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1 rapping a pair of antiparallel beta-strands (ribbon).
2 of endocytic activity close to the synaptic ribbon.
3 jor endocytic proteins close to the synaptic ribbon.
4 GRASP65 physically links Golgi stacks into a ribbon.
5 ation of a supramolecular H-bonded polymeric ribbon.
6 ant for the release of vesicles from the rod ribbon.
7 zone, which is localized at the base of the ribbon.
8 le is known about the structural dynamics of ribbons.
9 ciated with the release site at the synaptic ribbons.
10 du/du IHCs, forming clusters at presynaptic ribbons.
11 reduce noise-induced loss of Inner Hair Cell ribbons.
12 r the controlled preparation of polyaromatic ribbons.
13 tres including iron-sulfur clusters and Zinc ribbons.
14 imposed load) results in less tightly curled ribbons.
15 tic partners without the benefit of synaptic ribbons.
16 ned clustered in stripes underneath anchored ribbons.
17 nsmission at active zone structures known as ribbons.
18 nd expand outward from the far ends of flare ribbons.
19 PACRG is associated with the protofilament ribbon, a structure believed to dictate the regular arra
20 ade of two-dimensional topological insulator ribbons accounting for scattering with phonons and imper
21 es estimated to be docked at the base of the ribbon active zone, but without RIM1/2, only a few vesic
22 nd quantified synaptic vesicle number at the ribbon after light and dark adaptation using electron mi
24 s forming many-turn Mobius strips or twisted ribbons along closed loops around a central singularity.
27 have focused on the globular isomers as the ribbon and bead isomers typically have lower potency at
28 similarly associated with the protofilament ribbon and ciliary motility, also positively regulates l
29 n, which may lead to disruption of the Golgi ribbon and development of acute pancreatitis in mice.
30 ulations, we find two isomers, two-atom wide ribbon and single-atom chain, linked by a tension-driven
32 n of photoreceptor transduction proteins and ribbon and synaptic markers in fetal human and Macaca re
33 ol of vesicles (RRP) underneath the synaptic ribbons and a slowly releasable pool of vesicles (SRP) a
36 mpared with abneural-side short HCs with few ribbons and large efferent synapses.SIGNIFICANCE STATEME
39 d that the colocalization of presynaptic IHC ribbons and postsynaptic afferent terminals is greatly r
41 MO is a 1D energy band localized on the CuTe ribbons and that the 1D insulating band structure is als
43 well as by a reduction of the number of both ribbons and vesicles surrounding the ribbons in hair cel
44 thickness was computed on the whole cortical ribbon, and deep gray matter volumetry was performed aft
46 ts link to form longer 1D chains and even 2D ribbons, and how doping and annealing influences formati
48 ctron tomography revealed that the flagellar ribbons are distorted in the mutant cells, indicating th
49 uter plexiform layer, synaptic proteins, and ribbons are first reliably recognized in cone pedicles.
52 tic vesicles, and both vesicles and synaptic ribbons are reduced in synaptic regions of hair cells in
55 s show that RIBEYE is essential for synaptic ribbons as such, and may organize presynaptic nano-domai
57 number of synaptic vesicles associated with ribbons, as revealed by electron microscopy of recorded
58 umerous synaptic vesicles, some of which are ribbon associated, that have difference susceptibilities
59 overstimulation can induce loss of synaptic ribbons associated with loss of Inner Hair Cell - Audito
62 ilar to bipolar cells, fusion of the initial ribbon-associated synaptic vesicle cohort was not blocke
63 4 DKO photoreceptors, in which the number of ribbon-associated synaptic vesicles remained unchanged r
64 portant implication of these results is that ribbon-associated vesicles can form intervesicular SNARE
67 ber of synaptic vesicles associated with the ribbon base close to the release site was significantly
68 Moreover, the active layers for the helical ribbon-based photodetectors are solution-cast but have p
69 oreceptors both release vesicles at synaptic ribbons, but rods also exhibit substantial slow release
72 and stretchable metal and conductive polymer ribbons can be noninvasively laminated onto the skin sur
73 ive motor impairment and cell death, whereas ribbons cause a distinct histopathological phenotype dis
74 ees C), the resulting products are molecular ribbons composed of two twisted aromatic systems fused t
76 modulation in volume of very small synaptic ribbons correlates with the presence of reduced ABR peak
77 e property, a fabric/matrix made using these ribbons could be highly beneficial for powering wearable
78 ver a blade under a fixed load show that the ribbon curvature is generated over a restricted range of
79 ment and theory, examining the dependence of ribbon curvature on blade curvature, the longitudinal lo
80 bular (Cys(I)-Cys(III) and Cys(II)-Cys(IV)), ribbon (Cys(I)-Cys(IV) and Cys(II)-Cys(III)), or bead (C
83 the synapse, receptor saturation counteracts ribbon depression to produce rapid recovery and facilita
85 -actin mesh network attached to the synaptic ribbons directly influences the efficiency of otoferlin-
86 rt linkers led to selective formation of the ribbon disulfide isomer without requiring orthogonal pro
87 ernative catalysts, and conveniently, the Li ribbon does not require the removal of the oxide coating
88 veiled for the first time how the 4-Cys zinc ribbon domain and zinc ribbon-like domain bind ssDNA wit
89 erizing the initial as-adsorbed system with "ribbon" domain boundaries isolating rotationally offset
91 ukaryotes that also have multiple 4-Cys zinc ribbon domains required for their physiological function
95 is approach to fabricate 9- and 13-atom wide ribbons, enabling short-channel transistors with 10(5) o
97 structured peptide to mature amyloid twisted-ribbon fibrils over a few hours when incubated on polyst
100 ells, Mena and actin were required for Golgi ribbon formation after nocodazole washout; in vitro, Men
101 w here that endogenous FHDC1 regulates Golgi ribbon formation and has an apparent preferential associ
102 GM130-AKAP450 complex, which promotes Golgi ribbon formation in achieving polarized secretion for ce
105 d as well as increase the serum stability of ribbon GeXIVA while preserving activity at the alpha9alp
108 Morphologically, we found that enlarged ribbons had more associated vesicles and reduced presyna
109 ssembles into linear amyloid-like 1D helical ribbons having structural parameters that correlate to t
111 erent OC neurons as essential for regulating ribbon heterogeneity, dopaminergic terminal differentiat
112 width for detection results from the helical ribbons' high absorption coefficient, good electron mobi
114 icant reduction in the noise-induced loss of ribbons in both regions and changes in ABR sensitivity a
115 n was located near the apical domain and the ribbons in hair cells, and in the inner segment and the
117 ise there was a 26% and 38% loss of synaptic ribbons in regions 5.5 and 6.5 mm from apex, respectivel
120 generated numerous long-lived crypt-villus "ribbons," indicative of dedifferentiation of enterocyte
126 where the rate of vesicle recruitment to the ribbons is directly controlled by a synaptic F-actin net
127 In summary, a key function of RIM1/2 at rod ribbons is to enhance Cav1.4 channel activity, possibly
129 A recent report showed that the bead and ribbon isomers of GeXIVA are more potent than the globul
131 lucidated and revealed a transformation of a ribbon-like 1D building unit into 2D layers and finally
132 resence of [PSI(+) ] or [PIN(+) ], Swi1 ring/ribbon-like aggregates predominantly colocalize with the
133 or many current and future applications is a ribbon-like device that could simultaneously harvest and
134 me how the 4-Cys zinc ribbon domain and zinc ribbon-like domain bind ssDNA with primarily pi-stacking
138 Its crystal structure consists of planar ribbon-like molecular arrays packed into offset layers t
139 ns of porcine myocardium were laser-cut into ribbon-like shapes, decellularized, and mounted in speci
141 not amacrine cell synapses have presynaptic ribbon-like structures at their transmitter release site
143 show that Swi1 aggregates are initially ring/ribbon-like then become dot-like in mature [SWI(+) ] cel
147 s been implicated in both Golgi stacking and ribbon linking by forming trans-oligomers through the N-
148 lity that other proteins may help GRASP65 in ribbon linking, we used biochemical methods and identifi
151 that ribbon enlargement results in increased ribbon-localized calcium signals, yet reduces afferent s
155 Ca(2+)-buffer EGTA, suggesting that synaptic ribbons mediate nano-domain coupling of Ca(2+) channels
156 rared light reflected from a simple graphene ribbon metasurface can span over almost the entire 2pi r
159 e residues at the tip of the C-terminal zinc ribbon of TFS4; the inhibition likely involves an allost
161 he predicted structure of RbCuTe consists of ribbons of copper and telluride atoms placed antipolar t
163 tic ribbons show a size gradient with larger ribbons on the modiolar face and smaller ribbons on the
165 for CaV1.4 function, but is not required for ribbon organization, synaptogenesis, or synaptic transmi
166 truction consisting of 5.55 +/- 0.07 nm wide ribbons, oriented 10.4 degrees +/- 0.8 degrees relative
168 f outer segment-like structures and synaptic ribbons, photoreceptor neurotransmitter expression, and
169 ts N-linker and a disulfide to a stable beta-ribbon pillar near the center of the platform, can under
170 measure the cross-sectional widths of flare ribbons, post-flare loops and footpoint brighenings, whi
171 in unprecedented detail, including the flare ribbon propagating across the sunspots, coronal rain (ma
172 l interaction between Tulp1 and the synaptic ribbon protein RIBEYE, which is important to maintain sy
174 e capable of substantial slow release at non-ribbon release sites triggered by Ca(2+)-induced Ca(2+)
175 nt; where vesicles higher up on the synaptic ribbon replenish the rapidly releasing vesicle pool; and
176 dings revealed that hair cells with enlarged ribbons resulted in reduced spontaneous spike rates.
177 In addition to vesicle release at synaptic ribbons, rod photoreceptors are capable of substantial s
179 ifies the physical mechanisms underlying the ribbon's nonlinear response to an apparently simple defo
182 o pack into 2D crystalline unit cells within ribbon-shaped nanostructures, whereas the nine methylene
184 nd organic photovoltaics fabricated with the ribbons show efficiencies of approximately 8% without op
186 also exhibit substantial slow release at non-ribbon sites triggered by Ca(2+)-induced Ca(2+) release
188 These observations suggest that varying ribbon size alone can influence sensory encoding, and gi
189 MENT Numerous studies support that hair-cell ribbon size corresponds with functional sensitivity diff
192 Whereas the normal-developing IHCs display ribbon size gradients before hearing onset, ribbon sizes
194 Together, our work indicates that hair-cell ribbon size influences the spontaneous spiking and the p
197 ribbon size gradients before hearing onset, ribbon sizes are aberrant in APC cKOs from neonatal ages
198 results are consistent with a dual role for ribbon-specific complexin, acting as a brake on the SNAR
199 ubunit (GABAA Ralpha1 ), and that a synaptic ribbon-specific protein (RIBEYE) is found adjacent to so
202 d via highly mobile vesicles and specialized ribbon structures, but how this is achieved at central s
203 indicating that few vesicles outside of the ribbon-style active zones were initially fusion competen
204 the retinal bipolar cell are situated at the ribbon-style active zones, where they functionally inter
207 (dot subtype; n = 5) or confluent, wriggled (ribbon subtype; n = 3) lesions, sometimes forming irregu
208 s non-uniform over the sunspot: as the flare ribbon sweeps across, its different portions accelerate
209 nting magnetic flux through the feet and the ribbon-swept area reveals that the rope's core is more t
210 contribute to synaptic depression at the IHC ribbon synapse and spike rate adaptation in the auditory
213 pre- and postsynaptic mechanisms at the IHC ribbon synapse contribute to synaptic depression at the
215 degeneration, characterized by photoreceptor ribbon synapse deficiency and subsequent bipolar cell lo
216 lastin as a novel deafness gene required for ribbon synapse formation and function, which is critical
218 cells of auditory and vestibular organs, the ribbon synapse is required for the precise encoding of a
219 fates [short hair cells (HCs) are missing], ribbon synapse numbers, outward ionic currents, and effe
221 for a priming mechanism at the photoreceptor ribbon synapse that is independent of the formation of a
226 fundamental difference between photoreceptor ribbon synapses and conventional chemical synapses in sy
227 fundamental difference between photoreceptor ribbon synapses and conventional chemical synapses with
228 ndocytic machinery at the periactive zone of ribbon synapses and offer a new rationale and mechanism
230 r, the transfer characteristics at hair cell ribbon synapses are still poorly understood at different
231 ntials, the so called "receptor potentials." Ribbon synapses between IHCs and auditory nerve neurons
232 requires proper differentiation of afferent ribbon synapses between inner hair cells (IHCs) and spir
233 mobility and turnover of Ribeye at hair cell ribbon synapses by monitoring fluorescence recovery afte
234 ctural analyses to probe the architecture of ribbon synapses by perturbing the function of RIM-bindin
236 lding proteins RIM1/2 from rod photoreceptor ribbon synapses causes a dramatic loss of Ca(2+) influx
239 On the outer stratifying melanopsin cells, ribbon synapses from bipolar cells and conventional syna
241 e receptor family, D1b, tightly localizes to ribbon synapses in inner ear and lateral-line hair cells
242 We have shown previously that photoreceptor ribbon synapses in mouse retina are equipped with Cplx3
243 ential for the proper maturation of afferent ribbon synapses in sensory cells of the inner ear, and f
244 ells and directly from rod bipolar cells via ribbon synapses in the innermost ON layer of the inner p
245 e finding that synaptic transmission at cone ribbon synapses is regulated by Gbetagamma/SNAP-25 inter
246 which stimulus-evoked exocytosis in retinal ribbon synapses is SNARE-dependent; where vesicles highe
247 One molecular specialization of retinal ribbon synapses is the expression of complexin protein s
249 we show here that the sensory photoreceptor ribbon synapses most likely lack RIM1 and predominantly
250 not change Cav1.4 protein expression at rod ribbon synapses nor was the morphology of the ribbon alt
251 s (GPCRs) influence synaptic transmission at ribbon synapses of cones and other retinal neurons, it i
252 nd sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (
254 vate neural-side tall HCs, resulting in more ribbon synapses per HC compared with abneural-side short
255 roteinaceous scaffolds at the active zone of ribbon synapses that are specialized for rapid sustained
256 mainly expressed in photoreceptors that use ribbon synapses to communicate with the inner retina.
259 essential for glutamate release at hair cell ribbon synapses, suggesting close developmental, physiol
260 -type Ca(2+) channels to the active zones of ribbon synapses, thereby synchronizing vesicle exocytosi
261 rted previously that, at mouse photoreceptor ribbon synapses, vesicle priming is Munc13 independent.
262 nvestigate Cplx3/4 function in photoreceptor ribbon synapses, voltage-clamp recordings from postsynap
263 or synaptic vesicle priming at photoreceptor ribbon synapses, which represents a fundamental differen
273 tic disorders affecting inner hair cells and ribbon synapses; (ii) postsynaptic disorders affecting u
275 at lack of both Cplxs perturbs photoreceptor ribbon synaptic function; however, Cplx3/4 function in p
276 using two separate devices, here we report a ribbon that integrates a solar cell and a supercapacitor
277 otodetectors based on four different helical ribbons that differ in the wavelength of their response.
278 ontains a specialized structure-the synaptic ribbon-that supports both fast, transient and slow, sust
279 ution, flattens into a twofold helical screw ribbon to bind intimately to cellulose microfibrils in t
280 electrostatically tunable graphene plasmonic ribbons to create electrostatic modulation of mid-infrar
282 he combination of these functions allows the ribbon-type CAZ to achieve the continuous transmitter re
283 brillates rapidly and ultimately forms flat, ribbon-type fibrils evidenced by transmission electron m
284 interactions regulate synaptic function at a ribbon-type synapse, contributing to an emerging picture
285 BP2 did not impair synapse ultrastructure of ribbon-type synapses formed between rod bipolar cells (R
287 e features, building on the concept that the ribbon under the imposed deformation undergoes different
289 n contrast, exchange of Ribeye between other ribbons via the cell's cytoplasm takes several hours.
291 mation of many-turn Mobius strips or twisted ribbons when the topological charge of one of the compon
292 are stitched together as a perinuclear Golgi ribbon, which is required for the establishment of cell
293 a unique presynaptic structure, the synaptic ribbon, which organizes both synaptic vesicles and calci
294 s robust assembly of one-dimensional twisted ribbons, which behave as effective supramolecular polyme
295 nsforms the films from flat sheets to spiral ribbons, which subsequently translate large distances wi
296 range by changing the width of the graphene ribbons, while the amplitude of the reflection can be ma
299 that Ribeye can exchange between halves of a ribbon within 1 minute in a manner that is consistent w
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