ライフサイエンスコーパス: rigidity

1 s from their microenvironment such as matrix rigidity.

2 and, consequently, reduced PG thickness and rigidity.

3 eas increase with the silicone gel substrate rigidity.

4 ew strong correlations and imposing a higher rigidity.

5 enhanced thermal and chemical stability and rigidity.

6 sassemble along the cell edge to test matrix rigidity.

7 local contractile forces by CUs scales with rigidity.

8 ole of the pyrB gene in the regulation of CW rigidity.

9 y of genome-wide transcription to substratum rigidity.

10 nuate nuclear shape sensitivity to substrate rigidity.

11 core packing, surface polarity, and backbone rigidity.

12 ven in the presence of profound akinesia and rigidity.

13 e can be used as a direct probe for material rigidity.

14 ition and spatial variations in lithospheric rigidity.

15 separate domains without imposing structural rigidity.

16 ) embedded with a Pt skeleton for structural rigidity.

17 adaptation outweighs the cost of functional rigidity.

18 e gel becomes less permeable with increasing rigidity.

19 ffect cell behaviour without changing matrix rigidity.

20 in that regulates sarcomere organization and rigidity.

21 ion, intramolecular hindrance, and framework rigidity.

22 oly(dA) significantly enhances the polymer's rigidity.

23 ypokinetic score, combining bradykinesia and rigidity.

24 hoic acids and increases bacterial cell wall rigidity.

25 d morphology via its contribution to nuclear rigidity.

26 comprised of heterogeneous distributions of rigidity.

27 integral proteins into domains of different rigidity.

28 ne leafs to display a heterogeneity in splay rigidities.

29 They increase thoracic rigidity [8], which decreases speed of locomotion due to

30 presence of a rest tremor, bradykinesia, and rigidity; a modified Hoehn and Yahr stage of 2.5 or less

31 We investigate how material rigidity acts as a key control parameter for the failure

32 al processes in cell adhesion, motility, and rigidity adaptation are regulated by integrin-mediated a

33 Substrate rigidity affects many physiological processes through me

34 ts are discussed, and the covalent-bond CEE, rigidity-aggregated CEE, or supramolecular CEE in NCPDs

35 Changes in tremor, rigidity, akinesia, and gait scores were also assessed u

36 h suspected meningitis (eg, headache, nuchal rigidity, altered mental status) were screened consecuti

37 d APC maturation markers, making myeloid APC rigidity an additional feature of inflammation.

38 In this paper, a CT based structural rigidity analysis (CTRA) method that incorporates bone i

39 eoretical predictions using a combination of rigidity analysis and coarse-grained simulations of prot

40 y capture the filament bending and torsional rigidities and intersubunit torsional flexibility measur

41 als that Zn(2+) strongly increases cell wall rigidity and activates the adhesive function of SasG.

42 en pursued to improve peptide conformational rigidity and bio-availability.

43 The key clinical features of PD, rigidity and bradykinesia, result from neurotransmitter

44 -kappaB expression, whereas increased tissue rigidity and cell motility/contractility help mediate tu

45 ht beta-barrel structure, which provides the rigidity and chemical environment needed for effectual f

46 ials that localize deformation, by combining rigidity and compliance in a single material, have been

47 through experiments and simulations that the rigidity and connectivity of filaments in active biopoly

48 DNA engenders NFR formation by virtue of its rigidity and consequent exclusion of nucleosomes.

49 ws that the combination of the marginal band rigidity and cortical tension increases the ability of t

50 stems from the balance between marginal band rigidity and cortical tension.

51 h complex involving two macrocycles enhances rigidity and dramatically shifts the conformer distribut

52 This shows that both conformational rigidity and dynamics are essential for controlling prot

53 This connection between rigidity and dynamics at different timescales is likely

54 and 8) reveals an interplay between backbone rigidity and effects arising from the electron rich alke

55 rm allows for independent tuning of actuator rigidity and elasticity over broad ranges without changi

56 insights into the relative roles of backbone rigidity and electron rich side-chains on intramolecular

57 e protein, but long-ranged increases in both rigidity and flexibility are also frequently observed.

58 benefit from an appropriate balance between rigidity and flexibility to bind with sufficient affinit

59 to maintain a balance between cell wall (CW) rigidity and flexibility.

60 tecture that combines elements of structural rigidity and flexibility.

61 Finally, a combination of increased coat rigidity and force from actin polymerization enables rob

62 Myoclonus, rigidity and hallucinations were more frequent in patien

63 d framework, affected by the introduction of rigidity and in the presence of external stimuli (temper

64 We estimated the average intrinsic flexural rigidity and interdoublet shear stiffness of wild-type C

65 ed two major mechanical parameters, flexural rigidity and interdoublet shear stiffness, of the flagel

66 ecule under tension, contour length, bending rigidity and intrinsic stiffness decreased in hypermethy

67 arrest as a function of membrane stiffness, rigidity and kinetics of the adhesive proteins, and the

68 etylation genetically, we show both cellular rigidity and mechanosensitivity can be restored in Atat1

69 ndrome (SPS) is characterised by progressive rigidity and muscle spasms affecting the axial and limb

70 g-SPS and progressive encephalomyelitis with rigidity and myoclonus.

71 ion as well as outer hair cell stereociliary rigidity and organization during development.

72 erions significantly enhanced the structural rigidity and plasmonic properties of DNA-assembled metal

73 he tug-of-war between evolutionary forces of rigidity and plasticity over transcriptional regulatory

74 hydrogel and silicone gel substrates on the rigidity and porosity of the substrates have recently be

75 is approximately 60% fat; it therefore lacks rigidity and poses structural preservation challenges du

76 s from the intracapsid binding sites reduces rigidity and resilience in approximately 24% and 40%, re

77 a model of frameshifting based on structural rigidity and resistance to mechanical unfolding, and ins

78 ect where we have concentrated on mechanical rigidity and size.

79 This suggests that the rigidity and small size of this scaffold determines the

80 ediate phenotype, with fascin delivering the rigidity and strength for protrusive force and structura

81 rent behavior from alkanethiols, with higher rigidity and stronger intermolecular interactions, they

82 ondary plant cell walls, contributing to its rigidity and structural integrity in vascular plants.

83 can oligopeptides to provide vital cell wall rigidity and structural support.

84 physical properties of the membrane (bending rigidity and surface and dipole electrostatic potentials

85 On examination rigidity and tenderness all over abdomen were present.

86 developed a method to determine the bending rigidity and tilt modulus, for lipidic assemblies of arb

87 in C. albicans, involving increased membrane rigidity and TOR signaling.

88 stem performance as evinced by bradykinesia, rigidity and tremor, suggesting that network function mi

89 The similarities in rigidity and tunability between nanoribbons and biomolec

90 en at both fibril and fiber levels varies in rigidity and Young's modulus due to different physiologi

91 (higher conformational flexibility and lower rigidity) and greater water holding ability was founded

92 following the initial response of increased rigidity, and (iv) no changes in total protein content o

93 ayers yields increased bilayer thickness and rigidity, and an increased abundance of parallel double

94 ation marked by changes in the permeability, rigidity, and cytoadherence properties of the host eryth

95 ied with both detachment technique and plant rigidity, and deeper hooks enabled faster prey extractio

96 control motor function, resulting in tremor, rigidity, and gait abnormalities.

97 ait impairment, SNCA (rs356220; P = .04) and rigidity, and GAK (rs1564282; P = .03) and tremor.

98 esenchymal stem cells plated on soft, medium rigidity, and hard silicone gels we show that harder gel

99 Due to their unique periodicity, rigidity, and high aspect ratio, DNRs are efficiently in

100 ss, dysexecutive syndrome, predominant axial rigidity, and midbrain atrophy on brain magnetic resonan

101 histone modification state dictates nuclear rigidity, and modulating it is sufficient to both induce

102 ditional motor features (postural imbalance, rigidity, and postural abnormalities) and increasingly r

103 ude distractibility, impulsivity, behavioral rigidity, and reduced habituation to novel stimuli.

104 s and axonal growth cones, elevated neuronal rigidity, and reshaping of somatodendritic morphology.

105 ergistic balance between the flexibility and rigidity, and the unique molecular recognition for silic

106 resting tremor, akinesia, bradykinesia, and rigidity, and these motor abnormalities can be modeled i

107 operties of peptides by controlling backbone rigidity, and through the inclusion of electron rich sid

108 size, shape, surface chemistry, flexibility/rigidity, architecture, and elemental composition.

109 effective tissue properties, such as bending rigidity, are related explicitly to the parameters of th

110 actions between structural monomers or chain rigidity, are required if the collapse is to be a first-

111 anoids differentially modify native membrane rigidity as a function of their methylation state indica

112 residues have corresponding higher backbone rigidity as predicted by DynaMine from sequence, an effe

113 ndrome (CBS) is associated with asymmetrical rigidity as well as asymmetrical limb-kinetic and ideomo

114 the molecular building block yields greater rigidity, as evidenced by a larger toroid and a reductio

115 ggestive of CBS, including asymmetrical limb rigidity associated with both asymmetrical limb-kinetic

116 that spatial variations in membrane bending rigidity associated with lipid domains embedded within t

117 ies and found that a prevalence of high loop rigidity at the binding interface is an indicator of inc

118 h a range of Young's modulus values for bulk rigidity, at the subcellular level, tissues are comprise

119 arkinsonian syndrome featuring bradykinesia, rigidity (axial > appendicular), and positive pull-te

120 symptoms, comprising motor features (tremor, rigidity, balance impairments, neck pain or stiffness, a

121 Tether length and rigidity between the acceptors was crucial.

122 espite morphological differences in truncal 'rigidity' between species.

123 nfines cells to a micropatterned area with a rigidity border.

124 ety led to an increase in repetitiveness and rigidity, but not redundancy.

125 on is hypothesized to mediate sensing of ECM rigidity, but parsing the function of nucleus-cytoskelet

126 We quantitatively measure the GO bending rigidity by characterizing the flattening of thermal und

127 ed rod, we performed a second measure of its rigidity by deflecting it with a uniform magnetic field.

128 MSCs thus form a 'mechanical memory' of rigidity by progressively suppressing NKX2.5, thereby el

129 Cells responded to substrate rigidity by reorganizing the distribution and size of hi

130 nanomembranes with thinning-reduced flexural rigidities can be shaped into various 3D mesostructures,

131 Field's metal, Pb-based solder), mechanical rigidity can be actively tuned with external heating or

132 and variations in substrate positioning and rigidity, confirming previous kinetic and theoretical pr

133 cally investigated the influence of membrane rigidity, curvature induced by the protein coat, area co

134 ry hepatocytes on collagen matrix of tunable rigidity demonstrated that fibrotic levels of matrix sti

135 Here we show theoretically how the substrate rigidity dependence of the registry data can be mapped o

136 atic type, are considered to demonstrate the rigidity dependent adhesion properties.

137 ter associating with nascent adhesions under rigidity-dependent tension downstream of SFK activity.

138 originates from a cooperation of structural rigidity, dynamics at different timescales, and alloster

139 gate the rules underlying genome fluidity or rigidity, e.g., by comparing marker distances and marker

140 clude low cost, easy access to cell culture, rigidity, ease of transport, and minimal fluid handling.

141 oneme depends on both the intrinsic flexural rigidity (EI) and the elastic resistance to interdoublet

142 ess (recurrent behaviors or utterances), and rigidity (emphasis on fidelity and invariance).

143 d as a function of both feature diameter and rigidity, establishing the groundwork for a new generati

144 , although jamming indeed induces solid-like rigidity, even a strongly shear-thickened state still fl

145 The degree of stereochemical rigidity exhibited by the dioxo compound, as established

146 l residues being held rigid support that the rigidity/flexibility equilibrium in protein structure is

147 cted to unravel the impact of the structural rigidity/flexibility on the photophysical signatures.

148 environments, and with sufficient structural rigidity for manual handling, would open up a wealth of

149 that active forces from the cytoskeleton and rigidity from lamin A/C nucleoskeleton can together regu

150 Matrix rigidity has important effects on cell behavior and is i

151 formed to obtain the failure load as well as rigidities in both straight and curved cross sections.

152 ramolecular hydrogen-bonding can induce such rigidity in amphiphile backbone.

153 The effects of modifying surface rigidity in cold- and warm-active trypsins are demonstra

154 he notion of stress-free (Maxwell isostatic) rigidity in disordered molecular systems, while also rev

155 We hypothesized that increased matrix rigidity in fibrotic livers would activate mechanotransd

156 Increased appreciation of the role of matrix rigidity in modulating hepatocyte function will advance

157 o have a minimal amount of effective angular rigidity in order for cells to perform the various class

158 CW flexibility during exponential growth and rigidity in stationary phase.

159 We find that conformational rigidity in the backbone is an important feature for eli

160 suspensions are incompressible, the onset of rigidity in the standard jamming scenario requires an in

161 Thus, we conclude that 'rigidity' in the beta2-alpha2 loop region of the normal

162 es, such as membrane undulations and bending rigidity, in a PIP2-dependent manner.

163 The rigidity increases with reducing chemical functionalitie

164 to Asp salt bridges create highly localized rigidity increases.

165 The calculated bending rigidity indicates weak microtubule doublet coupling.

166 results of our study indicate that substrate rigidity induces some universal cellular responses indep

167 in motors and cross-linking proteins and the rigidity, initial orientation, and turnover of actin fil

168 ion of nature's learnings to build intrinsic rigidity into the design of clinical candidates.

169 h malignant tumors tend to exhibit increased rigidity, intracranial tumors presented as remarkably so

170 We therefore propose that backbone rigidity is a fundamental physical feature conserved by

171 The high shear rigidity is comparable to that for superhard gamma-B (G0

172 The increase in CDR H3 loop rigidity is consistent with other studies in the literat

173 ation that GM1 decreased the bilayer bending rigidity is important for understanding the role of this

174 In the two mutant strains, the flexural rigidity is not significantly different from wild-type (

175 ive tissue extracellular matrix suggests the rigidity laid down for conversion persists.

176 ed K14.ROCK(er)-mediated (p-Mypt1/tenascin C/rigidity) malignant conversion.

177 evidence that parkinsonian bradykinesia and rigidity may arise from an oversynchronization of affere

178 to a perturbation and provides a flexibility/rigidity measurement for a given position in the chain.

179 s of the tissue, and we asked whether matrix rigidity modulated the sensitive versus resistant states

180 Vascular rigidity, neurohormonal activation, tissue hypoxia, and

181 segment as well as the bending and twisting rigidities of flanking regions.

182 neous detection of changes in the masses and rigidities of polyester thin films during enzymatic hydr

183 e, ultra-incompressible and has a high shear rigidity of 201 GPa to rival hard/superhard material gam

184 ity of the ligand scaffold, we show that the rigidity of a meridionally coordinating ligand raises th

185 Here we demonstrate that rigidity of a phagocytosed cell also hyperactivates myos

186 their environment, little is known about the rigidity of APCs.

187 The unique planar structure and high rigidity of BN-compounds result in very high absorption

188 A origami in conjunction with the structural rigidity of colloidal particles, we demonstrate the para

189 n developed yet because of the bulkiness and rigidity of conventional imaging modules and their compo

190 Here the rigidity of cross-linked collagen synergizes with retino

191 The rigidity of elastic networks is characterized by a topol

192 e-beam exposure can significantly alter the rigidity of elastomeric poly(dimethylsiloxane) substrate

193 These results implied that diminish rigidity of enzyme might disturb the catalytic conformat

194 een fluorescence response and conformational rigidity of GFP-like chromophores.

195 t that for [MgATP] >/= 0.25 mM, the flexural rigidity of heavy meromyosin (HMM)-propelled actin filam

196 In addition, the rigidity of human T lymphocytes was lower than that of a

197 o orders of magnitude lower than the bending rigidity of neat graphene.

198 The rigidity of numerous biological filaments and crafted mi

199 The rigidity of poly-l-proline is an important contributor t

200 d the ultra-incompressibility and high shear rigidity of polycrystalline hexagonal epsilon-NbN using

201 A dependency, indicating that the structural rigidity of proline might contribute to the requirement

202 her C. elegans are really able to detect the rigidity of substrates or whether the migration to stiff

203 However, the mechanical rigidity of substrates traditionally used for photonic i

204 its considerable preorganization due to the rigidity of the "all equatorial" pyranyl sugar backbone,

205 Five combined mutations increased rigidity of the AB loop, as confirmed by NMR.

206 modeling suggests a 30-40% lowered flexural rigidity of the actin filaments at [MgATP] </= 0.1 mM an

207 s, we demonstrate that the apparent flexural rigidity of the axoneme depends on both the intrinsic fl

208 The rigidity of the backbone yields a sharp longest waveleng

209 rm that both cholesterol and PE can increase rigidity of the bilayer, suggesting that both can be use

210 on of wild-type-desmin increases the overall rigidity of the cells, whereas the expression of a mutat

211 an be smoothed out by increasing the bending rigidity of the coat, allowing for successful budding at

212 inding to DR1 correlates with the structural rigidity of the complex, and DM mediates peptide exchang

213 onformational change and increased molecular rigidity of the dye due to its hydrophobic interaction w

214 utes that describe the spatial structure and rigidity of the entire genomic site as well as those sur

215 The bending rigidity of the ER tubule membranes was found to be 10.9

216 echnique allowed measurements of the bending rigidity of the fluid phase only, whereas electrodeforma

217 t and the Li-metal anodes is poor due to the rigidity of the garnet, which leads to limited active si

218 rogel while avoiding a significant change in rigidity of the gel.

219 that induces nonideal bond angles due to the rigidity of the ligands.

220 starting point, we optimized the length and rigidity of the linker and its position along the peptid

221 lighted the importance of (i) the nature and rigidity of the linker between the two moieties for inhi

222 no acid sequences associated with structural rigidity of the loop also confer susceptibility to prion

223 ay an essential role in the organization and rigidity of the M. restricta cell wall.

224 continuously tuned by varying the underlying rigidity of the material while holding the amount of dis

225 e aspiration were used to assess the bending rigidity of the membrane as a function of GM1 content.

226 essibility modulus and, as such, the bending rigidity of the membrane is considerably reduced upon EN

227 of the molecule, indicating that the bending rigidity of the molecule was increased.

228 lation at two serines, thereby affecting the rigidity of the new-forming septin ring.

229 GN5 decreases the sturdiness, elasticity and rigidity of the nucleus.

230 f the [10]cyclacene-sidewall segment and the rigidity of the pentagon-dominating caps for the first t

231 The latter results from rigidity of the poly(rA/dT) tract and leads to base-pair

232 mes from a combined approach that models the rigidity of the protein using the first software suite a

233 Importantly, NMR experiments show the rigidity of the PYD forming the core of the filament as

234 ctral range remains a challenge owing to the rigidity of the resonator for the generation of coherent

235 ping and clamping" by the arginines, and the rigidity of the SWCNT introducing entropic penalties in

236 act on anion-pi catalysis increases with the rigidity of the turns.

237 Thus, length and rigidity of the unresolved head segment favor proper H t

238 he response of muscle cell precursors to the rigidity of their environment, but the mechanisms explai

239 The rigidity of these systems with respect to external pertu

240 erties of the brain, as well as the size and rigidity of traditional imaging technology, in vivo calc

241 habditis elegans are also able to detect the rigidity of underlying substrates and always migrate to

242 While the rigidity of various bis(bidentate) ligands causes the la

243 nsport, data that provide average superfluid rigidity on length scales covering the range from micros

244 e effect of actin polymerization and nuclear rigidity on the diffusive behavior of the nucleus.

245 e rod and hook, respectively, conferring the rigidity on the rod and flexibility on the hook.

246 ork within beta-sheets confers 20 times more rigidity on the structure than sequence-specific sidecha

247 To introduce more rigidity, one of the tpy units of the tris-dentate ligan

248 D) and the purely geometric FRODA (Framework Rigidity Optimized Dynamics Algorithm) were tested along

249 ently invoked factors such as conformational rigidity or fundamental length-scale limitations.

250 findings show that without varying substrate rigidity or ligand density, tether length alone can modu

251 nsitively on parameters like the length, the rigidity, or the folding state of its tether.

252 ostic motor (hypo- and bradykinesia, tremor, rigidity, postural imbalance, postural abnormalities) an

253 stretching capacity of MSP300 (nesprin) and rigidity provided by a perinuclear network of microtubul

254 within HIV-1 capsid lead to enhanced capsid rigidity, providing a possible mechanism for the reduced

255 esults are generated for pili with different rigidities ranging from very flexible to very stiff.

256 tomeric substrates with controlled patterned rigidity ranging from the micrometer to the nanoscale is

257 tumors are typically associated with altered rigidity relative to normal host tissue.

258 hese results reveal an intricate flexibility/rigidity response that accompanies affinity maturation.

259 vely small increase in the microbubble shell rigidity resulted in a significant increase in the deliv

260 nt cells exhibited increased plasma membrane rigidity, resulting in reduced azole accumulation and co

261 nsonian features, including bradykinesia and rigidity, return) of greater than 1.5 hours per day (exc

262 Thus, EGFR or HER2 can catalyse rigidity sensing after associating with nascent adhesion

263 ed on these results in which local CUs drive rigidity sensing and adhesion formation.

264 ntegrin adhesions has been well studied, but rigidity sensing by cadherins during cell adhesion is la

265 Extracellular matrix (ECM) rigidity sensing by integrin adhesions has been well stu

266 signaling molecules activated by E-cadherin rigidity sensing on PA gels contribute to actin organiza

267 Knockdown of alpha-actinin causes aberrant rigidity sensing, loss of CUs, loss of protrusion-retrac

268 osensitive, force-induced Rho signaling, and rigidity sensing.

269 show that Thy-1 is a regulator of fibroblast rigidity sensing.

270 EGFR or HER2 activity increase spreading and rigidity-sensing contractions on rigid, but not soft, su

271 nce of the regionalization of mechanical and rigidity-sensing properties within neuron microcompartme

272 elongated stack of beta-strands, and have a rigidity similar to that of silk (Young's modulus of 0.2

273 tributes of these chemotypes are (i) greater rigidity than conventional peptides, (ii) chiral and non

274 Depending on rigidity, the N,N'-disubstituted-dihydrodibenzo[a,c]phen

275 he envelope (ca. 40 to 50 mol%) imparts high rigidity, thereby acting against lipid bilayer restructu

276 rix by CAFs has been shown to increase tumor rigidity to indirectly regulate FAK Y397 phosphorylation

277 Despite conferring rigidity to support plant structures, the cell wall is a

278 patially close to cellulose, and has similar rigidity to the cellulose microfibrils, but reverts to t

279 n the topographies of the brain, and provide rigidity to the fragile tissue while eliminating backgro

280 (i) the coated membrane imposes a degree of rigidity to the system, which restricts the swelling of

281 thin the cartilage matrix provide structural rigidity to the tissue through extensive ionic-bonding n

282 hesion dynamics are locally regulated by ECM rigidity together with integrin/ECM association and myos

283 force, stress, and strain but also substrate rigidity, topology, and adhesiveness.

284 As the rigidity transition is approached, failure due to the ap

285 ochemical DNA sensors, the increase in probe rigidity upon target hybridization alters the accessibil

286 ts of linker type, shape, and conformational rigidity were manifested in dramatic differences in alte

287 al pathways revealed that repetitiveness and rigidity were predicted by an increase in heart rate, wh

288 icate that T lymphocytes face different cell rigidities when interacting with myeloid APCs in vivo an

289 gh-quality of 3D Au NFs with good structural rigidity, which allowed the detailed characterization of

290 cal moduli, such as torsional and dilational rigidity, which correspond to the protein's effective sh

291 enthalpy/entropy compensation due to network rigidity, which has been quite successful in elucidating

292 This is probably due to their high rigidity, which hinders some of the peptide catalysts to

293 line structure, depending on the DNA bending rigidity, which is influenced by the ionic strength.

294 2+) ions are critical to cadherin ectodomain rigidity, which is required for the activation of adhesi

295 reases heterochromatin and chromatin nuclear rigidity, which results in reduced nuclear blebbing in l

296 -kappaB expression and tenascin C-associated rigidity, with p-Mypt1 inactivation/actinomyosin-mediate

297 BD upon ribosome binding, and an increase in rigidity within TF when the NC is extended.

298 This amide provides structural rigidity within the cyclic peptidomimetic and promotes t

299 a critical obstacle of achieving structural rigidity without compromising environmental interaction.

300 and novel tenascin C, indicative of elevated rigidity; yet despite continued ROCK2 activities/p-Mypt1