ライフサイエンスコーパス: ribosome biogenesis

1 as well as c-Myc and its targets involved in ribosome biogenesis).

2 nses to the inhibition of different steps in ribosome biogenesis.

3 ion of genes encoding products that regulate ribosome biogenesis.

4 g complexes highlighted proteins involved in ribosome biogenesis.

5 th ribosomal protein S6, a committed step in ribosome biogenesis.

6 acrofacial disorders caused by disruption of ribosome biogenesis.

7 or Ubp10's known roles in gene silencing and ribosome biogenesis.

8 ependent ribosomal protein genes involved in ribosome biogenesis.

9 nism by which LARP1 links mTOR signalling to ribosome biogenesis.

10 cohesin ring are associated with defects in ribosome biogenesis.

11 ol of ribosomal DNA (rDNA) transcription and ribosome biogenesis.

12 ubunit and essential for rRNA processing and ribosome biogenesis.

13 n translation, no such probes exist to study ribosome biogenesis.

14 oncogenic stimuli and as a key regulator of ribosome biogenesis.

15 res due to an improved efficiency of plastid ribosome biogenesis.

16 ncers and functions as a global regulator of ribosome biogenesis.

17 een shown to play roles in multiple steps in ribosome biogenesis.

18 m to modulate rRNA processing and eukaryotic ribosome biogenesis.

19 n sensing these opposing signals to regulate ribosome biogenesis.

20 el therapeutic agents specifically targeting ribosome biogenesis.

21 studies aimed at fully deciphering mammalian ribosome biogenesis.

22 or signalling pathways and the regulation of ribosome biogenesis.

23 ce cell-cycle arrest in response to impaired ribosome biogenesis.

24 ns, thereby promoting the complex process of ribosome biogenesis.

25 bunit in a process crucial for mitochondrial ribosome biogenesis.

26 pathogenesis of diseases caused by impaired ribosome biogenesis.

27 acking the Sch9p protein kinase regulator of ribosome biogenesis.

28 icient processing of the rRNA termini during ribosome biogenesis.

29 t of Myc, Yorkie, Wingless signaling, and of ribosome biogenesis.

30 aspect of the highly coordinated process of ribosome biogenesis.

31 r and is a novel non-oncogene participant in ribosome biogenesis.

32 ymerase I is a central feature of eukaryotic ribosome biogenesis.

33 undance of Myc protein, a known regulator of ribosome biogenesis.

34 characterized nucleolar protein required for ribosome biogenesis.

35 nes play a critical role in nuclear steps of ribosome biogenesis.

36 U processome and for the function of Utp4 in ribosome biogenesis.

37 pecies amelioration, chaperone activity, and ribosome biogenesis.

38 mportant roles in regulating translation and ribosome biogenesis.

39 investigate the role of the NAIC mutation in ribosome biogenesis.

40 e cellular processes that are constituent to ribosome biogenesis.

41 sitol 4-phosphate 5-kinase, and required for ribosome biogenesis.

42 tion and repair, transcription, splicing and ribosome biogenesis.

43 mal protein haploinsufficiency or defects in ribosome biogenesis.

44 Here, we show that LepA functions in ribosome biogenesis.

45 uding genome integrity, gene expression, and ribosome biogenesis.

46 n block and down-regulates genes controlling ribosome biogenesis.

47 d TOP mRNA cap-binding protein that controls ribosome biogenesis.

48 riazinoindole-based inhibitors of eukaryotic ribosome biogenesis.

49 s of processing and maturation of mtRNAs and ribosome biogenesis.

50 the cells, asymmetric mRNA distribution and ribosome biogenesis.

51 s been associated with ssDNA interaction and ribosome biogenesis.

52 ein complexes involved in RNA processing and ribosome biogenesis.

53 ts in telomere maintenance, and (3) abnormal ribosome biogenesis.

54 onserved non-protein-coding RNAs involved in ribosome biogenesis.

55 off or on RP mRNA translation and subsequent ribosome biogenesis.

56 erase I represents the rate-limiting step in ribosome biogenesis.

57 Ribosome biogenesis, a complex multistep process, result

58 rowth potential is determined by the rate of ribosome biogenesis, a complex process that requires mas

59 e I (Pol-I) is the main driving force behind ribosome biogenesis, a fundamental cellular process that

60 TCR signaling was suboptimal, was linked to ribosome biogenesis, a rate-limiting factor in both cell

61 Among 41 mutants defective in ribosome biogenesis, a subset defective in 60S showed a

62 enewal to differentiation relies on enhanced ribosome biogenesis accompanied by increased protein syn

63 to be a solid platform for future studies of ribosome biogenesis across a host of model organisms.

64 enic signals from the BCR-ABL oncoprotein to ribosome biogenesis, affecting cellular growth.

65 ion of EIF2 signaling, steroid biosynthesis, ribosome biogenesis and activation of the cytochrome P45

66 n in several systems, we show that increased ribosome biogenesis and activity are a hallmark of prema

67 increase in RNA and DNA synthesis needed for ribosome biogenesis and anabolic growth.

68 ribosome assembly complexes captured during ribosome biogenesis and assembly under different perturb

69 from yeast to mammals, is essential for 60 S ribosome biogenesis and assembly.

70 Nucleolus size is an indicator of ribosome biogenesis and can correlate with cellular grow

71 However, the connection between ribosome biogenesis and cell fate is not well understood

72 merase III (Pol III) repressor that controls ribosome biogenesis and cell growth in yeast (Saccharomy

73 ontrol of the cluster of genes implicated in ribosome biogenesis and cell growth.

74 the transcription of host genes involved in ribosome biogenesis and cell proliferation.

75 ANRIL as a prototype of a circRNA regulating ribosome biogenesis and conferring atheroprotection, the

76 and II and has an unanticipated function in ribosome biogenesis and control of cell growth.

77 te protein machinery at the initial steps of ribosome biogenesis and conveys that information to the

78 ucleoli, that plays a number of functions in ribosome biogenesis and export, cell cycle control, and

79 l protein (RP) genes that lead to defects in ribosome biogenesis and function and result in ribosomal

80 Defects in ribosome biogenesis and function are present in a growin

81 The significance of AROS in relation to ribosome biogenesis and function is unknown.

82 n which genetic abnormalities cause impaired ribosome biogenesis and function, resulting in specific

83 t ribosomal proteins play important roles in ribosome biogenesis and function.

84 ibosomal protein gene expression and, hence, ribosome biogenesis and functions.

85 Gadd34 expression that facilitated enhanced ribosome biogenesis and global protein synthesis.

86 anine, tyrosine and tryptophan biosynthesis, ribosome biogenesis and glycolysis/gluconeogenesis were

87 bor" AAVS1 locus alleviated abnormalities in ribosome biogenesis and hematopoiesis.

88 l ribosomal protein, which also functions in ribosome biogenesis and is implicated in multiple diseas

89 esis, whereas up-regulated pathways included ribosome biogenesis and methanogenesis.

90 arly dynamics of phosphorylation and delayed ribosome biogenesis and mitochondrial activation.

91 on the contrary, essential for mitochondrial ribosome biogenesis and mitochondrial translation.

92 ovide important insights into how defects in ribosome biogenesis and mitotic spindle stabilization re

93 to various environmental cues by regulating ribosome biogenesis and mRNA translation at multiple lev

94 ue studies to unravel the systems biology of ribosome biogenesis and open the way to new methods for

95 polr1a loss of function led to perturbed ribosome biogenesis and p53-dependent cell death, result

96 al proteins, suggesting their direct role in ribosome biogenesis and plant development.

97 ghly fragmented nucleoli and defects in both ribosome biogenesis and protein translation.

98 t loss-of-function mutations in RUNX1 reduce ribosome biogenesis and provide pre-LSCs a selective adv

99 identify the first target of an inhibitor of ribosome biogenesis and provide the mechanism of inhibit

100 The p19ARF tumor suppressor limits ribosome biogenesis and responds to hyperproliferative s

101 dentify AROS as a factor with a role in both ribosome biogenesis and ribosomal function.

102 osomal proteins, including those involved in ribosome biogenesis and rRNA processing.

103 g diazaborine is the only known inhibitor of ribosome biogenesis and specifically blocks large subuni

104 , recombination, transcription, translation, ribosome biogenesis and splicing which regulate plant gr

105 widely available chemical probe of bacterial ribosome biogenesis and suggests a role for E. coli IF2

106 er, we demonstrate that Las1L is crucial for ribosome biogenesis and that depletion of Las1L leads to

107 model in which RbgA promotes a late step in ribosome biogenesis and that one role of GTP hydrolysis

108 We conclude that NMP4 is a key regulator of ribosome biogenesis and the UPR, which together play a c

109 rRNA transcription is fundamental for ribosome biogenesis and therefore protein synthesis, cel

110 TOR1) signaling, we suspected a link between ribosome biogenesis and TOR1 signaling in NKKY101.

111 is one mechanism to coordinate mitochondrial ribosome biogenesis and transcription in human mitochond

112 We report that glucose controls ribosome biogenesis and translation by modulating mRNA d

113 based on transcriptional changes related to ribosome biogenesis and translation, secondary metabolis

114 antly nucleolar protein, is also critical in ribosome biogenesis and, like c-Myc, is found overexpres

115 ene (but not to genes that are not linked to ribosome biogenesis) and that the presence of Tor1p is a

116 f acute resistance exercise on mechanisms of ribosome biogenesis, and (2) the impact of mammalian tar

117 ions direct nucleolar disorganization, alter ribosome biogenesis, and activate the Rpl11-Mdm2-p53 nuc

118 membrane trafficking, telomere maintenance, ribosome biogenesis, and apoptosis.

119 veal a mechanistic connection between FGFR2, ribosome biogenesis, and cellular stress that links cell

120 Numerous factors direct eukaryotic ribosome biogenesis, and defects in a single ribosome as

121 such as mRNA translation, pre-mRNA splicing, ribosome biogenesis, and double-stranded RNA sensing.

122 ll cycle control, flagella and basal bodies, ribosome biogenesis, and energy metabolism, all had dist

123 Ribosomal proteins are integral to ribosome biogenesis, and function in protein synthesis.

124 ng transcription, translation, RNA splicing, ribosome biogenesis, and more recently, different classe

125 nal regulation, elongation, and termination, ribosome biogenesis, and mRNA decay.

126 e impact of mammalian target of rapamycin on ribosome biogenesis, and muscle protein synthesis (MPS)

127 n nucleotide metabolism, glucose metabolism, ribosome biogenesis, and phosphorylation-based signal tr

128 is associated with impaired rRNA production, ribosome biogenesis, and protein synthesis in yeast and

129 tifaceted role of DDX21 in multiple steps of ribosome biogenesis, and provide evidence implicating a

130 ation and infection processes, mitochondrial ribosome biogenesis, and regulation of apoptosis and nuc

131 3 was required for proper Golgi function and ribosome biogenesis, and was necessary for efficient DNA

132 In yeast, Nle/Rsa4 is essential for ribosome biogenesis, and we show that its role in pre-60

133 ere, we report that the functions of Las1 in ribosome biogenesis are also conserved in S. cerevisiae.

134 In budding yeast, cell cycle progression and ribosome biogenesis are dependent on plasma membrane gro

135 cription, co-transcriptional processing, and ribosome biogenesis are highly coordinated processes tha

136 the molecular mechanisms by which they drive ribosome biogenesis are poorly understood.

137 Perturbations to many aspects of ribosome biogenesis are thought to contribute to 'nucleo

138 ntin, which function in transcription and in ribosome biogenesis, are also part of IGHMBP2-containing

139 xpected functions, including DNA-related and ribosome biogenesis-associated activities.

140 ols RE-induced changes in protein synthesis, ribosome biogenesis, autophagy, and the expression of pe

141 The nucleolus serves as a principal site of ribosome biogenesis but is also implicated in various no

142 The control of ribosome biogenesis by c-Myc through the regulation of t

143 es early steps of pre-rRNA processing during ribosome biogenesis by controlling spatial distribution

144 Furthermore, miR-542-3p suppressed ribosome biogenesis by downregulating a subset of riboso

145 ur data suggest that human PARP-1 may affect ribosome biogenesis by modifying certain nucleolar prote

146 ensitive mTOR could prevent the induction of ribosome biogenesis by RE, but it only partially inhibit

147 Here, we asked whether targeting of ribosome biogenesis can be used as the basis for selecti

148 how disruption to three major components of ribosome biogenesis can trigger nucleolar stress and act

149 echanisms whereby selective abnormalities in ribosome biogenesis cause specific clinical syndromes wi

150 gulates both QNPs and TAPs, and importantly, ribosome biogenesis, cell cycle and neuronal genes in th

151 blished roles in multiple pathways including ribosome biogenesis, cell cycle regulation, and mitochon

152 several growth-promoting processes, such as ribosome biogenesis, cellular detachment and pyrimidine

153 ed to limit muscle protein synthesis, making ribosome biogenesis central to skeletal muscle hypertrop

154 Nucleophosmin 1 (NPM1) acts in ribosome biogenesis, centrosome duplication, maintenance

155 complex leading to induction of the impaired ribosome biogenesis checkpoint (IRBC) and p53 stabilizat

156 The structure reveals how large ribosome biogenesis complexes assist the 5' external tra

157 re on cells to select for suppressors of the ribosome biogenesis defect, allowing them to reestablish

158 Ribosome biogenesis defects are accompanied by p53 activ

159 As the major function of the nucleolus, ribosome biogenesis demands a considerable amount of res

160 Ribosome biogenesis dictates the translational capacity

161 Consistent with a role in ribosome biogenesis, DIM1A is preferentially expressed i

162 Ribosome biogenesis drives cell growth and proliferation

163 While limiting ribosome biogenesis extends lifespan in several systems,

164 actor activating Pos9 (Fap7) is an essential ribosome biogenesis factor important for the assembly of

165 Ltv1 is a conserved 40S ribosome biogenesis factor that interacts with pre-40S c

166 Budding yeast Tsr1 is a ribosome biogenesis factor with sequence similarity to G

167 P2, the RNA helicase yRok1/hROK1(DDX52), the ribosome biogenesis factor yRrp7/hRRP7 and yUtp24/hUTP24

168 n yeast have established YVH1 as a novel 60S ribosome biogenesis factor.

169 While we know that >80 ribosome biogenesis factors are required throughout the

170 of the ribosomal subunits is facilitated by ribosome biogenesis factors.

171 How cells ensure quality control in ribosome biogenesis for the fidelity of its complex func

172 or the use of drugs that specifically impact ribosome biogenesis for the treatment of cancers lacking

173 an expansion factor (DEF), has a key role in ribosome biogenesis, functioning in pre-ribosomal RNA (p

174 ranslational proteins, especially those with ribosome biogenesis functions.

175 demonstrated reduced expression of multiple ribosome biogenesis genes and the key translation initia

176 Transcriptional profiling revealed that ribosome biogenesis genes were significantly up-regulate

177 , 17 fall into three functional classes: (1) ribosome biogenesis genes, (2) mitochondrial prohibitins

178 Ribosome biogenesis GTPase A protein (RbgA) is an essent

179 The ribosome biogenesis GTPase A protein RbgA is involved in

180 cribe a class of L9-dependent mutants in the ribosome biogenesis GTPase Der (EngA/YphC).

181 eQ (also called RsgA), RbfA, RimM and Era in ribosome biogenesis has been derived in part from the st

182 transcription and the concurrent increase in ribosome biogenesis has been linked to the high rates of

183 However, its exact role in ribosome biogenesis has been unknown.

184 However, its specific function in ribosome biogenesis has not been described.

185 l-cycle arrest in response to alterations of ribosome biogenesis have been described.

186 Mutations in other genes required for normal ribosome biogenesis have been implicated in other rare c

187 tion of select post-transcriptional steps of ribosome biogenesis holds potential for therapeutic targ

188 family of proteins is intimately involved in ribosome biogenesis in all organisms.

189 ese findings have important implications for ribosome biogenesis in bacteria.

190 how these findings shape our current view of ribosome biogenesis in bacteria.

191 yc expression, allowing a tightly controlled ribosome biogenesis in cells.

192 During ribosome biogenesis in eukaryotes, nascent subunits are

193 nsequence of activated nucleoli and enhanced ribosome biogenesis in HGPS-derived fibroblasts.

194 intricate, yet poorly described, process of ribosome biogenesis in higher eukaryotes.

195 (Pol) I and II to control multiple steps of ribosome biogenesis in human cells.

196 Our results reveal a novel role for PARN in ribosome biogenesis in human cells.

197 10 with testis-specific expression, disturbs ribosome biogenesis in late-prophase spermatocytes and p

198 During the early steps of ribosome biogenesis in mammals, the two ribosomal subuni

199 lative to demand for NADPH, including during ribosome biogenesis in metabolically synchronized yeast

200 nstream targets, which are known to regulate ribosome biogenesis in other cell types, were upregulate

201 king TOR signaling to rDNA transcription and ribosome biogenesis in plants.

202 tional silencing of rDNA genes and decreased ribosome biogenesis in quiescent old HSCs.

203 Ribosome biogenesis in Saccharomyces cerevisiae involves

204 work is incorporated into a model of in vivo ribosome biogenesis in slow-growing E. coli.

205 We provide a simplified model of ribosome biogenesis in slow-growing Escherichia coli.

206 iSAT allows for manipulation and analysis of ribosome biogenesis in the context of an in vitro transc

207 exonuclease-mediated pre-rRNA processing and ribosome biogenesis in vascular smooth muscle cells and

208 on does not cause growth defects or aberrant ribosome biogenesis in yeast, we show that an intact C-t

209 d with promoter regions of genes involved in ribosome biogenesis, in addition to its roles at telomer

210 where it acts to regulate events involved in ribosome biogenesis including the maturation of rRNA mol

211 Eukaryotic ribosome biogenesis involves approximately 200 assembly

212 Early eukaryotic ribosome biogenesis involves large multi-protein complex

213 Ribosome biogenesis is a complex process comprising tran

214 Ribosome biogenesis is a dynamic multistep process, many

215 ore the enormous complexity of 60S synthesis.Ribosome biogenesis is a dynamic process that involves t

216 Ribosome biogenesis is a fundamental cellular process in

217 Ribosome biogenesis is a highly complex process in eukar

218 Ribosome biogenesis is a highly regulated process ensuri

219 Ribosome biogenesis is a key process for maintaining pro

220 s a prerequisite for cell proliferation, and ribosome biogenesis is a limiting factor for cell growth

221 Ribosome biogenesis is a multi-step process that couples

222 We find that ribosome biogenesis is a parallel process, that blocks o

223 Ribosome biogenesis is a process required for cellular g

224 As ribosome biogenesis is a well-known downstream phenomeno

225 e DNA into proteins, and an understanding of ribosome biogenesis is central to cellular physiology.

226 Ribosome biogenesis is facilitated by a growing list of

227 In the yeast Saccharomyces cerevisiae, ribosome biogenesis is highly regulated at the transcrip

228 Ribosome biogenesis is orchestrated by the action of sev

229 The ancestral role of MYC as a regulator of ribosome biogenesis is reflected in reduced protein tran

230 we identified a means by which this step in ribosome biogenesis is regulated in concert with cell gr

231 Ribosome biogenesis is the primary determinant of transl

232 Mitochondrial ribosome biogenesis is therefore critical for oxidative

233 The molecular basis for the role of Fap7 in ribosome biogenesis is, however, not yet understood.

234 (snoRNA), a nucleolar component required for ribosome biogenesis, is a chaperone for pre-18S rRNA fol

235 Impairment of ribosome biogenesis leads to p53 induction and cell cycl

236 constitutes a mechanism by which cells adapt ribosome biogenesis level to the availability of growth

237 th both the RNA polymerase I complex and the ribosome biogenesis machinery.

238 olus, an organelle whose primary function in ribosome biogenesis makes it key for cell growth and siz

239 re-balance of the proteome via modulation of ribosome biogenesis may be a general adaptive response t

240 Deficiencies in ribosome biogenesis may result in varied faults in trans

241 During eukaryotic ribosome biogenesis, members of the conserved atypical s

242 found that proteins involved in translation, ribosome biogenesis, nuclear transport, and amino acid m

243 In addition to ribosome biogenesis, nucleoli are critical for control o

244 Ribosome biogenesis occurs successively in the nucleolus

245 ing mutant 30S subunits can be used to study ribosome biogenesis on the whole.

246 basal cellular process, Nle deletion affects ribosome biogenesis only in HSCs and immature progenitor

247 re, overexpression of individual REST target ribosome biogenesis or cell cycle genes is sufficient to

248 dimers also form after inhibition of either ribosome biogenesis or protein synthesis.

249 Dysregulation of ribosome biogenesis or translation can promote cancer, b

250 ha signaling up-regulates mTOR signaling and ribosome biogenesis pathways and perturbs the expression

251 ct of Pf1 in multiple regulatory arms of the ribosome biogenesis pathways.

252 uced activation of muscle protein synthesis, ribosome biogenesis, PGC-1alpha expression and hypertrop

253 Ribosome biogenesis plays key roles in cell growth by pr

254 idermis development is dependent upon proper ribosome biogenesis, possibly due to the sensitivity of

255 ons that are introduced during the multistep ribosome biogenesis process are essential for protein sy

256 regulates many cellular processes, including ribosome biogenesis, proliferation, and genomic integrit

257 tions in health and disease, focusing on the ribosome biogenesis protein Utp5/WDR43.

258 id assays, MAS2 interacted with splicing and ribosome biogenesis proteins, and fluorescence in situ h

259 developmental defects caused by mutations in ribosome biogenesis proteins-can exhibit tissue-specific

260 sphatase A, corticotropin hormone precursor, ribosome biogenesis regulatory protein, and leptin precu

261 of NPM1 in nucleolar chromatin dynamics and ribosome biogenesis remains unclear.

262 Thus, while ribosome biogenesis represents a potential site for the

263 and ribosome biogenesis, which suggests that ribosome biogenesis represents a promising therapeutic t

264 Ribosome biogenesis requires approximately 200 assembly

265 Ribosome biogenesis requires multiple nuclease activitie

266 Eukaryotic ribosome biogenesis requires nuclear import and hierarch

267 Ribosome biogenesis requires stoichiometric amounts of r

268 Eukaryotic ribosome biogenesis requires the nuclear import of appro

269 te that in human cells, as in budding yeast, ribosome biogenesis requires the presence of the modific

270 c, small cell phenotype and markedly reduced ribosome biogenesis (Ribi).

271 It has been shown that defect in ribosome biogenesis (ribosomal stress) induces apoptosis

272 The ribosome biogenesis role of NS3 is essential for proper

273 vealed marked enrichment of genes related to ribosome biogenesis, rRNA processing and translational i

274 Rather, oxaliplatin kills cells by inducing ribosome biogenesis stress.

275 1 (NPM1) is a nucleolar protein involved in ribosome biogenesis, stress responses and maintaining ge

276 53, thereby lending support to a RP-Mdm2-p53 ribosome biogenesis surveillance pathway.

277 ncover previously unsuspected differences in ribosome biogenesis that distinguish stem cells from res

278 egulation of mitochondrial transcription and ribosome biogenesis that likely contribute to cell cycle

279 suggest that BUD22 is involved in a step in ribosome biogenesis that not only affects general transl

280 d HDM2 also participate in the regulation of ribosome biogenesis, the involvement of CARF in this pro

281 ZNF658 thus links zinc homeostasis with ribosome biogenesis, the most active transcriptional, an

282 As expected for the cellular center of ribosome biogenesis, the nucleolus is essential for the

283 ome integrity and is activated by defects in ribosome biogenesis; this pathway appears to be a critic

284 Yeast and human ribosome biogenesis thus have both conserved and distinc

285 n ITS1 of pre-rRNAs at early stages of human ribosome biogenesis; thus, it is likely that RRP1 integr

286 e face of Ras(V12) or ARF signals, adjusting ribosome biogenesis to match the appropriate growth or a

287 er, the signals that link the cell cycle and ribosome biogenesis to membrane growth are poorly unders

288 in the pathways that link the cell cycle and ribosome biogenesis to membrane growth.

289 Msn2p, and Msn4p and by activating Sfp1p, a ribosome biogenesis transcription factor.

290 receptor signalling and the initial stage of ribosome biogenesis - transcription of rRNA genes.

291 ional phospho-protein with critical roles in ribosome biogenesis, tumor suppression, and nucleolar st

292 In eukaryotic ribosome biogenesis, U3 snoRNA base pairs with the pre-r

293 y Blm10 and contributes to the repression of ribosome biogenesis under nutrient depletion.

294 ies have uncovered distinct abnormalities in ribosome biogenesis underlying each of these 3 disorders

295 antagonism between PKA and Hog1 controlling ribosome biogenesis via mRNA stability in response to gl

296 el paradigm for calcineurin function in 60 S ribosome biogenesis via regulating the nuclear accumulat

297 of these proteins and the mechanisms driving ribosome biogenesis, we examined in detail one step in 6

298 of assembly factors required for eukaryotic ribosome biogenesis, we have focused on one specific ste

299 in synthesis, intracellular localization and ribosome biogenesis, which suggests that ribosome biogen

300 ediated depletion of AROS leads to deficient ribosome biogenesis with aberrant precursor ribosomal RN