ライフサイエンスコーパス: ribosomal protein S6 kinase

1 protein, 4E-BP1, and the activity of the p70 ribosomal protein S6 kinase.

2 tein kinase pathway, involving in particular ribosomal protein S6 kinase.

3 mTORC1 also phosphorylates the 70-kDa ribosomal protein S6 kinase 1 (p70S6K1), which subsequen

4 de evidence that IFNlambda activates the p90 ribosomal protein S6 kinase 1 (RSK1) and its downstream

5 l growth acting via two independent targets, ribosomal protein S6 kinase 1 (S6K1) and 4EBP1.

6 mTORC1 regulates p70 ribosomal protein S6 kinase 1 (S6K1) and eukaryotic init

7 These agonists activated ribosomal protein S6 kinase 1 (S6K1) and induced phospho

8 signaling axis and downstream effectors, the ribosomal protein S6 kinase 1 (S6K1) and the translation

9 Here we report the identification of ribosomal protein S6 kinase 1 (S6K1) as a novel substrat

10 rget of rapamycin complex 1 (mTORC1) and p70 ribosomal protein S6 kinase 1 (S6K1) axis.

11 Overexpression of Rheb activates 40S ribosomal protein S6 kinase 1 (S6K1) but not p90 ribosom

12 We found that targeting ribosomal protein S6 kinase 1 (S6K1) in Pten-deficient c

13 Suppression of the ribosomal protein S6 kinase 1 (S6K1) increases healthspa

14 p70 ribosomal protein S6 kinase 1 (S6K1) is regulated by mul

15 Leucine alone stimulated ribosomal protein s6 kinase 1 (S6K1) phosphorylation app

16 The p70 ribosomal protein S6 kinase 1 (S6K1) plays a key role in

17 tes the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase 1 (S6K1) signaling pathway i

18 Intriguingly, the homozygous deletion of ribosomal protein S6 kinase 1 (S6K1), an mTOR target, in

19 tor 4E-binding protein (4E-BP) and activates ribosomal protein S6 kinase 1 (S6K1), both of which stim

20 Outputs downstream of mTORC1 include ribosomal protein S6 kinase 1 (S6K1), eukaryotic transla

21 metabolic pathway via its downstream target ribosomal protein S6 kinase 1 (S6K1), which directly pho

22 Overexpression of ribosomal protein S6 kinase 1 (S6k1), which encodes a do

23 cell growth and proliferation by activating ribosomal protein S6 kinase 1 (S6K1).

24 ion factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1).

25 or 4E (eIF4E) binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1).

26 ion factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1).

27 iation factor-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1).

28 ediated substrate phosphorylation (e.g., p70 ribosomal protein S6 kinase 1 [S6K1] and eukaryotic init

29 of tuberin is associated with an increase in ribosomal protein S6 kinase 1 and eukaryotic initiation

30 S6 kinase 1 inhibitor implicated a role for ribosomal protein S6 kinase 1 in IL-33-induced mTOR-depe

31 Furthermore, use of a ribosomal protein S6 kinase 1 inhibitor implicated a rol

32 ed by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr(389) and Akt Ser(473),

33 of mammalian target of rapamycin complex 1, ribosomal protein S6 kinase 1, and eukaryotic translatio

34 with phosphorylation of the mTORC1 effector ribosomal protein S6 kinase 1, that the graft morphologi

35 tion of tuberin and downstream activation of ribosomal protein S6 kinase 1/4E-BP1 pathway.

36 ctivated phospho-ERK44/42, activated phospho-ribosomal protein S6 kinase-1 (RSK1) (a substrate of ERK

37 ion factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase-1 (S6K1), whereas HIF-1alpha

38 vation of its downstream targets Akt and the ribosomal protein S6 kinase-1 (S6K1).

39 e here that Rictor is a direct target of the ribosomal protein S6 kinase-1 (S6K1).

40 the T-loop of S6K1 alpha II (the 70-kDa 40 S ribosomal protein S6 kinase-1 alpha II isoform), and Thr

41 In this study, we evaluated p70 ribosomal protein S6 Kinase 2 (S6K2), a downstream effec

42 Similarly, ribosomal protein S6 kinase 2 (S6K2), a recently identif

43 ponents of the mammalian target of rapamycin/ribosomal protein S6 kinase, 70 kDa, pathway and thereby

44 the oncogenic mammalian target of rapamycin/ribosomal protein S6 kinase, 70 kDa, pathway, and the im

45 Ribosomal protein S6 kinase, 90 kDa, polypeptide 1 (RSK1

46 ammalian/mechanistic target of rapamycin and ribosomal protein S6 kinase A1.

47 inhibition resulted in TLR-4-mediated 70-kDa ribosomal protein S6 kinase activation and enhanced TNF-

48 urse experiment indicated that PI3K (AKT and ribosomal protein S6 kinase) activation occurred between

49 p70 ribosomal protein S6 kinase activity was induced by K-Ra

50 am target of the cyclooxygenase pathway, and ribosomal protein S6 kinase and eukaryotic translation i

51 nd p38 MAPK and suggested involvement of p90 ribosomal protein S6 kinase and mitogen and stress respo

52 ivated protein kinase (AMPK) and upstream of ribosomal protein S6 kinase and mTOR complex 1 (TORC1),

53 Furthermore, ribosomal protein S6 kinase and S6 phosphorylation were

54 hey show constitutive phosphorylation of the ribosomal protein S6 kinase and the eukaryotic initiatio

55 lving extracellular signal-regulated kinase, ribosomal protein S6 kinase, and protein kinase D (PKD)

56 ene ESR1, and another involving the RPS6KB1 (Ribosomal protein S6 kinase beta-1) were recurrently exp

57 ith and inhibited B-Raf but did not activate ribosomal protein S6 kinase, indicating that farnesylati

58 p70 Ribosomal protein S6 kinase is a critical down-stream ef

59 The 70/85 kDa ribosomal protein S6 kinase is regulated through the con

60 ing and mammalian target of rapamycin/70-kDa ribosomal protein S6 kinase (mTOR/p70S6K) were not invol

61 ein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and eukaryotic

62 ied, phosphoinositide 3-kinase p110alpha and ribosomal protein S6 kinase p70(S6K1), plus the MAP kina

63 ade induced a prompt deactivation of the p70 ribosomal protein S6 kinase (p70 S6K).

64 se (PI3-kinase) and their downstream targets ribosomal protein S6 kinase (p70(S6k)) and eukaryotic in

65 the serine-threonine kinase Akt and the p70 ribosomal protein S6 kinase (p70(S6K)).

66 /42 mitogen activated protein kinases (MAPK)/ribosomal protein S6 kinases (p70 S6K) pathway.

67 ucine also stimulated phosphorylation of the ribosomal protein S6 kinase, p70(S6k), resulting in incr

68 horylation state of two mTOR targets, 70-kDa ribosomal protein S6 kinase (p70S6K) and eukaryote initi

69 In the absence of ERK2, activation of the ribosomal protein S6 kinase (p70S6K) and its downstream

70 Akt/mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (p70S6K) and the extracellul

71 locking mTOR affects the activity of the 40S ribosomal protein S6 kinase (p70s6k) and the function of

72 tly attenuates phosphorylation of the 70 kDa ribosomal protein S6 kinase (p70S6K) in the basal state

73 The 70-kDa ribosomal protein S6 kinase (p70S6K) is known to regulat

74 The Akt/mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K) pathway is consider

75 onds with the activation of both Akt and p70 ribosomal protein S6 kinase (p70S6K1).

76 gnaling in the tumor, as measured by reduced ribosomal protein S6 kinase phosphorylation.

77 mitogen-activated protein kinase 2 (ERK) and ribosomal protein S6 kinase polypeptide 2 (p90RSK).

78 mycin (i.e., phosphorylation of AMPK and p70 ribosomal protein S6 kinase, respectively) and IL-6/IL-6

79 lular signal-regulated kinase) and S6K-RPS6 (ribosomal protein S6 kinase-ribosomal protein S6) axes.

80 Ribosomal protein S6 kinase (RPS6KA3 or RSK2) was the mo

81 (MAP) kinase and the Mr = 90,000 isoform of ribosomal protein S6 kinase (Rsk) by approximately 1.5-2

82 of SKAR, which is mediated by either the p90 ribosomal protein S6 kinase (RSK) or p70 S6 kinase (S6K1

83 defined positions in the active site of p90 ribosomal protein S6 kinase (RSK).

84 as in activation and phosphorylation of p90 ribosomal protein S6 kinases (RSKs).

85 The 40S ribosomal protein S6 kinase (S6K) acts downstream of mTO

86 We investigated the role of ribosomal protein S6 kinase (S6K) at the intersection of

87 The 40S ribosomal protein S6 kinase (S6K) is a conserved compone

88 anslational signalling intermediates, 70 kDa ribosomal protein S6 kinase (S6k), ribosomal protein S6

89 d activity in vitro, decreased basal Akt and ribosomal protein S6 kinase (S6K1) activation, and decre

90 Here we identify ribosomal protein S6 kinase (S6K1) as a major FMRP kinas

91 70-kDa ribosomal protein S6 (rp S6) and the ribosomal protein S6 kinase (S6K1).

92 ent mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (S6K1)/eukaryotic initiation

93 In mammalian cells, the ribosomal protein S6 kinases, S6K1 and S6K2, lie downstr

94 st known to regulate translation through the ribosomal protein S6 kinases (S6Ks) and the eukaryotic t

95 leading to the stimulation of the 70/85 kDa ribosomal protein S6 kinases, substantially blocks the a

96 D relative to control subjects was found for ribosomal protein S6 kinase, which did not change after

97 eroxide each caused inhibition of the 70-kDa ribosomal protein S6 kinase, while arsenite activated it