ライフサイエンスコーパス: ribosyltransferase

1 transferase designated SpyA (S. pyogenes ADP-ribosyltransferase).

2 1-diphosphate:decaprenyl-phosphate 5-phospho-ribosyltransferase.

3 no-associated viruses carrying a gene for C3 ribosyltransferase.

4 C-terminus (residues 232-453) encodes an ADP-ribosyltransferase.

5 e antibodies, suggesting that Sir2 is an ADP-ribosyltransferase.

6 ion of phospholipase D and cholera toxin ADP-ribosyltransferase.

7 locking ARF stimulation of cholera toxin ADP-ribosyltransferase.

8 otential for ExoS to function as an ecto-ADP-ribosyltransferase.

9 characterized as a diphthamide dependent ADP-ribosyltransferase.

10 bility of 14-3-3 to activate exoenzyme S ADP-ribosyltransferase.

11 xplore transition state analogue design in N-ribosyltransferases.

12 ress on their surfaces arginine-specific ADP ribosyltransferases.

13 y into hydrophobic subpockets in various ADP-ribosyltransferases.

14 nk between bacterial and vertebrate mono-ADP-ribosyltransferases.

15 guanidine, inhibitors of endogenous mono-ADP-ribosyltransferases.

16 P-ribosyltransferases than the bacterial ADP-ribosyltransferases.

17 ve been attributed to several vertebrate ADP-ribosyltransferases.

18 lyzed by a family of amino acid-specific ADP-ribosyltransferases.

19 anism of NAD binding and catalysis among ADP-ribosyltransferases.

20 ADP-ribose are conjugated to proteins by ADP-ribosyltransferases.

21 sted against a panel of homologous human ADP-ribosyltransferases.

22 e enzymatic activity of deacetylases and ADP ribosyltransferases.

23 oops, L1 and L4, not found in other mono-ADP-ribosyltransferases.

24 Full length cDNA encoding ADP-ribosyltransferase-1 (ART1) was generated from human ske

25 We found that an arginine-specific ADP ribosyltransferase-1 present on airway epithelial cells

26 First, IENK cells express high levels of ADP-ribosyltransferase 2 (a marker of regulatory T cells in

27 usly expressed CD38 and T cell-expressed ADP-ribosyltransferase 2 (ART2) are ectoenzymes competing fo

28 We found that in the absence of CD38, ADP-ribosyltransferase 2 preferentially activates apoptotic

29 e to NAD-induced cell death activated by ADP ribosyltransferase-2 (ART2)-mediated ADP ribosylation of

30 ctive inhibitor of diphtheria toxin-like ADP-ribosyltransferase 3 (ARTD3).

31 ADP-ribosyltransferase 5 (ART5), a murine transferase origin

32 ong these were genes encoding additional ADP-ribosyltransferases, a homolog of SrfC (a candidate effe

33 have two amino acid substitutions in the ADP-ribosyltransferase active center (E112K) and COOH-termin

34 lso carrying out ADP-ribosyl cyclase and ADP-ribosyltransferase activities, making SPN the only beta-

35 s both Rho GTPase-activating protein and ADP-ribosyltransferase activities.

36 agment, which possesses both the GAP and ADP-ribosyltransferase activities.

37 e (NAD) glycohydrolase (NADase) and auto-ADP-ribosyltransferase activities.

38 muscle increased NAD glycohydrolase and ADP-ribosyltransferase activities.

39 acked detectable ADP-ribosyl cyclase and ADP-ribosyltransferase activities.

40 possesses NAD-dependent deacetylase and ADP ribosyltransferase activities.

41 , we have used LFnDTA and its associated ADP-ribosyltransferase activity (DTA) to determine the requi

42 fector proteins include two enzymes with ADP-ribosyltransferase activity (ExoS and ExoT) and an acute

43 mutagenesis were quantified by measuring ADP-ribosyltransferase activity (i.e., auto-ADP-ribosylation

44 Using the translocation of C-domain ADP-ribosyltransferase activity across the endosomal membran

45 tein toxin that has diphthamide-specific ADP-ribosyltransferase activity against eukaryotic elongatio

46 hibition of ARF-stimulated cholera toxin ADP-ribosyltransferase activity and effects of ARF on mutant

47 Thus, redirection of TT is dependent on ADP-ribosyltransferase activity and GM1 binding and is assoc

48 l domain of ExoS possesses FAS-dependent ADP-ribosyltransferase activity and is cytotoxic to eukaryot

49 their ability to stimulate cholera toxin ADP-ribosyltransferase activity and later recognized as crit

50 their ability to stimulate cholera toxin ADP-ribosyltransferase activity and now recognized as critic

51 hat V. fischeri hvn null still possessed ADP-ribosyltransferase activity and that this activity is im

52 ubunit (S61F), which resulted in loss of ADP ribosyltransferase activity and toxicity.

53 ion of ExoS was monitored by a sensitive ADP-ribosyltransferase activity assay, and specific activiti

54 N222 so it could express FAS-independent ADP-ribosyltransferase activity at a linear rate.

55 omology, Exo53 has been shown to express ADP-ribosyltransferase activity at about 0.2% of the specifi

56 ExoT also affects PI3K signaling via its ADP-ribosyltransferase activity but does not act directly on

57 a E379D mutation inhibited expression of ADP-ribosyltransferase activity but had little effect on the

58 These data demonstrate ecto-ADP-ribosyltransferase activity by ExoS.

59 activity, and in J744-Eclone cells, ExoS ADP-ribosyltransferase activity caused a more severe inhibit

60 ein (GAP) activity, or ExoS defective in ADP-ribosyltransferase activity demonstrated that the virule

61 Recently, ExoS ADP-ribosyltransferase activity has been detected in the ple

62 otein stimulated cholera-toxin-catalyzed ADP-ribosyltransferase activity in a reaction that was depen

63 estigate the structural requirements for ADP-ribosyltransferase activity in human PARP13 and two of i

64 uggest that the reported histone/protein ADP-ribosyltransferase activity is a low-efficiency side rea

65 ted B-oligomer subunit of PTX that lacks ADP ribosyltransferase activity nor the related cholera toxi

66 The latent ADP-ribosyltransferase activity of cholera toxin (CT) that i

67 The ARF proteins stimulate the in vitro ADP-ribosyltransferase activity of cholera toxin and appear

68 purified by their ability to enhance the ADP-ribosyltransferase activity of cholera toxin and more re

69 tified by their ability to stimulate the ADP-ribosyltransferase activity of cholera toxin in vitro.

70 ons, the initial rate of FAS-independent ADP-ribosyltransferase activity of DeltaN222 was not linear

71 r NaCH3COOH, NaCl, or KCl stabilized the ADP-ribosyltransferase activity of DeltaN222.

72 Antibodies to this epitope blocked the ADP-ribosyltransferase activity of ETA and appeared to inter

73 The mechanism for the lower ADP-ribosyltransferase activity of Exo53 relative to ExoS wa

74 re, two aspects of the activation of the ADP-ribosyltransferase activity of ExoS by 14-3-3 proteins a

75 We investigated whether the ADP-ribosyltransferase activity of ExoS influences its GAP a

76 Although the ADP-ribosyltransferase activity of ExoS is dependent upon FA

77 GAP was identified as a substrate of the ADP-ribosyltransferase activity of ExoS.

78 The ADP-ribosyltransferase activity of ExoT stimulated depolymer

79 d NAD analogues and 32P-NAD to study the ADP-ribosyltransferase activity of several different sirtuin

80 r sirtuins, we propose that the reported ADP-ribosyltransferase activity of sirtuins is likely some i

81 e findings suggest that Sir2 contains an ADP-ribosyltransferase activity that is essential for its si

82 studies have localized the FAS-dependent ADP-ribosyltransferase activity to the carboxyl-terminus.

83 sis and analyzed both NAD(+) binding and ADP-ribosyltransferase activity using a fluorescence-based a

84 Thus, ADP-ribosyltransferase activity was essential for antigen tr

85 The ADP-ribosyltransferase activity was released from transforme

86 tically engineered PTX mutant (devoid of ADP-ribosyltransferase activity) altered TER.

87 (LT), and LTK63 (an LT mutant devoid of ADP-ribosyltransferase activity) to elicit murine CD8(+) CTL

88 activation of Rab5 was dependent on ExoS ADP-ribosyltransferase activity, and in J744-Eclone cells, E

89 fter PTX and were dependent on intrinsic ADP-ribosyltransferase activity, as neither the cell binding

90 t inhibited by mutant LT with attenuated ADP-ribosyltransferase activity, CT B or LT B subunit, which

91 r ability to activate cholera toxin (CT) ADP-ribosyltransferase activity, have a critical role in ves

92 ExoS(E381D), a mutant deficient in ADP-ribosyltransferase activity, isolated from cultured cell

93 r mutant CT nor mutant LTh-1, which lack ADP-ribosyltransferase activity, redirected TT antigen into

94 activity, have been reported to possess ADP-ribosyltransferase activity, too.

95 nce of ExoS was largely dependent on its ADP-ribosyltransferase activity.

96 codes a factor-activating ExoS-dependent ADP-ribosyltransferase activity.

97 while the C-terminal domain comprises a ADP-ribosyltransferase activity.

98 emiluminescence responses and had potent ADP-ribosyltransferase activity.

99 lls transfected with deltaN222 expressed ADP-ribosyltransferase activity.

100 ivating exoenzyme S (FAS) for expressing ADP-ribosyltransferase activity.

101 13 lacks the structural requirements for ADP-ribosyltransferase activity.

102 Most members have mono-ADP-ribosyltransferase activity.

103 gen processing correlated with A subunit ADP-ribosyltransferase activity.

104 ing positions in PARP15 abolished PARP15 ADP-ribosyltransferase activity.

105 ent enzymes with deacetylase and/or mono-ADP-ribosyltransferase activity.

106 although some sirtuins exhibit a weaker ADP-ribosyltransferase activity.

107 a number of reports that suggest protein ADP-ribosyltransferase activity.

108 concluded that ecto-NAD, as substrate of ADP ribosyltransferase, acts on naive, but not on activated

109 domain mutants of exoS revealed that the ADP-ribosyltransferase (ADP-r) activity of ExoS, but not the

110 at the type III effector HopU1 is a mono-ADP-ribosyltransferase (ADP-RT).

111 hat the pBC210 LF homologue contained an ADP-ribosyltransferase (ADPr) domain.

112 Point mutations in the ADP ribosyltransferase (ADPR) regions of ExoS or ExoT also i

113 ncludes both GTPase-activating (GAP) and ADP-ribosyltransferase (ADPRT) activities, and P. aeruginosa

114 rotein, with GTPase-activating (GAP) and ADP-ribosyltransferase (ADPRT) activities.

115 (GAP) activity and the carboxy-terminal ADP-ribosyltransferase (ADPRT) activity of ExoS have been fo

116 We assessed the ADP-ribosyltransferase (ADPRT) activity of various domains o

117 olecular-weight G (LMWG) proteins and an ADP-ribosyltransferase (ADPRT) activity that targets LMWG pr

118 Significantly higher levels of ExoS ADP-ribosyltransferase (ADPRT) activity were detected in cul

119 s a 591-amino-acid virulence factor with ADP-ribosyltransferase (ADPRT) and vacuolating activities.

120 ards Rho family GTPases and a C-terminal ADP ribosyltransferase (ADPRT) domain with minimal activity

121 bl-b and Crk, the substrate for the ExoT ADP ribosyltransferase (ADPRT) domain.

122 ng protein (GAP) domain and a C-terminal ADP-ribosyltransferase (ADPRT) domain.

123 having both GTPase-activating (GAP) and ADP-ribosyltransferase (ADPRT) functional domains.

124 The ADP-ribosyltransferase (ADPRT) gene encodes a zinc-finger DN

125 ADP-ribosyltransferase (ADPRT) is a glycosylphosphatidylinos

126 Preferred substrates of the ADP-ribosyltransferase (ADPRT) portion of ExoS include low m

127 on as found in the A chain of CRM197, an ADP-ribosyltransferase (ADPrT)-deficient form of DTx, we hyp

128 n, calmodulin-dependent protein kinases, ADP-ribosyltransferase (ADPRT/PARP) and tau.

129 at exhibits sequence similarity to known ADP-ribosyltransferases (ADPRTs) such as Bordetella pertussi

130 post-translational modification and the ADP-ribosyltransferases (also known as PARPs) responsible fo

131 vities from a single Sde polypeptide: an ADP-ribosyltransferase and a nucleotidase/phosphohydrolase.

132 ioinformatic strategy as a putative mono-ADP-ribosyltransferase and a possible virulence factor from

133 poly(ADP-ribose) polymerase (Tiparp), an ADP-ribosyltransferase and AHR repressor, increases sensitiv

134 Both ADP-ribosyltransferase and deacetylase activities of SIRT3 a

135 a operon encodes dinitrogenase reductase ADP-ribosyltransferase and dinitrogenase reductase-activatin

136 One ADP-ribosyltransferase and the SrfC homolog were tested and

137 ADP-ribosylation is governed by ADP-ribosyltransferases and a subclass of sirtuins (writers)

138 dification of proteins with NAD:arginine ADP-ribosyltransferases and ADP-ribosylarginine hydrolases (

139 NAD:arginine ADP-ribosyltransferases and ADP-ribosylarginine hydrolases c

140 ribooxacarbenium ion transition states of N-ribosyltransferases and are tightly bound as the N4' cat

141 ross talk exists between bacterial toxin ADP-ribosyltransferases and host ADP-ribosylation cycles.

142 The bacterial ADP-ribosyltransferases are a family of protein toxins that

143 We conclude that endogenous mono-ADP-ribosyltransferases are present in smooth muscle from bo

144 athologic process, PARP-1 and other poly(ADP-ribosyltransferases) are also localized within mitochond

145 Several proteins with NAD+:arginine ADP-ribosyltransferase (ART) activity are expressed in T cel

146 encodes a 68-kDa protein that possesses ADP-ribosyltransferase (ART) activity.

147 d to detect ecto-adenosine diphosphate (ADP)-ribosyltransferase (ART) activity.

148 n is catalyzed by ART2.2, a GPI-anchored ADP-ribosyltransferase (ART) that is constitutively expresse

149 ithelial cells express arginine-specific ADP ribosyltransferase (ART)-1, a GPI-anchored ART that tran

150 sence of NAD-metabolizing enzymes (e.g., ADP-ribosyltransferase (ART)2) on the surface of immune cell

151 but not ADPR provides the substrate for ADP-ribosyltransferase (ART-2)-mediated attachment of ADP-ri

152 Arginine-specific ADP-ribosyltransferases (ART) on the surface of these cells

153 human skeletal muscle arginine-specific ADP-ribosyltransferase (ART1).

154 Five mammalian ADP-ribosyltransferases (ART1--ART5) have been cloned and ex

155 Mono-ADP-ribosyltransferases (ART1-7) transfer ADP-ribose from NA

156 HvnB were presumptively designated mono-ADP-ribosyltransferases (ARTases), and it was hypothesized t

157 The diphtheria toxin-like ADP-ribosyltransferases (ARTDs) are an enzyme family that ca

158 Adenosine diphosphate ribosyltransferases (ARTDs; ARTD1-17 in humans) are emer

159 ADP-ribosyltransferases (ARTs) catalyze transfer of ADP-ribo

160 ADP-ribosyltransferases (ARTs) modify proteins with single u

161 y mediated by a family of mammalian ecto-ADP-ribosyltransferases (ARTs) that covalently modify target

162 All mutants were inactive in the ADP-ribosyltransferase assay; however, auto-ADP-ribosylation

163 similarly ADP-ribosylated by endogenous ADP-ribosyltransferase, but only one arginine is modified at

164 racterized for this enzyme from the mono-ADP-ribosyltransferase C3 toxin subgroup.

165 icroinjection of a Clostridium botulinum ADP-ribosyltransferase (C3) and treatment with a ROCK specif

166 Thus, mRt6.1 is an NAD:arginine ADP-ribosyltransferase capable of catalyzing a multiple turn

167 Protein ADP-ribosyltransferases catalyze the transfer of adenosine d

168 adenocarcinoma) cells with NAD:arginine ADP-ribosyltransferase cDNAs from Yac-1 murine lymphoma cell

169 l polysaccharide capsules, and the novel ADP-ribosyltransferase, Certhrax.

170 s protein modification is often added by ADP-ribosyltransferases, commonly known as PARPs, but it can

171 mma ADP-ribosylation, indicates that rod ADP-ribosyltransferase contains two isozymes, and that these

172 Thus, airway mono-ADP-ribosyltransferases could have an important regulatory r

173 indings reveal links between a mammalian ADP ribosyltransferase, cytokine-regulated metabolic activit

174 The ADP-ribosyltransferase-deficient CT-2* protein, which was in

175 deacetylation reactions and can also process ribosyltransferase, demalonylase, and desuccinylase acti

176 eptococcus pyogenes produces a C3 family ADP-ribosyltransferase designated SpyA (S. pyogenes ADP-ribo

177 y the DRAT-DRAG (dinitrogenase reductase ADP-ribosyltransferase-dinitrogenase reductase-activating gl

178 dependent of the dinitrogenase reductase ADP-ribosyltransferase/dinitrogenase reductase activating gl

179 Furthermore, comparing with a bacterial ADP-ribosyltransferase diphtheria toxin, the observed rate c

180 yme S, which represent the FAS-dependent ADP-ribosyltransferase domain (termed deltaN222), and a poin

181 rm of ExoS rounded cells, indicating the ADP-ribosyltransferase domain alone is sufficient to elicit

182 aeruginosa, which comprises a C-terminal ADP ribosyltransferase domain and an N-terminal Rho GTPase-a

183 this study was to define the role of the ADP-ribosyltransferase domain in the modulation of eukaryoti

184 ese data indicate that expression of the ADP-ribosyltransferase domain of exoenzyme S is cytotoxic to

185 ngle amino acid mutation in the putative ADP-ribosyltransferase domain of SIRT1 inhibits the interact

186 us (residues 233-453) is a FAS-dependent ADP-ribosyltransferase domain that targets Ras and Ras-like

187 mapping has localized the FAS-dependent ADP-ribosyltransferase domain to the carboxyl-terminus of Ex

188 This putative bacterial ADP-ribosyltransferase domain was denoted CerADPr.

189 ues 234-453 include the 14-3-3-dependent ADP-ribosyltransferase domain.

190 s 233 to 453 comprise a 14-3-3-dependent ADP-ribosyltransferase domain.

191 23 to 157) replaces the cholera toxin A1 ADP-ribosyltransferase domain.

192 es 234-453 comprise the 14-3-3-dependent ADP-ribosyltransferase domain.

193 -terminal RhoGAP domain and a C-terminal ADP-ribosyltransferase domain.

194 ity, whereas the C terminus comprises an ADP-ribosyltransferase domain.

195 es 233-453 comprise the 14-3-3-dependent ADP-ribosyltransferase domain.

196 tivating protein (RhoGAP) and C-terminal ADP-ribosyltransferase domains.

197 gulating enzymes dinitrogenase reductase ADP-ribosyltransferase (DRAT) and dinitrogenase reductase-ac

198 se reductase and dinitrogenase reductase ADP-ribosyltransferase (DRAT) from Rhodospirillum rubrum has

199 m a complex with dinitrogenase reductase ADP-ribosyltransferase (DRAT) from Rhodospirillum rubrum.

200 y inactivated by dinitrogenase reductase ADP-ribosyltransferase (DraT) in response to an increase in

201 lly regulated by dinitrogenase reductase ADP-ribosyltransferase (DRAT) via ADP-ribosylation of the ar

202 ase reductase by dinitrogenase reductase ADP-ribosyltransferase (DRAT).

203 member of the adenosine 5'-diphosphate (ADP)-ribosyltransferase ectoenzyme gene family.

204 Depending on the family member, ADP-ribosyltransferases either conjugate a single ADP-ribose

205 first structure of a DNA-targeting mono-ADP-ribosyltransferase enzyme; the structures of the apo-for

206 This unusual finding, of two ADP-ribosyltransferase enzymes produced by a microorganism,

207 a nonphosphorylated protein ligand, the ADP-ribosyltransferase Exoenzyme S (ExoS) from Pseudomonas a

208 t to show that ADP-ribosylation of rho by C3 ribosyltransferase (exoenzyme) inhibits IL-2 production

209 uctural genes, exoS, encoding the 49-kDa ADP-ribosyltransferase (ExoS), and exoT, encoding the 53-kDa

210 Pseudomonas aeruginosa produces two ADP-ribosyltransferases, exotoxin A and exoenzyme S (ExoS).

211 ARTC2.2 is a toxin-related, GPI-anchored ADP-ribosyltransferase expressed by murine T cells.

212 that CerADPr possessed several conserved ADP-ribosyltransferase features, including an alpha-3 helix,

213 Cholix toxin is an ADP-ribosyltransferase found in non-O1/non-O139 strains of V

214 r target protein, exoenzyme S (ExoS), an ADP-ribosyltransferase from Pseudomonas aeruginosa.

215 ene [yeast cytosine deaminase/uracil phospho-ribosyltransferase fusion (Fcy::Fur)] and the fusogenic

216 d initial characterization of a secreted ADP-ribosyltransferase, halovibrin (gene designation hvn), f

217 PtoG, HopPtoH, HopPtoI, and HopPtoS1 (an ADP-ribosyltransferase homolog).

218 ecognized by specific antibodies against ADP-ribosyltransferase in the coronary arterial homogenates

219 s, we have discovered >20 novel putative ADP-ribosyltransferases, including several new potential tox

220 of P gamma arginine mutants, effects of ADP-ribosyltransferase inhibitors on the P gamma ADP-ribosyl

221 tokinesis by microinjecting an inhibitor, C3 ribosyltransferase, into cultured cells.

222 served NAD(+)-dependent deacetylases and ADP-ribosyltransferases involved in the regulation of cell d

223 ART-1, a cell surface ADP-ribosyltransferase, is imbedded in the membrane by a gly

224 hich is ADP-ribosylated by an endogenous ADP-ribosyltransferase, is required for the phosphorylation.

225 omonas aeruginosa exoenzyme S (ExoS), an ADP-ribosyltransferase, is translocated into eukaryotic cell

226 e bacterial enzyme S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) catalyzes the unprec

227 The enzyme S-adenosylmethionine:tRNA ribosyltransferase-isomerase catalyzes the penultimate s

228 on of a novel gene, ADPRTL1, encoding an ADP-ribosyltransferase-like protein.

229 a 591-aa virulence factor with both mono-ADP ribosyltransferase (mART) and vacuolating activities kno

230 The mono-ADP-ribosyltransferase (mART) toxins are contributing factor

231 substrate for two enzyme families, mono-ADP-ribosyltransferases (mARTs) and poly(ADP-ribose) polymer

232 A putative mono-ADP-ribosyltransferase motif critical for the ubiquitination

233 Unlike most N-ribosyltransferases, N7 of the leaving group adenine is

234 e activity but functions as an efficient ADP-ribosyltransferase on histones and bovine serum albumin.

235 ART2 is an ADP-ribosyltransferase on naive CD4+ and CD8+ T cells.

236 CerADPr(E431D) did not possess ADP-ribosyltransferase or NAD glycohydrolase activities and

237 afCAAX, this was sufficient to allow polyADP ribosyltransferase (PARP)-degradative apoptosis, but in

238 Here we find that the ADP-ribosyltransferases Parp1 and Parp7 play a critical role

239 Here, we identify the mono-ADP-ribosyltransferase PARP10/ARTD10 as a novel PCNA binding

240 We show that the mono-ADP-ribosyltransferase PARP14 interacts with the DNA replica

241 We reported that ART1, a mammalian ADP-ribosyltransferase, present in epithelial cells lining t

242 able pores through which iota a (Ia), an ADP-ribosyltransferase, presumably enters the cytosol.

243 Exoenzyme S (ExoS) is an ADP-ribosyltransferase produced and directly translocated in

244 ADP-ribosyltransferases promote repair of DNA single strand

245 nserved NAD(+)-dependent deacetylases or ADP-ribosyltransferases, promote longevity in diverse organi

246 talytic domains of the nuclear-localized ADP-ribosyltransferase proteins (Adprt), two recently identi

247 yses of Tse6 show that it resembles mono-ADP-ribosyltransferase proteins, such as diphtheria toxin, w

248 Here we characterize Parp9, a mono-ADP-ribosyltransferase reported to be enzymatically inactive

249 pe III-secreted effector HopU1 is a mono-ADP-ribosyltransferase required for full virulence on Arabid

250 mbrane proteins on mouse T cells by ecto-ADP-ribosyltransferase(s) (ARTs) can down-regulate prolifera

251 Qiu et al. (2016) show that a mono-ADP-ribosyltransferase, SdeA, from Legionella pneumophila ca

252 Exoenzyme S (ExoS) is a mono-ADP-ribosyltransferase secreted by the opportunistic pathoge

253 r, inhibition of adenosine diphosphate (ADP) ribosyltransferase significantly decreased the response

254 Mammalian cells contain ADP-ribosyltransferases similar to CT and an ADP-ribosyl(arg

255 Rod ADP-ribosyltransferase solubilized from membranes by phospha

256 t in the production of the streptococcal ADP-ribosyltransferase SpyA generates lesions of reduced siz

257 ed heterohexamers in which the catalytic ADP-ribosyltransferase subunit is activated when exposed to

258 3 cells is not significantly perturbed by C3 ribosyltransferase suggested that RhoA does not play a m

259 These data suggest that proteolysis of ADP-ribosyltransferase synthesized in transformed NMU cells

260 We identify the ADP-ribosyltransferase tankyrase (TNKS) and the 19S assembly

261 The ADP-ribosyltransferase TccC3 from the insect bacterial patho

262 o acid homology with the vertebrate mono-ADP-ribosyltransferases than the bacterial ADP-ribosyltransf

263 An adenosine diphosphate (ADP)-ribosyltransferase that causes actin cytoskeletal disrup

264 EspJ as a unique adenosine diphosphate (ADP) ribosyltransferase that directly inhibits Src kinase by

265 eriments identify CerADPr as a cytotoxic ADP-ribosyltransferase that disrupts the host cytoskeleton.

266 enomic recombinant Sindbis virus C3), an ADP-ribosyltransferase that inactivates Rho, or dominant-neg

267 y of macrodomain-containing PARPs--is an ADP ribosyltransferase that interacts with Stat6, enhances i

268 ringae type III effector HopU1 is a mono-ADP-ribosyltransferase that is injected into plant cells by

269 nary toxin consisting of iota a (Ia), an ADP-ribosyltransferase that modifies actin, and iota b (Ib),

270 onas aeruginosa exoenzyme S (ExoS) is an ADP-ribosyltransferase that modifies low-molecular-weight GT

271 PT is an ADP-ribosyltransferase that modifies several mammalian heter

272 3-5, are NAD(+)-dependent deacylases and ADP-ribosyltransferases that are critical for stress respons

273 Mammalian cells contain mono-ADP-ribosyltransferases that catalyze the formation of ADP-r

274 Tankyrases are ADP-ribosyltransferases that play key roles in various cellu

275 of protein deacetylases, deacylases, and ADP-ribosyltransferases that regulate life span, control the

276 ylases (HDACs), are protein deacetylases/ADP ribosyltransferases that target a wide range of cellular

277 educed liver injury, and animals lacking ADP-ribosyltransferase, the enzyme that uses NAD to attach A

278 res of the Pierisin subgroup of the mono-ADP-ribosyltransferase toxin family.

279 nic Escherichia coli (ETEC) produces the ADP-ribosyltransferase toxin known as heat-labile enterotoxi

280 Each bacterial ADP-ribosyltransferase toxin modifies a specific host protei

281 dentity with the Pierisin family of mono-ADP-ribosyltransferase toxins.

282 protein, SpyA, with homology to C3-like ADP-ribosyltransferase toxins.

283 these toxins requires their activity as ADP-ribosyltransferases, transferring the ADP-ribose moiety

284 ribooxacarbenium character at all reported N-ribosyltransferase transition states.

285 features, including an alpha-3 helix, an ADP-ribosyltransferase turn-turn loop, and a "Gln-XXX-Glu" m

286 insecticidal protein 2 (VIP2), an actin ADP-ribosyltransferase, unexpectedly implicates two adjacent

287 ADP-ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine dinucleotid

288 Mouse ART2, which is an NAD:arginine ADP-ribosyltransferase, was able to modify HNP-1, but to a l

289 mum PJ34, a well known inhibitor of poly-ADP-ribosyltransferases, was shown to be the most potent inh

290 ual target for modification by bacterial ADP-ribosyltransferases, we quantitatively compared the acti

291 (PDE), is ADP-ribosylated by endogenous ADP-ribosyltransferase when P gamma is free or complexed wit

292 data identify ExoS as a biglutamic acid ADP-ribosyltransferase, where E381 is the catalytic residue

293 The latter is an ADP-ribosyltransferase, which activates the alpha-subunit of

294 In contrast, Cg-UbiA a ribosyltransferase, which catalyzes the first step of DP

295 enzyme S of Pseudomonas aeruginosa is an ADP-ribosyltransferase, which is secreted via a type III-dep

296 re NAD(+)-dependent protein deacetylases/ADP ribosyltransferases, which play decisive roles in chroma

297 cells expressing the cell surface enzyme ADP ribosyltransferase with nicotinamide adenine dinucleotid

298 Sirtuins are a family of deacylases and ADP-ribosyltransferases with clear links to regulation of ca

299 ibose) polymerase (PARP) family includes ADP-ribosyltransferases with diphtheria toxin homology (ARTD

300 generated in NMU cells by proteolysis of ADP-ribosyltransferase, with release of a carboxyl-terminal