ライフサイエンスコーパス: rigor

1 this state to the subsequent state on actin (Rigor).

2 nearly crystalline order of myosin heads in rigor.

3 es in relaxation, isometric contraction, and rigor.

4 nd inconsistent, and it lacks methodological rigor.

5 consistent across all levels of methodologic rigor.

6 vestigated, study design, and methodological rigor.

7 a high, medium, or low level of methodologic rigor.

8 ess" expertise is as important as scientific rigor.

9 attention should be given to methodological rigor.

10 onal dynamics indistinguishable from that of rigor.

11 and by ASCO methodologists for developmental rigor.

12 ed significant variability in methodological rigor.

13 nalysis may enable enhanced vigor as well as rigor.

14 to stimulate its scientific advancement and rigor.

15 ses and interpreting results with scientific rigor.

16 o investigator bias and a lack of scientific rigor.

17 ientations corresponding to the two heads in rigor.

18 alysis and describe the repertoire with more rigor.

19 ck of computational accuracy and statistical rigor.

20 tations of the LCD in active contraction and rigor.

21 ate between those observed in relaxation and rigor.

22 e stiffness of skeletal muscle myofibrils in rigor.

23 Firestone & Scholl (F&S) in calling for more rigor.

24 ds to be guarded against with scepticism and rigor.

25 ut only two of these (C2 and C4) remained in rigor.

26 and by ASCO methodologists for developmental rigor.

27 d significant improvements in methodological rigor.

28 sensitivity and is justified in statistical rigor.

29 resting part of biology to three-dimensional rigor.

30 es in relaxation, isometric contraction, and rigor.

31 their assumptions with similar quantitative rigor.

32 illations imposed on single muscle fibres in rigor.

33 can be verified with traditional scientific rigor.

34 es, raising concerns about potential lack of rigor.

35 dies (5; 13%), did not assess methodological rigor (10; 26%), did not conduct comprehensive searches

36 minus-end directed myosin VI motor domain in rigor (4.6 A) and Mg-ADP (5.5 A) states bound to F-actin

37 SH1-SH2 cross-linked (A.M'.D.P analog), and rigor (A.M.D).

38 High pressure processing (HPP) of post-rigor abalone at 300MPa for 10min extended the refrigera

39 response rate) perceived the level of study rigor accurately.

40 activity of isolated myosin, but it impairs rigor actin binding and actin-activation of myosin ATPas

41 During isometric contraction, but not during rigor, actin orientation oscillated between two values,

42 Interestingly, rigor activation was unchanged between the wild type and

43 of calcium but at low [ATP], consistent with rigor activation.

44 ns of the cleft interconverting, even in the rigor actomyosin complex.

45 o an experimentally determined EM map of the rigor actomyosin.

46 nditions that normally destabilize it, e.g., rigor ADP.

47 Researchers assume sampling rigor alone will lead to an accurate detection of respon

48 ed the SSO/ASTRO guideline for developmental rigor; an ASCO ad hoc review panel of experts reviewed t

49 he CAP/IASLC/AMP guideline for developmental rigor; an ASCO ad hoc review panel of experts reviewed t

50 al infarct-sparing therapies with a level of rigor analogous to multicenter, randomized, controlled c

51 unresolved because of a lack of statistical rigor and appropriate evolutionary framework.

52 ion of myo2-E1 and myo2-E1-Sup1 on available rigor and blebbistatin-bound myosin II structures sugges

53 is an important step toward ensuring greater rigor and comparability of pediatric tuberculosis diagno

54 Cancer was reviewed by ASCO for methodologic rigor and considered for endorsement.

55 We make recommendations to improve the rigor and consistency of modeling of health co-benefits.

56 The guideline was reviewed for developmental rigor and content applicability.

57 CCO guideline was reviewed for developmental rigor and content applicability.

58 The papers, which vary in rigor and content, have been selected on the basis of th

59 on of this program is to leverage scientific rigor and cross-program collaboration to advance the sci

60 or near-neighbor cooperative effects of both rigor and cycling cross-bridges on Ca(2+) binding to TnC

61 The effects of rigor and cycling cross-bridges on distributions of calc

62 onary disease had shorter time to enter into rigor and developed greater ischemic contracture.

63 For both factors studied (rigor and funding), one of the three possible variations

64 t experience-based paradigm lacks scientific rigor and is subject to the inaccuracies that plague ane

65 y probability varies among fiber states with rigor and isometric contraction at extremes where straig

66 As with clinical trials, the rigor and methods of the analysis are critical to the re

67 We also study actin-free myosin in both rigor and post-rigor conformations.

68 are difficult hurdles to achieving adequate rigor and practicality.

69 Overall methodological rigor and reporting of guidelines varied from fulfilling

70 A major reason is insufficient rigor and reproducibility in preclinical studies.

71 nt applicants have been asked to address the rigor and reproducibility of their proposed projects.

72 We also examined post-rigor and rigor conformations across several myosin spec

73 Methodological rigor and scope were variable.

74 echniques should be examined with scientific rigor and should demonstrate both a significant benefit

75 ls was associated with significantly reduced rigor and subsequent detection rates compared with asses

76 preclinical research as part of the agency's rigor and transparency initiative.

77 The AGREE II instrument was used to evaluate rigor and transparency of guideline development.

78 We sought to assess the methodological rigor and transparency of reporting of clinical practice

79 aff reviewed the guideline for developmental rigor and updated the literature search.

80 nd to analyze the findings in terms of their rigor and usefulness for global nutrition research and p

81 analytic methods have emerged and evolved in rigor and utility.

82 Incorporating both rigor and vigor into studies will provide a fuller under

83 of a myosin VI dimer bind actin strongly in rigor and with bound ADP.

84 However, the existing methods often lack rigor and/or computational efficiency and consequently d

85 parities researchers face tradeoffs between "rigor" and "vigor" in designing studies that demonstrate

86 tween actin-attached (strong binding: ADP or rigor) and actin-detached (weak binding: ATP or ADP.P(i)

87 reviewed the CCO guideline for methodologic rigor, and an ASCO panel of content experts reviewed the

88 trials had high, medium, or low methodologic rigor, and each report included one of three support dis

89 cles were reviewed for relevance, scientific rigor, and generalizability.

90 ribution intermediate between relaxation and rigor, and saturation transfer EPR revealed slow rotatio

91 underlying the regulations lack quantitative rigor, and the rules they enforce impose costly bureaucr

92 ndrome (grade 1 to 2) which included chills, rigors, and fever.

93 t lacking methodologic quality, particularly rigor applied during the development process.

94 ented and proposals for practices to improve rigor are appearing.

95 Additional studies with methodologic rigor are needed for a better understanding of the roles

96 ficers are encouraged to strive for analytic rigor as well as public health consequence, which requir

97 -activated ATPase, actin-sliding velocities, rigor binding to actin, and kinetics of ATP binding and

98 expressing kar3-1, a mutant that results in rigor binding to microtubules [2], were stabilized speci

99 on actin differs from the putative site for rigor binding.

100 elatively large strain of two-headed myosin (rigor) binding to actin.

101 Here, we used rigor-binding mutants of kinesin-1 as roadblocks to perm

102 bunit, a position distinct from the putative rigor-binding site.

103 ossessed of longer lifetimes under load than rigor bonds, although the load at which bond lifetime is

104 The rates of ADP release from rigor bridges and reported values of Pi release (corresp

105 large range of S2 angles indicates that some rigor bridges produce positive force that must be balanc

106 ed actin filaments in the absence of ATP (in rigor), but also close to those of the pair of heads fol

107 criminate among trials of varying degrees of rigor, but industry sponsorship negatively influences th

108 ramework of atomic detail and stereochemical rigor by conducting all-atom molecular dynamics and Brow

109 s of Oncology was reviewed for developmental rigor by methodologists, with content and recommendation

110 Breast Cancer was reviewed for developmental rigor by methodologists.

111 are Guideline was reviewed for developmental rigor by methodologists.

112 glioblastoma was reviewed for developmental rigor by methodologists.

113 Cancer (HRPC) was reviewed for developmental rigor by methodologists.

114 l Lung Cancer was reviewed for developmental rigor by methodologists.

115 cer guideline was reviewed for developmental rigor by methodologists.

116 ladder cancer was reviewed for developmental rigor by methodologists.

117 e Guidelines were reviewed for developmental rigor by methodologists.

118 ion Oncology, was reviewed for developmental rigor by methodologists.

119 tment of SCLC was reviewed for developmental rigor by methodologists.

120 prostatectomy was reviewed for developmental rigor by methodologists.

121 fatigue, anorexia, anemia, diarrhea, nausea, rigors/chills, leukopenia, fever, and transaminase eleva

122 Comparison to the myosin IIC-F-actin rigor complex reveals an almost complete lack of conserv

123 of myofilament longitudinal stiffness under rigor conditions demonstrated a significant reduction in

124 moduli amplitude under active, passive, and rigor conditions suggest that median-aged fibers become

125 t reductions also occurred under relaxed and rigor conditions, indicating that the phosphorylation-de

126 osin binding can switch on thin filaments in rigor conditions, it does not contribute significantly u

127 ed, upon maximal Ca(2+) activation and under rigor conditions, lower stiffness and disrupted actin-la

128 Under rigor conditions, the internal viscous load was signific

129 lead head rebinds to the motor and attains a rigor conformation when the rear head detaches.

130 as a closed actin-binding cleft, to the post-rigor conformation, in which the cleft is open.

131 the direction of their displacement from the rigor conformation, which has a closed actin-binding cle

132 We also examined post-rigor and rigor conformations across several myosin species.

133 udy actin-free myosin in both rigor and post-rigor conformations.

134 ing and contractile failure, but accelerated rigor contraction and increased Ca(2+) loading.

135 stroke begins approximately 170 ms after the rigor cross-bridge first binds ATP.

136 ge effect that grades with distance from the rigor cross-bridge for both cTn and sTn.

137 nce of MgATP(2-), the condition conducive to rigor cross-bridge formation, further increased the appa

138 In steady-state experiments, rigor cross-bridges and Ca2+ with vanadate to inhibit cr

139 Comparison to previous work on single rigor cross-bridges at the A-band periphery where the my

140 In rigor, cross-bridges at low concentration at the end of

141 For some GLs, the "Scientific rigor" domain flawed.

142 itical values, invoking scientific criteria (rigor, etc.) as their justification.

143 usness of variations entails an experimental rigor even greater than traditional Sanger sequencing-ba

144 tion of TnC-reduced I-band and overlap Ca in rigor fibers at pCa 5.6 to the same levels found in unex

145 S1 atomic model into EM tomograms of swollen rigor fibers identifies in situ for the first time the l

146 The angle between these two RLC lobes in rigor fibers was different from that in the crystal stru

147 Calcium in the overlap region of rigor fibers, after correction for that bound to thick f

148 However, when 1% stretch was applied to the rigor fibers, the lifetime decreased for ELC-127 and ELC

149 s in a holding tank before being killed, pre rigor filleted and stored in ice.

150 he subsequent effect on flesh quality of pre-rigor filleted Atlantic salmon (Salmo salar L.) was inve

151 es meets current standards of methodological rigor for evidence-based interventions is not clear.

152 constrained functionals sacrificing physical rigor for the flexibility of empirical fitting.

153 n interventions demonstrating methodological rigor has been increasing.

154 h anecdotal reporting, but little scientific rigor, has been applied to the study of methods to impro

155 Examples of lack of rigor have been extensively documented and proposals for

156 for the first bond to form between actin and rigor heavy meromyosin and the load-dependent durations

157 hly disordered and microsecond dynamics) and rigor (highly ordered and rigid), supporting the hypothe

158 ieving relatives, critics point to a lack of rigor in a large body of the research cited to underpin

159 ive standards, and the potential for greater rigor in experimental research.

160 Methodological rigor in families research also continues to increase, w

161 th ASCO's abiding commitment to methodologic rigor in guideline development.

162 nt small RNA discovery, demands an increased rigor in miRNA annotations.

163 The degree of rigor in model development and assessment can vary great

164 Methodological clarity and rigor in terms of biomarker discovery, validation and te

165 evealed considerable breadth, diversity, and rigor in the measurement approaches used to assess parti

166 ed temperature gave increased blood lactate, rigor index (Ir), drip loss (DL), content of astaxanthin

167 A similar trend was observed during rigor induction and relaxation.

168 ence in functional maturation, they lack the rigor inherent in controlled animal experiments.

169 terfilament spacing (from 52 nm to 67 nm) of rigor insect flight muscle fibers and exposes a tetherin

170 Increasing rigor is being applied to medical decision making, but m

171 a priori outcome of interest and statistical rigor jeopardizing estimations of potential effect size.

172 ore, binding B-lattice GDP microtubules to a rigor kinesin surface stabilizes them against shrinkage,

173 i-pSer-35 but not by anti-Ser-35, whereas in rigor, labeling was similar with both.

174 releases its secretory cargo, defining a new rigor-like state of a myosin V in vivo.

175 ly transporting Myo2 can be converted to the rigor-like state.

176 leotide-free states of myosins-known as the "rigor-like" state.

177 This inhibition results in 'rigor-like', tight association with microtubules in vitr

178 mptoms, including fever (>/=38.5 degrees C), rigors, malaise, lethargy, flank pain, hematuria, suprap

179 in ATPase and reduces actomyosin affinity in rigor more than 100-fold.

180 lear receptor interacting protein encoded by rigor mortis (rig) that is required for ecdysone respons

181 ibrillar proteins may be related to the meat rigor mortis and quality development.

182 residues in a closed active site in the post-rigor motor domain undergo subtle structural variations

183 Here we used electron tomography of rigor muscle swollen by low ionic strength to pull S2 cl

184 efore, patients' perspectives and scientific rigor must be compatible.

185 populations, a high level of methodological rigor must be maintained and studies should report suffi

186 e assembly pathway that involves both an Eg5 rigor mutant and the kinesin-12 Kif15.

187 expression of wild-type kinesin-5, but not a rigor mutant of kinesin-5, has the inverse effect on axo

188 ying the behavior of SVs and EEs in null and rigor mutants of kinesin-3 and kinesin-1 (UncA and KinA,

189 ATP or analogs were added to rigor myofibrils or purified thick filaments at 22 degre

190 a function of pCa and labeled Tn exchange in rigor myofibrils was used to estimate Tn dissociation ra

191 Binding of rigor myosin heads to thin filaments following MgATP dep

192 show that the azimuth of S2 origins of those rigor myosin heads, bound to the actin target zone of ac

193 binding sites on F-actin so that binding of rigor myosin is required to fully activate the thin fila

194 to measure the interhead distance of nearly rigor myosin VI molecules.

195 n paramagnetic resonance spectra obtained in rigor necessitated the development of a novel decomposit

196 ction (ATP plus Ca) and increased further in rigor (no ATP).

197 sible cardiac myofilament lattice induced by rigor not observed in the NTG and WT(t/t).

198 of funding, led physicians to downgrade the rigor of a trial (odds ratio, 0.63; 95% CI, 0.46 to 0.87

199 xpressiveness of rules with the mathematical rigor of Bayesian networks (BNs) to develop and evaluate

200 help to improve the logical and ontological rigor of bio-medical ontologies such as the OBO relation

201 The summary scores of the rigor of development (median, 28.6% [range, 16.7% to 100

202 ers should be aware of the difference in the rigor of development and quality of reporting of guideli

203 Four reviewers independently assessed the rigor of development and reporting of included guideline

204 he domains of "Stakeholder involvement" and "Rigor of Development" only scored 3/7, and "Applicabilit

205 scope and purpose, stakeholder involvement, rigor of development, and applicability domains varied c

206 poorly on AGREE II criteria, specifically in rigor of development, applicability, and editorial indep

207 Of the 21 guidelines, 17 showed considerable rigor of development.

208 Furthermore, the state-mandated rigor of diagnosis of ASD by a pediatrician or clinician

209 ial emphasis on assessing the methodological rigor of existing research, calling attention to problem

210 traction: 2 reviewers independently assessed rigor of guideline development using the Appraisal of Gu

211 An in vivo approach can complement the rigor of in vitro approaches: as studied in model organi

212 ns suggest shortcomings with authors and the rigor of journal practices.

213 as reinhardtii, demonstrated the utility and rigor of miRvial in detecting novel microRNAs and charac

214 f this new standard promises to increase the rigor of NHP transplantation studies and to ensure that

215 da-Escude and Tuomi question the statistical rigor of our analysis while ignoring the stellar activit

216 observational databases lack the scientific rigor of randomized controlled trials, they represent a

217 All methods were fully validated to the rigor of regulated bioanalysis requirements, with intrad

218 ress remaining uncertainties and improve the rigor of the field.

219 ar robust to variation in the methodological rigor of the included studies, based on the quality of c

220 The rigor of the method was verified in studies of guanine o

221 Lack of methodologic rigor of the reported studies precludes any conclusive s

222 The methodologic rigor of trials investigating simulation-based surgical

223 pecting to achieve longevity by enduring the rigors of a transplant.

224 t for resilience sufficient to withstand the rigors of a wound site.

225 ose of other vertebrates, must withstand the rigors of circulation in the absence of new protein synt

226 cacious prophylactic vaccine has not met the rigors of clinical trials.

227 To withstand the rigors of contraction, muscle fibers have specialized pr

228 minating in science that could withstand the rigors of emerging legal and cultural expectations.

229 Our data show that the rigors of exercise directly induce fibrinolytic genes an

230 amniote model system that is amenable to the rigors of extended, high-resolution imaging and cell tra

231 stimulation in a large population under the rigors of Food and Drug Administration-approved investig

232 s remained a mystery, particularly given the rigors of intrathymic developmental checkpoints, success

233 strategy allows the organism to survive the rigors of life within a mammalian host, yet generate mat

234 the ability of an organism to deal with the rigors of living.

235 ron-protected nanocrystals" to withstand the rigors of the coupling chemistry and the standard separa

236 nct physiological advantage to corals in the rigors of the reef, a crowded and fiercely competitive e

237 the standard t-test, either lack statistical rigor or resort to generalized statistical models that d

238 ng tendency to remain bound to actin by anti-rigor oriented cross-bridges (state II or state III cros

239 put operations is as important as scientific rigor" (p. 861).

240 cy and feasibility while maintaining ethical rigor, patient safety, information value, and scientific

241 cy and feasibility while maintaining ethical rigor, patient safety, information value, and scientific

242 These results indicate that post-rigor processing at 300MPa for 10min can significantly i

243 e C and E helices, and addition of Ca(2+) in rigor produced further changes characterized by increase

244 ally, analysis of the transition from ADP to rigor provides a structural rationale for force sensitiv

245 s tested (prehydrolysis, posthydrolysis, and rigor), reflects a mixture of these structural states, i

246 the center half of the I-band during 60 s of rigor, relaxation and contraction of muscle.

247 ifetimes of Tg-WT and Tg-D166V muscle during rigor, relaxation and contraction.

248 such trials sidestep mechanisms that promote rigor, relevance, efficiency, and fairness.

249 ition from the force-generating ADP state to Rigor requires a 9.5 degrees rotation of the myosin leve

250 action studies on papillary muscle fibers in rigor revealed a decreased interfilament spacing ( appro

251 Thus, tropomyosin inhibits binding of rigor S1 but not S1-ATP-like states.

252 eats (sensitivity, 27%; 95% CI, 20%-34%) and rigors (sensitivity, 19%; 95% CI, 15%-24%) are less comm

253 35 is exposed in the relaxed state, while in rigor, Ser-35 is also exposed.

254 gically coherent literature of unprecedented rigor, size, and scope.

255 ng the apparent rate of Tn dissociation from rigor skeletal myofibrils using labeled Tn exchange.

256 stroke studies now demonstrate considerable rigor, standardization, and emphasis on minimization of

257 es in interdisciplinary research, analytical rigor, standardization, and policy development for this

258 domain (subfragment 1) in the ADP-bound near-rigor state (lever arm =45 degrees to the helical actin

259 simulation of the myosin II S1 domain in the rigor state interacting with an actin filament.

260 icroscope, myofibrils were first placed in a rigor state then stretched and shortened at different di

261 As the complex went from the rigor state to the relaxed state, the head domain of the

262 subfragment-1 molecules, interacting in the rigor state with an actin filament, has been investigate

263 ion of MgATP-independent detachment from the rigor state, as suggested by previous single-molecule me

264 In other words, starting from the post-rigor state, turning on the ATPase activity requires not

265 he structure of their strongly bound complex-rigor state-is a key for delineating the functional mech

266 gressively closes in forming the acto-myosin rigor state.

267 ime resolution is insufficient to detect pre-rigor states.

268 high-resolution 2.75-A nucleotide-free near-rigor structure, we have identified a conserved complex

269 silico methodology was validated by forming rigor structures that perfectly fitted into an experimen

270 it meets the same standards of intellectual rigor that professionals use outside the courtroom.

271 hen the fibers were moved from relaxation to rigor, the fluorescence lifetime increased for all label

272 ral fronts, including increased experimental rigor, the softening of dichotomies that were crucial to

273 d the physicians' impressions of the trials' rigor, their confidence in the results, and their willin

274 hese factors form impediments to statistical rigor, they can to a large extent be overcome by restric

275 Despite variability in methodological rigor, this did not moderate any of the therapy effects,

276 observational and of varying methodological rigor; thus, these findings may not be generalizable.

277 The FLIPI model adds rigor to and facilitates comparisons among the different

278 re heterogeneous and lacked the methodologic rigor to draw any conclusions regarding the effects of d

279 ceptable if investigators use methodological rigor to eliminate bias, properly report to avoid misint

280 adolescents, most have lacked the scientific rigor to establish clear benefits over so-called convent

281 The work presented here brings additional rigor to FRET-based studies of membrane protein interact

282 r been evaluated with sufficient statistical rigor to permit their use in regulated drug development

283 the past year utilized methods of sufficient rigor to provide a useful comparison to more conventiona

284 gular change associated with transition from rigor to relaxation was less than 5 degrees for both lig

285 ng transition from the single orientation in rigor to the bimodal orientation distribution observed f

286 We add rigor to the determination of the used-new threshold by

287 amount to apply a strong level of scientific rigor toward a well-planned, step-wise sequence of precl

288 The cardinal symptoms (bradykinesia, rigor, tremor, and postural instability) are used for di

289 low-rigor trials than those tested in medium-rigor trials (odds ratio, 0.64; 95% confidence interval

290 igh-rigor trials than those tested in medium-rigor trials (odds ratio, 3.07; 95% CI, 2.18 to 4.32; P<

291 ess willing to prescribe drugs tested in low-rigor trials than those tested in medium-rigor trials (o

292 re willing to prescribe drugs tested in high-rigor trials than those tested in medium-rigor trials (o

293 ious studies have suggested that JAS induces rigor, videomicroscopy demonstrated that JAS treatment i

294 Methodological rigor was assessed using the relevant Critical Appraisal

295 Permeabilized skeletal muscle fibers in rigor were labeled with a fluorescent ATP analog, 3'-DEA

296 l fluctuations from fluorescent molecules in rigor were represented by a single Gaussian distribution

297 actin molecules in wild-type (WT) hearts in rigor were represented by perfect Gaussian curves.

298 milar in form to that observed for fibers in rigor where force was varied by changing length.

299 w that this is followed by pericyte death in rigor, which may irreversibly constrict capillaries and

300 The results of these efforts and the rigor with which they are implemented will determine whe