers to reversion and formation of PCA control the magnitude of

25 utants variably altered in Pfr-to-Pr thermal reversion and nuclear aggregation, and the D307A substit

26 s this function of phyB by accelerating dark reversion and thus depletion of Pfr forms in the night.

27 (IPUint) was found to be responsible for IPU reversion and was identified as a hydroperoxyl derivativ

28 We reveal that extensive epistasis prevents reversions and necessitates fixation of new mutations, l

29 , 64 (29.8%) had at least 1 incident of MSSA reversion, and 55 (25.6%) reverted to MSSA infections fo

30 alyzed to determine the rates of positivity, reversion, and conversion in serial testing data.

31 t to basic research on vaccines, attenuation reversion, and replication.

32 hunter-gatherer way of life through cultural reversion, and selection signals suggest a genetic adapt

33 th engineered nucleases, genomic inversions, reversions, and deletions of short nucleotide expansions

34 The rates of reversion are of the same order of magnitude as spontane

35 Indeed, using reversion assays, we show that the difference in the rat

36 Faster dark reversion attenuates red light-induced nuclear import an

37 ed for cell differentiation can also promote reversion back to a naive pluripotent cell state.

38 eles in the human lineage tends to result in reversion back to the ancestral forms at the RNA level.

39 erization interfaces is critical for thermal reversion back to the resting state.

40 be elucidated about malignant and phenotypic reversion behaviors of the HMT3522-T4-2 cells of this se

41 y irradiation with UV light and the expected reversion by either heating or irradiation with visible

42 At least a partial phenotypic reversion can be achieved by suppression of p38 and ERK1

43 r attenuating nucleotides and confirmed that reversion can occur in days to weeks after vaccination.

44 germline mutations with variable degrees of reversion caused by somatic repair.

45 Thus, analysis of various reversion conditions (including non-reverted) of HMT3522

46 We investigated whether reversions contributed to the variable disease expressio

47 nd little evidence for the occurrence of CTL reversions, CTL escape processes were found to be highly

48 fatigue (38%) after four irradiation-thermal reversion cycles.

49 All patients with reversions detected in tumor-derived DNA were resistant

50 Our results suggest genetic reversion due to cisplatin-induced mutations as a distin

51 during 1990-2000 of 213.65 km(2)/year, and a reversion during 2000-2015 with a net decrease of 251.58

52 replication, often leading to wild-type (WT) reversion during complementation of replication-defectiv

53 ontacts, also plays an important role in the reversion dynamics.

54 overexpression of CCN5 in SP results in EMT reversion, ER-alpha upregulation and delays in tumor gro

55 In developed countries, high rates of reversion following conversion have been described.

56 h exposure to IL-33 for onset and 1-2 wk for reversion following IL-33 removal.

57 We describe the mechanism of reversion for this strain and for a second clinical isol

58 The heating-induced reversion from [am + alpha-Al + multicomponent AlxMy] to

59 ties are likely to be maintained through the reversion from cells with intermediate transcription act

60 We report the first clearly defined case of reversion from methicillin susceptibility to methicillin

61 vation needs to be continually sustained, as reversion from senescence occurs rapidly with aggressive

62 perception through its temperature-dependent reversion from the active Pfr state to the inactive Pr s

63 nderstanding of the impact of CTL escape and reversion from the founder virus in HIV infection and co

64 Rather, regeneration occurs by reversion from the monomer to the dimer.

65 atic mosaicism, but this consisted mostly of reversion from trisomy to disomy and did not correspond

66 imary immunodeficiency diseases (PIDs) where reversions have been described also revealed a higher ra

67 AF reversion in conscious long-term tachypaced pigs: Pigs w

68 essible pathway to increase fitness in rCan, reversion in K33S-GPC rCan is likely to be lethal.

69 l culture conditions that readily select for reversion in the parental rCan virus.

70 for the first time the occurrence of somatic reversion in XLP.

71 of infection was 7.3%, whereas inclusion of reversions in the analysis showed that the actual risk o

72 e, the number of stationary-phase-associated reversions in the his, met, and leu alleles produced by

73 topsy of a patient with multiple independent reversions indicated that reversion-allele frequency in

74 tants is caused by an inactivating lesion in reversion-inducing cysteine-rich protein with Kazal moti

75 Here we show that the membrane protein RECK (Reversion-inducing cysteine-rich protein with kazal moti

76 tivity inactivates the Notch activator RECK (reversion-inducing cysteine-rich protein with kazal moti

77 luciferase assays and Western blot analysis, reversion-inducing cysteine-rich protein with kazal moti

78 Drug holidays at the IDTC state allow for reversion into parental cells re-sensitizing them to the

79 n populations reveals admixture and cultural reversion involving several Khoesan groups, and highligh

80 oint bioactivity at locations and times when reversion is a dominant trenbolone fate pathway.

81 Dark reversion is a temperature-dependent thermal relaxation

82 This reversion is highly efficient and synchronized, with mor

83 Because reversion is not observed with other disease-causing ker

84 phyB(Ser86Asp) Pfr into Pr, also termed dark reversion, is strongly enhanced both in vivo and in vitr

85 for conversions (kappa = 0.74), but poor for reversions (kappa = 0.12).

86 Here, we investigated the reversion kinetics of Gag(181-189)CM9 CD8(TL) escape-ass

87 The reversion likely occurred in a prethymic T-cell precurso

88 This product-to-parent reversion mechanism results in diurnal cycling and subst

89 c cell populations from this progression and reversion model of the breast cells using a tree-lineage

90 Throughout reversion, MreB localized to inwardly curved regions of

91 The frequencies of reversion mutants in the population were determined by m

92 e partial attenuation mutations and a single reversion mutation is less likely to cause a reversion t

93 Our findings indicate that a single reversion mutation will less likely cause a major revers

94 However, strain MP-12 with reversion mutations at those 3 sites was still highly at

95 Conclusion Reversion mutations can be detected in an unbiased analy

96 goal of this study was to determine whether reversion mutations could be found in an unbiased manner

97 Reversion mutations were only detected in tumor samples

98 combination (HR), which can result from BRCA reversion mutations.

99 cient tumour cells that do not develop Brca2 reversion mutations.

100 in-resistant clones did not harbor secondary reversion mutations; rather, PARPi and platinum resistan

101 However, secondary intragenic (reversion) mutations that restore protein function lead

102 uth, and Central Asia) could necessitate the reversion of 20-60 Mha of cropland from irrigated to rai

103 Otherwise, reversion of 2Q was found to occur at higher temperature

104 The activation barriers for thermal reversion of 2Q-4Q, as determined from Arrhenius and Eyr

105 Reversion of 5-HT7 blockade was performed by intraperito

106 Importantly, naive reversion of a broad repertoire of conventional hiPSCs r

107 nitial designs failed to fold correctly, but reversion of a small number of mutations indicated by ba

108 leading to inhibition of self pollen or for reversion of A. thaliana to its fully self-incompatible

109 We observed that reversion of amino acid 375 to a serine (H375S) resulted

110 psychomotor development, along with dramatic reversion of biochemical abnormalities.

111 s restored in advanced prostate cancers upon reversion of both repressive signals.

112 Genetic reversion of BRCA1-inactivating mutations can be the und

113 tin-specific mutation types as causes of the reversion of BRCA2 mutations in emerging cisplatin-resis

114 , cisplatin-resistant clones lacking genetic reversion of BRCA2 show de novo loss of CHD4 expression

115 , in vitro and in vivo, results in long-term reversion of CAF-associated proinvasive activity and res

116 We document the reversion of CGD inflammatory status by the mammalian ta

117 ating mouse heart revealed a transcriptional reversion of CM differentiation processes, including rea

118 hese results show that BMP signaling enables reversion of committed populations to a stem-like state,

119 gh, and one strain accommodated the complete reversion of CUG identity from Ser back to Leu.

120 We evaluated phenotypic reversion of deoptimized human respiratory syncytial vir

121 r differentiation of stem cells, or to cause reversion of differentiated cells to stem cells.

122 Spontaneous reversion of disease-causing mutations has been observed

123 effects in vitro and in vivo, including the reversion of EMT, the loss of TIC-mediated clonogenic co

124 GC specification, it is not required for the reversion of epiSCs to ESCs and for their maintenance th

125 We found that it induces reversion of epithelial to mesenchymal transition.

126 ally were those with enhanced fitness due to reversion of escape mutations.

127 rge (i.e., compensatory substitutions versus reversion of existing attenuating mutations).

128 we identified a prominent hydrophobic patch; reversion of four hydrophobic residues in this patch to

129 throid differentiation program, leading to a reversion of gamma-globin silencing in adult human eryth

130 Widespread reversion of genetic disease is rare; however, such even

131 traction, MV collapse to GMP, and subsequent reversion of GMP to normal microvessels, all without ext

132 We attempted site-specific reversion of hSH3BGRL amino-acid sequence to mSH3BGRL an

133 Reversion of hydrophobic residues in these patches to th

134 malized blood phenylalanine concomitant with reversion of hypopigmentation in a dose-dependent manner

135 Reversion of IGHV mutations to germline configuration re

136 naling, removal of klu function prevents the reversion of immature INPs.

137 lung metastasis, and suggest that epigenetic reversion of IRX1 activation may be beneficial for contr

138 Three clusters showed evidence of reversion of K103N or T215Y/F.

139 As with KRT10 mutations causing IWC, reversion of KRT1 mutations occurred via mitotic recombi

140 To assess the dynamics of genetic reversion of live poliovirus vaccine in humans, we studi

141 o inflammation resolution, consisting of the reversion of LPS effects on Kv and Kir currents in macro

142 metastatic breast cancer cells results in a reversion of mesenchymal-like (EMT) state to epithelial-

143 loci confirmed earlier findings and revealed reversion of methylation levels toward the non-psoriatic

144 This allows the reversion of mitophagy failure reflected in the recovery

145 Strikingly, after reversion of motor neuron identity, virtually all firing

146 pervasiveness of sign epistasis--a complete reversion of mutational effects, particularly in protein

147 is method facilitates efficient induction or reversion of mutations associated with human disease in

148 o the vacuole, providing a rationale for the reversion of nramp3nramp4 phenotypes.

149 uppressive cytokines was demonstrated by the reversion of oligomer-induced protection after in vivo b

150 from the original parental strain P1 led to reversion of P2 to the P1 phenotype.

151 that inhibit or promote photoconversion and reversion of Pfr back to Pr, thus allowing Phys to dynam

152 the outcome of global DNA demethylation with reversion of primed PSCs to the naive ground state, we u

153 on in circulating RBCs and urine, as well as reversion of skin photosensitivity on bortezomib treatme

154 Results showed the successful in vitro reversion of such an activity by perturbation of in sili

155 Reversion of such epigenetic variants occurred rarely, r

156 In many cases, full reversion of the Ab-framework mutations back to germline

157 he hypothesis that the origin and subsequent reversion of the B(1) duplication are mediated by unequa

158 n suppressors of mpk4, resulted in a partial reversion of the CA-MPK3 phenotypes.

159 A biosynthesis or JA signaling led to a full reversion of the cpk28 growth phenotype, while modificat

160 tic location, many carcinoma cells display a reversion of the epithelial-to-mesenchymal transition th

161 This is indicative of reversion of the framework to the wide-channel form unde

162 tions achievable in human subjects, caused a reversion of the gene expression profile in multiple scl

163 ines to a demethylating agent caused partial reversion of the High-M phenotype and inhibition of prol

164 ls, and 5 passages in MDCK cells revealed no reversion of the I221L substitution.

165 ome patient T cells was associated with both reversion of the inactivating mutation and a variant wit

166 Reversion of the K65R increased susceptibility to tenofo

167 Although reversion of the mutation at residue 291 or 295 from tha

168 This resulted in reversion of the mutation in 10% (6.7-20.1%) of hepatocy

169 vement originated from a spontaneous genetic reversion of the MYSM1 mutation in a hematopoietic stem

170 ulation of TCV in conjunction with a partial reversion of the primary mutation (TCV-rev1) but had neu

171 kinetics experiments, we determined that the reversion of the quadricyclanes occurs via a free radica

172 We also identified an instability leading to reversion of the single mutation to a wild-type genotype

173 ty to tenofovir and other nucleosides, while reversion of the T69del showed increased resistance to z

174 Reversion of the traA mutation restored plasmid transmis

175 shRNAi lentivirus (shR-SOCS1) led to partial reversion of the tumorigenic phenotype of B16F10-Nex2 me

176 eloped TFH cells back to the T cell zone and reversion of their phenotype to non-TFH effector cells,

177 h acquired resistance to OXA, leading to the reversion of their resistant phenotype, through the inhi

178 Reversion of these CD9 changes abolished the effects of

179 expression of vimentin and c-Myc, suggesting reversion of these cells to a less differentiated state.

180 and the dynamics of CTL escape mutations and reversion of these mutations after transmission in the c

181 FR signaling, as evidenced by the pronounced reversion of these oncogenic attributes upon EGFR-specif

182 Partial reversion of these phenotypes when traces of active comp

183 d Smad7 re-expression results in significant reversion of these phenotypes.

184 ute to their progression to HCC and that the reversion of this condition may represent a possible the

185 Conversely, full reversion of virulence of BTV8H required at least five g

186 e are no systematic studies on the survival, reversion of virulence, and molecular basis for gamma-ra

187 ings offer a general strategy to control the reversion of virus to a virulent phenotype: a simultaneo

188 many recurring deletions, more specifically, reversions of an ancient hominin-specific duplication of

189 rs' relative abundances may frequently drive reversions of generalist mutualisms to autonomy.

190 d resistance, including multiple independent reversions of germline BRCA1 or BRCA2 mutations in indiv

191 None of these mutations were reversions of ML29 to the sequences of the parental Lass

192 Upon "phenotypic reversion" of malignant cells, both CAMo and spherical a

193 uencing from tissues revealed no evidence of reversion or compensatory mutations.

194 only initial sputum culture conversion, not reversion or long-term relapse.

195 s strongly inversely associated with risk of reversion (P < 0.0001).

196 odelled a newly discovered product-to-parent reversion pathway for trenbolone acetate (TBA) metabolit

197 This novel reversion phenomenon is encouraging for obtaining the [a

198 served polymerase motif A because of the low reversion potential inherent in the single UGG codon.

199 Reversion, predicted by baseline reticulocyte count >/=4

200 nonical mutations associated with phenotypic reversion present at high levels (>90%).

201 e applied a computationally guided framework-reversion procedure to two broadly neutralizing anti-HIV

202 degrees than wild-type cry1, and has a dark reversion rate 1.7 times lower than that of the wild typ

203 to dementia (10 of 36 patients [27.8%]) and reversion rate to normal cognition (7 of 36 [19.4%]).

204 ate was 0.8% (range, 0.0-2.5%), and the mean reversion rate was 17.6%.

205 Reversion rates depend strongly on conservation.

206 In contrast, during growth, the reversion rates in the three alleles tested were signifi

207 high rates of positivity and high conversion/reversion rates on retesting.

208 ST conversion concordance was higher and QFT reversion rates were lower than reported in low-burden s

209 linical significance of IGRA conversions and reversions remains to be established, repeated IGRA test

210 paths of differentiation and undergo lineage reversion, respectively, during regeneration.

211 phan auxotroph revertants and found that the reversion resulted from a synonymous G-to-A nucleotide m

212 ng proteins PCH1 and PCHL suppress phyB dark reversion, resulting in plants with dramatically enhance

213 QFT reversion risk was inversely associated with interferon-

214 risks were 14.0 and 13.0%, respectively, and reversion risks were 5.1 and 4.1%, respectively.

215 se design did not rely on prior knowledge of reversion sequences.

216 lts in a greater propensity for 17alpha-TBOH reversion than 17beta-TBOH.

217 Moreover, any pseudo-reversion that restored the dynamics of the pore regions

218 B2-T271A, PB2-D701N, HA-V195I, and PB2-E627K reversion) that may enhance viral replication in pigs.

219 into PhyB confers robust Pfr --> Pr thermal reversion, that assembled with the cyanobacterial versio

220 in cfDNA from patients with a tumor-detected reversion (three of five).

221 cell fates is more probable and feasible via reversion to a developmentally immature state.

222 efractoriness to key metabolic hormones, and reversion to a fetal-like gene expression pattern.

223 Loss of XOR then results in a reversion to a more rudimentary, less efficient, apocrin

224 Such changes are consistent with reversion to a more stem-like state upstream of cancerou

225 resent another form of tumor plasticity with reversion to a neural crest cell migratory phenotype.

226 ition of STAT3 or SMAD3 resulted in a marked reversion to a non-invasive, epithelial phenotype.

227 nt basal-like cell lines, and decreased upon reversion to a nonmalignant phenotype.

228 Reversion to a quiescent NK-cell phenotype was associate

229 the potential for infections arising from a reversion to a virulent form in live pathogens, unproduc

230 fusions restarted immediately in the case of reversion to abnormal velocities.

231 Lentiviral knockdown of MBNL3 resulted in reversion to an embryonic alternative splice isoform pro

232 In summary, MBNL3 down-regulation-related reversion to an embryonic alternative splicing program,

233 ine candidate in chicken eggs can select for reversion to avian receptor preference.

234 using zero-error-clamp trials has shown that reversion to baseline is not obligatory and can be overc

235 as interplay between learning from error and reversion to baseline, a form of forgetting.

236 nsitivity of eer5-1 and are at least in part REVERSION TO ETHYLENE SENSITIVITY 1 (RTE1)-dependent, er

237 Mutations at the Green-ripe (Gr) and reversion to ethylene sensitivity1 (rte1) loci, which en

238 n in adults induced severe heart failure and reversion to fetal splicing and gene expression patterns

239 We developed a fluctuation test based on reversion to fluorescence in a set of virally encoded mu

240 under nonselective conditions, as phenotypic reversion to fluorescence requires only either a single-

241 ccumulation of myelin proteins, and causes a reversion to less mature stages.

242 de an escape from specialist pollination via reversion to more generalist pollination strategies.

243 that occurs in pre-implantation embryos and reversion to naive ground state pluripotent stem cells (

244 lopment (when Celf1 is downregulated) show a reversion to neonatal splicing patterns after Celf1 re-e

245 onths times 2, then annually unless there is reversion to nondysplastic Barrett's esophagus.

246 This reversion to normal activity of a truncated 5-HT2B recep

247 origin, served as an intermediary step in MV reversion to normal microvessels.

248 Reversion to normal rhythm was associated with QT prolon

249 cle conjugates targeting IKKbeta resulted in reversion to normoglycemia in 50% of streptozotocin-indu

250 ic pH, which is the only condition where its reversion to parent TBA metabolite occurred.

251 ells are susceptible to inflammation-induced reversion to pathogenic effector T cells.

252 for attenuation raise the prospect of facile reversion to pathogenicity.

253 d in experimentally infected chickens, where reversion to PB2 627E occurred.

254 table during virus propagation, resulting in reversion to PB2 627E or the accumulation of the additio

255 muropeptides, deletion of MurM results in a reversion to penicillin sensitivity in strains that were

256 henotype is modulated by NUC therapy and its reversion to quiescence mirrors efficient HBV-specific T

257 However, repeated reversion to scheduled insecticide applications has resu

258 te of reversion and a lower probability that reversion to sensitivity on the population level occurs

259 observed across all dosage regimens; partial reversion to susceptibility was observed in 6 of 8 bacte

260 Reversion to the 'dry seed' state of DNA methylation upo

261 is coincides with their facilitation of UVR8 reversion to the ground state by redimerization and thei

262 However, upon reversion to the original feeder-based culture condition

263 instead result in mtDNA genotypic drift and reversion to the original genotype.

264 product with visible wavelengths results in reversion to the parent Os(VIII) complex.

265 the molecular tags are highly stable with no reversion to the parental sequence detected in >2 years

266 in creating an evolutionary barrier against reversion to the pathogenic genotype.

267 l dehydration in dark conditions, leading to reversion to the primary cycloaddition photoproduct on a

268 is competitive with C-O cleavage, leading to reversion to the protonated reactant to varying degrees

269 CV subpopulation by reducing the rate of SCV reversion to the wild type.

270 of the E182D mutant with IDI-6273 yielded a reversion to the wild-type protein sequence and phenotyp

271 e of MLV as a vaccine virus due to the rapid reversion to virulence during replication in pigs.

272 ations responsible for the attenuation of or reversion to virulence during this evolutionary process.

273 However, reversion to virulence has been demonstrated in several

274 sion mutation will less likely cause a major reversion to virulence of the MP-12 vaccine.

275 reversion mutation is less likely to cause a reversion to virulence of the MP-12 vaccine.

276 e stability of live vaccines and the risk of reversion to virulence.

277 raising concerns regarding the potential for reversion to virulence.

278 s towards gynodioecy (n = 11), but also many reversions to nongynodioecy (n = 29).

279 hanges in the chimpanzee clade, and all were reversions to the ancestral condition.

280 frequently evolved also have a high rate of reversions to the nongynodioecious state.

281 ATED1, physically interacts with Arabidopsis REVERSION-TO-ETHYLENE SENSITIVITY1 (RTE1), an ethylene r

282 east assay, we found that maize RTE1 homolog REVERSION-TO-ETHYLENE SENSITIVITY1 LIKE4 (ZmRTL4) and Zm

283 signaling protein ETHYLENE-INSENSITIVE2 and REVERSION-TO-ETHYLENE SENSITIVITY1 reside.

284 nt learning process that has the property of reversion toward baseline and that can suppress other fo

285 Reversions towards the ancestral HIV-1 sequence are obse

286 Increased rates of thermal reversion upon exposing Arabidopsis seedlings to warm en

287 This phenotypic reversion was accelerated by anti-inflammatory therapy.

288 A reversion was also obtained with the triple mutant N12S/

289 isk was not significantly increased, and QFT reversion was common, following QFT conversion at interf

290 However, reversion was found at all mutated sites within five vir

291 In the case of NpF2164g7, dark reversion was so rapid that reverse photoconversion of t

292 solution size, photoconversion, and thermal reversion, we identified both proximal and distal featur

293 Higher degrees of reversion were associated with recombination-mediated re

294 Conversion and reversion were not associated with HIV status.

295 located in genomic islands, although genetic reversions were also observed.

296 Patients who had reversions were older and had less severe allergic disea

297 ation of 1 individual indicated that somatic reversions were postnatally selected.

298 occurred in 9% (n = 63 of 718), whereas IGRA reversions were seen in 33% (n = 25 of 76) of individual

299 ves under noninductive conditions and floral reversion when shifted from inductive to noninductive co

300 h 50% frequency, followed by an N332-to-N334 reversion, which took 66 weeks.