ライフサイエンスコーパス: ribosomal frameshift

1 the HIV-1 Pol mRNA requires a programmed -1 ribosomal frameshift.

2 enzyme were synthesized following an unusual ribosomal frameshift.

3 e product that is expressed by translational ribosomal frameshift.

4 covery of a novel HCV protein synthesized by ribosomal frameshift.

5 tion is strongly dependent upon a programmed ribosomal frameshift.

6 2 nucleotides capable of stimulating -1-type ribosomal frameshifts.

7 structure are required for the programmed -1 ribosomal frameshifting.

8 tau and a truncated gamma that is created by ribosomal frameshifting.

9 ading frames required for programmed -1 mRNA ribosomal frameshifting.

10 1) regulates the efficiency of programmed -1 ribosomal frameshifting.

11 eing a truncated version of tau arising from ribosomal frameshifting.

12 nce of a novel structure that can facilitate ribosomal frameshifting.

13 oacyl synthetase recognition, and programmed ribosomal frameshifting.

14 requirements and mechanism of programmed -1 ribosomal frameshifting.

15 promote significant levels of programmed -1 ribosomal frameshifting.

16 rocess may also have an impact on programmed ribosomal frameshifting.

17 tidyltransferase center affect programmed -1 ribosomal frameshifting.

18 l antiviral agents that target programmed -1 ribosomal frameshifting.

19 PKs to decipher the mechanism of programmed ribosomal frameshifting.

20 y alter the efficiency of -1, but not of +1, ribosomal frameshifting.

21 shifted registers reminiscent of programmed ribosomal frameshifting.

22 protein can function as a transactivator of ribosomal frameshifting.

23 s mainly due to PA-X, which was expressed by ribosomal frameshifting.

24 d open reading frame ("X-ORF"), accessed via ribosomal frameshifting.

25 through, ribosome biogenesis, and programmed ribosomal frameshifting.

26 All four pseudoknots cause -1 programmed ribosomal frameshifting.

27 active TK (TK-low phenotype), evidently via ribosomal frameshifting.

28 cane yellow leaf virus (ScYLV) stimulates -1 ribosomal frameshifting.

29 investigate the structure of a -1 programmed ribosomal frameshift (-1 PRF) sequence element located i

30 e polycistronic messages where programmed -1 ribosomal frameshift (-1 PRF) signals direct ribosomes t

31 researchers identify potential programmed -1 ribosomal frameshift (-1 PRF) signals in eukaryotic gene

32 Programmed -1 ribosomal frameshift (-1 PRF) signals redirect translati

33 d signals that are involved in programmed -1 ribosomal frameshifting (-1 PRF) are typically two-stemm

34 determinants of stimulation of -1 programmed ribosomal frameshifting (-1 PRF) by RNA pseudoknots are

35 Programmed -1 ribosomal frameshifting (-1 PRF) is a gene-expression me

36 Programmed -1 ribosomal frameshifting (-1 PRF) is a mechanism that dir

37 Programmed -1 ribosomal frameshifting (-1 PRF) is a widely used transl

38 Programmed -1 ribosomal frameshifting (-1 PRF) is used by many positiv

39 In viruses, programmed -1 ribosomal frameshifting (-1 PRF) signals direct the tran

40 Programmed -1 ribosomal frameshifting (-1 PRF) stimulated by mRNA pseu

41 WNV uses programmed -1 ribosomal frameshifting (-1 PRF) to synthesize the NS1'

42 d related alphaviruses utilize programmed -1 ribosomal frameshifting (-1 PRF) to synthesize the viral

43 These viruses utilize programmed -1 ribosomal frameshifting (-1 PRF) to synthesize the viral

44 oit one such mechanism, termed -1 programmed ribosomal frameshifting (-1 PRF), to engineer ligand-res

45 have a stimulatory function in programmed -1 ribosomal frameshifting (-1 PRF).

46 vious studies have identified operational -1 ribosomal frameshifting (-1 RF) signals in eukaryotic ge

47 Programmed -1 ribosomal frameshifting (-1PRF) is tightly regulated by

48 Programmed -1 ribosomal frameshifting (-1PRF) is used in various syste

49 express 0.09% of wild-type TK activity via a ribosomal frameshift 24 nucleotides upstream of the muta

50 g, and a Gag-Pol fusion protein made by a -1 ribosomal frameshift, a coding strategy used by many ret

51 However, in programmed -1 ribosomal frameshifting, a specific subversion of frame

52 Programmed ribosomal frameshifting allows one mRNA to encode regula

53 on of full-length p43 relies on a programmed ribosomal frameshift, an extremely rare translational me

54 pe and increased efficiency of programmed -1 ribosomal frameshifting and conferred paromomycin sensit

55 the genomic mRNA was critical for sufficient ribosomal frameshifting and EIAV replication, while conc

56 rts a trans-dominant effect on programmed -1 ribosomal frameshifting and killer virus maintenance.

57 product of the mof4-1 allele affects both -1 ribosomal frameshifting and mRNA turnover.

58 nsferase activity, stimulating programmed -1 ribosomal frameshifting and promoting virus propagation

59 er refine the relationship between efficient ribosomal frameshifting and pseudoknot structure and sta

60 oted increased efficiencies of programmed -1 ribosomal frameshifting and rendered cells unable to mai

61 of the potential link between -1 programmed ribosomal frameshifting and response of a pseudoknot (PK

62 " model in which viruses use both programmed ribosomal frameshifting and translational attenuation to

63 not just unconventional initiation, but also ribosomal frameshifting and/or imperfect repeat DNA repl

64 sion is counteracted by TraR antiactivation, ribosomal frameshifting, and FseA antiactivation.

65 Thus, as is also the case for ribosomal frameshifting, antiviral therapies targeting r

66 molecular mechanisms governing programmed -1 ribosomal frameshifting are almost identical from yeast

67 protein that is synthesized by translational ribosomal frameshift at codons 9 to 11 of the core prote

68 ope whose expression results from incidental ribosomal frameshifting at a sequence element within the

69 f functional antizyme requires programmed +1 ribosomal frameshifting at the 3' end of the first of tw

70 mutation that increased the efficiency of -1 ribosomal frameshifting at the L-A virus frameshift site

71 t pDEST17 is intrinsically susceptible to -1 ribosomal frameshifting at the sequence C-AAA-AAA.

72 structure provides parallels with programmed ribosomal frameshifting at the translation level.

73 he molecular mechanisms governing programmed ribosomal frameshifting by using two viruses of the yeas

74 because of their key role in the control of ribosomal frameshifting by viral RNAs.

75 ency, low levels of enzyme synthesized via a ribosomal frameshift can suffice.

76 in testing the hypothesis that programmed -1 ribosomal frameshifting can be used to control cellular

77 he basis of studies using cell-free systems, ribosomal frameshifting can explain this ability to expr

78 Changes in the efficiency of ribosomal frameshifting can have major effects on the ab

79 identification of novel frameshift proteins, ribosomal frameshifting, coding sequence detection and t

80 of translational recoding events (programmed ribosomal frameshifting, codon redefinition and translat

81 The database deals with programmed ribosomal frameshifting, codon redefinition and translat

82 The Programmed Ribosomal Frameshift Database (PRFdb) provides an interf

83 Synthesis of a proportion of non-ribosomal frameshift derived GagPol would be relevant in

84 t killer virus phenotype, suggesting that -1 ribosomal frameshifting does not occur after the peptidy

85 there is an unusually high level, 15%, of +1 ribosomal frameshifting due to features of the nascent p

86 ni but unique in their C termini due to a -1 ribosomal frameshift during translation.

87 pe 1 (HIV-1) has an absolute requirement for ribosomal frameshifting during protein translation in or

88 It is generally believed that significant ribosomal frameshifting during translation does not occu

89 ion of the PEMV-1 pseudoknot greatly reduces ribosomal frameshifting efficacy.

90 tidyl-transfer reaction affect programmed -1 ribosomal frameshift efficiencies and interfere with vir

91 hree- to fourfold increases in programmed -1 ribosomal frameshift efficiencies and loss of the M1 kil

92 viral particle morphogenesis, and changes in ribosomal frameshift efficiencies can severely inhibit v

93 PAP does not affect programmed -1 ribosomal frameshift efficiencies, nor does it have a no

94 t signals, promoting increased programmed -1 ribosomal frameshifting efficiencies and subsequent loss

95 e inhibitors, anisomycin and sparsomycin, on ribosomal frameshifting efficiencies and the propagation

96 otic paromomycin and increased programmed -1 ribosomal frameshift efficiency resulting in loss of the

97 Ribosomal frameshifting entails slippage of the translat

98 e frameshift sequencing errors), investigate ribosomal frameshifts, etc.

99 enes from different nematodes also require a ribosomal frameshift event for their expression.

100 d of the gag gene performing a programmed -1 ribosomal frameshift event to enter the overlapping pol

101 in of Rous sarcoma virus (RSV) requires a -1 ribosomal frameshifting event at the overlap region of t

102 lyses of alphavirus genomes suggested that a ribosomal frameshifting event occurs during translation

103 e RNA sequence that directs a programmed, +1 ribosomal frameshifting event required for Gag-Pol trans

104 t al. describe a novel, antibiotic-dependent ribosomal frameshifting event that activates translation

105 iciency virus (HIV) requires a programmed -1 ribosomal frameshift for Pol gene expression.

106 All three genes appear to require ribosomal frameshifting for expression of catalytically

107 ation depends upon a polyamine-stimulated +1 ribosomal frameshift, forming a complex negative feedbac

108 that a specific conformation is required for ribosomal frameshifting, further implying a specific int

109 li an autoregulatory mechanism of programmed ribosomal frameshifting governs the level of polypeptide

110 Programmed -1 ribosomal frameshifting has become the subject of increa

111 ghly accurate, a number of cases of directed ribosomal frameshifting have been reported in RNA viruse

112 nals are associated with sites of programmed ribosomal frameshifting, hopping, termination codon supp

113 synthesized as a fusion protein through a -1 ribosomal frameshift in a region where gag and pol open

114 constitute the structural elements for a -1 ribosomal frameshift in the GLV transcript.

115 The efficiency of programmed ribosomal frameshifting in decoding antizyme mRNA is the

116 ecific mRNA elements required for sufficient ribosomal frameshifting in equine anemia infectious viru

117 ation, specifically inhibits Ty1-directed +1 ribosomal frameshifting in intact yeast cells and in an

118 that provide one of the signals required for ribosomal frameshifting in mouse mammary tumor virus hav

119 h is a mutant of the pseudoknot required for ribosomal frameshifting in mouse mammary tumor virus, ha

120 The pseudoknot causes efficient -1 ribosomal frameshifting in mouse mammary tumor virus.

121 fluenza virus virulence protein generated by ribosomal frameshifting in segment 3 of influenza virus

122 e cis-acting elements that promote efficient ribosomal frameshifting in the -1 (5') direction have be

123 We identified a potential site of +1 ribosomal frameshifting in the EST3 coding sequence and

124 ATP7B, the human homolog of copA, and direct ribosomal frameshifting in vivo.

125 these drugs also change the efficiency of -1 ribosomal frameshifting in yeast and mammalian in vitro

126 odon of the polyprotein sequence followed by ribosomal frameshift into the -2/+1 reading frame.

127 the HCV type 1 frameshift signal facilitate ribosomal frameshifts into both overlapping reading fram

128 A polyamine-stimulated ribosomal frameshift is required for decoding antizyme1

129 A ribosomal frameshift is required for the synthesis of an

130 Programmed -1 ribosomal frameshifting is a mechanism of gene expressio

131 Programmed ribosomal frameshifting is a molecular mechanism that is

132 totiviruses, the efficiency of programmed -1 ribosomal frameshifting is critical for ensuring the pro

133 Programmed -1 ribosomal frameshifting is employed in the expression of

134 Apparently, a site of ribosomal frameshifting is encoded within parB, at which

135 y support the mechanistic hypothesis that -1 ribosomal frameshifting is enhanced by torsional resista

136 Because ribosomal frameshifting is essential for HIV-1 replicati

137 e slippery sequence and stem-loop to promote ribosomal frameshifting is influenced by the flanking up

138 Programmed -1 ribosomal frameshifting is necessary for translation of

139 In T. thermophilus ribosomal frameshifting is not required: the dnaX mRNA i

140 Ribosomal frameshifting is one potential target that has

141 iae double-stranded RNA virus, programmed -1 ribosomal frameshifting is responsible for translation o

142 Programmed ribosomal frameshifting is used by many viruses to regul

143 Polyamine-regulated programmed ribosomal frameshifting is used in decoding antizyme2 mR

144 Programmed -1 ribosomal frameshifting is utilized by a number of RNA v

145 Ribosomal frameshifting is utilized for the synthesis of

146 Programmed -1 ribosomal frameshifting is widely used in the expression

147 shift/slippage site, which is important for ribosomal frameshifting, is shown here to limit reverse

148 that it is expressed via a novel programmed ribosomal frameshifting mechanism.

149 Since ribosomal frameshifting occurs during the elongation pha

150 Ribosomal frameshifting occurs when a ribosome slips a f

151 ed exclusively as a Gag-Pol fusion either by ribosomal frameshifting or by read-through of the gag st

152 pathogenic RNA viruses and retroviruses use ribosomal frameshifting or stop codon readthrough to reg

153 unclear, a novel viral protein expressed by ribosomal frameshifting, PA-X, was found to play a major

154 ing mRNA elements that promote programmed -1 ribosomal frameshifting present a natural target for the

155 Here we show that a +1 programmed ribosomal frameshift (PRF) fuses the coding sequences of

156 Coronavirus (SARS-CoV) employ programmed -1 ribosomal frameshifting (PRF) for their protein expressi

157 Programmed -1 ribosomal frameshifting (PRF) is a distinctive mode of g

158 Programmed ribosomal frameshifting (PRF) is a process by which ribo

159 Translational control through programmed ribosomal frameshifting (PRF) is exploited widely by vir

160 nse and activating a unique -2/-1 programmed ribosomal frameshifting (PRF) signal for the expression

161 In +1 programmed ribosomal frameshifting (PRF), ribosomes skip one nucleo

162 Programmed ribosomal frameshifting produces alternative proteins fr

163 Programmed ribosomal frameshifting provides a mechanism to decode i

164 putative feline immunodeficiency virus (FIV) ribosomal frameshifting pseudoknot (PK) has been investi

165 tected as an increased rate of -1 programmed ribosomal frameshift read-through in a dual-luciferase a

166 e that, in metazoa, promotes a +1 programmed ribosomal frameshift required for AZ expression.

167 This ribosomal frameshift requires only codons 8-14 of the co

168 s on killer virus maintenance, programmed -1 ribosomal frameshifting, resistance/hypersensitivity to

169 LRV presumably expresses its polymerase by a ribosomal frameshift, resulting in a capsid-polymerase f

170 We examined here the role of the ribosomal frameshift signal in HIV-1 RNA packaging by st

171 this study, we examined whether the Gag-Pol ribosomal frameshift signal is important for HIV-1 RNA p

172 Pol is supplied in trans, none of the tested ribosomal frameshift signal mutants has defects in RNA p

173 reported that a region including the Gag-Pol ribosomal frameshift signal plays an important role in H

174 We conclude that although the ribosomal frameshift signal plays an important role in r

175 nt a novel 'cellular class' of programmed -1 ribosomal frameshift signal, but rather are similar to v

176 Three mutants with altered ribosomal frameshift signal, either through direct delet

177 in the triple decoding activities of the HCV ribosomal frameshift signal.

178 to that of a virus containing the wild-type ribosomal frameshift signal.

179 gag p1-p6 domain and overlapping the Gag-Pol ribosomal frameshift signal.

180 The ribosomal frameshifting signal of the mouse embryonal ca

181 The ribosomal frameshifting signal present in the genomic RN

182 ts demonstrated that consensus programmed -1 ribosomal frameshift signals can be identified in a subs

183 Eukaryotic ribosomal frameshift signals generally contain two eleme

184 iseases would disrupt putative programmed -1 ribosomal frameshift signals, suggesting that the frames

185 search large DNA databases for consensus -1 ribosomal frameshift signals.

186 Ribosomal frameshifting signals are found in mobile gene

187 At -1 ribosomal frameshifting sites, several types of pseudokn

188 frames, the over-reading of stop codons via ribosomal frameshifting, the existence of an antizyme an

189 Ribosomal frameshifting therefore provides a unique targ

190 many retroviruses, utilizes a -1 programmed ribosomal frameshift to generate viral enzymes in the fo

191 L-A uses a -1 ribosomal frameshift to produce a Gag-Pol fusion protein

192 randed RNA virus, which uses a programmed -1 ribosomal frameshift to produce its Gag-Pol fusion prote

193 Many viruses use programmed -1 ribosomal frameshifting to express defined ratios of str

194 A1 undergo highly efficient +1/-2 programmed ribosomal frameshifting to generate previously undescrib

195 Many pathogenic viruses use programmed -1 ribosomal frameshifting to regulate translation of their

196 isiae killer virus system uses programmed -1 ribosomal frameshifting to synthesize its gene products.

197 part of its life cycle, termed programmed -1 ribosomal frameshifting, to produce the required ratio o

198 e codons and/or the process of programmed -1 ribosomal frameshifting used by viruses to control their

199 distribution of recoding with a focus on the ribosomal frameshifting used for gene expression in bact

200 any viruses regulate protein synthesis by -1 ribosomal frameshifting using an RNA pseudoknot.

201 h whether thymidine kinase synthesized via a ribosomal frameshift was sufficient for reactivation und

202 doknots in controlling the extent of -1-type ribosomal frameshifting, we determined the crystal struc

203 th sequences that trigger genuine programmed ribosomal frameshifting; we have experimentally confirme

204 ally mimic these RNA structures to induce +1 ribosomal frameshifting when annealed downstream of the

205 roduced from one gene, dnaX, by a programmed ribosomal frameshift which generates the C terminal of g

206 g-Pol polyproteins, by using a programmed -1 ribosomal frameshift which requires a slippery sequence

207 n immunodeficiency virus (HIV) requires a -1 ribosomal frameshift, which is directed by a highly cons

208 te tRNA slippage is the driving force for +1 ribosomal frameshifting while the presence of a 'hungry