ライフサイエンスコーパス: rheostat

1 hose in the N-lobe are stiff, analogous to a rheostat.

2 lation of mVEGFR1 in its role as a molecular rheostat.

3 tions as an oxygen-dependent transcriptional rheostat.

4 this family of two-component systems exhibit rheostat activity that likely confers versatility as mic

5 This class of siRNA may act broadly as a rheostat allowing prolonged stimulation to dampen gene e

6 m of copy number control acts as a molecular rheostat, allowing high levels of retrotransposition whe

7 e predictors requires distinguishing between rheostat and toggle positions.

8 Glutamylation acts as a rheostat and tunes microtubule severing as a function of

9 any toggle positions are conserved, and most rheostats are not, predictors appear to annotate positio

10 This Rop signal transduction rheostat balances the ability to increase ethanolic ferm

11 opose that Blimp-1 acts as a transcriptional rheostat balancing effector function and T cell exhausti

12 gesting that the ESL operates as a conserved rheostat between long inverted repeats upstream of each

13 We demonstrate that Bim acts as a molecular rheostat by controlling macrophage function not only in

14 Thus, this pathway acts as a 'rheostat' by translating TCR signal strength via graded

15 Most importantly, this rheostat can be reprogrammed experimentally.

16 mide levels could act as a general apoptotic rheostat controlling cell survival by regulating PI(3)K

17 rtum, the normalization of the physiological rheostat controlling IFN signaling depends on IFNL3 geno

18 MHC-I-bound peptide functions as a molecular rheostat controlling NK cell function.

19 ge itself, miR-223 functions as an important rheostat controlling NLRP3 inflammasome activity.

20 We propose that Rap1 acts as a rheostat controlling nucleotide pools in response to sho

21 r findings implicate eIF5A as a cytoskeletal rheostat controlling RhoA/ROCK protein expression during

22 ulation through REDD1/TXNIP is physiological rheostat controlling stress-induced autophagy.

23 otein Ambra1 as the first described 'spatial rheostat' controlling the Src/FAK pathway.

24 These results show that the SPHK rheostat does not play a major role in tumor cell viabil

25 missing regulatory link that controls the SL rheostat during the cell cycle.

26 1a acts as an intrinsic antigen sensitivity "rheostat" during T cell development.

27 findings provide a molecular mechanism for a rheostat effect of increasing or decreasing RANTES expre

28 interplay between Zfp521 and Ebf1 as a novel rheostat for bone homeostasis.

29 Therefore, FGF21 is a critical rheostat for bone turnover and a key integrator of bone

30 ate that hypoxia-inducible mir-210 acts as a rheostat for cellular adaptation and survival by inhibit

31 These findings identify a cell-intrinsic rheostat for destabilizing ground-state pluripotency to

32 a model wherein tumor eHsp90 functions as a rheostat for EZH2 expression and activity to orchestrate

33 ted molecules with the potential to act as a rheostat for fetal Vdelta2 cells.

34 the notion of the existence of a biological rheostat for lymphocyte homing.

35 uences, but can also function as a molecular rheostat for maintaining oncogene expression at optimal

36 C1-Plzf functional interaction as a critical rheostat for maintenance of the spermatogonial pool and

37 energy supply/demand and thereby, serve as a rheostat for mitochondrial nutrient utilization.

38 RNMT, allowing it to function as a molecular rheostat for mRNA cap methylation.

39 ents, we found that PGE2 signaling acts as a rheostat for muscle stem-cell function.

40 Thus, GBP5 serves as a unique rheostat for NLRP3 inflammasome activation and extends o

41 182's gene silencing activity functions as a rheostat for PDFR signaling and thus profoundly impacts

42 RasGTP-SOS feedback loop that functions as a rheostat for Ras activity.

43 and argue that Sox2 functions as a molecular rheostat for the control of a key transcriptional regula

44 ose--has evolved in eukaryotes to serve as a rheostat for the Hsp90 chaperone machine.

45 HP-1 competition for Ly108 ITSM binding as a rheostat for the magnitude of T cell help to B cells.

46 fine-tune Nodal output, acting as a specific rheostat for the Nodal/TGFbeta pathway during the earlie

47 us genetic programs and serve as pleiotropic rheostats for diverse physiological processes.

48 Srcasm may act as a molecular "rheostat" for activated SFKs, and cellular levels of Src

49 Variable phosphorylation thus serves as a "rheostat" for cell signaling to fine-tune transcription

50 0, whose inducible expression provides for a rheostat function by which other inflammatory stimuli ca

51 gs and their different potentials to serve a rheostat function for integrating fluctuating hormone le

52 as PD-1 and LAG-3 seem to serve more subtle rheostat functions.

53 than H2(b) mice, providing evidence that the rheostat hypothesis regarding Ly49 affinities for MHC an

54 ments suggest that AhR serves as a molecular rheostat in B cells to brake the effector response, poss

55 ole for the ceramide/sphingosine-1-phosphate rheostat in maintaining lung cell survival, vascular bar

56 ciated role for decoy receptors as molecular rheostats in controlling the timing and extent of GPCR-m

57 monstrate that mTORC1 acts as a fundamental 'rheostat' in T(reg) cells to link immunological signals

58 opose that downhill folders may be molecular rheostats, in which effects could be modulated by alteri

59 This report demonstrates that this rheostat is an evolutionarily conserved stress-regulator

60 The ceramide-sphingosine 1-phosphate (S1P) rheostat is important in regulating cell fate.

61 at NK cell responsiveness is comparable to a rheostat: it is tuned to an optimal set point depending

62 cule, TGFbeta1-induced-1, which is a TGFbeta-rheostat known to have antagonistic effects on the endot

63 linker whose conformational state exercises rheostat-like control over the kinase activity.

64 titution at position 311 (T311M) suggested a rheostat-like function.

65 Pin1's effect, however, suggests a rheostat-like influence on Rta function.

66 DNA-binding protein MECP2 and functions in a rheostat-like manner to fine-tune the cell-type-specific

67 tory interactions that can be unmasked, in a rheostat-like manner, by coincident regulatory factors t

68 tatively controlling promoter occupancy in a rheostat-like manner.

69 ariation in leaf shape can be created with a rheostat-like mechanism that alters the KNOX1 protein in

70 hat the level of FLC activity acts through a rheostat-like mechanism to control flowering time in Ara

71 Here we describe a new rheostat-like mechanistic relationship between PKM2 acti

72 at acetylation and deacetylation provide the rheostat-like regulation for the cytokine receptor PRLR

73 different partners and generate a graded or rheostat-like response to phosphorylation.

74 dPDZ-GEF-dependent signaling functions as a rheostat linking Rap activity to the regulation of cell

75 cytoplasmic process regulated by the energy rheostats mammalian target of rapamycin and AMP kinase (

76 ell types, and resetting of the ceramide/SPP rheostat may account for the pro-apoptotic effects of DM

77 to metabolic challenges, yet this metabolic rheostat may be downregulated under conditions of signif

78 evels of ceramide and S1P (the "ceramide/S1P rheostat") may determine cell survival, we investigated

79 A graded rheostat mechanism obtained when either transactivators

80 These results are explained by a rheostat mechanism whereby CD45 differentially regulates

81 rization in asthmatic patients and propose a rheostat model of barrier dysfunction that implicates th

82 This study supports a rheostat model of Merlin in NHERF1 binding and contribut

83 The rheostat model suggests that both genetic and epigenetic

84 e results are consistent with the "molecular rheostat" model for RRE function, which suggests that Re

85 main potassium channel, KCNK3, as a built-in rheostat negatively regulating thermogenesis.

86 than rheostat non-neutrals, while toggle and rheostat neutrals were incorrectly predicted to be diffe

87 ever, toggle non-neutrals were distinct from rheostat neutrals.

88 correctly predicted as more non-neutral than rheostat non-neutrals, while toggle and rheostat neutral

89 we discovered that TBX1 acts as an intrinsic rheostat of BMP signalling: it is a gatekeeper that gove

90 e c-FLIP is a good candidate for a molecular rheostat of caspase-8 activity.

91 cotransporters, and functions as a molecular rheostat of cell volume in the mammalian brain.

92 cific phosphatase cofactor activity can be a rheostat of cellular homeostasis that initiates a functi

93 propose that SIRT1 functions as an enzymatic rheostat of circadian function, transducing signals orig

94 d functional genomics approach to identify a rheostat of DNA and RNA sensing-the inflammasome compone

95 lly, we identify SOX9 as a crucial chromatin rheostat of hair follicle stem cell super-enhancers, and

96 ts demonstrate that mTOR acts as a molecular rheostat of NK cell reactivity controlled by educating r

97 cancer progression by serving as the common rheostat of Stat-3 and Wnt-signaling activation.

98 tions and membrane topology, is an important rheostat of T-cell signaling.

99 GRP78 is the rheostat of the ER stress transducers.

100 Our findings identify FOXO1 as a critical rheostat of vascular expansion and define the FOXO1-MYC

101 ession genome-wide by acting as a 'molecular rheostat' of target genes.

102 hether the protein sequence position class - rheostat or toggle - affects these predictions.

103 utions at toggle positions are binary, while rheostat positions show progressive changes.

104 The data indicate that p120 acts as a rheostat, promoting a sessile cellular phenotype when as

105 it to serve as a phosphorylation-controlled rheostat, providing a new paradigm for regulating the af

106 Thus, PDGFRalpha signaling acts like a rheostat rather than generic ON switch, with signal stre

107 ion, suggesting that BACH1 may function as a rheostat regulating levels of intracellular free heme.

108 refore, S1P can function as an extracellular rheostat regulating tonic and acutely evoked functions.

109 Thus, NK cells can act as rheostats, regulating CD4 T-cell-mediated support for th

110 o play a cell-autonomous role as a migratory rheostat restricting migration of D6-expressing cells su

111 We propose a rheostat role for HIF-2alpha that allows for the mainten

112 Our data reveal LSD1 as a molecular rheostat selectively regulating H3K9 demethylation at ce

113 ond to build high-performance conformational rheostat sensors.

114 We propose that NIP45 acts as a molecular rheostat serving to amplify the type-2 immune response.

115 We conclude that Six1 homeoproteins act as a rheostat system to ensure proper regeneration of the tis

116 ta herein indicate that HIV-1 uses CD81 as a rheostat that controls different stages of the infection

117 mocytes during selection constitutes a novel rheostat that controls the maintenance of IL-7-expressin

118 nce cognition by interfering with the rhythm rheostat that controls the sleep/wake cycle.

119 represent an important facet of the cellular rheostat that determines survival and death decisions.

120 on is an important component of the cellular rheostat that determines susceptibility to DNA-damaging

121 ive cellular level has been proposed to be a rheostat that determines the fate of cells.

122 a model in which UPF3A serves as a molecular rheostat that directs developmental events.

123 el reveals that cytoplasmic Ca(2+) acts as a rheostat that fine-tunes autophagic and apoptotic respon

124 kinase signaling acts as a myelin thickness rheostat that instructs oligodendrocytes to generate axo

125 f rapamycin (mTOR) kinase acts as a cellular rheostat that integrates signals from a variety of cellu

126 stress and suggests that Hcm1 functions as a rheostat that integrates stimulatory and inhibitory sign

127 h an energy source and a protein-translation rheostat that is responsive to WNT and suggest that mani

128 FoxO may act as a rheostat that maintains homeostatic balance between Akt

129 AC progression by functioning as a molecular rheostat that modulates cell-ECM interactions to reduce

130 s indicate that TAZ functions as a molecular rheostat that modulates MSC differentiation.

131 r phosphorylation functions as a biochemical rheostat that modulates mTORC1 signaling in accordance w

132 our findings identify p130Cas as a molecular rheostat that regulates the delicate balance between can

133 Our results implicate SET-4 as a sensory rheostat that reinforces developmental fates in response

134 hus, acetyl-CoA functions as a carbon-source rheostat that signals the initiation of the cellular gro

135 Our work identifies RHBDL4 as a rheostat that tunes secretion dynamics and abundance of

136 cascades of modifications serve as molecular rheostats that fine-tune the control of transcription in

137 have identified a novel function for them as rheostats that modulate the strength of antigen receptor

138 We thus elucidate novel epigenetic rheostats that promote ionizing radiation hypersensitivi

139 ity, suggesting that it acts as a "molecular rheostat" that finely calibrates PRC2 functions at devel

140 AP/TAZ acting as an intracellular mechanical rheostat--that stores information from past physical env

141 oxidoreductases is thought to act as a redox rheostat, the sequence of which determines its reduction

142 According to the proposed rheostat theory, SPHK activity shifts the intracellular

143 monstrate that RECK controls this angiogenic rheostat through a novel complex with cell surface recep

144 act dynamic properties required in molecular rheostats, thus supporting a biological role for one-sta

145 d that the CP1 domain evolved as a molecular rheostat to balance multiple functions.

146 gs indicate that PR functions as a molecular rheostat to control ERalpha chromatin binding and transc

147 ong-distance trafficking of SlCyp1 acts as a rheostat to control the shoot-to-root ratio, by mediatin

148 Multisite phosphorylation thus acts as a rheostat to enhance binding to CBP/p300 and provides a p

149 cting partner that acts as a transcriptional rheostat to fine tune the expression of the fab genes ba

150 dynamic acetylation/deacetylation acts as a rheostat to fine-tune Aurora B activity during mitotic p

151 RAS/ERK signaling thus acts as a rheostat to influence neural cell fate selection in both

152 This SCA network acts as a signalling rheostat to integrate signals between dimer partners, li

153 igomerization potential serve as a molecular rheostat to precisely co-ordinate B. subtilis cell size

154 Mechanistically, USP7 acts as a molecular rheostat to precisely fine-tune endosomal F-actin levels

155 eam networks that serve as a transcriptional rheostat to regulate Etv2 gene expression.

156 hus, acetylation of chromatin functions as a rheostat to regulate pH(i) with important implications f

157 binary switch, but rather acts as a tunable rheostat to regulate replication initiation events.

158 Bub1 and Sgo1 act as a rheostat to regulate the chromatin spring and maintain f

159 20(ctn) may accomplish this is to serve as a rheostat to regulate the levels of cadherin.

160 5-HT2CR functional status acting as a neural rheostat to regulate, in part, the intersection between

161 ivation of the calcineurin pathway acts as a rheostat to shape both the phenotype and effector potent

162 differential phosphorylation, SMO acts as a rheostat to translate graded HH signals into distinct re

163 microRNAs (miRNAs) function as genetic rheostats to control gene output.

164 gration, and feedback loops act as molecular rheostats to fine-tune gene expression levels and physic

165 that for most interactions microRNAs act as rheostats to make fine-scale adjustments to protein outp

166 of thrombin and that AR2 may be a "molecular rheostat" to promote thrombin inhibition in the presence

167 Disturbed migratory rheostat tone could account for variations in interindiv

168 ed feedback from adaptive immunity engages a rheostat, TYRO3, on innate immune cells to limit the int

169 We show that the RNA thermometer acts as a rheostat, whose stability is optimized to respond in a s

170 er, the results support a role for CD45 as a rheostat, with both positive and negative regulatory fun

171 point to a mechanism in which lncRNAs act as rheostats within lncRNA-TF gene duplex loci that buffer