ライフサイエンスコーパス: ribosomal protein S6

1 RvE1 also stimulated the phosphorylation of ribosomal protein S6.

2 with reduced tumor levels of phosphorylated ribosomal protein S6.

3 hinery, including S6k1 and its substrate the ribosomal protein S6.

4 ty and its downstream effectors GSK3beta and ribosomal protein S6.

5 2 of 22 (100%) p-p70S6K, and 5 of 20 (25%) p-ribosomal protein S6.

6 in phosphorylation of the p70S6K substrate, ribosomal protein S6.

7 of the translation factors eIF4E, 4EBP1, and ribosomal protein S6.

8 ng p70 S6 kinase and, consequently, the 40 S ribosomal protein S6.

9 structural gatekeepers on the folding of the ribosomal protein S6.

10 G, eIF4E, 4E-binding protein 1 (4E-BP1), and ribosomal protein S6.

11 tration resulted in the dephosphorylation of ribosomal protein S6.

12 tion: eukaryotic initiation factor eIF4E and ribosomal protein S6.

13 y virtue of its ability to phosphorylate the ribosomal protein S6.

14 esponsible for its enzymatic activity toward ribosomal protein S6.

15 e sdgH class affects rpsF, which encodes the ribosomal protein S6.

16 irus results in increased phosphorylation of ribosomal protein S6.

17 m response factor, c-Fos, Nur77, and the 40S ribosomal protein S6.

18 by phosphorylation of the downstream target, ribosomal protein S6.

19 ated with increased levels of phosphorylated ribosomal protein S6.

20 ORC1, as reflected by phosphorylation of the ribosomal protein S6.

21 es, and decreased phosphorylation of AKT and ribosomal protein S6.

22 of protein synthesis by phosphorylating the ribosomal protein, S6.

23 lso abrogated the phosphorylation of p70S6K, ribosomal protein S6, 4E-BP1, and eIF4E induced by PDGF-

24 d its downstream effector molecules, p70S6K, ribosomal protein S6, 4E-BP1, and eIF4E.

25 activity and phosphorylation of Akt, p70S6K, ribosomal protein S6, 4E-BP1, and eIF4E.

26 nstrate that both S18 proteins interact with ribosomal protein S6, a committed step in ribosome bioge

27 ultimately regulates the phosphorylation of ribosomal protein S6, a critical step in the insulin sig

28 culocytes show high levels of phosphorylated ribosomal protein S6, a downstream target of mTORC1.

29 Here, we show that ribosomal protein S6, a structural component of the ribo

30 40 S ribosomal protein S6, a target of p70(S6K), and 4E-BP1,

31 The 30-kDa protein was identified as ribosomal protein S6, a translational regulator, and its

32 uced Akt, mammalian target of rapamycin, and ribosomal protein S6 activation was significantly attenu

33 -LTD, through a mechanism involving mTOR and ribosomal protein S6 activation.

34 targets of mTORC1, S6 kinase 1 (S6K1) and S6 ribosomal protein (S6), after administration of the FAS

35 crease in immunoreactivity of phosphorylated ribosomal protein S6, an AKT pathway downstream target.

36 lation of BHD reduces the phosphorylation of ribosomal protein S6, an indicator of TORC1 activity.

37 clone displayed prolonged phosphorylation of ribosomal protein S6, an integrator of MAPK and AKT acti

38 , we found that the translational regulators ribosomal protein S6 and 4E-BP1 are constitutively phosp

39 ects of MTI on proliferation, apoptosis, and ribosomal protein S6 and 4E-BP1 phosphorylation in cell

40 M(-/-) splenic CD8(+) T cells have increased ribosomal protein S6 and Akt phosphorylation and do not

41 Ribosomal protein S6 and an S6 kinase are phosphorylated

42 S6K, and 4E-BP1 and their effector molecules ribosomal protein S6 and eIF4E.

43 t analysis indicated that phosphorylation of ribosomal protein S6 and extracellular-signal regulated

44 s, insulin stimulates phosphorylation of the ribosomal protein S6 and hence protein synthesis about e

45 les displayed lower levels of phosphorylated ribosomal protein S6 and higher levels of phosphorylated

46 anabolic factors acetyl-CoA carboxylase and ribosomal protein S6 and inhibiting aerobic glycolytic p

47 rylation of initiation factors 4B and 4G and ribosomal protein S6 and is due at least in part to mult

48 (S6K1), through phosphorylation of the 40 S ribosomal protein S6 and regulation of 5'-terminal oligo

49 ll internal antigen-1 with eIF3b, eIF4E, and ribosomal protein S6 and studied eIF2 and eIF4F complex.

50 Ang II stimulated phosphorylation of the 40S ribosomal protein S6 and the eukaryotic translation init

51 inversely correlates with phosphorylation of ribosomal protein S6 and tumour angiogenesis in mouse an

52 amycin pathway, decreased phosphorylation of ribosomal protein-S6 and 4E-BP1, down-regulation of cycl

53 aracteristic of ribosomal proteins including ribosomal protein S6, and a number of additional unident

54 4E (eIF4E), eIF4E-binding protein 1 (4EBP1), ribosomal protein S6, and eIF4F cap-complex formation, a

55 bundances of insulin receptor, GLUT4, AS160, ribosomal protein S6, and FOXO1.

56 ding a proline-rich Akt substrate of 40 kDa, ribosomal protein S6, and glycogen synthase kinase-3.

57 arget of rapamycin, p70 ribosomal S6 kinase, ribosomal protein S6, and mitogen activated protein kina

58 xin XI-A, the p80 subunit of the Ku antigen, ribosomal protein S6, and other unknown autoantigens cou

59 ion factor 4E-binding protein-1, p70S6K, and ribosomal protein S6, are highly phosphorylated in ALK+

60 ng MOR161-2 in vivo using the phosphorylated ribosomal protein S6 as a marker.

61 e) and S6K-RPS6 (ribosomal protein S6 kinase-ribosomal protein S6) axes.

62 ha, the catalytic activity of p70beta toward ribosomal protein S6 could be rapidly activated by serum

63 domain of pKi-67, the KIAA1671 gene product, ribosomal protein S6, cyclin K, elongation factor-2, Grb

64 Phosphorylation of ribosomal protein S6 [downstream of the mammalian target

65 that targets of the mTOR kinase, such as the ribosomal protein S6, eIF4G, and Akt, are hyperphosphory

66 entally, a set of circular permutants of the ribosomal protein S6 from Thermus thermophilus was analy

67 Using conditional inactivation of the ribosomal protein S6 gene in laboratory mice, we found t

68 e two genes share a common ancestor with the ribosomal protein S6:glutamate ligase and a putative alp

69 d-alanine:d-alanine ligase and the bacterial ribosomal protein S6:glutamate ligase have been vertical

70 was associated with decreased phosphorylated ribosomal protein S6 immunoreactivity.

71 d moderate or strong hyperphosphorylation of ribosomal protein S6 in 78/107 melanomas (73%).

72 IL-7 treatment increased levels of phospho-ribosomal protein S6 in HIV-specific CD8 T cells, sugges

73 stimulates the phosphorylation of STAT5 and ribosomal protein S6 in the hypothalamic arcuate nucleus

74 g behavior, and increased phosphorylation of ribosomal protein S6 in the medial prefrontal cortex (mP

75 inocyte proliferation and phosphorylation of ribosomal protein S6 in vitro.

76 protein kinase that phosphorylates the 40 S ribosomal protein S6 in vitro.

77 horylation of both S6 kinase 1 (S6K1) and S6 ribosomal protein (S6) in the LF group.

78 ger influence of pERK on pS6 (phosphorylated-ribosomal protein S6), in naive cells as compared with a

79 B (trkB), namely, phosphorylation of Akt and ribosomal protein S6, in SN neurons.

80 We report here that the mammalian 40S ribosomal protein S6 is a DAPK substrate.

81 Ribosomal protein S6 is a downstream target of the PI3K/

82 Folding of the ribosomal protein S6 is a malleable process controlled b

83 Phosphorylation of ribosomal protein S6 is requisite for prothoracicotropic

84 The phosphorylation of ribosomal protein S6 is thought to be required for biosy

85 ing and mammalian target of rapamycin/70-kDa ribosomal protein S6 kinase (mTOR/p70S6K) were not invol

86 ade induced a prompt deactivation of the p70 ribosomal protein S6 kinase (p70 S6K).

87 se (PI3-kinase) and their downstream targets ribosomal protein S6 kinase (p70(S6k)) and eukaryotic in

88 the serine-threonine kinase Akt and the p70 ribosomal protein S6 kinase (p70(S6K)).

89 horylation state of two mTOR targets, 70-kDa ribosomal protein S6 kinase (p70S6K) and eukaryote initi

90 In the absence of ERK2, activation of the ribosomal protein S6 kinase (p70S6K) and its downstream

91 Akt/mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (p70S6K) and the extracellul

92 locking mTOR affects the activity of the 40S ribosomal protein S6 kinase (p70s6k) and the function of

93 tly attenuates phosphorylation of the 70 kDa ribosomal protein S6 kinase (p70S6K) in the basal state

94 The 70-kDa ribosomal protein S6 kinase (p70S6K) is known to regulat

95 The Akt/mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K) pathway is consider

96 onds with the activation of both Akt and p70 ribosomal protein S6 kinase (p70S6K1).

97 Ribosomal protein S6 kinase (RPS6KA3 or RSK2) was the mo

98 (MAP) kinase and the Mr = 90,000 isoform of ribosomal protein S6 kinase (Rsk) by approximately 1.5-2

99 of SKAR, which is mediated by either the p90 ribosomal protein S6 kinase (RSK) or p70 S6 kinase (S6K1

100 defined positions in the active site of p90 ribosomal protein S6 kinase (RSK).

101 The 40S ribosomal protein S6 kinase (S6K) acts downstream of mTO

102 We investigated the role of ribosomal protein S6 kinase (S6K) at the intersection of

103 The 40S ribosomal protein S6 kinase (S6K) is a conserved compone

104 anslational signalling intermediates, 70 kDa ribosomal protein S6 kinase (S6k), ribosomal protein S6

105 d activity in vitro, decreased basal Akt and ribosomal protein S6 kinase (S6K1) activation, and decre

106 Here we identify ribosomal protein S6 kinase (S6K1) as a major FMRP kinas

107 70-kDa ribosomal protein S6 (rp S6) and the ribosomal protein S6 kinase (S6K1).

108 ent mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (S6K1)/eukaryotic initiation

109 mTORC1 also phosphorylates the 70-kDa ribosomal protein S6 kinase 1 (p70S6K1), which subsequen

110 de evidence that IFNlambda activates the p90 ribosomal protein S6 kinase 1 (RSK1) and its downstream

111 l growth acting via two independent targets, ribosomal protein S6 kinase 1 (S6K1) and 4EBP1.

112 mTORC1 regulates p70 ribosomal protein S6 kinase 1 (S6K1) and eukaryotic init

113 These agonists activated ribosomal protein S6 kinase 1 (S6K1) and induced phospho

114 signaling axis and downstream effectors, the ribosomal protein S6 kinase 1 (S6K1) and the translation

115 Here we report the identification of ribosomal protein S6 kinase 1 (S6K1) as a novel substrat

116 rget of rapamycin complex 1 (mTORC1) and p70 ribosomal protein S6 kinase 1 (S6K1) axis.

117 Overexpression of Rheb activates 40S ribosomal protein S6 kinase 1 (S6K1) but not p90 ribosom

118 We found that targeting ribosomal protein S6 kinase 1 (S6K1) in Pten-deficient c

119 Suppression of the ribosomal protein S6 kinase 1 (S6K1) increases healthspa

120 p70 ribosomal protein S6 kinase 1 (S6K1) is regulated by mul

121 Leucine alone stimulated ribosomal protein s6 kinase 1 (S6K1) phosphorylation app

122 The p70 ribosomal protein S6 kinase 1 (S6K1) plays a key role in

123 tes the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase 1 (S6K1) signaling pathway i

124 Intriguingly, the homozygous deletion of ribosomal protein S6 kinase 1 (S6K1), an mTOR target, in

125 tor 4E-binding protein (4E-BP) and activates ribosomal protein S6 kinase 1 (S6K1), both of which stim

126 Outputs downstream of mTORC1 include ribosomal protein S6 kinase 1 (S6K1), eukaryotic transla

127 metabolic pathway via its downstream target ribosomal protein S6 kinase 1 (S6K1), which directly pho

128 Overexpression of ribosomal protein S6 kinase 1 (S6k1), which encodes a do

129 cell growth and proliferation by activating ribosomal protein S6 kinase 1 (S6K1).

130 ion factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1).

131 or 4E (eIF4E) binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1).

132 ion factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1).

133 iation factor-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1).

134 ediated substrate phosphorylation (e.g., p70 ribosomal protein S6 kinase 1 [S6K1] and eukaryotic init

135 of tuberin is associated with an increase in ribosomal protein S6 kinase 1 and eukaryotic initiation

136 S6 kinase 1 inhibitor implicated a role for ribosomal protein S6 kinase 1 in IL-33-induced mTOR-depe

137 Furthermore, use of a ribosomal protein S6 kinase 1 inhibitor implicated a rol

138 ed by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr(389) and Akt Ser(473),

139 of mammalian target of rapamycin complex 1, ribosomal protein S6 kinase 1, and eukaryotic translatio

140 with phosphorylation of the mTORC1 effector ribosomal protein S6 kinase 1, that the graft morphologi

141 tion of tuberin and downstream activation of ribosomal protein S6 kinase 1/4E-BP1 pathway.

142 In this study, we evaluated p70 ribosomal protein S6 Kinase 2 (S6K2), a downstream effec

143 Similarly, ribosomal protein S6 kinase 2 (S6K2), a recently identif

144 ammalian/mechanistic target of rapamycin and ribosomal protein S6 kinase A1.

145 inhibition resulted in TLR-4-mediated 70-kDa ribosomal protein S6 kinase activation and enhanced TNF-

146 p70 ribosomal protein S6 kinase activity was induced by K-Ra

147 am target of the cyclooxygenase pathway, and ribosomal protein S6 kinase and eukaryotic translation i

148 nd p38 MAPK and suggested involvement of p90 ribosomal protein S6 kinase and mitogen and stress respo

149 ivated protein kinase (AMPK) and upstream of ribosomal protein S6 kinase and mTOR complex 1 (TORC1),

150 Furthermore, ribosomal protein S6 kinase and S6 phosphorylation were

151 hey show constitutive phosphorylation of the ribosomal protein S6 kinase and the eukaryotic initiatio

152 ene ESR1, and another involving the RPS6KB1 (Ribosomal protein S6 kinase beta-1) were recurrently exp

153 p70 Ribosomal protein S6 kinase is a critical down-stream ef

154 The 70/85 kDa ribosomal protein S6 kinase is regulated through the con

155 ein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and eukaryotic

156 ied, phosphoinositide 3-kinase p110alpha and ribosomal protein S6 kinase p70(S6K1), plus the MAP kina

157 gnaling in the tumor, as measured by reduced ribosomal protein S6 kinase phosphorylation.

158 mitogen-activated protein kinase 2 (ERK) and ribosomal protein S6 kinase polypeptide 2 (p90RSK).

159 urse experiment indicated that PI3K (AKT and ribosomal protein S6 kinase) activation occurred between

160 ponents of the mammalian target of rapamycin/ribosomal protein S6 kinase, 70 kDa, pathway and thereby

161 the oncogenic mammalian target of rapamycin/ribosomal protein S6 kinase, 70 kDa, pathway, and the im

162 Ribosomal protein S6 kinase, 90 kDa, polypeptide 1 (RSK1

163 lving extracellular signal-regulated kinase, ribosomal protein S6 kinase, and protein kinase D (PKD)

164 ith and inhibited B-Raf but did not activate ribosomal protein S6 kinase, indicating that farnesylati

165 ucine also stimulated phosphorylation of the ribosomal protein S6 kinase, p70(S6k), resulting in incr

166 mycin (i.e., phosphorylation of AMPK and p70 ribosomal protein S6 kinase, respectively) and IL-6/IL-6

167 D relative to control subjects was found for ribosomal protein S6 kinase, which did not change after

168 eroxide each caused inhibition of the 70-kDa ribosomal protein S6 kinase, while arsenite activated it

169 ctivated phospho-ERK44/42, activated phospho-ribosomal protein S6 kinase-1 (RSK1) (a substrate of ERK

170 ion factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase-1 (S6K1), whereas HIF-1alpha

171 e here that Rictor is a direct target of the ribosomal protein S6 kinase-1 (S6K1).

172 vation of its downstream targets Akt and the ribosomal protein S6 kinase-1 (S6K1).

173 the T-loop of S6K1 alpha II (the 70-kDa 40 S ribosomal protein S6 kinase-1 alpha II isoform), and Thr

174 lular signal-regulated kinase) and S6K-RPS6 (ribosomal protein S6 kinase-ribosomal protein S6) axes.

175 protein, 4E-BP1, and the activity of the p70 ribosomal protein S6 kinase.

176 tein kinase pathway, involving in particular ribosomal protein S6 kinase.

177 /42 mitogen activated protein kinases (MAPK)/ribosomal protein S6 kinases (p70 S6K) pathway.

178 as in activation and phosphorylation of p90 ribosomal protein S6 kinases (RSKs).

179 st known to regulate translation through the ribosomal protein S6 kinases (S6Ks) and the eukaryotic t

180 In mammalian cells, the ribosomal protein S6 kinases, S6K1 and S6K2, lie downstr

181 leading to the stimulation of the 70/85 kDa ribosomal protein S6 kinases, substantially blocks the a

182 AKT serine/threonine-protein-kinase (AKT3), ribosomal-protein-S6, MAP-kinases, and NF-kappaB-activat

183 SH-mediated activation of the mTOR complex 1/ribosomal protein S6 (mTORC1/RPS6) pathway as well as th

184 it independently impaired phosphorylation of ribosomal protein S6 on the preinitiation complex.

185 overexpression increased phosphorylation of ribosomal protein S6 (p-rpS6) in SNpc neurons, a readout

186 sphate feeding, generate less phosphorylated ribosomal protein S6 (P-S6) than the WT.

187 Here, the signal from phosphorylated ribosomal protein S6 (P-S6) was defined as a surrogate m

188 wed no measurable kinase activity toward the ribosomal protein S6 peptide.

189 Thus, HU-308 increased ribosomal protein S6 phosphorylation and 5-bromo-2'-deox

190 min following exercise (336%, P = 0.06) with ribosomal protein S6 phosphorylation being maximally act

191 In contrast, suppression of S6K1 and ribosomal protein S6 phosphorylation by DNA damage is Ak

192 n of cAMP-dependent protein kinase, to drive ribosomal protein S6 phosphorylation.

193 t not related monomeric G proteins, promotes ribosomal protein S6 phosphorylation.

194 ing, and caused decreases in Akt Ser-473 and ribosomal protein S6 phosphorylation.

195 mechanism that can function independently of ribosomal protein S6 phosphorylation.

196 Immunohistochemistry showed patches of ribosomal protein S6 positivity in a similar distributio

197 of this study was to examine the role of the ribosomal protein S6 protein kinase (p70S6K), a protein

198 fasting plasma C-peptide, and phosphorylated ribosomal protein S6 (pS6) in skin biopsies.

199 phorylated (p)-4E-BP1, p-p70S6 kinase, and p-ribosomal protein S6, resulting in apoptosis and cell cy

200 increased the phosphorylation of the 70-kDa ribosomal protein S6 (rp S6) and the ribosomal protein S

201 mTORC1 functions by regulating p70S6K/ribosomal protein S6 (RPS6) and eukaryotic translation i

202 e demonstrate here that nsP2 associates with ribosomal protein S6 (RpS6) and that nsP2 is present in

203 Functionally, the phosphorylation of ribosomal protein S6 (rpS6) and the amount of phosphoryl

204 evealed increased phosphorylation of the 40S ribosomal protein S6 (rpS6) and the eukaryotic translati

205 rs prolonged signaling through activation of ribosomal protein S6 (RPS6) and the upstream kinase 90-k

206 ockout endothelial cells, phosphorylation of ribosomal protein S6 (rpS6) at Ser235/236 was mostly abr

207 1 (4E-BP1) and increased phosphorylation of ribosomal protein S6 (rpS6) in activated renal tubules.

208 Here, we show that ribosomal protein S6 (RPS6) interacts with LANA.

209 Ribosomal protein S6 (rpS6) is a critical component of t

210 Ribosomal protein S6 (rpS6) is an essential component of

211 In this study, we demonstrate that ribosomal protein S6 (RPS6) is highly expressed in prima

212 Ribosomal protein S6 (RPS6) is located in the mRNA bindi

213 The ribosomal protein S6 (RPS6) is one of the well known dow

214 Ribosomal protein S6 (rpS6) is phosphorylated in vivo by

215 Gain- and loss-of-function Ribosomal Protein S6 (RPS6) mutants additionally show th

216 bservations showed a paradoxical increase in ribosomal protein S6 (rpS6) phosphorylation and a decrea

217 x protein PALL interacts with phosphorylated ribosomal protein S6 (RpS6) to promote its ubiquitylatio

218 was measured by increased phosphorylation of ribosomal protein S6 (rpS6), a downstream target of the

219 Here, we focus on ribosomal protein S6 (rpS6), an mTOR effector not implic

220 s, 70 kDa ribosomal protein S6 kinase (S6k), ribosomal protein S6 (rpS6), eukaryotic elongation facto

221 r was associated with the phosphorylation of ribosomal protein S6 (rpS6), suggesting activation of th

222 ibosomal subunit contains the key regulatory ribosomal protein S6 (rpS6), we considered that myc loss

223 or eIF4E-binding protein 1 (4E-BP1), but not ribosomal protein S6 (rpS6).

224 lls derived from the hematopoietic organs of ribosomal protein S6 (RpS6air8) mutant animals express h

225 Moreover, we demonstrate that ribosomal protein S6 (rS6) and Akt, downstream targets o

226 ition of the latter process by knockdowns of ribosomal proteins S6, S14, or L4 reduced ribosome conte

227 presses the phosphorylation of GSK3betaser9, ribosomal protein S6(S240/244), and AKT(Thr308).

228 factor 4E binding protein 1 (4E-BP1) and the ribosomal protein S6 (S6), increased in comparison with

229 We found that ribosomal protein S6 (S6), which exerts translational co

230 he effects of aspirin on mTOR signaling, the ribosomal protein S6, S6 kinase 1 (S6K1), and eukaryotic

231 6 kinase (p70S6K) and its downstream target, ribosomal protein S6 (S6RP), was impaired at a critical

232 platform of the 30 S subunit upon binding of ribosomal proteins S6, S8, S11, S15, S18 and S21.

233 binding protein 1 (Thr-37/46 and Thr-70) and ribosomal protein S6 (Ser-235/236) and increased the pho

234 sphorylation of p70 S6 kinase (Thr-389), and ribosomal protein S6 (Ser-235/236) in Rh1, Rh18, and Rh3

235 es expressed higher levels of phosphorylated ribosomal protein S6 than paired fibroblasts from normal

236 -E1A12 increased phosphorylation of AKT1 and ribosomal protein S6 through independent mechanisms in d

237 Phosphorylation of ribosomal protein S6, typically a downstream target of m

238 ion and the transition state ensemble of the ribosomal protein S6 using a Monte Carlo (MC) Go model i

239 Phosphorylation of ribosomal protein S6 was also modulated by inhibition of

240 ls, and decreased phosphorylation of phospho-ribosomal protein S6 was also observed, a finding sugges

241 y, activation of S6 Kinase and its target S6 ribosomal protein (S6) was demonstrated in cells lacking

242 nd phosphorylation levels of Akt, FoxO3, and ribosomal protein S6 were determined by Western blotting

243 oposed to be regulated by phosphorylation of ribosomal protein S6, which is a common effect of mitoge