ライフサイエンスコーパス: rheumatoid factor

1 psoriasis, antinuclear antibodies [ANA], and rheumatoid factor).

2 ucleoproteins (snRNPs), dsDNA, and self IgG (rheumatoid factor).

3 ng peak levels of antihistone, anti-DNA, and rheumatoid factor.

4 n of disease, level of formal education, and rheumatoid factor.

5 of symptom onset) who were seropositive for rheumatoid factor.

6 ow-affinity, polyreactive human (h)IgM/kappa rheumatoid factor.

7 Both DQ8.CD8(-/-) and DQ8 mice produced rheumatoid factor.

8 t nodules in the absence of detectable serum rheumatoid factor.

9 y stronger in patients who were positive for rheumatoid factor.

10 ted to patients whose sera were negative for rheumatoid factor.

11 ic, nuclear, and platelet autoantibodies and rheumatoid factor.

12 anti-chromatin, anti-dsDNA, anti-ssDNA, and rheumatoid factor.

13 23- B cell secreting immunoglobulin M, kappa rheumatoid factor.

14 mentation rate, C-reactive protein level, or rheumatoid factor.

15 red for the development of antichromatin and rheumatoid factor.

16 VH gene that partially encodes an anti-IgG2a rheumatoid factor.

17 reased levels of endogenous anti-DNA Abs and rheumatoid factor.

18 inatus correlated with the presence of ACPAs/rheumatoid factor.

19 trullinated peptide (anti-CCP) antibody, and rheumatoid factor.

20 -cyclic citrullinated peptide (anti-CCP) and rheumatoid factor.

21 evels of anti-dsDNA, anti-chromatin, and IgM rheumatoid factors.

22 ing to the pathogenic potential of 6-19 IgG3 rheumatoid factors.

23 Anti-CCP2 had greater specificity than rheumatoid factor (96% vs. 86%), with similar sensitivit

24 ma cells producing an IgG3 cryoglobulin with rheumatoid factor activity against IgG2a of allotype a p

25 profile, level of alanine aminotransferase, rheumatoid factor activity, C4 fraction of complement, a

26 -69 encoded antibodies that have anti-IgG or rheumatoid factor activity.

27 te in women and more frequent positivity for rheumatoid factor among both men and women.

28 t circulating autoantibodies, including both rheumatoid factor and anti-citrullinated protein antibod

29 he ability of baseline serum measurements of rheumatoid factor and anti-cyclic citrullinated peptide

30 Although, reduced titers of rheumatoid factor and anti-cyclic citrullinated peptide

31 x studies examined outcome predictions using rheumatoid factor and antikeratin/anticyclic citrullinat

32 mmation, and autoantibodies (particularly to rheumatoid factor and citrullinated peptide).

33 Rheumatoid factor and complement C4 levels were normal i

34 ve B cells producing antinuclear antibody or rheumatoid factor and exhibit the skewed Ig V gene reper

35 Rheumatoid factor and SE were also predictors to a lesse

36 e, disease duration, and baseline values for rheumatoid factor and the tender and swollen joint count

37 imited range of motion (1 point), absence of rheumatoid factor and/or anti-citrullinated protein anti

38 aracteristics of IgG binding by gE-gI and by rheumatoid factors and bacterial Fc receptors such as St

39 high-sensitivity C-reactive protein (hsCRP), rheumatoid factor, and anti-citrullinated protein antibo

40 a combination of the CSQ, joint examination, rheumatoid factor, and anti-cyclic citrullinated peptide

41 ogic studies for antinuclear antibody (ANA), rheumatoid factor, and antibodies to extractable nuclear

42 A combination of age, sex, smoking, rheumatoid factor, and anticyclic citrullinated peptide

43 Serum IgE, rheumatoid factor, and antinuclear antibodies and skin s

44 High mean platelet volume, positive rheumatoid factor, and antinuclear antibodies were all s

45 on rate, hemoglobin, white count, platelets, rheumatoid factor, and antinuclear factor.

46 une features such as hypergammaglobulinemia, rheumatoid factor, and circulating immune complexes are

47 d for optimal production of IgG autoAbs, IgM rheumatoid factor, and other clinical parameters of dise

48 sociated with serum anti-SSA/SSB positivity, rheumatoid factor, and the ocular component of SS, but n

49 with childhood-onset RA, which is defined as rheumatoid factor- and/or anti-citrullinated protein ant

50 including anti-DNA, anti-Smith antigen, and rheumatoid factor; and glomerulonephritis.

51 No association with rheumatoid factor, anti-cyclic citrullinated peptide, or

52 YYAA mice, like SKG mice, develop rheumatoid factor antibodies, but fail to develop autoim

53 otein, erythrocyte sedimentation rate (ESR), rheumatoid factor, anticitrullinated protein antibodies

54 idence of interaction between the effects of rheumatoid factor, antinuclear antibodies, positive skin

55 looked for a broad range of autoantibodies (rheumatoid factor, antinuclear antibody, smooth muscle a

56 The frequency of rheumatoid factor at 3 years postinfection was 29.5% and

57 us nodules or finger clubbing, low titers of rheumatoid factor at onset of lung disease, lymphocytosi

58 more severe lupus, as judged by anti-DNA and rheumatoid factor autoantibodies, total serum Ig isotype

59 D88, had markedly reduced chromatin, Sm, and rheumatoid factor autoantibody titers.

60 pendent autoreactive EF response elicited in rheumatoid-factor B cells by DNA-containing immune compl

61 n non-B cells, we transferred anti-self-IgG (rheumatoid factor) B cells and their physiologic target

62 i-IgG2a rheumatoid factor, but not 46-42 IgA rheumatoid factor bearing the same IgA allotype, develop

63 ents have clonal expansions of hypermutated, rheumatoid factor-bearing marginal zone-like IgM(+)CD27(

64 rence from other serum proteins, prealbumin, rheumatoid factor, bilirubin, estrogen, or C-reactive pr

65 tive binding to ssDNA, dsDNA, and IgG (i.e., rheumatoid factor), but not to histones or Sm.

66 with hybridoma secreting 6-19 IgA anti-IgG2a rheumatoid factor, but not 46-42 IgA rheumatoid factor b

67 ndent Ags, including 23 anti-HIV mAbs and 51 rheumatoid factors, but differed from that of 43 Abs to

68 Mice with FIA possess rheumatoid factor, circulating immune complexes, and ant

69 tions such as the presence of high levels of rheumatoid factors, circulating immune complexes, anti-D

70 o arthritis-related self proteins, including rheumatoid factor, citrullinated peptide, and type II co

71 rent, and the VH and V kappas encoding these rheumatoid factors contained a high frequency of somatic

72 o patients randomized to receive MTX who had rheumatoid factor data.

73 Monoclonal 6-19 IgG3 anti-IgG2a rheumatoid factor derived from lupus-prone MRL-Fas(lpr)

74 phenotype studies, anti-nuclear antibody and rheumatoid factor determinations, marrow cytogenetics, a

75 l IgG, IgG anti-chromatin, anti-DNA, and IgM rheumatoid factor directed against IgG1 and against IgG2

76 stations in terms of increased production of rheumatoid factors due to TLR ligation on B cells.

77 rted cells, we show that these predominantly rheumatoid factor-encoding V(H)1-69/J(H)4 and V(kappa)3-

78 of severe human RA, including production of rheumatoid factor, enhanced T cell production, and monoc

79 The presence of IgG rheumatoid factor (IgG-RF) preceded the development of a

80 The presence of IgM rheumatoid factor (IgM-RF), IgG-RF, IgA-RF, and IgG anti

81 o histones (H1-H5) and chromatin and for IgM rheumatoid factors (IgM-RFs).

82 Small IgG rheumatoid factor immune complexes may provide the trigg

83 ied the presence of these autoantibodies and rheumatoid factor in blood donors who later developed rh

84 electively binds IgG molecules, an important rheumatoid factor in RA.

85 It is characteristic that the rheumatoid factor in serum is absent.

86 y (accumulation of anti-dsDNA antibodies and rheumatoid factor in serum, deposits of IgG and IgM in k

87 tions support a model for the origin of some rheumatoid factors, in which they represent anti-idiotyp

88 gion of mouse IgA and suggests that 6-19 IgA rheumatoid factor-induced GN could serve as an experimen

89 The rheumatoid factor is characteristically absent in the se

90 citrullinated peptide antibodies and/or >/=2 rheumatoid factor isotypes (a profile that is 96% specif

91 ambda(s) 29.5), leukocytosis (lambda(s) 25), rheumatoid factor (lambda(s) 11.0), anemia (lambda(s) 1.

92 otein level, erythrocyte sedimentation rate, rheumatoid factor level, tender joint count in 68 joints

93 IgG rheumatoid factor levels were significantly lower in the

94 ctive B cells in BALB/c AM14 transgenic (Tg) rheumatoid factor mice are not subject to central or per

95 The monoclonal rheumatoid factors (mRF) that bear the WA cross-idiotype

96 ing hyper IgM (n = 9), hyper IgG (n = 8), or rheumatoid factor (n = 55) did not cross-react with the

97 rheumatoid factor positive and 42 (40%) were rheumatoid factor negative.

98 Seven rheumatoid factor-negative JRA patients with polyarticul

99 In 358 children with oligoarthritis and rheumatoid factor-negative polyarthritis, erythrocyte se

100 of juvenile idiopathic arthritis (JIA), IgM rheumatoid factor-negative polyarticular JIA and oligoar

101 the most common subtypes (oligoarticular and rheumatoid factor-negative polyarticular JIA), and 13,05

102 with persistent oligoarticular JIA, 45 with rheumatoid factor-negative polyarticular JIA, and 20 wit

103 g); the donor was the patient's HLA-matched, rheumatoid factor-negative sister.

104 ssion analysis determined that psoriasis and rheumatoid factor negativity were the most important fea

105 otein level, erythrocyte sedimentation rate, rheumatoid factor, nodular disease, modified Health Asse

106 t the Health Assessment Questionnaire score, rheumatoid factor, nodules, and swollen joint counts wer

107 Blood chemistry tests revealed a rheumatoid factor of 8.5 IU/mL (normal range, 0-13.9 IU/

108 marker for serodiagnosis of acute infection, rheumatoid factor often causes false-positive reactions.

109 urface of T cells, except in the presence of rheumatoid factor or activated monocytes.

110 rheumatoid arthritis (RA) include those with rheumatoid factor or anti-citrullinated protein antibody

111 CFA was also associated with the presence of rheumatoid factor or antinuclear antibodies, but not wit

112 /lpr mice; however, they did not develop IgG rheumatoid factors or anti-dsDNA, and lacked histologic

113 duction of antibodies to autoantigens (e.g., rheumatoid factor) or exogenous antigens, or it may repr

114 re disease progression, including a positive rheumatoid factor, or anti-cyclic citrullinated peptide

115 IgG deposition, levels of anti-dsDNA Ab and rheumatoid factor, or spleen weights between the two gro

116 Nevertheless, B cells representative of this rheumatoid factor population proliferate vigorously in r

117 Sixty-four (60%) RA cases were rheumatoid factor positive and 42 (40%) were rheumatoid

118 Children, especially girls, with rheumatoid factor positive polyarticular juvenile idiopa

119 -reactive protein level 42 mg/liter, and 65% rheumatoid factor positive).

120 Sixty percent of the patients with RA were rheumatoid factor positive.

121 All patients were rheumatoid factor positive.

122 69% of whom were female and 66% of whom were rheumatoid factor positive.

123 time of initiation of HCQ treatment (31-43% rheumatoid factor positive; no previous disease-modifyin

124 E) alleles were significantly more common in rheumatoid factor-positive (RF+) patients fulfilling the

125 iduals, Toxoplasma IgG-negative individuals, rheumatoid factor-positive persons, and persons determin

126 of peripheral blood CD34+,CD45+ HPCs from 63 rheumatoid factor-positive RA patients and 48 controls m

127 n and 1.7% for men, and the lifetime risk of rheumatoid factor-positive RA was 2.4% for women and 1.1

128 Adolescent girls with polyarticular rheumatoid factor-positive subtype appear to be most vul

129 other self-report items, was associated with rheumatoid factor positivity (P = 0.047) and higher dise

130 proved significance when modeling DRB1*04 or rheumatoid factor positivity as covariates.

131 It was shown that rheumatoid factor positivity does not exclude a diagnosi

132 positive predictive value (PPV) (80.0%), and rheumatoid factor positivity the lowest (44.6%).

133 adjustment for CVD risk factors, joint pain, rheumatoid factor positivity, and inflammatory markers (

134 te models, the mean ESR, mean grip strength, rheumatoid factor positivity, and tender joint count wer

135 as no significant association with male sex, rheumatoid factor positivity, or erosive disease.

136 ge, sex, body mass index (BMI), smoking, and rheumatoid factor positivity.

137 er adjusting for age, sex, BMI, smoking, and rheumatoid factor positivity.

138 rmalities including antinuclear antibody and rheumatoid factor positivity.

139 ful in establishing the diagnosis of RA, but rheumatoid factor potentially provides the most useful p

140 We have previously shown that rheumatoid factors produced by Fas-deficient autoimmune-

141 that iNKT cells suppress IgG anti-DNA Ab and rheumatoid factor production and reduce IL-10-secreting

142 ain whether the combination of anti-CCP2 and rheumatoid factor provides additional benefit over anti-

143 indings of others that while the spontaneous rheumatoid factor response of lpr/lpr mice was oligoclon

144 ion pathways at early and late stages of the rheumatoid factor response.

145 B6-derived B cells produced more rheumatoid factor (RF) against their own IgG2b(b), while

146 Rheumatoid factor (RF) and anti-CCP were measured in ser

147 Rheumatoid factor (RF) and anti-cyclic citrullinated pep

148 Rheumatoid factor (RF) and autoantibodies against cyclic

149 Blood was obtained and analyzed for rheumatoid factor (RF) and CRP concentration.

150 Cigarette smoking is known to increase rheumatoid factor (RF) and nodule formation in patients

151 Serum rheumatoid factor (RF) and other heterophilic antibodies

152 linical surrogates to substitute for missing rheumatoid factor (RF) and radiologic erosion data was a

153 prone MRL-lpr/lpr (MRL-lpr) background, AM14 rheumatoid factor (RF) B cells are activated, differenti

154 Rheumatoid factor (RF) B cells function as highly effici

155 AM14 rheumatoid factor (RF) B cells in the MRL/lpr mice are a

156 High-affinity pathologic rheumatoid factor (RF) B cells occur in autoimmune disea

157 Rheumatoid factor (RF) B cells proliferate during second

158 The proliferative response of autoreactive rheumatoid factor (RF) B cells to mammalian chromatin-co

159 ortant insights on RA and on the function of rheumatoid factor (RF) become apparent.

160 an diseases, autoreactive B cells expressing rheumatoid factor (RF) binding activity are prominent.

161 -cyclic citrullinated peptide (anti-CCP) and rheumatoid factor (RF) has been established.

162 In this study, we show in rheumatoid factor (RF) Ig-transgenic autoimmune-prone mi

163 .6 years prior to diagnosis) were tested for rheumatoid factor (RF) isotypes, anti-cyclic citrullinat

164 ept significantly reduced immunoglobulin and rheumatoid factor (RF) levels, but not anti-citrullinate

165 Here, using AM14 site-directed transgenic rheumatoid factor (RF) mice, we report that B cells can

166 k was higher among patients with RA who were rheumatoid factor (RF) positive (HR 2.59, 95% CI 1.95-3.

167 l as for the subgroups who were and were not rheumatoid factor (RF) positive at baseline.

168 s with early inflammatory arthritis who were rheumatoid factor (RF) positive, but were predictive in

169 Sixty-three percent were rheumatoid factor (RF) positive.

170 e swollen joints (8 versus 7), more frequent rheumatoid factor (RF) positivity (93% versus 84%), high

171 population studies have suggested that both rheumatoid factor (RF) production and rheumatoid arthrit

172 Rheumatoid factor (RF) production in rheumatoid arthriti

173 Rheumatoid factor (RF) production was found to be associ

174 study was to define the structural basis for rheumatoid factor (RF) specificity and for the expressio

175 In separate analyses, we corrected for rheumatoid factor (RF) status and/or the presence of the

176 The rheumatoid factor (RF) status, C-reactive protein levels

177 Urinalysis and rheumatoid factor (RF) tests were conducted to evaluate

178 viral titers of WB and Pl, percentage of CP, rheumatoid factor (RF) titer, and serum alanine transami

179 osoma parasites, heterophile antibodies, and rheumatoid factor (RF) titers.

180 We have analyzed B cell tolerance in a rheumatoid factor (RF) transgenic mouse model.

181 Patients with RA who were seropositive for rheumatoid factor (RF) were more likely to have moderate

182 eline specimens, we measured serum anti-CCP, rheumatoid factor (RF), and antinuclear antibody in a de

183 ous combinations of ICD code 714, a positive rheumatoid factor (RF), and prescription for a disease-m

184 to cyclic citrullinated peptide (anti-CCP), rheumatoid factor (RF), and the 620W PTPN22 allele.

185 Autoantibodies, including rheumatoid factor (RF), are an important characteristic

186 Rheumatoid factor (RF)-expressing B lymphocytes in norma

187 persistent oligoarticular and polyarticular rheumatoid factor (RF)-negative juvenile idiopathic arth

188 Rheumatoid factor (RF)-negative patients with exposure t

189 an biomarkers for the classification of both rheumatoid factor (RF)-positive and negative RA patients

190 he onset of rheumatoid arthritis (RA) in 182 rheumatoid factor (RF)-positive European American patien

191 ), particularly in those with polyarticular, rheumatoid factor (RF)-positive JRA.

192 Patients ages 2-18 years with rheumatoid factor (RF)-positive or RF-negative polyarthr

193 ll-cause and CVD mortality were increased in rheumatoid factor (RF)-positive patients and in this sub

194 when restricted to more seriously affected (rheumatoid factor (RF)-positive) patients.

195 IgG) make a class of autoantibodies known as rheumatoid factor (RF).

196 the severity of rheumatoid arthritis than is rheumatoid factor (RF).

197 zyme-linked immunosorbent assay [ELISA]) and rheumatoid factor (RF; by nephelometry or ELISA for IgA,

198 ism, and approximately 16% were positive for rheumatoid factor (RF; including isotypes) and/or anti-c

199 Rheumatoid factors (RF) and the disease-specific anti-ci

200 Rheumatoid factors (RF) associated with arthritic joint

201 Rheumatoid factors (RF) recognize conformational determi

202 Half of 30 human polyclonal IgM rheumatoid factors (RF) showed positive ELISA reactions

203 tibodies including IgA-, IgM-, and IgG-class rheumatoid factors (RF), and of antibodies to cyclic cit

204 tended oligoarthritis, polyarthritis (either rheumatoid factor [RF] positive or RF negative), or syst

205 stemic inflammation and RA disease severity (rheumatoid factor [RF] seropositivity, erythrocyte sedim

206 B cells with specificity for self-IgG2a (the rheumatoid factor [RF] specificity) to understand how no

207 isit for any of 5 RA-related autoantibodies (rheumatoid factor [RF], anti-cyclic citrullinated peptid

208 , 42 with persistent oligoarthritis, 45 with rheumatoid factor [RF]-negative polyarthritis, and 21 wi

209 Rheumatoid factors (RFs) are a dominant class of autoant

210 mapped the specificity of 28 monoclonal IgM rheumatoid factors (RFs) produced by heterohybridomas de

211 and serum levels of BLyS, IgM, IgA, and IgG rheumatoid factors (RFs), anti-cyclic citrullinated pept

212 resence of erosions at baseline, presence of rheumatoid factor, rheumatoid factor titer, and HLA-DRB1

213 In contrast to the functional, rheumatoid factor-secreting CD27(+)CD21(high) subset, th

214 and does not efficiently differentiate into rheumatoid factor-secreting plasmablasts, suggesting tha

215 Within the RA group, rheumatoid factor seropositivity and higher cumulative p

216 isability scores, C-reactive protein levels, rheumatoid factor seropositivity, and a lack of current

217 deformed joint counts, subcutaneous nodules, rheumatoid factor seropositivity, and erythrocyte sedime

218 ed CIA predominantly in females and produced rheumatoid factors, similar to the features of human RA.

219 AB29 transgenic mice expressing a hIgM/kappa rheumatoid factor specific for human IgG, with no detect

220 n between the presence of erosive disease or rheumatoid factor status and the dose of rheumatoid epit

221 odified Larsen score, demographic variables, rheumatoid factor status, and carriage of HLA-DRB1 share

222 age but were largely similar across sex and rheumatoid factor status, as were the HRs for VTE across

223 for age, sex, body mass index, smoking, and rheumatoid factor status.

224 as were the HRs for VTE across age, sex, and rheumatoid factor status.

225 ic and nephritogenic activities of 6-19 IgG3 rheumatoid factor, terminal sialylation attenuated the n

226 toantibodies to histones, DNA, or IgG (i.e., rheumatoid factors), the Vkappa regions, with those from

227 edimentation rate [ESR], C-reactive protein, rheumatoid factor, the HLA-DRB1 shared epitope, and cumu

228 pondyloarthropathies are not associated with rheumatoid factor, they show a strong association with H

229 at baseline, presence of rheumatoid factor, rheumatoid factor titer, and HLA-DRB1*04 alleles, partic

230 Rheumatoid factor titer, HLA-DRB1 polymorphisms, age, an

231 unt of fibrosis and the percentage of CP and rheumatoid factor titer, yet neither of the latter param

232 antibody titers among SLE patients and with rheumatoid factor titers among seropositive RA patients.

233 -small nuclear ribonucleoprotein (snRNP) and rheumatoid factor titers, but failed to promote the deve

234 lysozyme BCR transgenic strain and the AM14 rheumatoid factor transgenic strain.

235 d two distinct more galactosylated 6-19 IgG3 rheumatoid factor variants.

236 Rheumatoid factor was not detected.