ライフサイエンスコーパス: ribosyl

1 inobenzoic acid (pABA) and 5-phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) to produce 4-(beta-D-ribo

2 f large quantities of substrate tRNA, and [U-ribosyl-(14)C]AdoMet was synthesized.

3 The large [2'-(3)H] KIEs indicate a ribosyl 2'-C-endo conformation at the transition states.

4 hanism in which a histidine deprotonates the ribosyl 2'-hydroxyl pinned in place by a serine, leading

5 e complex of the cyclase with an NAD analog, ribosyl-2'F-2'deoxynicotinamide adenine dinucleotide (ri

6 Disrupting the ribosyl 5'-hydroxyl interaction of transition state anal

7 -(3)H] KIE of 1.4% indicate that significant ribosyl 5'-reconfiguration and purine rotation occur on

8 dation pathway, resulting from action of ADP ribosyl-acceptor hydrolase (ARH) 3.

9 enzyme responsible for cADPR synthesis, ADP-ribosyl (ADPR) cyclase, is rapidly induced by ABA in bot

10 veal how these enzymes differentiate between ribosyl and deoxyribosyl nucleotides or nucleosides and

11 nate motion for NAMPT to be migration of the ribosyl anomeric carbon from the pyrophosphate leaving g

12 ate motion involves a 2.1-A excursion of the ribosyl anomeric carbon, whereas the adenine ring and th

13 ribosyltransferases similar to CT and an ADP-ribosyl(arginine)protein hydrolase (ADPRH), which cleave

14 We previously reported that ADP-ribosyl-arginine is converted nonenzymatically to ornith

15 A damage, and increase the cellular poly(ADP-ribosyl)ate response.

16 t Drosophila insulator proteins are poly(ADP-ribosyl)ated and that mutation of the poly(ADP-ribose) p

17 efined its substrate specificity as mono(ADP-ribosyl)ated aspartate and glutamate but not lysine resi

18 urther, we demonstrated that LXR is poly(ADP-ribosyl)ated by PARP-1, a potential mechanism by which P

19 both subunits of the XPC-RAD23B are poly(ADP-ribosyl)ated by PARP1.

20 osyl)ation reactions, E2F-1 was not poly(ADP-ribosyl)ated by wild-type PARP-1 in vitro, indicating th

21 , our understanding of the roles of poly(ADP-ribosyl)ated Hrp38 on development is limited.

22 and preferentially associates with poly(ADP-ribosyl)ated PARP-1 in vitro and in vivo.

23 A joining in the presence of either poly(ADP-ribosyl)ated PARP-1 or poly(ADP-ribose).

24 38- to 87-kDa and the 17- to 38-kDa poly(ADP-ribosyl)ated protein expression increased by 74% and 275

25 ng elevated intracellular levels of poly(ADP-ribosyl)ated proteins (PAR(high)) responded to pharmacol

26 PARP is expressed in lens, and poly(ADP-ribosyl)ated proteins are primarily localized in the 38-

27 to hydrolyze ADP-ribose groups from mono(ADP-ribosyl)ated proteins.

28 Single or double deletion of the poly(ADP-ribosyl)ated regions and PARP inhibition increased the h

29 oisomerase I or by the formation of poly(ADP-ribosyl)ated topoisomerase I.

30 ere a significant amount of CTCF is poly(ADP-ribosyl)ated.

31 Tankyrase, which poly(ADP-ribosyl)ates and thereby destabilizes AXIN, also can pol

32 presence of DNA and NAD(+), PARP-1 poly(ADP-ribosyl)ates itself and Ku70/80 but not WRN, and gel-shi

33 Tankyrase1 poly(ADP-ribosyl)ates TRF1 in vitro, and its nuclear overexpressi

34 report that HMGN1 affects the self-poly(ADP-ribosyl)ation (i.e., PARylation) of poly(ADP-ribose) pol

35 ankyrase 1 usually results in their poly(ADP-ribosyl)ation (PARsylation) and can lead to ubiquitylati

36 bitor) also prevented mitochondrial poly(ADP-ribosyl)ation (PARylation) and ROS formation.

37 Protein poly(ADP-ribosyl)ation (PARylation) has a role in diverse cellula

38 PARP1 binds to and modifies PAP by poly(ADP-ribosyl)ation (PARylation) in vitro, which inhibits PAP

39 Poly(ADP-ribosyl)ation (PARylation) is a post-translational modif

40 Poly(ADP-ribosyl)ation (PARylation) is a post-translational prote

41 Poly(ADP-ribosyl)ation (PARylation) is a posttranslational modifi

42 Poly(ADP-ribosyl)ation (PARylation) is mainly catalysed by poly-A

43 polymerase 1 (PARP1) catalyzes the poly(ADP-ribosyl)ation (PARylation) of proteins, a posttranslatio

44 Poly(ADP-ribosyl)ation (PARylation) plays diverse roles in many m

45 ociated with an increase in protein poly(ADP-ribosyl)ation (PARylation), and was blocked by pharmacol

46 ranslational modifications, such as poly(ADP-ribosyl)ation (PARylation), regulate chromatin-modifying

47 s subject to negative regulation by poly(ADP-ribosyl)ation (PARylation).

48 ction occurs with or without PARP-1 poly(ADP-ribosyl)ation (PARylation).

49 on mixture stimulates total protein-poly(ADP-ribosyl)ation 3- to 4-fold.

50 Inhibition of TNKS1/2 poly(ADP-ribosyl)ation activity by JW55 led to stabilization of A

51 domain of WRN strongly inhibits the poly(ADP-ribosyl)ation activity in H2O2-treated control cell line

52 OGG1 stimulated the poly(ADP-ribosyl)ation activity of PARP-1, whereas decreased poly

53 hat couples DNA damage detection to poly(ADP-ribosyl)ation activity through a poorly understood mecha

54 function being involved both in the poly(ADP-ribosyl)ation and being a constituent of the NAD(+) salv

55 odifies various nuclear proteins by poly(ADP-ribosyl)ation and functions as a key enzyme in the base

56 ctivity controls reversible protein poly(ADP-ribosyl)ation and potentially of how the defects in this

57 se of the AMP/ADP ratio during hyperpoly(ADP-ribosyl)ation and preserves mitochondrial coupling.

58 der hypoxic conditions, we detected poly(ADP-ribosyl)ation and reduced activity of GAPDH; inhibition

59 Moreover, RECQ1 regulates PARP1 auto-(ADP-ribosyl)ation and the choice between long-patch and sing

60 Protein poly(ADP-ribosyl)ation and ubiquitination are two key post-transl

61 ty is required for PARP-1-dependent poly(ADP-ribosyl)ation at the promoters of commonly regulated tar

62 Suppression of DNA damage-induced poly(ADP-ribosyl)ation by PARP inhibitors impairs early DNA damag

63 cells and serves as an acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in vitro.

64 In vitro, TIN2 protected TRF1 from poly(ADP-ribosyl)ation by tankyrase 1 without affecting tankyrase

65 hows that XPC-RAD23B is a target of poly(ADP-ribosyl)ation catalyzed by PARP1, which can be regarded

66 ore, our results suggest that Hrp38 poly(ADP-ribosyl)ation controls eye pattern formation via regulat

67 PARP-1 poly(ADP-ribosyl)ation correlated directly with induction of apop

68 Interestingly, p65 NF-kappaB poly(ADP-ribosyl)ation decreased its interaction with Crm1 in vit

69 We mapped the poly(ADP-ribosyl)ation domains and engineered MeCP2 mutation cons

70 Importantly, poly(ADP-ribosyl)ation facilitates intrachromosomal interactions

71 unohistochemistry revealed enhanced poly(ADP-ribosyl)ation in all experimental groups manifesting neu

72 view, we discuss recent findings on poly(ADP-ribosyl)ation in DNA damage response as well as the mole

73 viously, we hypothesized a role for poly(ADP-ribosyl)ation in plant defense responses when we detecte

74 The role of poly(ADP-ribosyl)ation in plant defenses was more extensively inv

75 and provided evidence for a role of poly(ADP ribosyl)ation in Stat-mediated transcriptional responses

76 Moreover, the rates of CD auto-poly(ADP-ribosyl)ation increased with second-order kinetics as a

77 Our data show that poly(ADP-ribosyl)ation inhibits Hrp38 binding to the Nanos 3' UTR

78 Poly(ADP-ribosyl)ation is a common post-translational modificatio

79 Poly(ADP-ribosyl)ation is a critical post-translational modificat

80 We conclude that poly(ADP-ribosyl)ation is a functional component in plant respons

81 Poly(ADP-ribosyl)ation is a posttranslational protein modificatio

82 Poly(ADP-ribosyl)ation is a posttranslational protein modificatio

83 Poly(ADP-ribosyl)ation is a reversible post-translational modific

84 Poly(ADP-ribosyl)ation is a reversible post-translational protein

85 Our results suggest that PARP-1 poly(ADP-ribosyl)ation is a terminal event in the apoptotic respo

86 In animals, poly(ADP-ribosyl)ation is associated with DNA damage responses an

87 The reversion of poly(ADP-ribosyl)ation is catalysed by poly(ADP-ribose) (PAR) gly

88 Poly(ADP-ribosyl)ation is catalyzed by a family of enzymes known

89 Poly(ADP-ribosyl)ation is involved in diabetes-induced renal over

90 Arsenite inhibition of poly(ADP-ribosyl)ation is one likely mechanism for the reported c

91 Recent studies suggest that poly(ADP-ribosyl)ation is one of the first steps of cellular DNA

92 Poly(ADP-ribosyl)ation is rapidly stimulated in cells after DNA d

93 results suggest that p65 NF-kappaB poly(ADP-ribosyl)ation may be a critical determinant for the inte

94 s, our results suggest that protein poly(ADP-ribosyl)ation may be a general mechanism to target prote

95 We find that poly(ADP-ribosyl)ation mediated primarily by poly(ADP-ribose) pol

96 Posttranslational poly(ADP-ribosyl)ation of an oscillator component may contribute

97 We propose that poly(ADP-ribosyl)ation of chromatin-associated Parp1 serves as a

98 Interestingly, defective poly(ADP-ribosyl)ation of CTCF and dissociation from the molecula

99 vivo data support a model in which poly(ADP-ribosyl)ation of DDB2 suppresses DDB2 ubiquitylation and

100 d pathogen-dependent changes in the poly(ADP-ribosyl)ation of discrete proteins were also observed.

101 entation and resulted in persistent poly(ADP-ribosyl)ation of DNAS1L3; it did not, however, prevent t

102 Here we show poly(ADP-ribosyl)ation of endogenous MeCP2 in mouse brain tissue.

103 onclusion, these data indicate that poly(ADP-ribosyl)ation of GAPDH and the subsequent inhibition of

104 on was found to be a consequence of poly(ADP-ribosyl)ation of GAPDH by poly(ADP-ribose) polymerase (P

105 Elevated glucose increased poly(ADP-ribosyl)ation of GAPDH in WT aortae, but not in the aort

106 The biological functions of poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoprotein

107 Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoprotein

108 ors of PARP-1 auto-modification and poly(ADP-ribosyl)ation of histone H1 in the absence of free DNA e

109 However, poly(ADP-ribosyl)ation of K566 in CP190 promotes protein-protein

110 , and gel-shift assays showed that poly-(ADP-ribosyl)ation of Ku70/80 decreases the DNA-binding affin

111 Significantly, (ADP-ribosyl)ation of Ku70/80 reduces the ability of this fac

112 Numerous bacterial toxins catalyze mono(ADP-ribosyl)ation of mammalian proteins to influence cell ph

113 (PARP-1) can be hyperactivated, causing (ADP-ribosyl)ation of nuclear proteins (including itself), re

114 1 itself becomes activated, but the poly(ADP-ribosyl)ation of other cellular proteins is severely imp

115 Our results show that the covalent poly(ADP-ribosyl)ation of p53 is a time-dependent protein-poly(AD

116 B sites and showed that TNF induced poly(ADP-ribosyl)ation of RelA when bound to the Phex promoter.

117 nds to DNA breaks and catalyzes the poly(ADP-ribosyl)ation of several substrates involved in DNA dama

118 that Parg null mutation does cause poly(ADP-ribosyl)ation of Squid and hrp38 protein, as well as the

119 ollowing that, we demonstrated that poly(ADP-ribosyl)ation of Squid and hrp38 proteins inhibits splic

120 ing to nicked DNA, PARP-1 catalyzes poly(ADP-ribosyl)ation of the acceptor proteins and itself using

121 ing to nicked DNA, PARP-1 catalyzes poly(ADP-ribosyl)ation of the acceptor proteins using NAD (+) as

122 proximal tubules after IRI leads to poly(ADP-ribosyl)ation of the key glycolytic enzyme glyceraldehyd

123 Phosphorylation, acetylation, or poly(ADP-ribosyl)ation of the linker residues may therefore act a

124 The poly(ADP-ribosyl)ation of three of these yeast proteins, together

125 RP-1 action) or by the formation of poly(ADP-ribosyl)ation of topoisomerase I (PARP-1/NAD action).

126 Poly(ADP-ribosyl)ation of topoisomerase I by PARP-1 in the presen

127 Poly(ADP-ribosyl)ation of transcription factors and coregulators,

128 g factor 2 (TRF2) and is capable of poly(ADP-ribosyl)ation of TRF2, which affects binding of TRF2 to

129 e demonstrate that DDB2 facilitated poly(ADP-ribosyl)ation of UV-damaged chromatin through the activi

130 Poly(ADP-ribosyl)ation of various nuclear proteins catalyzed by a

131 Poly(ADP-ribosyl)ation often involves the addition of long chains

132 RP-interacting protein that removes mono(ADP-ribosyl)ation on glutamate amino acid residues in PARP-m

133 that WS cells are deficient in the poly(ADP-ribosyl)ation pathway after they are treated with the DN

134 Poly(ADP-ribosyl)ation plays a major role in DNA repair, where it

135 ed on the signaling role of PARP in poly(ADP-ribosyl)ation rather than any role that can be ascribed

136 of p53 is a time-dependent protein-poly(ADP-ribosyl)ation reaction and that the addition of this tum

137 t with the conclusion that the auto-poly(ADP-ribosyl)ation reaction catalyzed by PARP-1 facilitates t

138 rast to p53, a positive acceptor in poly(ADP-ribosyl)ation reactions, E2F-1 was not poly(ADP-ribosyl)

139 ational modification of proteins by poly(ADP-ribosyl)ation regulates many cellular pathways that are

140 gether, these findings suggest that poly(ADP-ribosyl)ation regulates the interaction between hnRNPs a

141 sses Nanos translation, whereas its poly(ADP-ribosyl)ation relieves the repression effect, allowing r

142 An inhibitor of poly(ADP-ribosyl)ation rescued the period phenotype of tej mutant

143 WRN by PARP-1 was influenced by the poly(ADP-ribosyl)ation state of PARP-1.

144 the suppression of topoisomerase I poly(ADP-ribosyl)ation through the competition with NAD for the b

145 crease in activity of GAPDH and its poly(ADP-ribosyl)ation were prevented by overexpression of either

146 tion), or nucleotides (for example, poly(ADP-ribosyl)ation).

147 In response to DNA damage, poly(ADP-ribosyl)ation, a unique post-translational modification,

148 ction, which caused increased Hrp38 poly(ADP-ribosyl)ation, also resulted in the rough-eye phenotype

149 gh aberrant crosstalk between CTCF, poly(ADP-ribosyl)ation, and DNA methylation may be a general mech

150 Poly(ADP-ribosyl)ation, attaching the ADP-ribose polymer chain to

151 ilization is largely independent of poly(ADP-ribosyl)ation, it cannot solely explain the chromatin re

152 ot an efficient covalent target for poly(ADP-ribosyl)ation, our results are consistent with the concl

153 onally, DDB2 itself was targeted by poly(ADP-ribosyl)ation, resulting in increased protein stability

154 We hypothesize that poly (ADP-ribosyl)ation, that is, poly (ADP-ribose) polymerase (PA

155 idly modified by tankyrase-mediated poly(ADP-ribosyl)ation, which promotes the proteolysis of Axin an

156 eta-catenin signaling by preventing poly(ADP-ribosyl)ation-dependent AXIN degradation, thereby promot

157 efense-associated expression of the poly(ADP-ribosyl)ation-related genes PARG2 and NUDT7 and observed

158 to the sites of DNA-damage-induced poly(ADP-ribosyl)ation.

159 E988Q mutant, which only catalyzes mono(ADP-ribosyl)ation.

160 lso required for post-translational poly(ADP-ribosyl)ation.

161 tion are similar to the kinetics of poly(ADP-ribosyl)ation.

162 ity regulates the extent of in vivo poly(ADP-ribosyl)ation.

163 onsumed in lysine deacetylation and poly(ADP-ribosyl)ation.

164 1 foci coincide with these areas of poly(ADP-ribosyl)ation.

165 but its function can be modified by poly(ADP-ribosyl)ation.

166 spartate residues in the process of poly(ADP-ribosyl)ation.

167 e of the genome may be modulated by poly(ADP-ribosyl)ation.

168 ibose glycosidic bond formed during poly(ADP-ribosyl)ation.

169 cellular processes are regulated by poly(ADP-ribosyl)ation.

170 magnesium salt present did they generate the ribosyl cation by binding to the leaving group and then

171 used to probe the mechanism of nicotinamide-ribosyl cleavage and acetyl group transfer.

172 We demonstrate that nicotinamide-ribosyl cleavage is distinct from acetyl group transfer

173 pports a mechanism where, after nicotinamide-ribosyl cleavage, the carbonyl oxygen of acetylated subs

174 on involves the cleavage of the nicotinamide-ribosyl, cleavage of an amide bond, and transfer of the

175 artial 3'-OH polarization and H3'-endo-->exo ribosyl configuration at the spMTAN transition state.

176 eotides at sGC alpha1beta1 require a 3'-endo ribosyl conformation (versus 3'-exo in 3'-MANT-2'-dATP).

177 Mammalian CD38 and its Aplysia homolog, ADP-ribosyl cyclase (cyclase), are two prominent enzymes tha

178 zed by multifunctional enzymes, CD38 and ADP-ribosyl cyclase (cyclase).

179 r molecular inhibition of CD38 abolished ADP-ribosyl cyclase activity and disrupted elongation of the

180 show that CD38 expression and endogenous ADP-ribosyl cyclase activity are developmentally regulated d

181 a glucocorticoid, on CD38 expression and ADP-ribosyl cyclase activity in HASM cells stimulated with T

182 is a multifunctional protein possessing ADP-ribosyl cyclase activity responsible for both the synthe

183 time PCR, and Western blot analysis, and ADP-ribosyl cyclase activity was assayed with nicotinamide g

184 ificant augmentation of CD38 expression, ADP-ribosyl cyclase activity, and Ca2+ responses to the agon

185 TNF-alpha augmented CD38 expression and ADP-ribosyl cyclase activity, which were attenuated by dexam

186 is of beta-NAD(+), but also carrying out ADP-ribosyl cyclase and ADP-ribosyltransferase activities, m

187 ydrolytic activity and lacked detectable ADP-ribosyl cyclase and ADP-ribosyltransferase activities.

188 sis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and (ii) covalent binding of the BF

189 ibitors of cADPR hydrolysis by the human ADP-ribosyl cyclase CD38 catalytic domain (shCD38), illustra

190 ous assay with sirtuin-1 (Sirt1) and the ADP-ribosyl cyclase CD38, the resulting steady-state kinetic

191 CD38 belongs to the ADP-ribosyl cyclase family and possesses both ectoenzyme and

192 CD38, which belongs to the ADP-ribosyl cyclase family, catalyzes synthesis of both NAAD

193 family of related enzymes, including the ADP-ribosyl cyclase from Aplysia california (ADPRAC) and CD3

194 SAN4825, an ADP-ribosyl cyclase inhibitor that reduces cADPR and NAADP s

195 enzymatically using Aplysia californica ADP-ribosyl cyclase or mammalian NAD glycohydrolase.

196 Aplysia californica ADP-ribosyl cyclase tolerates even the bulky 8-phenyl-nicoti

197 te properties toward Aplysia californica ADP-ribosyl cyclase were investigated.

198 sly reported that cADPR, produced by the ADP-ribosyl cyclase, CD38, controls calcium influx and chemo

199 We have evaluated the role of the ADP-ribosyl cyclase, CD38, in bone remodeling, a process by

200 PR), which is generated by an ectoenzyme ADP-ribosyl cyclase, CD38.

201 enzymatically using Aplysia californica ADP-ribosyl cyclase.

202 second messenger synthesized from NAD by ADP-ribosyl cyclases (ADPR cyclases).

203 y, a family of ectocellular enzymes, the ADP-ribosyl cyclases (ARCs), has emerged as being able to ch

204 substrate: poly(ADP-ribose) polymerases, ADP-ribosyl cyclases (CD38 and CD157), and sirtuins (SIRT1-7

205 ADP-ribosyl cyclases are structurally conserved enzymes that

206 Ribosyl destabilization and transition state stabilizati

207 a-linked nucleotide N(1) -(5-phospho-alpha-D-ribosyl)-DMB (alpha-ribazole-5'-P, alpha-RP), a precurso

208 e result of nicotinamide intercepting an ADP-ribosyl-enzyme-acetyl peptide intermediate with regenera

209 Elongation of the linker between the ribosyl group and the MANT group and substitution of N-a

210 Using the ADP-ribosyl group as a distinct marker, we observe conformat

211 F159 covers the top (beta) surface of the ribosyl group at the catalytic site.

212 in GdAGA by the presence of a more flexible ribosyl group at the deoxyadenosine site.

213 he enzyme and a conformational change in the ribosyl group leading to migration of the anomeric carbo

214 s with oxacarbenium mimics replacing the NMN-ribosyl group of NAD(+) show 200-620-fold increased affi

215 gresses, carbocation character builds on the ribosyl group, the distance between the purine and the c

216 e phosphate anion and the 5'-hydroxyl of the ribosyl group.

217 nd BcmB that prefer substrates containing 2'-ribosyl groups have a phenylalanine positioned in the ac

218 ansferase (ART-2)-mediated attachment of ADP-ribosyl groups to cell surface proteins; expression of A

219 rase, the enzyme that uses NAD to attach ADP-ribosyl groups to cell surfaces, are also resistant to C

220 ce ART-2 uses NAD but not ADPR to attach ADP-ribosyl groups to the cell surface, and that these group

221 thine and that ADP-ribosylated HNP-1 and ADP-ribosyl-HNP-(ornithine) were isolated from bronchoalveol

222 On incubation of di- or mono-ADP-ribosyl-HNP-1 at 37 degrees C, ADP-ribosylarginine was p

223 The finding of ADP-ribosyl-HNP-1 in BALF but not in leukocyte granules sugg

224 BALF from an IPF patient contained ADP-ribosyl-HNP-ornithine as well as mono- and di-ADP-ribosy

225 Therefore, nsP3 mono(ADP-ribosyl)hydrolase activity is critical for CHIKV replica

226 proteins, these toxins also act as NAD(+)-N-ribosyl hydrolases.

227 inding of DNA, although the presence of a 3'-ribosyl hydroxyl group partially overcame this requireme

228 ormed to study the effect of polarization of ribosyl hydroxyls, torsional angles, and the effect of b

229 The ADP-ribosyl is removed by the dinitrogenase reductase-activa

230 he difficulty of generating the sensitive N1-ribosyl link.

231 in-H and DADMe-Immucillin-H synthesized with ribosyl mimics of l-stereochemistry.

232 (N-methyl)anthraniloyl substitutions at the ribosyl moiety and compared the data with that for the s

233 methylated on the 2'-O-hydroxyl site of the ribosyl moiety at position 34 (Um34).

234 pectively, which catalyze the removal of the ribosyl moiety from nucleosides so that the nucleotide b

235 ed coenzyme and of (13)C introduced into the ribosyl moiety of AdoCbl.

236 ide base and required the 2'-OH group of the ribosyl moiety of ATP for activity.

237 recedented transfer and isomerization of the ribosyl moiety of S-adenosylmethionine (AdoMet) to a mod

238 )2-like transition-state model, in which the ribosyl moiety possesses significant bond order to both

239 8-Chloroadenosine (8-Cl-Ado) is a ribosyl nucleoside analog currently in phase I testing f

240 8-Aminoadenosine (8-NH(2)-Ado), a ribosyl nucleoside analog, in preclinical models of mult

241 es in hPNP cause this stack, centered on the ribosyl O-4' oxygen, to squeeze together and push electr

242 the enzyme's capacity to contact individual ribosyl OH groups reduced the k(cat)/K(m) value of the T

243 ects predicted a 3-endo conformation for the ribosyl oxacarbenium-ion corresponding to H1'-C1'-C2'-H2

244 on and transition state stabilization of the ribosyl oxocarbenium ion occur from neighboring group in

245 y Asp85, interacts with the O2 of T4 and O4' ribosyl oxygens of A23 and T4.

246 ]Galf for galactan biosynthesis and 5-P-[14C]ribosyl-P-P as a donor of [14C]Araf for arabinan synthes

247 We used these findings to develop a novel ribosyl phosphate-modified derivative of c-di-GMP contai

248 Combined deficiencies of poly(ADP)ribosyl polymerase 1 (PARP1) and ataxia telangiectasia m

249 ase in Bcl2-like protein 4, cleaved Poly ADP-Ribosyl Polymerase 1 and cleaved Caspase 3 levels with a

250 -regulated iNOS, nitrotyrosine, and poly-ADP-ribosyl polymerase expression and inhibited CAR-induced

251 peroxynitrite-poly-adenosine 5'-diphosphate ribosyl polymerase pathway contributes to the cellular i

252 ble nitric oxide synthase (iNOS) or poly(ADP-ribosyl) polymerase (PARP1) in only their marrow-derived

253 rtners from DNA ligase IIIalpha and poly(ADP-ribosyl) polymerase 1.

254 y an H. pylori toxin, the intrinsic poly(ADP-ribosyl) polymerase activity of PARP-1 is activated by a

255 es place CoaSt6 in a superfamily of poly(ADP-ribosyl)polymerase (PARP)-like proteins.

256 bases and fluorescent groups at the 2',3'-O-ribosyl position.

257 rs) that recognize specific parts of the ADP-ribosyl posttranslational modification, and is removed b

258 es to form purine and alpha-D-phosphorylated ribosyl products.

259 on, and further evidence suggests a role for ribosyl pseudorotation.

260 ith varied C1'-N9, C1'-Ophosphate distances, ribosyl pucker configurations and N7-protonation states.

261 nsition states are characterized by C2'-endo ribosyl pucker, based on the beta-secondary [2'-(3)H] KI

262 Derivatives of ribosyl pyrophosphate have been synthesized, and examine

263 F159W-Leuko-PNP) as a reporter group for the ribosyl region of the catalytic site.

264 ; anti-Hib capsular polysaccharide IgG, poly-ribosyl-ribitol-phosphate (PRP), IgG subclass, and cellu

265 (C1'-Ophosphate distance = 2.26 A), 2'-C-exo-ribosyl ring pucker and the O5'-C5'-C4'-O4' dihedral ang

266 tion by the substrate phosphodianion and the ribosyl ring, respectively, and an 8.6 kcal/mol stabiliz

267 nding to the pyrimidine base, sulfate, and a ribosyl species, which can be modeled as a glycal.

268 a three-site mAC pharmacophore; the 2',3'-O-ribosyl substituent and the polyphosphate chain have the

269 bases, revealing an unprecedented effect of ribosyl substitution on electronic energy relaxation.

270 , is not a substrate for tankyrase1 poly(ADP-ribosyl)sylation in vitro.

271 nuclear enzyme poly-adenosine 5'-diphosphate ribosyl synthetase, and eventual severe energy depletion

272 A nucleoside queuosine (Q), an unprecedented ribosyl transfer from the cofactor S-adenosylmethionine

273 eptidylimidate, whereas the mechanism of ADP-ribosyl transfer to proteins is undetermined.

274 teins and in some cases catalyze protein ADP-ribosyl transfer.

275 robe for mechanisms of sirtuin-catalyzed ADP-ribosyl transfer.

276 It was shown in system (b) that oligo(ADP-ribosyl) transfer to histone H(1) is 1% of that of auto(

277 to significantly lower adenosine diphosphate ribosyl transferase (ADPRT)/PARP-1 activities in respons

278 either the receptor binding (CRM107) or ADP-ribosyl transferase (CRM197) activities do not inhibit t

279 osyl transferases, including human adenosine ribosyl transferase 5 (ART5) and Cholera toxin subunit A

280 The ADP-ribosyl transferase domain inhibits late steps of cytoki

281 tivating protein domain and a C-terminal ADP-ribosyl transferase domain.

282 d increased affinity in the hydrolytic and N-ribosyl transferase reactions catalyzed by CTA.

283 stabilization, but DTA and PTA catalyze ADP-ribosyl transferase reactions more from ground-state des

284 Inhibition of the NAD(+) hydrolysis and ADP-ribosyl transferase reactions of DTA gave K(i) values fr

285 PARP-3 is a member of the ADP-ribosyl transferase superfamily of unknown function.

286 PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates

287 /NtrC, and DRAT (dinitrogenase reductase ADP-ribosyl transferase)-DRAG (dinitrogenase reductase-activ

288 catalyzed by the dinitrogenase reductase ADP-ribosyl transferase-dinitrogenase reductase-activating g

289 of a nucleophilic transition state for an N-ribosyl transferase.

290 f PARP-1 occur independently of its poly(ADP-ribosyl) transferase activity.

291 s a catalytic domain with mammalian mono(ADP-ribosyl)transferase activity.

292 transition states previously reported for N-ribosyl transferases and is the first demonstration of a

293 ed PARP12, a member of a large family of ADP-ribosyl transferases, as an interferon-induced gene (ISG

294 N(tz)AD(+) also serves as a substrate for ribosyl transferases, including human adenosine ribosyl

295 d of science in motion-the field of poly(ADP-ribosyl) transferases (PARPs) and ADP-ribosylation.

296 unctions of intracellular mammalian mono(ADP-ribosyl)transferases, such as any ability to regulate Ab

297 ransfers (UDP-glucose), and electron and ADP-ribosyl transfers (NAD(P)H/NAD(P)(+)) to drive metabolic

298 at 2.7A and with product PR-ATP at 2.9A (the ribosyl-triphosphate could not be resolved).

299 The terminal ribosyl unit at one end of the intermediate formed a clo

300 cts predicted a 3'-endo conformation for the ribosyl zwitterion, corresponding to a H1'-C1'-C2'-H2' t