ライフサイエンスコーパス: ribonucleoside

1 (60-75%) without any 4-substituted imidazole ribonucleoside.

2 s dipyridamole and nitrobenzylmercaptopurine ribonucleoside.

3 with 2'-deoxyribonucleosides, as compared to ribonucleosides.

4 action with the 2'-alpha-hydroxy moieties of ribonucleosides.

5 boxylic acid derivatives of all four natural ribonucleosides.

6 HCMV to four different 3-substituted indole ribonucleosides.

7 a series of heterobase-modified 2'-C-methyl ribonucleosides.

8 h Bu3SnH and then converted to carbocyclic C-ribonucleosides 1, 3, and 4.

9 uted, the 5,6-dimethyl, and the 5,6-difluoro ribonucleosides (19, 20, and 2, respectively), were inac

10 on from the corresponding 5'-O-DMTr-2'-O-TBS-ribonucleosides (1a-1d).

11 Ribonucleoside 2',3'-cyclic phosphates (N>p's) are gener

12 cient formation of stable and yet reversible ribonucleoside 2'-conjugates in yields of 69-82%.

13 avage at genomic ribonucleotides can produce ribonucleoside-2',3'-cyclic phosphate-terminated nicks.

14 emistry thus suggests a prebiotic route from ribonucleoside-2',3'-cyclic phosphates to predominantly

15 The recent synthesis of pyrimidine ribonucleoside-2',3'-cyclic phosphates under prebiotical

16 5,6-trichloro analog (TCRB), the 5,6-dibromo ribonucleoside 3 was active against HCMV (IC50 approxima

17 lid-phase synthesis using 5'-O-DMTr-2'-O-TBS-ribonucleoside 3'-N,N-dimethyl-S-(2,4-dichlorobenzyl) ph

18 The phosphomonoesterase converts a terminal ribonucleoside 3'-PO4 or deoxyribonucleoside 3'-PO4 of a

19 irst removed to yield a primer strand with a ribonucleoside 3'-PO4 terminus, and (ii) the 3'-PO4 is h

20 bonucleotide to yield a primer strand with a ribonucleoside 3'-PO4 terminus, requires the vicinal 2'-

21 bonucleotide to yield a primer strand with a ribonucleoside 3'-PO4 terminus.

22 he phosphomonoesterase converts the terminal ribonucleoside 3'-PO4 to a 3'-OH.

23 e have examined the effect of 3'-deoxy-2'-5'-ribonucleoside (3'-deoxynucleoside) incorporation into C

24 logy is based on 5'- O -(DMTr)-2'- O -(Fpmp)-ribonucleoside-3'- H -phosphonate building blocks 10.

25 nitiates reduction of the 2' position of the ribonucleoside 5'-diphosphate substrate by abstracting t

26 aerobic enzymes catalyzing the reduction of ribonucleoside 5'-diphosphates by a mechanism that requi

27 Ribonucleoside 5'-monophosphates (rNMPs) are the most co

28 structure of HCoV-OC43 N-NTD complexed with ribonucleoside 5'-monophosphates to identify a distinct

29 n of the DNA template by RNAP on addition of ribonucleoside 5'-triphosphates (NTPs) in sequential AFM

30 quencies in RNA and the balance of dNTPs and ribonucleoside 5'-triphosphates (rNTPs) in the cellular

31 as a steric gate to preclude the binding of ribonucleoside 5'-triphosphates, prevents the effective

32 additional substrates including 6-oxopurine ribonucleosides, 6-aminopurine ribonucleosides, and to a

33 iodo-2'-deoxyuridine (5-IdU), as well as the ribonucleosides 8-bromoguanosine and 8-bromoadenosine.

34 We discovered five ribonucleosides-8-azaadenosine, formycin A, 3-deazauridi

35 5-Aminoimidazole-4-carboxamide ribonucleoside, a pharmacological AMPK activator that is

36 5'-Aminoimidazole-4-carboxamide ribonucleoside activation of the kinase AMPK is known to

37 cation in tumor cells by increasing cellular ribonucleoside activity.

38 unds were less active than the benzimidazole ribonucleosides against human cytomegalovirus (HCMV) and

39 of AMPK with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) also resulted in an approximate t

40 g of 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside (AICAR) and N-acetyl cysteine (NAC) to at

41 ting compound 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) ex vivo.

42 treated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in vivo, and also in muscles incu

43 ated directly from aminoimidazolecarboxamide ribonucleoside (AICAR) or from inhibition of purine synt

44 e presence of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) or metformin, 2 known AMPK activa

45 reatment with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) prevents this heat-induced sudden

46 we show that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) reverses the sensitivity of Akt-e

47 s of 5-aminoimidazole-4-carboxamide 1-beta-d-ribonucleoside (AICAR) were used to activate AMPK in mal

48 e report that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a 5'-AMP kinase activator, rapid

49 al muscle with 5-aminoimidazole-4carboxamide ribonucleoside (AICAR), a compound that activates 5'-AMP

50 muscles with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a compound that results in incre

51 we show that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a pharmacological activator of A

52 ells with 5-aminoimidazole-4-carboxamide 1-D-ribonucleoside (AICAR), a prototypical AMPK activator, c

53 nd C (CC) or 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR), an inhibitor and activator of AM

54 se activator, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), in active and passive EAE induce

55 of cells with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), so as to simulate elevated AMP l

56 oth H2O2 and 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR)-induced downstream signaling.

57 sociated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)-stimulated glucose transport medi

58 cose, 5-aminoimidazole-4-carboxamide-1beta-4-ribonucleoside (AICAR; an activator of AMP kinase), or g

59 heir iminoether functions to give the native ribonucleosides along with the innocuous nitrile side pr

60 An evolved fluorescent ribonucleoside alphabet comprising isomorphic purine ((t

61 in as well as 5-aminoimidazole-4-carboxamide ribonucleoside, an AMPK agonist, significantly increased

62 e, we report the antiviral mechanism for the ribonucleoside analog 5-azacytidine (5-AZC).

63 The ribonucleoside analog ribavirin (1-beta-D-ribofuranosyl-

64 Therefore, ribonucleoside analogs as inhibitors of viral RNA polyme

65 y described here, we investigated a panel of ribonucleoside analogs for their ability to affect HIV-1

66 ovide the first demonstration of a series of ribonucleoside analogs that can target HIV-1 reverse tra

67 were less cytotoxic than their corresponding ribonucleoside analogs.

68 ur phosphoramidate ProTide technology to the ribonucleoside analogue 4'-azidouridine to generate nove

69 This ribonucleoside analogue accumulates as a triphosphate an

70 or the synthesis of a fluorescent pyrimidine ribonucleoside analogue and its enzymatic incorporation

71 synthesis of 8-nitro-2'-O-methylguanosine, a ribonucleoside analogue of this lesion, which is suffici

72 Despite this, the ribonucleoside analogue, 8-chloro-adenosine (8-Cl-Ado),

73 A new fluorescent ribonucleoside analogue, containing 5-aminoquinazoline-2

74 Novel purine ribonucleoside analogues (9-13) containing a 4-substitut

75 idate ProTides can deliver monophosphates of ribonucleoside analogues and suggest a potential path to

76 ied protein nanopore can be used to identify ribonucleoside and 2'-deoxyribonucleoside 5'-monophospha

77 scribe the synthesis of the furan-containing ribonucleoside and its triphosphate, as well as their ba

78 Vanadyl ribonucleoside and orthovanadate are commonly employed a

79 Facile syntheses of C-6 azidopurine ribonucleosides and 2'-deoxyribonucleosides have been de

80 ecific combinations of amino acids or purine ribonucleosides and amino acids are required for efficie

81 sponding series of chlorinated benzimidazole ribonucleosides and the fact that 5'-deoxy analogues of

82 2'-C-methyl-4-amino-pyrrolo[2,3-d]pyrimidine ribonucleosides and their improved pharmacokinetic prope

83 ribose aminooxazoline to the pyrimidine beta-ribonucleosides and their phosphate derivatives that inv

84 from the four deoxyribonucleosides, the four ribonucleosides, and 5-methyl-2'-cytidine, a RNA methyla

85 lysis, reversed-phase HPLC resolution of the ribonucleosides, and identification and quantification o

86 to apply to D-ribose, D-ribose 1-phosphate, ribonucleosides, and ribonucleotides in general.

87 g 6-oxopurine ribonucleosides, 6-aminopurine ribonucleosides, and to a lesser extent purine arabinosi

88 , traditional methods for detecting modified ribonucleosides are labor- and time-intensive, they requ

89 2'-O-Aminooxymethyl ribonucleosides are prepared from their 3',5'-disilylate

90 proach, the relative proportions of modified ribonucleosides are quantified in several micrograms of

91 The Raman spectra of purine ribonucleoside as well as a stable model compound (1-met

92 cribe the synthesis of novel 5-haloimidazole ribonucleosides as precursors of modified cobalamins.

93 e base to yield 1-hydroxyl-1,6-dihydropurine ribonucleoside, as suggested earlier by X-ray crystallog

94 Introduction of a single ribonucleoside at the scissile phosphate of an otherwise

95 oward enantiomerically pure (S)-methanocarba ribonucleosides based on several functional group transf

96 80 7-(het)aryl- and 7-ethynyl-7-deazapurine ribonucleosides bearing a methoxy, methylsulfanyl, methy

97 /or that either or both have a benzimidazole ribonucleoside binding site.

98 h, only inhibitors of the de novo pyrimidine ribonucleoside biosynthesis mimicked observations seen i

99 ntification and quantification of individual ribonucleosides by LC-MS via dynamic multiple reaction m

100 eplication in macrophages is unique and that ribonucleoside chain terminators may be a new class of a

101 In addition, the 2'-O-methylated ribonucleosides (Cm and Am) are present at higher levels

102 to RNase A inhibitors, sensitive to vanadyl ribonucleoside complex, and dependent on magnesium.

103 eased by treatment of viral RNP with vanadyl ribonucleoside complexes, no change in the pattern of de

104 ly inhibited by ethidium bromide and vanadyl ribonucleoside complexes.

105 substituted and N7, C8-disubstituted guanine ribonucleosides comprise a class of small molecules with

106 ve cleavage of O2' and O3' ester groups from ribonucleoside derivatives has been accomplished with Do

107 ric series of new thieno-fused 7-deazapurine ribonucleosides (derived from 4-substituted thieno[2',3'

108 of its four activities, vaccinia virus-coded ribonucleoside diphosphate (rNDP) reductase shows respon

109 alytically essential free radical of class I ribonucleoside diphosphate (rNDP) reductase, thereby blo

110 in an as yet undefined stoichiometry to form ribonucleoside diphosphate reductase (ribonucleotide red

111 nrdE, and nrdF, which encode the subunits of ribonucleoside diphosphate reductase and which are not p

112 rotein to the enzymatic mechanism of aerobic ribonucleoside diphosphate reductase from Escherichia co

113 The smallest known intein, found in the ribonucleoside diphosphate reductase gene of Methanobact

114 e find specific alleles of bunched (bun) and Ribonucleoside diphosphate reductase large subunit (RnrL

115 teraction of the adenosylcobalamin-dependent ribonucleoside diphosphate reductase of Corynebacterium

116 as either a substrate or an inhibitor of the ribonucleoside diphosphate reductase of Escherichia coli

117 te the apparent equilibrium constants of the ribonucleoside diphosphate reductase reaction and the ri

118 Inactivation of ribonucleoside diphosphate reductase with 2'-azido-2'-de

119 Prereduced R1 dimer of ribonucleoside diphosphate reductase, in the presence of

120 ses a diferric-tyrosyl radical essential for ribonucleoside diphosphate reduction.

121 uman FMN cyclase, which splits FAD and other ribonucleoside diphosphate-X compounds to ribonucleoside

122 nes encoding the large and small subunits of ribonucleoside-diphosphate reductase) originated before

123 otein FtsZ, chaperonins GroES and GroEL, and ribonucleoside-diphosphate reductase.

124 the enzyme that catalyzes the conversion of ribonucleoside diphosphates (NDP) to deoxyribonucleoside

125 ole in RNA degradation, generating a pool of ribonucleoside diphosphates (rNDPs) that can be converte

126 quantitation of nanomolar concentrations of ribonucleoside diphosphates (rNDPs).

127 inding of effectors indicate that binding of ribonucleoside diphosphates at the catalytic site influe

128 esponsible for the de novo conversion of the ribonucleoside diphosphates to deoxyribonucleoside dipho

129 f the 5'-O-tosylates for both the deoxy- and ribonucleosides enabled preparation of the diphosphate e

130 ma cells through integrated Photoactivatable-Ribonucleoside-Enhanced Cross-Linking and Immunoprecipit

131 -seq and AGO2 PAR-CLIP-seq (photoactivatable-ribonucleoside-enhanced cross-linking and immunoprecipit

132 Combining photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipita

133 at interact with eIF3 using photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipita

134 Photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipita

135 d WIG1-binding motifs using photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipita

136 Using photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipita

137 on of AMPK by 5-aminoimidazole-4-carboxamide ribonucleoside exacerbated damage.

138 on of AMPK by 5-aminoimidazole-4-carboxamide ribonucleoside facilitates tight junction assembly under

139 e syntheses of a group of 4'-thiaspirocyclic ribonucleosides featuring both pyrimidine and purine cla

140 acetals, provides reversible 2'-O-protected ribonucleosides for potential applications in the solid-

141 nclude that the strong preference of guanine ribonucleosides for the anti conformation is the driving

142 amidate prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides form a novel class of HCV NS5B RNA-depen

143 (Q) and archaeosine (G(+)) are hypermodified ribonucleosides found in tRNA.

144 model compound (1-methoxyl-1,6-dihydropurine ribonucleoside), free in solution and bound into its com

145 of 5'-modified 2,5,6-trichlorobenzimidazole ribonucleosides has been synthesized and tested for acti

146 As compared with previous reports on ribonucleosides, higher levels of triphosphate were form

147 Introduction of a single ribonucleoside immediately 5' of the scissile phosphate

148 s of the biologically important 6-arylpurine ribonucleoside in a single step from unactivated and unp

149 2,6-Diaminopurine ribonucleoside in RNA is not a substrate for ADAR, in co

150 tem-level analysis of the dozens of modified ribonucleosides in ncRNA, characterization of novel long

151 tility and uniqueness of 2'-O-aminooxymethyl ribonucleosides in the preparation of modified RNA seque

152 tation by uniquely reprogramming 40 modified ribonucleosides in tRNA, which correlate with selective

153 ue for the quantitative analysis of modified ribonucleosides in tRNA.

154 a stress-specific reprogramming of modified ribonucleosides in tRNA.

155 A and -RNA target strands suggest that 2'-5'-ribonucleoside incorporation into 3'-5'-oligodeoxyribonu

156 Ribonucleosides inhibit human immunodeficiency virus typ

157 alpha, beta, and gamma) and 2'-beta-C-methyl ribonucleoside inhibitors.

158 The most commonly used fluorescent ribonucleoside is 2-aminopurine, a highly responsive pur

159 5-[19F]Fluoropyrimidin-2-one ribonucleoside is strongly fluorescent, making it possib

160 4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine ribonucleoside, is orally bioavailable in the rat.

161 NA sequences capable of cleaving an internal ribonucleoside linkage.

162 Thus, mutagenic ribonucleosides may represent an important class of anti

163 assay and 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG) as substrate and a robot-based enz

164 iF-rU/C represents rare examples of "locked" ribonucleoside mimics that lack a bicyclic ring structur

165 quencing method that exploits the paucity of ribonucleoside modifications at the 3'-end of tRNAs to q

166 nalysis revealing seven post-transcriptional ribonucleoside modifications in the 5S rRNA.

167 f novel RNA species and post-transcriptional ribonucleoside modifications, and an emerging appreciati

168 These compounds are ribonucleoside mono- and disulfates derived from guanosi

169 er ribonucleoside diphosphate-X compounds to ribonucleoside monophosphate and cyclic X-phosphodiester

170 a nick generated by DNA topoisomerase I at a ribonucleoside monophosphate residue.

171 transcriptase (RT) efficiently incorporates ribonucleoside monophosphates (rNMPs) during DNA synthes

172 Ribonucleotide excision repair (RER) removes ribonucleoside monophosphates (rNMPs) from genomic DNA,

173 DNA polymerases incorporate ribonucleoside monophosphates (rNMPs) into genomic DNA a

174 pecialized to remove single ribonucleotides [ribonucleoside monophosphates (rNMPs)] from duplex DNA,

175 n of mutations arising from mis-insertion of ribonucleoside monophosphates during DNA replication.

176 ssing-gap filling that mediates tolerance of ribonucleoside monophosphates in the genome.

177 MR resonance of 5-[19F]fluoropyrimidin-2-one ribonucleoside moves upfield when it is bound by wild-ty

178 tion of SLC29A1 by nitrobenzylmercaptopurine ribonucleoside (NBMPR) caused a 33% to 45% reduction of

179 hatase (AphA), and the produced nicotinamide ribonucleoside (NmR) enters the cell via the PnuC transp

180 stion mark2,3-dimidazoles and the N1- and N3-ribonucleosides of 2-substituted 6,7-dichloroimidazo inv

181 The effects of methylated ribonucleosides on translation could be attributed to th

182 in the tissue preparation containing vanadyl ribonucleoside or orthovanadate.

183 on of AMPK by 5-aminoimidazole-4-carboxamide ribonucleoside or transfection with an adenovirus encodi

184 sidues in the N-conformation as observed for ribonucleosides or 2'-deoxy-2'-fluororibonucleosides.

185 K) activator 5'-aminoimidazole-4-carboxamide ribonucleoside partially reversed the inhibition of insu

186 Conversion of the thiosugar into the four ribonucleoside phosphoramidite building blocks was accom

187 xymethyl group for 2'-hydroxyl protection of ribonucleoside phosphoramidites 9a-d has been implemente

188 otides and have motivated the development of ribonucleoside phosphoramidites that would exhibit coupl

189 4(5)-haloimidazoles produces 5-haloimidazole ribonucleosides predominantly in the alpha-configuration

190 U) have been prepared in high yield from the ribonucleoside, protected, and incorporated into an olig

191 nd prevented 5-aminoimidazole-4-carboxyamide ribonucleoside-reduced STAT1 phosphorylation.

192 e examined the effects of MDL101731, a novel ribonucleoside reductase inhibitor, against human gliobl

193 hod involves protection of the 2-aminopurine ribonucleoside, reduction to the deoxyribonucleoside and

194 t for 3'-phosphatase activity but not for 3' ribonucleoside removal (Arg-14, Asp-15, Glu-21, Gln-40,

195 tical for 3'-phosphatase activity but not 3'-ribonucleoside removal; and (iii) at Lys66 and Arg76, wh

196 noncytotoxic concentrations by benzimidazole ribonucleosides requires a halogen not only at the 2-pos

197 Here we characterize the 3'-ribonucleoside-resecting activity of Candidatus Korarcha

198 nucleotides containing 2'-O-(2-methoxyethyl) ribonucleoside residues and phosphorothioate and phospho

199 e efficiently than wild type on a variety of ribonucleoside (rNMP)-containing DNA substrates.

200 The structure of the enzyme with a bound ribonucleoside shows that the nucleophilic oxygen atom o

201 ibitor of SLC29A1, nitrobenzylmercaptopurine ribonucleoside, significantly reduced the potency of the

202 Ribonucleosides stabilized by borate mobilize borate and

203 vator 5-aminoimidazole-4-carboxamide1-beta-D-ribonucleoside stimulated AMPK phosphorylation and gluco

204 The benzimidazole D-ribonucleosides TCRB and BDCRB are potent and selective

205 tive N(2)-2',3',5'-tetraacetyl-6-bromopurine ribonucleoside, the synthesis of which is reported here

206 the human enzyme is specific for 6-oxopurine ribonucleosides, the Escherichia coli enzyme accepts add

207 version of 2-amino-6-mercapto-7-methylpurine ribonucleoside to 2-amino-6-mercapto-7-methylpurine by p

208 he ability of 5-aminoimidazole-4-carboxamide ribonucleoside to suppress ethanol-mediated induction of

209 eversible phosphorolysis of purine (2'-deoxy)ribonucleosides to give the corresponding purine base an

210 reversible phosphorolysis of 2'-deoxypurine ribonucleosides to the free bases and 2-deoxyribose 1-ph

211 termined by deoxyribonucleoside triphosphate/ribonucleoside triphosphate (dNTP/rNTP) ratios, by the a

212 ncentrations and a greater disparity between ribonucleoside triphosphate (rNTP) and dNTP concentratio

213 uired for proviral DNA synthesis whereas the ribonucleoside triphosphate (rNTP) levels remain in the

214 Finally, ribonucleoside triphosphate (rNTP) pools have been shown

215 We measured ribonucleoside triphosphate (rNTP) pools in rat mitochon

216 and cell-free PV synthesis that a pyrimidine ribonucleoside triphosphate analogue (rPTP) with ambiguo

217 t T7 RNA polymerase accepts this fluorescent ribonucleoside triphosphate as a substrate in in vitro t

218 olecules of RNAP under various conditions of ribonucleoside triphosphate concentration, applied load,

219 that, at a consensus promoter, at saturating ribonucleoside triphosphate concentrations, abortive-pro

220 roblasts arrested in response to DNA damage, ribonucleoside triphosphate depletion, and spindle poiso

221 The total time for the synthesis of ribonucleoside triphosphate is approximately 6 days, and

222 Furan-modified ribonucleoside triphosphate is synthesized in two steps

223 The adenosylcobalamin-dependent ribonucleoside triphosphate reductase (RTPR) from Lactob

224 catalytic mechanism of nucleotide reduction, ribonucleoside triphosphate reductase (RTPR) from Lactob

225 The ribonucleoside triphosphate reductase (RTPR) from Lactob

226 Ribonucleoside triphosphate reductase (RTPR) from Lactob

227 The ribonucleoside triphosphate reductase (RTPR) from Lactob

228 oside diphosphate reductase reaction and the ribonucleoside triphosphate reductase reaction with vari

229 Ribonucleoside triphosphate synthesis required PEP as th

230 Binding of a ribonucleoside triphosphate to an RNA polymerase II tran

231 e chain of this residue and the 2'-OH of the ribonucleoside triphosphate.

232 synthesis where RNAP accepts two initiating ribonucleoside triphosphates (iNTPs) and performs the fi

233 sis, is allosterically regulated by all four ribonucleoside triphosphates (NTPs) in a nonlinear manne

234 t physiologically relevant concentrations of ribonucleoside triphosphates (NTPs), few MCMs are found.

235 Any of the four ribonucleoside triphosphates (rNTPs) can act as precurso

236 e transcriptase (RT) frequently incorporates ribonucleoside triphosphates (rNTPs) during proviral DNA

237 The concentration of ribonucleoside triphosphates (rNTPs) in cells is far gre

238 Replicative DNA polymerases misincorporate ribonucleoside triphosphates (rNTPs) into DNA approximat

239 is compatible with 2'-fluoro-modified (2'F) ribonucleoside triphosphates (rNTPs), which may be inclu

240 ability to grow in cells with low levels of ribonucleoside triphosphates (rNTPs).

241 and both complementary and noncomplementary ribonucleoside triphosphates (rNTPs).

242 The F12A mutant of Dbh incorporates ribonucleoside triphosphates almost as efficiently as de

243 Primers are synthesized from ribonucleoside triphosphates and are four to fifteen nuc

244 ched oligonucleotide primer by incorporating ribonucleoside triphosphates and biotinylated UTP, are i

245 t1p displays broad specificity in converting ribonucleoside triphosphates and deoxynucleoside triphos

246 e product), which catalyzes the synthesis of ribonucleoside triphosphates and deoxyribonucleoside tri

247 eferentially interacts with dNTP rather than ribonucleoside triphosphates and initiates RNA as well a

248 tion from P(minor) incorporates nontemplated ribonucleoside triphosphates at the 5' end of the P(mino

249 h in wild-type enzyme fails to guard against ribonucleoside triphosphates incorporation with sufficie

250 Asn-297 is involved in selection of ribonucleoside triphosphates over 2'-dNTPs, a role media

251 illus leichmannii catalyzes the reduction of ribonucleoside triphosphates to deoxyribonucleoside trip

252 hanges include: (i) oxidative degradation of ribonucleoside triphosphates using methylamine at lower

253 tants were isolated and shown to incorporate ribonucleoside triphosphates virtually as efficiently as

254 specificity of T7 RNA polymerase (RNAP) for ribonucleoside triphosphates vs deoxynucleoside triphosp

255 hesize an unnatural polymer from 2'-O-methyl ribonucleoside triphosphates were immobilized and isolat

256 templates, B. subtilis RNA polymerase, four ribonucleoside triphosphates, and the purified B. subtil

257 i) after priming in the presence of the four ribonucleoside triphosphates, or (iv) after complementar

258 it occurs at physiological concentrations of ribonucleoside triphosphates, this reaction may determin

259 eir natural substrates, deoxy- as opposed to ribonucleoside triphosphates, with a selectivity greater

260 e, a component of peptidoglycan, followed by ribonucleoside triphosphates.

261 es as substrate is higher than corresponding ribonucleoside triphosphates.

262 triphosphates, and GTP is the best among the ribonucleoside triphosphates.

263 not compete with transcribing particles for ribonucleoside triphosphates.

264 and by the presence of the DNA primase with ribonucleoside triphosphates.

265 itiate DNA chain synthesis in the absence of ribonucleoside triphosphates.

266 unction of the ambient concentrations of the ribonucleoside triphosphates; and 2), the distribution o

267 ites at which phosphorylation might occur in ribonucleosides under conditions that make it possible,

268 bonucleosides (deoxycytidine) and pyrimidine ribonucleosides (uridine) and is partially NBMPR-sensiti

269 e first example of a conformationally locked ribonucleoside version in the Southern hemisphere.

270 The structure of the 5-fluoroimidazole ribonucleoside was confirmed by X-ray crystallography an

271 In addition, glycinamide ribonucleoside was neither a substrate for, nor an inhib

272 vity against HCMV of the dihalobenzimidazole ribonucleosides was I approximately equal to Br approxim

273 via steady-state kinetics and PCR, while the ribonucleosides were characterized by the transcription

274 Inexpensive ribonucleosides were used as starting materials.

275 is a member of a new class of benzimidazole ribonucleosides which inhibit human cytomegalovirus (HCM

276 eric oligonucleotides with 2'-O-methoxyethyl ribonucleoside wings and a central DNA phosphorothioate

277 The reaction of these novel ribonucleosides with 1-pyrenecarboxaldehyde results in t

278 ence, the conjugation of 2'-O-aminooxymethyl ribonucleosides with aldehydes, including those generate

279 Screening of 7-(het)aryl-7-deazaadenine ribonucleosides with Mtb and human (h) ADKs and testing