ライフサイエンスコーパス: ribosylate

1 ory of smoking was, in fact, mono- or di-ADP-ribosylated.

2 e wild-type ART2a, ART2a(Y204R) was auto-ADP-ribosylated.

3 ins of 50 and 25 kDa were preferentially ADP-ribosylated.

4 ty returned as GRP78 became increasingly ADP-ribosylated.

5 n of signals through TCRs, which are not ADP-ribosylated.

6 is study, ExoS is shown to be capable of ADP-ribosylating 6 candidate arginine residues that are loca

7 The fact that ExoS could ADP-ribosylate a target protein at multiple sites, along wit

8 H. pylori strains release a factor that ADP-ribosylates a mammalian target protein.

9 Pertussis toxin ADP-ribosylates a specific Cys side chain in the alpha-subun

10 Although the ADP-ribosylating A subunit has been implicated in augmenting

11 (Clostridium difficile transferase) that ADP-ribosylates actin and induces microtubule-based cell pro

12 racellular virulence factor, spvB, which ADP-ribosylates actin, strongly inhibited VAP formation in H

13 rected mutagenesis demonstrates that the ADP-ribosylating activity of SpvB is essential for Salmonell

14 osely related to ExoT but has additional ADP-ribosylating activity, can substitute for ExoT as an ant

15 arp1 or Parp7, or upon inhibition of the ADP-ribosylating activity, ES cells exhibit a decrease in gr

16 no acids associated with NAD binding and ADP-ribosylating activity, similar to pertussis toxin (PTX)

17 diverse human serum proteins and possess NAD-ribosylating activity.

18 t the N-terminal region is essential for ADP-ribosylating activity.

19 combinant protein exhibits a strong auto-ADP-ribosylating activity.

20 core structure forms the active site of ADP-ribosylating (ADPRT) toxins, the limited-sequence homolo

21 cities of ART1-Pro257 and ART1-Leu257 to ADP-ribosylate agmatine or fibroblast growth factor-2 were s

22 Tiparp ADP-ribosylated AHR but not its dimerization partner, the AH

23 We found that PT efficiently ADP ribosylated AM G proteins both in vitro and after intran

24 CerADPr ADP-ribosylated an ~120 kDa protein in HeLa cell lysates and

25 a mitochondrial enzyme that uses NAD to ADP-ribosylate and downregulate glutamate dehydrogenase (GDH

26 ance was due to the inability of HA22 to ADP-ribosylate and inactivate EF2.

27 e resistant cell line, HA22 is unable to ADP ribosylate and inactivate elongation factor-2 (EF2), owi

28 inum toxin C3 exoenzyme has been used to ADP-ribosylate and inactivate rho.

29 th C3 exoenzyme to adenine diphosphate (ADP)-ribosylate and inactivate RhoA, and the function of inte

30 e from clostridium botulinum to specifically ribosylate and inhibit the function of the rho gene prod

31 tryptophan mutant ART2b(R204W) was auto-ADP-ribosylated and exhibited enhanced NADase activity.

32 only ten amino acids, only ART2b is auto-ADP-ribosylated and only ART2a is glycosylated.

33 Our results support that ExoS ADP-ribosylates and affects the function of the cytosolic pr

34 Treatment with pertussis toxin, which ADP-ribosylates and inactivates G(i), blocked S1P-mediated i

35 Treatment with pertussis toxin, which ADP-ribosylates and inactivates G(i)-coupled receptors, bloc

36 C3 exoenzyme ADP-ribosylates and inactivates Rho with high specificity, w

37 The C3 exoenzyme, which ADP-ribosylates and inactivates Rho, fully inhibited both th

38 nsferase of Clostridium botulinum, which ADP-ribosylates and inactivates RhoA, to investigate the inv

39 Pertussis toxin, which ADP-ribosylates and inactivates susceptible G proteins, prom

40 lostridium botulinum, which specifically ADP-ribosylates and inactivates the small G protein Rho.

41 We found that PARP-1 ADP-ribosylates and inhibits negative elongation factor (NEL

42 Clostridium botulinum C3, an enzyme that ADP-ribosylates and specifically inactivates RhoA, inhibited

43 maged cells during inflammation, ARTC2.2 ADP-ribosylates and thereby gates the P2X7 ion channel.

44 lls) efficiently adenosine diphosphate (ADP)-ribosylates and thus inactivates the guanosine triphosph

45 oxin that kills CD22-expressing cells by ADP-ribosylating and inactivating elongation factor-2 (EF2).

46 ribution of the unique adenosine diphosphate-ribosylating and vacuolating Community Acquired Respirat

47 y reported that an M. pneumoniae-derived ADP-ribosylating and vacuolating toxin called community-acqu

48 Recently, we identified an ADP-ribosylating and vacuolating toxin of M. pneumoniae, des

49 VahC was shown to ADP-ribosylate Arg-177 of actin, and the kinetic parameters

50 In this study, we show that Certhrax ADP-ribosylates Arg-433 of vinculin, a protein that coordina

51 hat the hydrophobic amino acid mimics an ADP-ribosylated arginine.

52 The P gamma domain containing ADP-ribosylated arginines was shown to be involved in its in

53 Based on the change in mobility of auto-ADP-ribosylated ART5 by SDS-polyacrylamide gel electrophores

54 Auto-ADP-ribosylated ART5 isolated after incubation with NAD was

55 small GTP-binding protein family Rho by ADP-ribosylating asparagine 41, which depolymerizes the acti

56 somerization include PARPs, enzymes known to ribosylate aspartate residues in the process of poly(ADP

57 ine, the +2 position, are preferentially ADP-ribosylated at the +2 residue.

58 We demonstrate that the pool of ADP-ribosylated Axin, which is degraded under basal conditio

59 the toxicity and cellular effects of the ADP-ribosylating bacterial toxin and reveal that mutants def

60 ture distinct from other well-recognized ADP-ribosylating bacterial toxins.

61 evated levels of adenosine diphosphate (ADP)-ribosylated BiP in the inactive pancreas of fasted mice

62 Interestingly, MPN372 ADP ribosylates both identical and distinct mammalian protei

63 sults from this study indicate that ExoS ADP-ribosylates both normal and mutant Ras proteins in vivo

64 T-cadherin could be ADP-ribosylated by a transferase that was also present in th

65 orylation but that arginine 33, which is ADP-ribosylated by an endogenous ADP-ribosyltransferase, is

66 However, rather than being ADP-ribosylated by an H. pylori toxin, the intrinsic poly(AD

67 Thus, arginines 14 and 24, which can be ADP ribosylated by ART1, are critical to the regulation of t

68 ar mass 80-110 kDa were more extensively ADP-ribosylated by ART1-Pro257 than ART1-Leu257, in accordan

69 P-ribosylation comigrated with a protein ADP-ribosylated by cholera toxin and was recognized and immu

70 40Q dinitrogenase reductase could not be ADP-ribosylated by DRAT, although it still formed a cross-li

71 unit of cGMP phosphodiesterase (PDE), is ADP-ribosylated by endogenous ADP-ribosyltransferase when P

72 rginine 33 and arginine 36 are similarly ADP-ribosylated by endogenous ADP-ribosyltransferase, but on

73 of the Ras GTPase subfamily that can be ADP ribosylated by ExoS and indicates that ExoS can inhibit

74 The 27-kDa protein ADP-ribosylated by ExoS was determined to be apolipoprotein

75 cterized the mammalian proteins that are ADP-ribosylated by ExoT, using two-dimensional SDS-PAGE and

76 Several mammalian cell proteins are ADP-ribosylated by MYPE9110, and the full-length recombinant

77 ranscription factor NFAT binds to and is ADP-ribosylated by PARP-1 in an activation-dependent manner.

78 , and the catalytic subunit of DNA-PK is ADP-ribosylated by PARP.

79 29 human epithelial cells, where Rac1 is ADP-ribosylated by TTS-ExoS, Rac1 was activated and relocali

80 The Rho ADP-ribosylating C3 exoenzyme (C3bot) is a bacterial protein

81 crophages, express ADPRT and are able to ADP-ribosylate cell surface proteins.

82 enine dinucleotide phosphate, and/or may ADP-ribosylate cell-surface receptors, resulting in activati

83 to provide the first genome-wide view of ADP-ribosylated chromatin.

84 of Ibp was necessary for docking of the ADP-ribosylating component, iota a (Ia).

85 tion, and ExoT was subsequently shown to ADP-ribosylate Crk (CT10 regulator of kinase)-I and Crk-II.

86 ExoS did not ADP-ribosylate Crk-I.

87 -down and far Western assays showed that ADP-ribosylated Crk-I or Crk-I(R20K) failed to bind p130cas

88 ADP-ribosylated defensin-1 had decreased antimicrobial and c

89 We identified ADP-ribosylated defensin-1 in bronchoalveolar lavage fluid f

90 Further, ADP-ribosylated defensin-1 inhibited cytotoxic and antimicro

91 s of aminoglycosides and their corresponding ribosylated derivatives synthesized by attaching a beta-

92 noglycoside scaffolds neamine and nebramine, ribosylated derivatives were both more potent antimicrob

93 ctase, in that both oxygen-denatured and ADP-ribosylated dinitrogenase reductase fail to form a cross

94 ngation factor 2 (eEF2) is the target of ADP ribosylating diphtheria toxin (DT) and Pseudomonas exoto

95 It is shown that ART-1 ADP-ribosylates distinct cell surface molecules, causing inh

96 al permeability were associated with the ADP-ribosylating domain of ExoS, as bacteria expressing plas

97 egulator of actin polymerization; and an ADP-ribosylating domain that affects the ERM proteins, which

98 not allow the toxin's translocating and ADP-ribosylating domains to reach the cytosol but rather cau

99 Ras was found to be ADP-ribosylated during coculture with 388 but not with 388De

100 Purified PARP1 can ribosylate EBNA1 at multiple sites throughout its amino

101 s of eukaryotic ribosomes complexed with ADP-ribosylated eEF2 (ADPR-eEF2), before and after GTP hydro

102 ion and found that DTM has no ability to ADP-ribosylate EF-2 at 18 or 30 degrees C.

103 than by direct recognition of either ToxA or ribosylated EF2.

104 slational inhibitor Exotoxin A (ToxA), which ribosylates elongation factor 2 (EF2), upregulates a sig

105 hen translocates to the cytosol where it ADP-ribosylates elongation factor 2 and inhibits protein syn

106 ent that translocates to the cytosol and ADP-ribosylates elongation factor 2.

107 fects of ExoS on RalA, ExoS was found to ADP-ribosylate endogenous RalA and recombinant RalADeltaCAAX

108 chimeric toxin DC3B (10(-6) M, 48 h; ; ) ADP-ribosylated endogenous RhoA, including cytosolic RhoA co

109 The ADP-ribosylating enterotoxins, cholera toxin (CT) and the Es

110 The structure of a ribosylated enzyme intermediate reveals movements that o

111 eraldehyde-3-phosphate dehydrogenase and ADP-ribosylating enzyme activities that may relate to early

112 Production of the ADP-ribosylating enzyme exoenzyme S (ExoS) by Pseudomonas ae

113 r beta signaling mediated by the nuclear ADP-ribosylating enzyme poly-(ADP-ribose) polymerase 1 (PARP

114 Exoenzyme S (ExoS), an ADP-ribosylating enzyme produced by the opportunistic pathog

115 ine where they secrete cholera toxin, an ADP-ribosylating enzyme that is responsible for the volumino

116 we present evidence that spvB encodes an ADP-ribosylating enzyme that uses actin as a substrate and d

117 g EGFR inhibition, particularly the poly-ADP-ribosylating enzymes tankyrase 1 and 2 that positively r

118 9 stabilizes axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 and tankyrase 2.

119 ADP-ribosylating enzymes, such as cholera and diphtheria tox

120 DP-ribosyl transferase (C3) toxin, a Rho-ADP-ribosylating exoenzyme, potently inhibited migration.

121 Auto-ADP-ribosylated ExoS analyzed from eukaryotic cells displaye

122 50-kDa protein was determined to be auto-ADP-ribosylated ExoS, whereas the 25-kDa protein appeared to

123 I secreted ExoS but more basic than auto-ADP-ribosylated ExoS.

124 J774A.1 macrophages, where Rac1 was not ADP-ribosylated, ExoS caused a decrease in the levels of act

125 CT, a member of the bacterial ADP-ribosylating exotoxin (bARE) family, is most potent as a

126 ) is a member of the family of bacterial ADP-ribosylating exotoxins (bAREs).

127 unization is not restricted to CT or the ADP-ribosylating exotoxins as adjuvants.

128 Consistent with the latter finding, non-ADP-ribosylating exotoxins, including an oligonucleotide DNA

129 t of such toxins is the NAD(+)-dependent ADP-ribosylating exotoxins, which include pertussis, cholera

130 Exoenzyme S is an ADP-ribosylating extracellular protein of Pseudomonas aerugi

131 icles, was identified with antibodies to ADP-ribosylating factor and to epsilon-COP.

132 IT1 and GIT2) are scaffold proteins with ADP-ribosylating factor GTPase activity.

133 n intermediate in which the phosphate is ADP-ribosylated followed by a presumed transesterification t

134 ied by ARTs, the sites on these proteins ADP-ribosylated following DNA damage and the ARTs that catal

135 de resulted in the selective loss of the ADP-ribosylated form of GRP78 and increased sensitivity of e

136 mune cells independent of its ability to ADP-ribosylate G proteins.

137 se treatment with pertussis toxin, which ADP-ribosylates G proteins of the G(i/o) family, caused a si

138 ivity nor the related cholera toxin that ADP-ribosylates G(s) (but not G(i)) proteins blocked EAU ind

139 at PT can affect neutrophils directly by ADP ribosylating G(i) proteins associated with surface chemo

140 ly shown to inhibit the ability of PT to ADP-ribosylate Gi proteins in intact CHO cells also inhibite

141 ia this pathway and is required by PT to ADP-ribosylate Gi proteins.

142 ibosylation assay, the ability of PT and ADP-ribosylate Gi-2 and Gi-3 intact CHO cells was not inhibi

143 5%, did not inhibit the ability of PT to ADP-ribosylate Gi-2 and Gi-3.

144 The cytosolic CTA1 then ADP ribosylates Gsalpha, resulting in adenylate cyclase acti

145 (SIR2) protein family employs NAD(+) to ADP-ribosylate histones, deacetylate histones, or both.

146 we find no evidence that these proteins ADP-ribosylate histones.

147 PARP-1 binds to nucleosomes and poly(ADP-ribosylates) histones and several chromatin-associated f

148 d nonenzymatically to ornithine and that ADP-ribosylated HNP-1 and ADP-ribosyl-HNP-(ornithine) were i

149 n the surface of airway epithelial cells ADP-ribosylated HNP-1 specifically on arginines 14 and 24, w

150 ADP-ribosylated HNP-1 was identified in bronchoalveolar lava

151 Di- and mono-ADP-ribosylated HNP-1 were isolated from bronchoalveolar lav

152 yl-HNP-ornithine as well as mono- and di-ADP-ribosylated HNP-1, consistent with in vivo conversion of

153 (both GTP- and GDP-bound forms) was not ADP-ribosylated; however, agmatine, which cannot interact wi

154 ubtyping showed that ExoS preferentially ADP-ribosylated human IgG3 and that ADP-ribosylation occurre

155 ntified the previously unknown structures of ribosylated imidazoleacetic acids in rat, bovine, and hu

156 combinant Gialpha1-subunits were rapidly ADP-ribosylated in the absence of betagamma-subunits, with a

157 , which cannot interact with Talpha, was ADP-ribosylated in the presence of Talpha, suggesting that a

158 Analysis of ADP-ribosylated in vitro transcribed/translated Ras mutants

159 nd Smad5, interact with PARP1 and can be ADP-ribosylated in vitro, whereas PARG causes deribosylation

160 sin homologs ezrin and radixin were also ADP-ribosylated, indicating the ERMs collectively represent

161 hway in the cytosol and then proceeds to ADP ribosylate its target G(s)alpha, triggering the downstre

162 (ADP-ribose) polymerase 1 (PARP1), which ADP ribosylates KDM4D after damage.

163 irulence factor of Bordetella pertussis, ADP ribosylates mammalian G(i) proteins and plays an importa

164 rements were made of their capacities to ADP-ribosylate membrane-associated proteins on the surface o

165 ivered exoenzyme S (ExoS) preferentially ADP-ribosylated membrane-associated His(6)HRas, relative to

166 negligible, and so was the formation of the ribosylated metabolites by human purine nucleoside phosp

167 vitro led to an early increase of poly(ADP) ribosylated modified protein levels.

168 Type III delivered ExoS ADP-ribosylated moesin and ezrin (and/or radixin) in culture

169 The ADP-ribosylated moiety of ubiquitin is a substrate for the n

170 ADP-ribosylated molecules were identified as LFA-1, CD8, CD2

171 in auto-ADP-ribosylated rat RT6.2, auto-ADP-ribosylated mouse Rt6, and ADP-ribosylhistone synthesize

172 ysis also revealed that levels of a poly(ADP-ribosylated) Mr 100,000 protein, tentatively identified

173 seudomonas aeruginosa exoenzyme S (ExoS) ADP-ribosylates multiple eukaryotic targets to promote cytop

174 ndicated that ribose selectively formed mono-ribosylated N(6) adenine, but in the presence of (Ade)2C

175 plexes and their hydrolysis products of mono-ribosylated N(6) and N(9) adenine adducts and di-ribosyl

176 sylated N(6) and N(9) adenine adducts and di-ribosylated N(6,9) adenine.

177 adione via the oxidation of N-alkylated or N-ribosylated nicotinamides.

178 niae, enable transformants to reversibly ADP-ribosylate nitrogenase Fe protein in response to the pre

179 ith earlier observations that ExoS could ADP-ribosylate numerous target proteins, were properties tha

180 While both chains are ADP-ribosylated on the extracellular domain of the molecule,

181 ties were tested for their ability to be ADP-ribosylated or to form a complex with dinitrogenase redu

182 ons, these observations suggest that the ADP-ribosylated P gamma cannot interact with GTP/T alpha.

183 (s) to release the radioactivity of [32P]ADP-ribosylated P gamma in concentration- and time-dependent

184 P)-ribose] polymerase 1 (PARP1) and mono-ADP-ribosylates PARP1 on lysine residue 521, thereby stimula

185 osylation acceptor sites but also boosts ADP-ribosylated peptide identifications.

186 lation reaction intermediate to yield an ADP-ribosylated peptide.

187 generate large amounts of site-specific, ADP-ribosylated peptides would provide a useful tool for dec

188 to most biglutamate ADPRTs, was able to ADP-ribosylate poly-l-arginine.

189 We have recently reported that certain ribosylated polyhalogenated benzimidazoles are potent an

190 These potentially ADP-ribosylated precursors were then selected and analyzed v

191 vity of the combined vector requires the ADP-ribosylating property of CTA1.

192 hemical analysis showed that the 150-kDa ADP-ribosylated protein was immunoglobulin of the immunoglob

193 by generating protein-free PAR from poly-ADP ribosylated protein, makes PAR translocation possible.

194 and intrinsic pathways as well as poly(ADP)-ribosylating protein (PARP) activity in myocardial and p

195 Tankyrase (TNKS) is a poly-ADP-ribosylating protein (PARP) whose activity suppresses ce

196 ing 1 to 10 weeks after injection of the ADP-ribosylating protein diphtheria toxin (DTX) into one-hal

197 ublicly available database encapsulating ADP-ribosylated proteins identified from the past 40 years,

198 have led to the discovery of hundreds of ADP-ribosylated proteins in both cultured cells and mouse ti

199 We found increased amounts of poly(ADP) ribosylated proteins in diabetic kidneys of Lepr(db/db)

200 statistically significant enrichment of ADP-ribosylated proteins in non-membranous RNA granules.

201 expression, resulting in increased poly-ADP-ribosylated proteins in the nucleus.

202 tilized a variety of methods to identify ADP-ribosylated proteins, recent proteomics studies bring th

203 tion, respectively) from mono- and poly(ADP)-ribosylated proteins, respectively.

204 e have created ADPriboDB - a database of ADP-ribosylated proteins.

205 and has the potential to illuminate the ADP-ribosylated proteome and the molecular mechanisms used b

206 e human aspartic acid- and glutamic acid-ADP-ribosylated proteome.

207 We showed that tankyrases interact with and ribosylate PTEN, which promotes the recognition of PTEN

208 ible for this inhibition is one in which ADP-ribosylated Rap binds inefficiently to C3G, relative to

209 In this study, we report that ExoS ADP ribosylates Rap1b at Arg41 and that ADP ribosylation of

210 of Ras, which suggested that ExoS could ADP-ribosylate Ras at more than one arginine residue.

211 onal electrophoresis found the former to ADP-ribosylate Ras at two sites, while the latter modified R

212 cells but limited the ability of ExoS to ADP-ribosylate Ras GTPases.

213 to HeLa cells, or the ability of ExoS to ADP-ribosylate Ras GTPases.

214 tants were examined for their ability to ADP-ribosylate Ras in vitro or in vivo.

215 r eukaryotic cells and has been shown to ADP-ribosylate Ras in vivo and uncouple a Ras-mediated signa

216 keleton (a Rho GAP activity), it did not ADP-ribosylate Ras.

217 Initial experiments showed that ADP-ribosylated Ras (ADP-r-Ras) and unmodified Ras (Ras) int

218 Previous studies showed that ExoS ADP ribosylated Ras at Arg41 which interfered with the abili

219 seudomonas aeruginosa exoenzyme S (ExoS) ADP-ribosylated Ras at multiple sites.

220 try of V8 protease generated peptides of ADP-ribosylated Ras identified the sites of ADP-ribosylation

221 e ADP-ribosylation of Ras by ExoS, where ADP-ribosylated Ras loses the ability to bind guanine nucleo

222 gel electrophoresis analysis showed that ADP-ribosylated Ras possessed a slower mobility than non-ADP

223 Under saturating conditions, ExoS ADP-ribosylated Ras to a stoichiometry of 2 mol of ADP-ribos

224 seudomonas aeruginosa exoenzyme S (ExoS) ADP-ribosylated Ras to a stoichiometry of approximately 2 mo

225 Ras possessed a slower mobility than non-ADP-ribosylated Ras.

226 ExoS ADP-ribosylates Ras and prevents it from interacting with an

227 seudomonas aeruginosa exoenzyme S double ADP-ribosylates Ras at Arg(41) and Arg(128).

228 The ADP-ribosyl-protein bonds in auto-ADP-ribosylated rat RT6.2, auto-ADP-ribosylated mouse Rt6, a

229 ExoT ADP-ribosylated recombinant Crk-I at a rate similar to the A

230 ExoS ADP-ribosylated recombinant moesin at a linear velocity that

231 etreatment of myocytes with C3 exoenzyme ADP-ribosylated Rho and inhibited the characteristic alpha1-

232 oximately eightfold, consistent with the ADP-ribosylated Rho functioning as a dominant negative inhib

233 ith exoenzyme C3 for 48 hours completely ADP-ribosylated Rho in vivo.

234 Exoenzyme C3 of Clostridium botulinum ADP-ribosylates Rho at Asn41, a modification that functional

235 e for C3 transferase, which specifically ADP-ribosylates Rho GTPases.

236 C3 transferase ribosylates Rho in its effector domain thereby abolishin

237 e from Clostridium botulinum selectively ADP-ribosylates Rho in its effector-binding domain and there

238 Clostridium botulinum which selectively ADP-ribosylates Rho within its effector domain and thereby a

239 inant negative form of RhoA, or in vitro ADP-ribosylated RhoA impaired the ability of cells to migrat

240 hich prevents immunoprecipitation of non-ADP-ribosylated RhoA.

241 ns to be defined, ExoS has been shown to ADP-ribosylate several eukaryotic proteins in vitro, includi

242 One of these effectors, ExoS, ADP-ribosylates several host cell proteins, including Ras an

243 LTA also ADP-ribosylates simple guanidino compounds (e.g., arginine)

244 acellular membranes and targeted ExoS to ADP-ribosylate small molecular weight membrane proteins as o

245 unknown, but may involve its ability to ADP-ribosylate-specific G-proteins.

246 All the Salmonella SeoC/SboC homologues ADP-ribosylate Src E310 in vitro Ectopic expression of SeoC/

247 Brefeldin-A ADP-ribosylated substrate (BARS) and dynamin function in mem

248 We now show that Brefeldin-A ADP-Ribosylated Substrate (BARS) plays a critical role in th

249 nding protein, brefeldin A (BFA)-induced ADP-ribosylated substrate (CtBP1/BARS) regulates neutral lip

250 e C-terminal binding protein/brefeldin A-ADP ribosylated substrate protein ANGUSTIFOLIA1, and our res

251 carboxy-terminal binding protein/brefeldin A-ribosylated substrate), a transcription co-repressor tha

252 rom the macrodomain family can hydrolyze ADP-ribosylated substrates and therefore reverse this post-t

253 an reverse ADP-ribosylation by acting on ADP-ribosylated substrates through the hydrolytic activity o

254 deletion peptide of ExoS (DeltaN222) to ADP-ribosylate target proteins in the absence of FAS.

255 ostasis and Wnt signaling, by covalently ADP-ribosylating target proteins and consequently regulating

256 Recombinant PARP was able to ADP-ribosylate TEF-1 in vitro.

257 ton dynamics, and the ability of ExoS to ADP-ribosylate the ERM proteins links ADP-ribosylation with

258 ect either the ability of PT to directly ADP-ribosylate the heterotrimeric G protein, Gt, or the bind

259 ExoS ADP-ribosylated the double mutant, RasR41K,R128K, to a stoic

260 Dtx3L/Parp9 ADP-ribosylates the carboxyl group of Ub Gly76.

261 Within the cell, ExoS ADP-ribosylates the cell signaling protein Ras and causes in

262 HopU1 ADP-ribosylates the conserved arginine 49 of GRP7, and this

263 Pertussis toxin, which ADP-ribosylates the Gi proteins known to couple to the C5a r

264 to the 5'-UTR of L1 loci, where it mono-ADP ribosylates the nuclear corepressor protein, KAP1, and f

265 ses the ER membrane, enters the cytosol, ADP-ribosylates the stimulatory alpha subunit of the heterot

266 After the PB2 and PA proteins are poly(ADP-ribosylated), they are associated with the region of ZAP

267 ortality, additionally produce the actin-ADP-ribosylating toxin C. difficile transferase (CDT).

268 rbidity and mortality, produce the actin-ADP ribosylating toxin Clostridium difficile transferase (CD

269 that SpvB functions as an intracellular ADP-ribosylating toxin critical for the pathogenesis of Salm

270 ifficile transferase) is a binary, actin ADP-ribosylating toxin frequently associated with hypervirul

271 Domain II resembles the ADP-ribosylating toxin from Bacillus cereus, but the active

272 rd C. difficile toxin, is a binary actin-ADP-ribosylating toxin that causes depolymerization of actin

273 This proposed bipartite ADP-ribosylating toxin turn-turn (ARTT) motif places the VIP

274 AB genes have the potential to encode an ADP-ribosylating toxin with similarity to pertussis toxin.

275 is organism, termed SpyA, for S. pyogenesADP-ribosylating toxin.

276 onsistent with the action of a bacterial ADP-ribosylating toxin.

277 he ytxAB locus, which encodes a putative ADP-ribosylating toxin.

278 ADP-ribosylating toxins comprise a large family, including t

279 AD-binding beta-sandwich fold with other ADP-ribosylating toxins despite little sequence conservation

280 ction confers resistance not only to the ADP-ribosylating toxins PE and DT, but also to tumor necrosi

281 rfere with apoptosis mediated by TNF and ADP-ribosylating toxins suggests that CAS may play a role in

282 neral recognition motif region for other ADP-ribosylating toxins that have a similar beta-structure f

283 in this study may also apply to several ADP-ribosylating toxins that move from the endosomes to the

284 Unlike the ADP-ribosylating toxins that possess the active site loop ne

285 from Bordetella pertussis is one of the ADP-ribosylating toxins which are the cytotoxic agents of se

286 oxin belonging to a larger family of A/B ADP-ribosylating toxins.

287 resistant to several different bacterial ADP-ribosylating toxins.

288 active site loop observed in many other ADP-ribosylating toxins.

289 Human tankyrase 1 is reported to ADP-ribosylate TRF1 and to down-regulate the telomeric repea

290 Tankyrase 1 ADP-ribosylates TRF1 in vitro, and its overexpression induce

291 Tankyrase 1 ADP-ribosylates TRF1, inhibiting its binding to telomeric DN

292 ExoT ADP-ribosylated two cytosolic proteins in cell lysates upon

293 e have observed that ExoS preferentially ADP-ribosylated two extracellular serum proteins with molecu

294 ate serine residues in substrates via an ADP-ribosylated ubiquitin intermediate.

295 activates ubiquitin by the formation of ADP-ribosylated ubiquitin.

296 ion that approximately 50% of P gamma is ADP-ribosylated under these conditions, these observations s

297 ecent studies observed that ExoS is auto-ADP-ribosylated upon delivery into eukaryotic cells.

298 a 2000-fold reduction in the capacity to ADP-ribosylate, were transiently expressed in eukaryotic cel

299 /BARS is an NAD-binding protein that becomes ribosylated when cells are exposed to BFA.

300 rboxy-terminal catalytic fragment became ADP-ribosylated with [32P]-3'-dNAD+ as a substrate.