ライフサイエンスコーパス: rhodopsin

1 retinal ligand and transmembrane helices in rhodopsin.

2 eceptors, defined as expressing a particular rhodopsin.

3 ordings display blunted dephosphorylation of rhodopsin.

4 rgy diagram for the regeneration reaction of rhodopsin.

5 hose containing exclusively unphosphorylated rhodopsin.

6 ation of phosphorylated and unphosphorylated rhodopsin.

7 the visual G protein-coupled receptor (GPCR) rhodopsin.

8 lation is signaled through photobleaching of rhodopsin.

9 domeric targeting of newly synthesized Aaop1 rhodopsin.

10 munohistochemistry analysis of R/G opsin and rhodopsin.

11 ultraviolet (UV)-sensitive (Spineless(OFF)) Rhodopsin.

12 rocesses involves the binding of arrestin to rhodopsin.

13 nd hydrolysis in the SHUV pigment and bovine rhodopsin.

14 ket can occur in the activation mechanism of rhodopsin.

15 oisomerization of the retinal chromophore in rhodopsin.

16 the extremely low thermal activation rate of rhodopsin.

17 x formed by the second intracellular loop of rhodopsin.

18 residue to Ile, the corresponding residue in rhodopsin.

19 ciency of this photoconversion is similar to rhodopsin.

20 tor replaced the third intracellular loop of rhodopsin.

21 tors (GPCRs)-the somatostatin receptor 3 and rhodopsin.

22 t BEAF-32 differentially regulates warts and Rhodopsins.

23 n kinetics observed between human and bovine rhodopsins.

24 ce observed between the microbial and animal rhodopsins.

25 r conserved acidic amino acids in Drosophila Rhodopsin 1 (Rh1) may serve as the counterion of this vi

26 activated Na(+) pump, Krokinobacter eikastus rhodopsin 2 (KR2), was resolved at atomic resolution.

27 Here, we study Krokinobacter eikastus rhodopsin-2 (KR2), a microbial light-driven sodium or pr

28 We then expressed channel rhodopsin-2 in MCH neurons and photostimulated MCH proje

29 Here, we expressed channel rhodopsin-2 under the CaMKIIalpha promoter in mice and p

30 ling induces Rhodopsin 6 (Rh6) and represses Rhodopsin 5 (Rh5), whereas in the other subtype, inactiv

31 e R8 subtype, active Hippo signaling induces Rhodopsin 6 (Rh6) and represses Rhodopsin 5 (Rh5), where

32 Rhodopsin, a G-protein coupled receptor, most abundant p

33 g disease often associated with mutations in rhodopsin, a light-sensing G protein-coupled receptor an

34 rumental learning, using our newly developed rhodopsin-A2AR chimeras (optoA(2A)R).

35 ng competition with the rods by knocking out rhodopsin accelerated cone dark adaptation, demonstratin

36 stability of dark-state and light-activated rhodopsin, accelerating the decay of ligand-bound forms.

37 ing newly synthesized and glycosylated Aaop1 rhodopsin accumulate within the cytoplasm.

38 to the outer segments, as we identified that rhodopsin accumulates in the inner segments and around t

39 We reveal a new allosteric mode of rhodopsin activation incurred by the non-biological memb

40 cate that in a native-like lipid environment rhodopsin activation is not analogous to a simple binary

41 studies to propose a two-stage mechanism for rhodopsin activation.

42 vealed a complex, double-square mechanism of rhodopsin activation.

43 d in the rod outer segment by photoactivated rhodopsin after light excitation.

44 overexpressing P23H rod opsin, and increased rhodopsin aggregation in the P23H-1 rat retina, suggesti

45 -base in bacteriorhodopsin, isorhodopsin and rhodopsin, all of which exhibit similar chromophores but

46 Expression of non-glycosylated rhodopsin alone showed that it is unstable and is regula

47 ice, there were intra-retinal differences in rhodopsin and cone opsin trafficking.

48 We measured the expression of melanopsin, rhodopsin and cone opsin, as well as other retinal marke

49 lowly post-induction, starting distally, but rhodopsin and cone pigments trafficked normally for more

50 Furthermore, we assessed key residues in rhodopsin and cone visual pigments by mutation analysis

51 ently described scramblases including bovine rhodopsin and fungal TMEM16 proteins.

52 d within the interior of the visual receptor rhodopsin and isomerizes to the all-trans configuration

53 es (albeit all in vitro) have suggested that rhodopsin and its chromophore-free apoprotein, R-opsin,

54 The seven-helical bundle of rhodopsin and other G-protein coupled receptors undergoe

55 r functions in sensory perception (including rhodopsin and other twilight-vision-associated genes), h

56 VPA ameliorated RD associated with P23H rhodopsin and promoted clearing of mutant rhodopsin from

57 ed primary cilium enrichment of a chimera of rhodopsin and somatostatin receptor 3, where the dual Ax

58 lecular photosensitivity as unphosphorylated rhodopsin and that flash responses measured by trans-ret

59 characterized chimeric receptor composed of rhodopsin and the beta2-adrenergic receptor (Opto-beta2A

60 ts are highly enriched in the visual pigment rhodopsin and the omega-3 fatty acid docosahexaenoic aci

61 cess in mice expressing the non-glycosylated rhodopsin and the RHO(hT17M) mice is likely the cause of

62 majority stems from ligand associations with rhodopsin- and secretin-like receptors.

63 ally linking the therapeutic effects in P23H rhodopsin animals and negative effects in other models w

64 Here conformational substates of the GPCR rhodopsin are investigated in micelles of dodecyl maltos

65 Several intriguing features of garter snake rhodopsin are suggestive of a more cone-like function.

66 Microbial rhodopsins are a family of photoactive retinylidene prot

67 Microbial rhodopsins are light-activated, seven-alpha-helical, ret

68 Rhodopsins are light-driven ion-pumping membrane protein

69 Microbial rhodopsins are remarkable for the diversity of their fun

70 The functions of microbial and animal rhodopsins are triggered by the isomerization of their a

71 cture reveals an overall architecture of the rhodopsin-arrestin assembly in which rhodopsin uses dist

72 Our results show that formation of the rhodopsin-arrestin complex markedly influences partition

73 ectron laser (XFEL) crystal structure of the rhodopsin-arrestin complex, in which the phosphorylated

74 ins characterized thus far, Anabaena sensory rhodopsin (ASR) is a photochromic sensor that interacts

75 transmembrane (TM) protein, Anabaena Sensory Rhodopsin (ASR) reconstituted in lipids.

76 rane helical photoreceptor, Anabaena sensory rhodopsin (ASR), prepared in the Escherichia coli inner

77 integral membrane protein, Anabaena sensory rhodopsin (ASR), reconstituted in a lipid environment.

78 rhodopsin, suggesting a role for RPGRIP1 in rhodopsin-bearing vesicle trafficking.

79 ccessive fusion events between intracellular rhodopsin-bearing vesicles or the evagination of the pla

80 Their archetype rhodopsin becomes naturally light sensitive by binding c

81 s dimers or multimers, F45L, V209M and F220C rhodopsins behave as monomers.

82 Here we show that a chimeric rhodopsin/beta2 adrenergic receptor (opto-beta2AR) is si

83 ominant retinal degeneration associated with rhodopsin biosynthesis defects, while frameshift phenoty

84 rtions and deletions in three genes encoding rhodopsin by co-injection of Cas9 mRNA, eGFP mRNA, and s

85 Phosphorylation was detected at rhodopsin C-terminal tail residues T336 and S338.

86 These observations show that rhodopsin can bind its agonist in equilibrium like a tra

87 Light-gated rhodopsin cation channels from chlorophyte algae have tr

88 omplex genetic constructs, to deliver murine rhodopsin cDNA or gDNA.

89 red in cryptophyte algae are the most active rhodopsin channels known.

90 hat these proteins form distinct families of rhodopsin channels.

91 Unique among the microbial rhodopsins characterized thus far, Anabaena sensory rhod

92 onserved amino acid residues surrounding the rhodopsin chromophore identified both close and distant

93 otes faster clearance of the photoisomerized rhodopsin chromophore.

94 Furthermore, Rab8, the key regulator of rhodopsin ciliary trafficking, was mislocalized in photo

95 esonance order parameter measurements at low rhodopsin concentrations.

96 e and the deprotonated Glu134 residue of the rhodopsin-conserved ERY sequence motif that helps break

97 cellular signaling processes for modulating rhodopsin content during this cycle.

98 revealed no difference in opsin expression, rhodopsin content was decreased in diabetic retinas, as

99 th our Exoc5 fl/fl mouse line crossed with a rhodopsin-Cre driver line.

100 uggest the existence of several circuits for rhodopsin-dependent circadian entrainment.

101 ster senses day-night cycles in part through rhodopsin-dependent light reception in the compound eye

102 rod photoreceptors the relationship between rhodopsin dephosphorylation and recovery of visual sensi

103 f the photoreceptor layer, reduced levels of rhodopsin, disrupted rod outer segments, and widespread

104 lastocladiella emersonii, combining a type I rhodopsin domain with a guanylyl cyclase domain.

105 gnificantly faster in the UV pigment than in rhodopsin due to the difference in the structural and el

106 We find that retinal influences rhodopsin dynamics using an ensemble of all-atom molecul

107 scs, and mislocalization of and reduction in rhodopsin early in postnatal development without loss of

108 ponsible for the daily renewal of rhodopsin: rhodopsin endocytosis at dawn and inhibition of rhodopsi

109 In this kinetic scheme, the human rhodopsin exhibited more Schiff base deprotonation than

110 In contrast, each Rhodopsin exhibits characteristic single-bp substitution

111 sults thus reveal different contributions of rhodopsin-expressing photoreceptors and suggest the exis

112 Four of the six rhodopsin-expressing photoreceptors can mediate circadia

113 s, known as 'pale' or 'yellow', depending on Rhodopsin expression in R7 and R8.

114 owever, because generating precise levels of rhodopsin expression is critical; overexpression causes

115 ng factors of a bi-stable loop regulating R8 Rhodopsin expression.

116 cargo, including multiple reported and novel rhodopsin family G protein-coupled receptors (GPCRs) and

117 The extent to which Rhodopsin family G-protein-coupled receptors (GPCRs) for

118 tor (OX2R) belongs to the beta branch of the rhodopsin family of GPCRs, and can bind to diverse compo

119 The members of the rhodopsin family of proteins are involved in many essent

120 R) and pheromones (Vomeronasal, VN1R) in the rhodopsin family, known to contain the chemosensory olfa

121 ll models, metformin treatment improved P23H rhodopsin folding and traffic.

122 second messenger in photoreceptors, requires rhodopsin for intracellular stability and outer segment

123 d retinae showed little dephosphorylation of rhodopsin for up to 4 h in darkness, even under conditio

124 x, in which the phosphorylated C terminus of rhodopsin forms an extended intermolecular beta sheet wi

125 stinguishing newly synthesized, glycosylated rhodopsin from mature nonglycosylated rhodopsin to chara

126 3H rhodopsin and promoted clearing of mutant rhodopsin from photoreceptors.

127 s a robust response, losing nearly all Aaop1 rhodopsin from the rhabdomeric membranes during the shed

128 A class of rhodopsins from cryptophyte algae show close sequence ho

129 Here, we investigate the evolution of rhodopsin function in an Andean mountain catfish system

130 In this study, lipid-order and bovine rhodopsin function in proteoliposomes composed of the sn

131 due at this position is essential for normal rhodopsin function in vivo.

132 ssful DNA extraction fragment of the nuclear rhodopsin gene (RH1) and 9 microsatellite regions (SSRs)

133 ndance of rhodopsins in Bacteria, as well as rhodopsin gene expression, was highest in the smallest s

134 egions (bacteria plasmid backbone, promoter, rhodopsin gene, and scaffold/matrix attachment region) o

135 Contrary to expectation, serine-only rhodopsin generated prolonged step-like single-photon re

136 bruptly and randomly, whereas threonine-only rhodopsin generated responses that were only modestly sl

137 We inserted eGFP or point mutations into rhodopsin genes by co-injection of repair fragments with

138 Proteorhodopsin (PR) and Gloeobacter rhodopsin (GR) are retinal-based light-driven proton pum

139 inal-binding pocket of Gloeobacter violaceus rhodopsin (GR) that tune its spectral properties.

140 ble reactivity of RPSB in the visual pigment rhodopsin has been attributed to potential energy surfac

141 lete dark adaptation can only occur when all rhodopsin has been dephosphorylated, a process that requ

142 dopsin spectra show that regenerated phospho-rhodopsin has the same molecular photosensitivity as unp

143 These findings show that channel function in rhodopsins has evolved via multiple routes.

144 One of these, endocytosis of rhabdomeric rhodopsin, has been described previously.

145 Phylogenetic analysis indicated that rhodopsins have adapted independently to the marine-brac

146 contrast, VPA exacerbated RD caused by T17M rhodopsin in light, but had no effect in darkness.

147 interaction of arrestin-1 and phosphorylated rhodopsin in native disc membranes.

148 he deployment of an additional red-sensitive Rhodopsin in P. xuthus, allowing for the evolution of ex

149 nto the ligand-receptor binding reaction for rhodopsin in particular, and for GPCRs more broadly.

150 actin polymerisation and mislocalisation of rhodopsin in photoreceptors.

151 emonstrates that ectopic expression of human rhodopsin in the inner retina, mediated by viral gene th

152 The normalised genomic abundance of rhodopsins in Bacteria, as well as rhodopsin gene expres

153 arine environments, with less exploration of rhodopsins in brackish waters.

154 We investigated microbial rhodopsins in the Baltic Sea using size-fractionated met

155 The abundance of rhodopsins in the two smaller size fractions displayed a

156 f photointermediates of the human and bovine rhodopsins in their native membranes revealed a complex,

157 lgae are far more homologous to haloarchaeal rhodopsins, in particular the proton pump bacteriorhodop

158 RP is frequently caused by mutations in Rhodopsin; in some animal models, RD is exacerbated by l

159 Changes in lipid order parameters upon rhodopsin incorporation vanished for bilayers with a hyd

160 ical rearrangements during the activation of rhodopsin involve a variety of angular and linear motion

161 Rhodopsin is a G protein-coupled receptor found in the r

162 Rhodopsin is a prototypical G-protein-coupled receptor (

163 The visual photoreceptor rhodopsin is a prototypical G-protein-coupled receptor (

164 hat dephosphorylation of the opsin moiety of rhodopsin is an extremely slow but requisite step in the

165 Like other GPCRs, rhodopsin is deactivated through receptor phosphorylatio

166 n calorimetry to show that ligand binding in rhodopsin is enthalpy driven with -22 kcal/mol, which is

167 The rhabdomeric rhodopsin is moved into large cytoplasmic vesicles at da

168 f receptor sensitivity is then achieved when rhodopsin is regenerated through a series of steps that

169 Rhodopsin is the most abundant outer segment protein and

170 ntal molecular event after photobleaching of rhodopsin is the recombination reaction between its apop

171 Rhodopsin is thus a functional biomarker for rod photore

172 The endocytosed rhodopsin is trafficked back to the photosensitive membr

173 we investigated whether the visual pigment, rhodopsin, is critical for delivering other signaling pr

174 he anterograde movement of newly synthesized rhodopsin, is revealed here for the first time.

175 ific AAV (adeno-associated virus)-hRK (human rhodopsin kinase)-sh_c-fos or a chemical inhibitor subst

176 ameliorating retinal disease phenotypes in a rhodopsin knockout (RKO) mouse model of retinitis pigmen

177 Analyses of retinoids and rhodopsin levels showed <20% in BC(-/-) versus wild-type

178 In the G protein-coupled receptor rhodopsin, light-induced cis/trans isomerization of the

179 For cone opsin genes, the rhodopsin-like (Rh2) and long-wave-sensitive (LWS) genes

180 ht activated (lambdamax = 532 nm) with a non-rhodopsin-like action spectrum peaking at 610 nm for sta

181 The dopamine D3 receptor is a class A, rhodopsin-like G protein-coupled receptor that can form

182 ptors (ORs) belong to a large gene family of rhodopsin-like G protein-coupled receptors (GPCRs).

183 Although rhodopsin-like G protein-coupled receptors can exist as

184 e arginine component of the ionic lock among Rhodopsin-like G-protein-coupled receptors suggests that

185 Our evolutionary analysis of rhodopsin-like GPCRs suggest that specific allosteric si

186 Interestingly, RNAi against two GPCRs (a Rhodopsin-like receptor and a Dopamine D2-like receptor)

187 ransmembrane helices TM3 and TM6 of class-A (rhodopsin-like) G protein-coupled receptors (GPCRs) is a

188 44 of these GPCRs belong to the A-family (or rhodopsin-like), 5 belong to the B-family (or secretin-l

189 brane G protein-coupled receptors (class A/1 rhodopsin-like), including receptors for chemokines, PGs

190 1-PC, 18:0d35-18:1-PC, or 20:0d39-20:1-PC at rhodopsin/lipid molar ratios from 1:70 to 1:1000 (mol/mo

191 dopsin endocytosis at dawn and inhibition of rhodopsin maturation until dusk.

192 ts though a novel signaling pathway to block rhodopsin maturation, thus inhibiting the deglycosylatio

193 itch protein recoverin, which is involved in rhodopsin-mediated signaling in mammalian visual sensory

194 We have developed rhodopsin mimics, using intracellular lipid binding prot

195 equent single cause of RP in the USA, causes rhodopsin misfolding and induction of the unfolded prote

196 in the photoreceptor connecting cilia cause rhodopsin mislocalisation and eventual retinal degenerat

197 Effects in T4K and Q344ter rhodopsin models were also negative.

198 Live mice regenerate rhodopsin more rapidly in blue light.

199 ed cone loss, while AAV92YF-RdCVFL increased rhodopsin mRNA and reduced oxidative stress by-products.

200 est that improving the traffic of misfolding rhodopsin mutants is unlikely to be a practical therapy,

201 gain of function', such as the dominant P23H rhodopsin mutation that causes retinitis pigmentosa (RP)

202 Rhodopsin OCT can bring significant impact into ophthalm

203 alisation of certain outer segment proteins (rhodopsin, opn1lw, opn1sw1, GNB3 and PRPH2), and disrupt

204 were the most abundant while Actinobacteria rhodopsins, or actinorhodopsins, were common at lower sa

205 that this is the bilayer thickness at which rhodopsin packs in bilayers at the lowest membrane pertu

206 For stimuli that photoactivated one rhodopsin per Galphat the rod OS swelling response reach

207 t process that is partially modulated by the rhodopsin phosphatase retinal degeneration C (RDGC).

208 utational studies on subnanosecond events in rhodopsins, photoactive yellow proteins, phytochromes, a

209 he OS a biochemical machinery transforms the rhodopsin photoisomerization into electrical signal.

210 hythms relies on either CRY or the canonical rhodopsin phototransduction pathway, which requires the

211 A subfamily of rhodopsin pigments was recently discovered in bacteria a

212 Proton-pumping rhodopsins (PPRs) are photoactive retinal-binding protei

213 Here, we show that rhodopsin preferentially enters the OS in the dark.

214 f a palladium-binding peptide to an archaeal rhodopsin promotes intimate integration of the lipid-emb

215 g function of IAR is intrinsic to the single rhodopsin protein and enables study of the transport act

216 coupled fast voltage-sensing domains from a rhodopsin protein to bright fluorophores through resonan

217 vesicles (RLVs) in the cell body and reduced rhodopsin protein.

218 re coordinated with expression of additional Rhodopsin proteins in the remaining photoreceptors, and

219 es express a broad range of colour-sensitive Rhodopsin proteins in three types of ommatidia (unit eye

220 al chromophore sterically constrained inside rhodopsin proteins represents an outstanding example of

221 ons defined by expression of light-detecting Rhodopsin proteins.

222 ow close sequence homology with haloarchaeal rhodopsin proton pumps rather than with previously known

223 ase proton acceptor and donor, a hallmark of rhodopsin proton pumps, are conserved in these cryptophy

224 ing thermal stability of UV cone pigment and rhodopsin provide insight into molecular evolution of ve

225 roteins, like photoactive yellow protein and rhodopsin, provide potential strategies for improving th

226 ed into phospholipid/detergent bicelles with rhodopsin reconstituted into detergent micelles.

227 We compared the regeneration of purified rhodopsin reconstituted into phospholipid/detergent bice

228 that the step-like responses of serine-only rhodopsin reflect slow and stochastic arrestin binding.

229 RD) as compared with WT, indicating impaired rhodopsin regeneration in KI/KI.

230 l MMAR-containing holoproteins are the first rhodopsins retaining significant pump activity under nea

231 observed absorption maxima in both A1 and A2 rhodopsins, reveal a Barlow-type relationship between th

232 Vertebrate rhodopsin (Rh) contains 11-cis-retinal as a chromophore

233 t brain clock neurons, whereas six different rhodopsins (RH) are present in the light-sensing organs.

234 Rhodopsin (RH1), the temperature-sensitive visual pigmen

235 oreceptors that each express one of the four rhodopsins RH3-RH6.

236 ere we describe a previously uncharacterized rhodopsin, Rh7, which contributes to circadian light ent

237 Mutations in rhodopsin (RHO) are a common cause of retinal dystrophy

238 2 (MAP2) as Ran-SPION-rIgP/cIgY-MAP2, or to rhodopsin (Rho) as anti-Rho-SPION-Ran.

239 To interfere with RHODOPSIN (RHO) gain-of-function mutations we engineered

240 The vertebrate visual photoreceptor rhodopsin (Rho) is a unique G protein-coupled receptor a

241 RhoGC is a rhodopsin (Rho)-guanylyl cyclase (GC) gene fusion molecu

242 ) signaling system, in which light-activated rhodopsin (Rho*) is the GPCR catalyzing the exchange of

243 ocesses responsible for the daily renewal of rhodopsin: rhodopsin endocytosis at dawn and inhibition

244 afficking serves as a mechanism to segregate rhodopsin-rich and peripherin2/rds-rich discs into alter

245 There was no effect on the traffic of rhodopsin, Rom1 or peripherin/rds; however, the retinal

246 Most RP-associated mutations affect rhodopsin's activity or transport to disc membranes.

247 These findings expand rhodopsin's role in vision from being a visual pigment a

248 nanoparticle (NP)-mediated intron-containing rhodopsin (sgRho) vs. intronless cDNA in ameliorating re

249 otential mechanistic role of dimerization in rhodopsin signaling.

250 ply engrained notion that the visual pigment rhodopsin signals light as a monomer, even though many G

251 Microspectrophotometeric determinations of rhodopsin spectra show that regenerated phospho-rhodopsi

252 During Meta II decay, the arrestin-rhodopsin stoichiometry shifts from 1:1 to 1:2.

253 t the importance of hydrophobic matching for rhodopsin structure, oligomerization, and function.

254 A comprehensive survey of bovine rhodopsin structures shows that the helical rearrangemen

255 uter segments and display mislocalization of rhodopsin, suggesting a role for RPGRIP1 in rhodopsin-be

256 PK activator metformin could affect the P23H rhodopsin synthesis and folding.

257 ramblase activity show that unlike wild-type rhodopsin that functionally reconstitutes into liposomes

258 for a functional and unusually blue-shifted rhodopsin that is expressed in small single "cones." Mor

259 uced decrease in kinetic rates-properties of rhodopsin that mediate rod sensitivity and visual perfor

260 K is part of a protective response to mutant rhodopsin that ultimately limits photoreceptor cell deat

261 ly, some mutations produce apparently normal rhodopsins that nevertheless cause disease.

262 that induces spontaneous insertion of bovine rhodopsin, the eukaryotic GPCR, into both lipid- and pol

263 Mutations in rhodopsin, the light-sensitive protein of rod cells, are

264 Rhodopsin, the mammalian dim-light receptor, is a unique

265 Rhodopsin, the photoreceptor of rod cells, absorbs light

266 In the bovine photoreceptor rhodopsin, this is accompanied by proton uptake at Glu(1

267 We show that the dissociation reaction of rhodopsin to 11CR and opsin has a 25-pM equilibrium diss

268 ng cascade that conveys photon absorption by rhodopsin to a change in current at the rod photorecepto

269 ylated rhodopsin from mature nonglycosylated rhodopsin to characterize the fate of Aaop1 during the s

270 We sought to impart the logic of rhodopsin to light-insensitive Family A GPCRs in order t

271 s with experimental in vitro measurements of rhodopsins to investigate dim-light adaptation.

272 not act synergistically and did not prevent rhodopsin trafficking to rod outer segments.

273 arly ages, rods displayed normal morphology, rhodopsin trafficking, and light responses, but underwen

274 fects in mitochondrial function and aberrant Rhodopsin trafficking.

275 ts into the gross conformational features of rhodopsin-transducin interactions and setting the stage

276 Our results suggest that cDNA of the rhodopsin transgene and bacteria backbone interfered wit

277 dence for matching of hydrophobic regions on rhodopsin transmembrane helices and hydrophobic thicknes

278 in the connecting cilium, thus facilitating rhodopsin transport to photoreceptor outer segments.

279 e photoreceptor connecting cilium, regulates rhodopsin transport to the outer segment through its eff

280 rientation observed in the inactive state of rhodopsin under conditions favoring the Meta-I state.

281 of the rhodopsin-arrestin assembly in which rhodopsin uses distinct structural elements, including t

282 Such MMAR-based rhodopsin variants present very promising opportunities

283 This analogue red-shifted all of the rhodopsin variants tested, accompanied by a strong broad

284 arious members of the GPCR family, including rhodopsin (visual receptor), opioid receptors, adrenergi

285 4 h in darkness, even under conditions when rhodopsin was completely regenerated.

286 Rhodopsin was depleted from primary cilia but gained acc

287 The metformin-rescued P23H rhodopsin was still intrinsically unstable and led to in

288 A notable diversity of viral-like rhodopsins was also detected in the dataset and potentia

289 ucture on the kinetics, the human and bovine rhodopsins were inserted into 1-palmitoyl-2-oleoyl-sn-gl

290 Proteobacteria and Bacteroidetes rhodopsins were the most abundant while Actinobacteria r

291 disrupt the structure of the visual receptor rhodopsin, whereas sites in packing cluster 1 (e.g., pos

292 d more Schiff base deprotonation than bovine rhodopsin, which could arise from the approximately 7% s

293 stable character of the rod visual pigment, rhodopsin, which evolved from less stable cone visual pi

294 uences partitioning in the decay kinetics of rhodopsin, which involves the simultaneous formation of

295 xpressing human P23H, T17M, T4K, and Q344ter rhodopsins, which are associated with RP in humans.

296 segments of transgenic mice expressing human rhodopsin with a T17M mutation (hT17M), suggesting that

297 and site-specific bioorthogonal labeling of rhodopsin with Alexa488 to enable, to our knowledge, a n

298 ase in some biologic systems, the example of rhodopsin with its strictly local single-quantum mode of

299 inally, a new clade of likely proton-pumping rhodopsin with non-canonical amino acids in the spectral

300 motif, required for efficient enrichment of rhodopsin within rod photoreceptor sensory cilia, inhibi