ライフサイエンスコーパス: rhombic lip

1 of granule precursor cells derived from the rhombic lip.

2 igate tangential neuronal migration from the rhombic lip.

3 of the mesencephalon and metencephalon, the rhombic lip.

4 ch are localized to the exterior face of the rhombic lip.

5 cerebellar nuclei that arise from the caudal rhombic lip.

6 een the non-neural roof plate and the neural rhombic lip.

7 euroepithelia: the ventricular zone (VZ) and rhombic lip.

8 ral auditory system neurons derived from the rhombic lip.

9 rsal neuroectodermal progenitor cells of the rhombic lip.

10 lockade reduces the length of the cerebellar rhombic lip.

11 expression of Math1 and Tcf4 throughout the rhombic lip.

12 n trajectories, i.e. the floor plate and the rhombic lip.

13 have a predetermined spatial address in the rhombic lip.

14 onset of their genesis in the mouse anterior rhombic lip.

15 ated protein kinase pathway is active in the rhombic lip, a germinal zone that generates diverse type

16 Expression of atonal1 in the rhombic lip adjacent at the roof plate boundary is acute

17 eal molecular organization of the cerebellar rhombic lip and introduce Lmx1a as an important regulato

18 Math1 expression delimits the extent of the rhombic lip and is required for the generation of the hi

19 for specification of the adjacent cerebellar rhombic lip and its derivative fates.

20 cification of cerebellar cell types from the rhombic lip and its upregulation inhibits their producti

21 indbrain, arise from precursors in the lower rhombic lip and migrate anteroventrally to reach their f

22 that DCN neurons in mice are produced in the rhombic lip and migrate rostrally in a subpial stream to

23 Our results suggest that UBCs arise from the rhombic lip and migrate via novel pathways to their fina

24 h are critical for maintenance of the entire rhombic lip and normal cerebellar morphogenesis.

25 of Lmx1a, these cells precociously exit the rhombic lip and overmigrate into the anterior vermis.

26 1 is the defining molecule of the cerebellar rhombic lip and Pax6 is downstream in the Math1 pathway.

27 associated with premature regression of the rhombic lip and posterior vermis hypoplasia in Lmx1a(-/-

28 hl1 homeobox gene is highly expressed by the rhombic lip and rhombic lip-derived migratory neurons.

29 The cerebellar rhombic lip and telencephalic cortical hem are dorsally

30 ere derived from neuronal progenitors of the rhombic lip and that cerebellar ectopia were derived fro

31 jor precerebellar nuclei that arise from the rhombic lip and that issue mossy fibers.

32 arate progenitor pools located mainly in the rhombic lip and the cerebellar ventricular zone, respect

33 existence of spatial compartmentation in the rhombic lip and the interplay between Wls, Math1, and Pa

34 However, the cerebellum's upper rhombic lip and the optic tectum are abnormal in clo.

35 f cells originating from both the cerebellar rhombic lip and the telencephalic cortical hem.

36 The rhombic lip and ventral midline express Slit2 and both e

37 iferative state, order of emergence from the rhombic lip, and molecular profile of either the constit

38 Thus, proliferating precursors within the rhombic lip are specified to be granule cells very early

39 the earliest granule cell progenitors at the rhombic lip as they separate from the ventricular zone o

40 g granule cell progenitors isolated from the rhombic lip at E14 or from the external germinal layer a

41 nce for an hCPe contribution directly by the rhombic lip at late embryonic stages when hRPe is no lon

42 ansformed our understanding of the embryonic rhombic lip by revealing the inductive cues, regional or

43 We also examine five rhombic lip cell markers (Wls, Math1, Pax6, Lmx1a, and T

44 introduce Lmx1a as an important regulator of rhombic lip cell-fate decisions, which are critical for

45 ggests that Sef may normally function in non-rhombic lip cells and prevent them from responding to FG

46 In the mouse embryo, rhombic lip cells express a number of granule neuron mar

47 When transplanted into younger neural tube, rhombic lip cells maintain their characteristic molecula

48 Isolation of rhombic lip cells reveals a homogenous population of pre

49 mutant mice, Tbr2+ UBCs accumulated near the rhombic lip, consistent with impaired migration through

50 Cerebellar rhombic lip derivatives demonstrate a temporal organisat

51 n hindbrain specification and generate upper rhombic lip derivatives on exposure to bone morphogeneti

52 trin orchestrates the migration of hindbrain rhombic lip derivatives to form the precerebellar nuclei

53 gregate the roof plate lineage from neuronal rhombic lip derivatives.

54 A subset of rhombic lip-derived cells also express reelin, a key reg

55 The rhombic lip-derived cells express transcription factors

56 which have a severe cerebellar malformation, rhombic lip-derived cells migrated to the NTZ, despite r

57 nd positioning of fissures, whereas in upper rhombic lip-derived cells the genes are more important i

58 mic FGF signals is required for induction of rhombic lip-derived cerebellar neurons.

59 -lateral coordinates into the adult, whereas rhombic lip-derived granule cells undergo lateral to med

60 ineage appears to be unique among the varied rhombic lip-derived lineages in its proliferative respon

61 e is highly expressed by the rhombic lip and rhombic lip-derived migratory neurons.

62 ctive deficit occurs without affecting other rhombic lip-derived nuclei, despite expression of Math1

63 poptosis, indicating that VZ/SVZ-derived and rhombic lip-derived progenitor cells show differential r

64 selective knock-out of P/Q-type channels in rhombic-lip-derived neurons including the PF and MF path

65 l precursor cells generated within the upper rhombic lip directly.

66 more than one cell type, indicating that the rhombic lip does not consist of a homogeneous population

67 ull mice have embryonic abnormalities of the rhombic lip due to loss of mesenchyme-secreted signaling

68 our molecularly distinct compartments in the rhombic lip during cerebellar development.

69 ulture experiments, Tbr2+ UBCs migrated from rhombic lip explants directly into the developing white

70 Dorsal midline cells adjacent to the rhombic lip express Bmp6, Bmp7 and Gdf7, three genes enc

71 d in grafted progenitors: transplanted early rhombic lip fails to subsequently produce granule cell p

72 The rhombic lip, from which granule cell precursors arise, a

73 We find that the anterior rhombic lip gives rise to more than one cell type, indic

74 Thus, we demonstrate that the cerebellar rhombic lip gives rise to multiple cell types within rho

75 The rhombic lip gives rise to neuronal populations that cont

76 d along the dorsal-most region of the caudal rhombic lip, gives rise to the cochlear and precerebella

77 Ablation of the rhombic lip in organotypic slice cultures substantially

78 ence of Wls-positive cells in the Math1-null rhombic lip indicates that Wls expression is independent

79 The rhombic lip is a discrete strip of neuroepithelium borde

80 These findings suggest that the rhombic lip is dynamically patterned by the expression o

81 eed, the production interval for hCPe by the rhombic lip is surprisingly extensive.

82 The rhombic lip is thus emerging as a spatiotemporally disti

83 from the Math1 locus, a molecular marker of rhombic lip lineages.

84 s are more frequently expressed in the lower rhombic lip (LRL) and embryonic dorsal brainstem than in

85 The lower rhombic lip (LRL) is a germinal zone in the dorsal hindb

86 ield that adjoins a germinal zone, the lower rhombic lip (LRL), functions as a progenitor domain by c

87 ins within and outside the hindbrain (lower) rhombic lip (LRL).

88 We uncover a Math1-dependent rostral rhombic-lip migratory stream (RLS) that generates some n

89 ve cells and their progeny that arise in the rhombic lip of the cerebellar primordium during embryoge

90 Sef is expressed immediately adjacent to the rhombic lip, overlapping with FGF15 and FGFR1, which is

91 zone precursors and glutamatergic cell from rhombic lip precursors, mirroring distinct origins for t

92 ental progression has been assumed, with the rhombic lip producing non-mitotic hRPe, and seemingly un

93 e neural tube, derivatives of early and late rhombic lip progenitors display patterns of migration an

94 Modelling of mutations in mouse lower rhombic lip progenitors that generate WNT-subgroup tumou

95 addition, Lmx1a is expressed in a subset of rhombic lip progenitors which produce granule cells that

96 in restricting vz progenitors from becoming rhombic lip progenitors.

97 nterplay between Wls, Math1, and Pax6 in the rhombic lip provides novel views of early cerebellar dev

98 dbrain dorsal interneurons that comprise the rhombic lip relay sensory information and coordinate mot

99 valent to the medial ganglionic eminence and rhombic lip, resembling the gnathostome brain.

100 imordium contains two germinative zones, the rhombic lip (RL) and the ventricular zone (VZ), which ge

101 The rhombic lip (RL) is an embryonic proliferative neuroepit

102 The rhombic lip (RL) is the neuroepithelium immediately adja

103 equirement of Pax6 in the development of all rhombic lip (RL) lineages.

104 ral progenitors originating from the rostral rhombic lip (RRL).

105 blishment of a neural progenitor population (rhombic lip) that gives rise to multiple hindbrain struc

106 rsors of cerebellar granule neurons from the rhombic lip, the dorsal aspect of the midbrain/hindbrain

107 erivatives is intrinsically specified at the rhombic lip, the orderly temporal transition in cell typ

108 use many precerebellar nuclei originate from rhombic lips, the first analysis of neuronal migrations

109 ker of the cells in the interior face of the rhombic lip throughout normal mouse cerebellar developme

110 postnatally, after their migration from the rhombic lip to the external germinal layer.

111 granule cell precursors are generated at the rhombic lip together with neurons of the lateral pontine

112 The neurons generated at the germinal rhombic lip undergo long distance migration along diverg

113 embryonic dorsal brainstem than in the upper rhombic lip (URL) and developing cerebellum.

114 The upper rhombic lip (URL), a germinal zone in the dorsoanterior

115 red gene interactions during the presence of Rhombic lip versus the presence of distinct internal gra

116 2+ UBCs appeared to migrate out of the upper rhombic lip via two cellular streams: a dorsal pathway i

117 In organotypic slice cultures, the rhombic lip was necessary and sufficient to produce cell

118 which gives rise to isthmic nuclei, and the rhombic lip, which generates deep cerebellar nuclei and

119 enitor zones, the ventricular zone and upper rhombic lip, which give rise to distinct cell types in t

120 n orientated, active migration away from the rhombic lip, which is apparently independent of either g