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1 homodimeric HIV-1 protease and heterodimeric ribonucleotide reductase).
2 deoxyribonucleoside diphosphates (dNDPs) by ribonucleotide reductase.
3 2 substitutes for protein R2 as a subunit of ribonucleotide reductase.
4 HSV mutations in ICP6, the large subunit of ribonucleotide reductase.
5 as it does in eukaryotes, via inhibition of ribonucleotide reductase.
6 G levels and expression of the p53-inducible ribonucleotide reductase.
7 ation is through subcellular localization of ribonucleotide reductase.
8 disulfide reduction and electron donation to ribonucleotide reductase.
9 ease of dGTP due to allosteric regulation of ribonucleotide reductase.
10 receptors on lymphoma cells, and inhibiting ribonucleotide reductase.
11 e triphosphate pools through the activity of ribonucleotide reductase.
12 tumor suppressor p53, is a small subunit of ribonucleotide reductase.
13 which inhibits DNA replication by inhibiting ribonucleotide reductase.
14 akin to the tyrosine dyad (Y730 and Y731) of ribonucleotide reductase.
15 xposure to hydroxyurea (HU), an inhibitor of ribonucleotide reductase.
16 vating catalysts in numerous enzymes such as ribonucleotide reductase.
17 nome of Escherichia coli encodes two class I ribonucleotide reductases.
18 nown mechanisms of upregulated expression of ribonucleotide reductase, 14-3-3sigma expression is dram
23 port a new mechanism for regulation of yeast ribonucleotide reductase activity that occurs during iro
24 l2 reduces intracellular dNTPs by inhibiting ribonucleotide reductase activity, thereby providing ins
26 aprenol kinase, homoserine kinase, anaerobic ribonucleotide reductase, adenylosuccinate lyase, and a
27 lating the expression of the RNR2 subunit of ribonucleotide reductase, an enzyme essential for the re
28 at low doses of hydroxyurea, an inhibitor of ribonucleotide reductase and an important drug in the tr
30 n are respectively complemented by mammalian ribonucleotide reductase and GADD34, whose genes are exp
31 ext two deal with specific cases, the enzyme ribonucleotide reductase and iron/manganese homeostasis
33 sidue that is structurally conserved in both ribonucleotide reductase and mycobacterial putative acyl
34 on of the gene encoding the small subunit of ribonucleotide reductase and of the K3L gene to allow ad
38 likely involves the allosteric regulation of ribonucleotide reductase and severe limitations of the d
39 droxyurea, is a highly specific inhibitor of ribonucleotide reductase and therefore of DNA synthesis;
40 these types of altered growth and mammalian ribonucleotide reductase and topoisomerases are targets
41 educing equivalents for cofactor assembly in ribonucleotide reductases and highlight issues associate
42 ut with hydroxyurea (HU), thereby inhibiting ribonucleotide reductase, and bringing about damage-inde
43 nt thymidylate synthase, thymidylate kinase, ribonucleotide reductase, and deoxycytidylate deaminase,
44 active site similar to that in hemerythrin, ribonucleotide reductase, and methane monooxygenase, all
45 . patens proliferating cell nuclear antigen, ribonucleotide reductase, and minichromosome maintenance
46 ers may inhibit thymidylate synthase (TS) or ribonucleotide reductase, and the nucleoside/nucleobase
47 uene monooxygenases, bacterial and mammalian ribonucleotide reductases, and stearoyl acyl carrier pro
48 lux backbone appears to buffer deficiency in ribonucleotide reductase by enabling a compensatory incr
49 R2) subunit of the class 1a Escherichia coli ribonucleotide reductases by reaction with O2 followed b
54 de the large and small subunits of the human ribonucleotide reductase complex, respectively, markedly
55 ivated the ICP6 gene (UL39, large subunit of ribonucleotide reductase), constructing ICP6 mutants wit
58 failure to mediate histone deacetylation of ribonucleotide reductase, dihydrofolate reductase, and t
59 physiologically relevant electron donor for ribonucleotide reductase during DNA precursor synthesis.
60 cluding those formed in the essential enzyme ribonucleotide reductase during its action on substrates
61 and that negative feedback between dATP and ribonucleotide reductase ensures tight control of dNTP c
62 d mass spectrometry, we identified RRM2 (the ribonucleotide reductase family member 2) as an interact
63 r, a "missing link" intermediary form of the ribonucleotide reductase family, vestigial pi-helices, a
64 esis is further complicated by the lack of a ribonucleotide reductase for the conversion of nucleosid
66 tly reported that the R2 subunit of class Ic ribonucleotide reductase from Chlamydia trachomatis cont
68 tructures of the eukaryotic alpha subunit of ribonucleotide reductase from Saccharomyces cerevisiae.
70 se mutations in viral ICP6 (encoding a viral ribonucleotide reductase function) and/or gamma34.5 func
71 ertion or in-frame deletion in the anaerobic ribonucleotide reductase gene failed to grow under stric
72 iron(II/II) cluster in protein R2 of class I ribonucleotide reductase generates the enzyme's essentia
73 s of deletion mutants, titratable alleles of ribonucleotide reductase genes, and measurements of intr
74 o Crt1, the repressor of model MMS-inducible ribonucleotide reductase genes, was found not to play a
75 many DNA damage induced genes, including the ribonucleotide reductase genes, which regulate cellular
77 kinase, or deletion of the Spd1 inhibitor of ribonucleotide reductase has little additional effect on
78 work by Wang et al. (2014), reveal that HSV ribonucleotide reductase has opposing activities in eith
79 We conclude that the regulatory subunit of ribonucleotide reductase has tumor suppressor activity t
83 on, thus eliminating inducible expression of ribonucleotide reductase in mec1-21, rates of spontaneou
84 lear recruitment suggests an active role for ribonucleotide reductase in the cellular response to CPT
86 and likely repair of the metallocofactor of ribonucleotide reductases in both bacteria and the buddi
88 imultaneous depletion of dATP pools (through ribonucleotide reductase inhibition) and accumulation in
90 idine-2-carboxaldehyde thiosemicarbazone), a ribonucleotide reductase inhibitor, has been extensively
91 rosine kinase inhibitor, plus hydroxyurea, a ribonucleotide reductase inhibitor, in patients with rec
92 at the response to BrdU is influenced by the ribonucleotide reductase inhibitor, Spd1, suggesting tha
95 tically active form aerobic Escherichia coli ribonucleotide reductase is a complex of homodimeric R1
100 The essential catalytic radical of Class-I ribonucleotide reductase is generated and delivered by p
101 The rate-limiting enzyme of dNTP synthesis, ribonucleotide reductase, is inhibited by endogenous lev
106 ciency, complementation group 1 (ERCC1), and ribonucleotide reductase M1 (RRM1) expression levels hav
108 A analysis showed a strong increase of rrm1 (ribonucleotide reductase M1) expression in the resistant
109 vealed that the TC-1-GR cells over-expressed ribonucleotide reductase M1, which was likely the cause
111 ons substantially increase the expression of ribonucleotide reductase, most likely by altering the in
112 ible protein (hli), transaldolase (talC) and ribonucleotide reductase (nrd)--are transcribed together
117 is a natural product that inhibits cellular ribonucleotide reductase, prolonging the S phase of the
119 ystem II, the phytochrome photoreceptor, and ribonucleotide reductase R2 illustrate the power and ver
121 e small betabeta subunit of Escherichia coli ribonucleotide reductase (R2) contains a binuclear iron
122 , very similar to the active site of class I ribonucleotide reductase (R2) providing open coordinatio
123 semblance to the spectra of Escherichia coli ribonucleotide reductase (R2), and density functional th
124 homologous to the small subunit of class Ic ribonucleotide reductase (R2c) but has a completely diff
127 e beta protein (betaC19) of Escherichia coli ribonucleotide reductase (RNR) allows for the temporal m
128 y of their respective rate-limiting enzymes, ribonucleotide reductase (RNR) and deoxycytidine kinase
130 ate synthase, dihydrofolate (DHF) reductase, ribonucleotide reductase (RNR) and Escherichia coli nucl
131 3-fluorotyrosine (3-FY) in the R2 subunit of ribonucleotide reductase (RNR) and present the EPR spect
133 ino acid radicals [photosystem II (PSII) and ribonucleotide reductase (RNR) as compared to tyrosine-m
136 ates accumulate during activation of class I ribonucleotide reductase (RNR) beta subunits, which self
162 A conventional class I (subclass a or b) ribonucleotide reductase (RNR) employs a tyrosyl radical
164 (DTNB), and the manganese-containing type Ib ribonucleotide reductase (RNR) from B. anthracis in the
167 22.) production in the R2 subunit of class I ribonucleotide reductase (RNR) from Escherichia coli.
170 ed a novel function for Rap1, regulating the ribonucleotide reductase (RNR) genes that are required f
172 n the alpha2 (R1) subunit of class I E. coli ribonucleotide reductase (RNR) has been investigated by
174 t does not suppress their sensitivity to the ribonucleotide reductase (RNR) inhibitor hydroxyurea (HU
175 ture studies of the class I Escherichia coli ribonucleotide reductase (RNR) intermediate X and three
176 els for the active site structure of class I ribonucleotide reductase (RNR) intermediate X have been
179 The beta(2) subunit of a class Ia or Ib ribonucleotide reductase (RNR) is activated when its car
191 b1-Cul4(Cdt)(2) ubiquitin ligase complex and ribonucleotide reductase (RNR) to be required for HR rep
192 Many pathogenic organisms require class Ib ribonucleotide reductase (RNR) to catalyze the conversio
195 cifically incorporated into E. coli class Ia ribonucleotide reductase (RNR) using the recently evolve
196 ive copies of nrdB, encoding beta-subunit of ribonucleotide reductase (RNR), a critical enzyme involv
200 mic proteins, including the essential enzyme ribonucleotide reductase (RNR), are maintained in the re
204 droxyurea (HU) specifically inhibits class I ribonucleotide reductase (RNR), depleting dNTP pools and
205 of dNTP biosynthesis in mammals, the enzyme ribonucleotide reductase (RNR), impacts cancer susceptib
206 ression of RNR1, encoding a large subunit of ribonucleotide reductase (RNR), rescued the petite-induc
208 As clofarabine is a potent inhibitor of ribonucleotide reductase (RnR), we hypothesized that clo
224 plication and DNA repair and is catalyzed by ribonucleotide reductases (RNR), which convert ribonucle
225 anslation elongation factor 3 (YEF3) and the ribonucleotide reductase (RNR1 and RNR3) large subunits
226 easing nucleotide pools by overexpression of ribonucleotide reductase (RNR1) suppressed mtDNA replica
227 ithin the gene encoding the large subunit of ribonucleotide reductase (RNR1), the enzyme that catalys
244 Essential for DNA biosynthesis and repair, ribonucleotide reductases (RNRs) convert ribonucleotides
245 A fascinating discovery in the chemistry of ribonucleotide reductases (RNRs) has been the identifica
248 s Ib (NrdEF) and anaerobic class III (NrdDG) ribonucleotide reductases (RNRs) that perform the essent
251 phosphate (F(2)CDP) is a potent inhibitor of ribonucleotide reductases (RNRs), enzymes that convert n
254 p53R2 is a newly identified small subunit of ribonucleotide reductase (RR) and plays a key role in su
260 ath pathways using the large subunit (R1) of ribonucleotide reductase (RR) to suppress apoptosis by b
261 dicted interaction between EBV BPLF1 and EBV ribonucleotide reductase (RR), a functional clone of the
262 ors targeting transferrin receptor (TfR) and ribonucleotide reductase (RR), is proven to be effective
263 intertwined roles for ATM: the regulation of ribonucleotide reductase (RR), the rate-limiting enzyme
264 underexpressed thymidylate synthase (TS) and ribonucleotide reductase (RR), two enzymes required for
265 roduct (ERCC1) and the regulatory subunit of ribonucleotide reductase (RRM1) have been reported as be
266 th the specific messenger RNA (M2 subunit of ribonucleotide reductase (RRM2)) and the protein (RRM2)
269 ne non-redundant homologous genes, including ribonucleotide reductase small subunit (a gene conserved
275 lved in nucleotide metabolism, including the ribonucleotide reductase subunit cdc22 and phosphate- an
276 c delivery of a siRNA nanoparticle targeting ribonucleotide reductase subunit M2 (RRM2), and evaluate
279 by mass spectrometry revealed R1, the large ribonucleotide reductase subunit, in purified mitochondr
281 The effects of siRNA-mediated knockdown of ribonucleotide reductase subunit-2 (RRM2), a rate-limiti
282 d the Rad53 checkpoint-mediated induction of ribonucleotide reductase subunits Rnr1 and Rnr3, thereby
284 ansgenic mouse that overexpresses the enzyme ribonucleotide reductase (TgRR), which catalyzes the rat
285 d cellular targets is the beta(2) subunit of ribonucleotide reductase that requires a diferric-tyrosy
286 ential cofactor for non-heme enzymes such as ribonucleotide reductase, the limiting enzyme for DNA sy
287 is the DNA damage-inducible small subunit of ribonucleotide reductase, the rate-limiting enzyme in de
289 otide triphosphates (dNTPs) and instead uses ribonucleotide reductase to convert imported ribonucleot
290 n site modifies the endogenous ligand set of ribonucleotide reductase to match that of the binuclear
291 ntaining a siRNA targeting the M2 subunit of ribonucleotide reductase to non-human primates are repor
292 otoxicity using hydroxyurea, an inhibitor of ribonucleotide reductase, to decrease the endogenous dGT
294 s in the R2 subunit of Chlamydia trachomatis ribonucleotide reductase using x-ray absorption spectros
296 S phase, and DNA polymerase-alpha, PCNA, and ribonucleotide reductase, which are essential for the in
297 function as the electron donor for class Ib ribonucleotide reductases, which convert ribonucleotides
298 rofolate reductase, thymidylate synthase and ribonucleotide reductase, while also spotlighting new en
299 ocking the cytotoxicity of AZA by inhibiting ribonucleotide reductase with high concentrations of thy
300 Inc, New Haven, CT) is a potent inhibitor of ribonucleotide reductase, with activity in preclinical t
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