ライフサイエンスコーパス: rigorous

1 to make species delimitation hypotheses more rigorous.

2 re merely "associational" and therefore less rigorous.

3 ost of the studies were not methodologically rigorous.

4 bursement and systematic implementation of a rigorous accountability framework.

5 clude potential residual confounding despite rigorous adjustments, and potentially limited generalisa

6 Here, we present a novel and statistically rigorous algorithm for detecting missense mutation hotsp

7 quantitative data and underline the need for rigorous analyses of any utilized barcode library in ter

8 The need for rigorous analyses of climate impacts has never been more

9 Rigorous analyses of titling campaigns are rare, and rel

10 dels of epigenetic perturbations, studied by rigorous analysis and interpretation of genomic data.

11 nd other factors play important roles, but a rigorous analysis of academic surgeons and their experie

12 d associated statistical principles, ensures rigorous analysis of NGS data and is essential for its f

13 Rigorous analysis of our data - excluding false-positive

14 ominantly given point estimates precluding a rigorous analysis of the implications of uncertainty.

15 We present a critical and rigorous analysis of the increasing volume of multivalen

16 This is a first rigorous analytical and computational approach for a mod

17 We present a rigorous and accurate description of phonon scattering a

18 rmal conductivity calculations and provide a rigorous and comprehensive physical description of therm

19 For the first time, a rigorous and detailed physical investigation is presente

20 Herein we develop a rigorous and general model for defect formation in the p

21 Here, I provide a rigorous and intuitive explanation for the universality

22 elopmental Cell, Hosios et al. (2016) take a rigorous and quantitative approach to analyze metabolite

23 rucial for developing cost-effective and yet rigorous and reproducible assays against diverse example

24 limited mechanistic insights have prevented rigorous and reproducible PBM clinical protocols.

25 ve estimates of analyte distribution require rigorous and systematic analysis of sensor functionality

26 A rigorous and systematic fabrication and characterization

27 anding of life, it makes biological concepts rigorous and testable, and it provides a reference map t

28 analyses in scientifically and statistically rigorous and thoughtful ways.

29 ting, training, and retaining the brightest, rigorous, and most diverse scientists.

30 We illustrate an alternative and more rigorous approach for MBI characterization through deter

31 ic (14)C determinations, herein, we report a rigorous approach to column bleed identification and qua

32 models, from the field of economics, offer a rigorous approach to cope with those limitations.

33 agenomic method which offers a statistically rigorous approach to extract novel microbial genomes whi

34 ch as sequence alignment and phylogeny, more rigorous approaches that work directly with the matrix e

35 eceived significant attention; however, more rigorous approaches to the statistical analysis of qPCR

36 with regular repeat sampling allow for more rigorous assessment and monitoring of changes to the ree

37 n aging population in many countries to make rigorous assessment for frailty increasingly important f

38 A standardized protocol with rigorous assessment of circumferential margins and the R

39 that all new therapies for diabetes undergo rigorous assessment of CV safety through large-scale CV

40 f broad exploration followed by increasingly rigorous assessment of generalizability across samples,

41 ion process in safety-critical applications, rigorous assessment of model credibility will be require

42 Systematic parameter estimation and rigorous assessment of model uncertainty are often lacki

43 ng techniques have allowed increasingly more rigorous assessment of the cardiac structure and functio

44 ife expectancy are often prioritised without rigorous assessment of the individual's health and psych

45 vant issues that must be addressed to ensure rigorous assessment of the safety and efficacy of mesenc

46 alve replacement clinical pathway requires a rigorous assessment to determine its efficacy, safety, a

47 nder the tight-binding approximation and the rigorous band structure analysis based on the transfer-m

48 The lack of rigorous baseline data limits the implementation of effi

49 Based on the rigorous benchmarking of CCN-BLPred using both leave-one

50 nking phylogenies to transmission trees is a rigorous but flexible statistical foundation for molecul

51 with increased cardiovascular risk and more rigorous cardiovascular disease screening, such as type

52 Here, we put this hypothesis to a rigorous, causal test by combining the FCM with a transc

53 ry clinical study was to develop and apply a rigorous clinical accuracy assessment algorithm, using f

54 uropean ancestry, and 100 Hispanic) who meet rigorous clinical criteria for idiopathic DCM along with

55 owever, were based on expert opinion because rigorous clinical data are not available.

56 Rigorous clinical monitoring was done before, during, an

57 Further rigorous clinical studies are needed to determine their

58 e part because they are not well informed by rigorous clinical studies.

59 gingly, the infrastructure needed to conduct rigorous clinical trials in HCM has recently emerged bec

60 Methodologically rigorous clinical trials on DCM are lacking.

61 A rigorous community-based assessment of the utility of SN

62 terized somatic mutations in this disease, a rigorous comparison between different patient population

63 Here we provide a rigorous comparison of eight commonly used indexes of se

64 Through rigorous comparison of the spatial temperature profile,

65 that they lack a solid empirical foundation: rigorous comparisons between body size and vocalization

66 oncurrent with mental processes that require rigorous computation and control, a series of automated

67 biological discovery, and yet it requires a rigorous computational toolkit for widespread adoption.

68 The Dre-rox system permits rigorous control of Cre-loxP recombination in lineage tr

69 e current study reinforces the importance of rigorous control of serum TSH in PTC patients.

70 proach is expected to assist in establishing rigorous control over a broad class of biological proces

71 alidity of this hypothesis in humans through rigorous controlled trials is highlighted.

72 More rigorous costing methods are needed with a more common q

73 We have designed the patterns using rigorous coupled wave analysis (RCWA) together with S-ma

74 cterized spectroscopically and modeled using rigorous coupled wave analysis.

75 By combining analytical methods with Rigorous Coupled-Wave Analysis, absorption of plasmons i

76 A total of 290 inpatients meeting rigorous criteria for borderline personality disorder an

77 ality of the scientific evidence, satisfying rigorous criteria for causality, we conclude strongly th

78 e at 6 and 12 months, defined using the most rigorous criteria reported.

79 assionate nursing care has been reported, no rigorous critical overview exists.

80 When tested by the most rigorous cross-validation on the same high-quality bench

81 Rigorous cross-validation tests have indicated that IENH

82 Rigorous cross-validations demonstrate the superior pred

83 Rigorous cross-validations showed that the proposed pred

84 Rigorous cross-validations via a set of multi-label metr

85 Our conclusions are strongly supported by rigorous data analysis and by numerical simulations, all

86 tion volume ratio realizes the need for more rigorous data analysis procedures, as surface effects su

87 o seamlessly carry out sequential steps in a rigorous data analysis workflow, including normalization

88 essionals; development of a methodologically rigorous data and research base specific to LMICs that e

89 of top-down effects on perception requires a rigorous definition of what qualifies as perceptual to b

90 ences is context dependent, and propose that rigorous definitions of inputs and outputs may bring cla

91 Faced with these rigorous demands, only approximately 70% of dogs that en

92 In macromolecular crystallography, the rigorous detection of changed states (for example, ligan

93 our test with a potential application to the rigorous detection of gerrymandering in Congressional di

94 hile maintaining its commitment to using the rigorous development methods that minimize the biases th

95 This hypothesis will now require rigorous direct and functional testing.

96 capacities with high speed and low cost, but rigorous discrimination between synaptic and non-synapti

97 Rigorous double-blind, placebo-controlled, randomized co

98 Our results provide a rigorous dynamical system framework that can be extended

99 ayesian approach is described to demonstrate rigorous efficacy criteria for pediatric trials incorpor

100 Using rigorous electrical and optical modeling methods, we the

101 ugh to accommodate diverse data sources, yet rigorous enough to provide a strong mechanism for ADE id

102 mic evaluations of complex interventions and rigorous epidemiological studies are lacking.

103 Rigorous estimates for clearance rates of untreated chla

104 More research with rigorous evaluation and consistent reporting is needed i

105 istration indicate that such treatments need rigorous evaluation before acceptance.

106 ts of breastfeeding promotion at scale using rigorous evaluation designs.

107 This approach however needs rigorous evaluation for feasibility, safety, patient and

108 service scale-up in these regions, based on rigorous evaluation in the context of specific health sy

109 the underlying neurobiology of addiction and rigorous evaluation of brain stimulation methods has the

110 This metric allows rapid and rigorous evaluation of specimen preparation methods, ass

111 cterizing their relative merits will require rigorous evaluation of their performance characteristics

112 prove their predictive ability, but requires rigorous evaluation.

113 Rigorous evaluations of standardized palliative care int

114 ectiveness of antiepileptic medications, and rigorous examination of effectiveness of care delivery i

115 ns proceed in conventional glassware without rigorous exclusion of either moisture or oxygen, and use

116 iopsies with transplant glomerulopathy after rigorous exclusion of immune complexes of other cause, p

117 carried out at room temperature without the rigorous exclusion of molecular oxygen, thus making this

118 dicine is the randomized controlled trial, a rigorous experiment.

119 between-species comparisons on the basis of rigorous experimental and species-appropriate tests subs

120 Future research employing rigorous experimental designs, careful statistical analy

121 cific stem cell marker genes along with more rigorous experimental methodologies, to delineate the co

122 urgently needed, particularly studies using rigorous experimental or quasi-experimental designs.

123 Through a combination of rigorous experimental screening and in silico virtual sc

124 Our results provide rigorous experimental tests of new and old theory, demon

125 Rigorous experimental verifications are presented.

126 We have done rigorous experiments to evaluate NRGC by taking a set of

127 ion within the active molecule would allow a rigorous exploration of the pathway and mechanism of pho

128 Two of these laws can be regarded as rigorous extensions of previously known laws: One gives

129 s were processed in a series of increasingly rigorous extraction buffers to separate proteins by solu

130 ese microbiomes presents a challenge, as the rigorous extraction required to elute these proteins als

131 y levels of description in a mechanistic and rigorous fashion, while avoiding biological reductionism

132 demonstrating elevated long-term donor risk, rigorous follow-up and reporting of outcomes are now man

133 In this work we provide a rigorous formulation and analysis of the "ability to wal

134 c hematology: the exchange of age limits for rigorous frailty screening, development of disease-speci

135 tions based on alchemical pathways provide a rigorous framework for affinity predictions and could th

136 tion of the Smoluchowski equation provides a rigorous framework for describing the motion of the perm

137 The rigorous framework for simultaneously quantifying moveme

138 first time in a large-scale validation, that rigorous free energy calculations can be used to predict

139 ere, we present the broadest validation of a rigorous free energy-based approach applied to protein s

140 Rigorous genetic experiments revealed that Notch signali

141 ombination with remote sensing, supported by rigorous ground-truthing, we project changes in suitabil

142 mit of detection that is well below the most rigorous guidelines for the toxin.

143 [Formula: see text] This significance is not rigorous, however, without good bounds on the mixing tim

144 EPS enables rigorous hypothesis testing of pleiotropy and tissue-spe

145 Rigorous hypothesis-driven studies are needed to ultimat

146 e outline the value of a more systematic and rigorous implementation of PRO assessment in the current

147 practices in nursing education, they must be rigorous in design.

148 stems, and our methodology paves the way for rigorous in situ measurements of the behavioral rules th

149 llution studies that are more scientifically rigorous in terms of the decisions made to approximate a

150 pment of a LC-MS/MS method which underwent a rigorous in-house validation.

151 Here we show, using rigorous, independent animal models, that endogenous MLL

152 In this paper, we propose a rigorous inference procedure to perform integrative asso

153 , particularly over high albedo surfaces and rigorous instrument calibration is required to reduce gr

154 nisms of AF initiation and perpetuation, and rigorous integration of ablation into a multidisciplinar

155 We provide a rigorous interpretation of positive or negative values o

156 r its inclusion in paediatric oncology care, rigorous investigation has provided important insights.

157 Coupled with more rigorous investigation, this novel technique may help re

158 We developed a rigorous ion exchange method to purify enzymatically gen

159 Rigorous laboratory good practice was required to minimi

160 mocytes by dependence on the kinase TAK1 and rigorous lineage-exclusion criteria.

161 ion, trafficking, and electrophysiology in a rigorous manner.

162 sembly of the horse MHC class II region with rigorous manual gene annotation, and it will serve as an

163 Its rigorous mathematical foundations allow scalable and rob

164 Recently, a rigorous mathematical theory has been developed for spat

165 unts, serum anti-Mullerian hormone levels (a rigorous measure of the ovarian reserve), and fertility.

166 Here we apply a rigorous metadata analysis and new ensemble-hindcasting

167 Here we present a rigorous method that overcomes these problems based on B

168 tterns of cancer alterations, we developed a rigorous methodology for cancer mutation pattern discove

169 ing perspective, and how in conjunction with rigorous methodology it can guide the delineation of unc

170 based on high-quality longitudinal data and rigorous methodology.

171 We used rigorous methods to evaluate the fits of expression read

172 predict MI in a multicenter HIV cohort with rigorous MI adjudication.

173 y by combining multimode network theory with rigorous mode matching method, which has nearly the same

174 We present here a mathematically rigorous model for conditioning inspired by numerical an

175 We conclude that rigorous model validation, including comparison against

176 Through rigorous modeling of the nanowire mode as well as the ap

177 ping modern multi-herb prescriptions through rigorous molecular-level investigations and standardized

178 We show that it is possible to construct a rigorous Monte Carlo algorithm that visits points in sta

179 anatomical localization, we rely on the most rigorous MR coregistration of fNIRS data to date to imag

180 on cosmogenic radionuclide geochronology and rigorous numerical modeling.

181 wed from the model are confirmed in a set of rigorous numerical studies.

182 ic health information, (3) ensure the use of rigorous observational research methodologies, (4) promo

183 powering clinical trials for rare outcomes, rigorous observational studies are needed to clarify the

184 ced on optical and electronic devices, their rigorous operation and equipment requirements seriously

185 Combining it with rigorous optical modeling avoids otherwise typical misin

186 ting approaches are either not statistically rigorous or are inefficient for high-dimensional data th

187 Together with rigorous paleomagnetic experimental procedures, this stu

188 ement with experiment could be improved with rigorous parameter derivation.

189 Blood-Brain-Barrier (BBB) is a rigorous permeability barrier for maintaining homeostasi

190 solvent molecular dynamics simulations, is a rigorous physics-based approach for calculating thermody

191 from sequence-based empirical approaches to rigorous physics-based free energy methods.

192 R/Bioconductor package scater to facilitate rigorous pre-processing, quality control, normalization

193 conventional), and then with the use of more rigorous projections incorporating expected trends in ag

194 posed beneficial cardiovascular effects, but rigorous prospective studies that examine the associatio

195 The rigorous prospective, observational study design avoided

196 margins may be required for sites with less rigorous protocol compliance, but in general, SUV is a h

197 The methodology was prespecified in a rigorous protocol using the Systematic Review Centre for

198 trahost diversity and suggested the need for rigorous quality control in such studies.

199 rts, using an existing calling algorithm and rigorous quality control steps, using SNP genotyping arr

200 mentation of optimized procedures and a more rigorous QuantiFERON-TB conversion definition (an increa

201 A rigorous quantification framework and software tool are

202 However, rigorous quantification of these effects necessitates in

203 Using rigorous quantification, we identified 252 phosphosites

204 Here, we present the first rigorous quantitative assessment of the roles of giant p

205 the O-R phase boundary and EB may serve as a rigorous quantitative measure of the degree of polarizat

206 he conventional outflow tissues according to rigorous quantitative ultrastructural analyses, but did

207 Large, rigorous, randomized control trials are needed to determ

208 It has been a challenge to design rigorous, randomized, placebo-controlled trials, in part

209 Methodologically rigorous RCTs have demonstrated that mindfulness interve

210 mall effects, but these findings still await rigorous replication.

211 of the spectral features demonstrates that a rigorous representation of nuclear quantum effects as we

212 knowledge that need to be addressed through rigorous research and multidisciplinary collaborations.

213 ng results, but has never been tested with a rigorous research design.

214 Liberia showed the capability of conducting rigorous research during an outbreak.

215 Rigorous research is key to improving the identification

216 ht against this devastating disease, further rigorous research is warranted.

217 Future studies need to use rigorous research methods, clearly identify methodologic

218 ement skills and provides direction for more rigorous research.

219 NA editing events in RNA-seq reads, with our rigorous rMATS statistical model for identifying differe

220 prehensive definition, there has been little rigorous scientific attempt to use it to measure and ass

221 f health care services, but few apps undergo rigorous scientific evaluation.

222 rapy are common, few strategies are based on rigorous scientific principles.

223 With the call for more rigorous scientific reporting, authentication, and trans

224 For this reason, a rigorous scientific study of writing is of fundamental i

225 t technology development must be paired with rigorous scientific validation and discuss academic and

226 ma HIV-1 Qualitative RNA assay was used in a rigorous screening approach designed to identify individ

227 All patients underwent rigorous screening to determine whether they had experie

228 Despite the application of rigorous selection criteria, measured temperature data d

229 Rigorous selection was applied to 1,689 IR64 transgenic

230 when the cell lineages have been subject to rigorous selective pressure during development.

231 However, integrating such a rigorous set of requirements imposes substantial complex

232 screen in haploid human cells, followed by a rigorous single and double-mutant epistasis analysis usi

233 h engine data bias levels through the use of rigorous spatial sampling strategies.

234 mangrove forest conservation is the lack of rigorous spatially resolved estimates of mangrove sedime

235 arkers and geography) were applied providing rigorous species validation criteria with an acceptably

236 evaluating these skills which have undergone rigorous standard-setting to determine pass/fail cut poi

237 evaluating these skills which have undergone rigorous standard-setting to determine pass/fail cut poi

238 for other infiltrates despite attempts at a rigorous standardization process.

239 ata cloud was subjected to a newly developed rigorous standardization technique to reduce interscanne

240 s helped pave the way for the development of rigorous standards for the training of ophthalmologists

241 Indeed, rigorous statistical analysis of high-throughput FG scre

242 We urge the research community to adopt rigorous statistical and biological approaches coupled w

243 Here we develop a rigorous statistical framework based on Approximate Baye

244 We developed a rigorous statistical framework to test the infinite site

245 children with hepatoblastoma on the basis of rigorous statistical interrogation of what is, to the be

246 children with hepatoblastoma on the basis of rigorous statistical interrogation of what is, to the be

247 sed as a basis for subsequent application of rigorous statistical methods, with the ultimate goal bei

248 We present a rigorous statistical model that infers the structure of

249 Three rigorous statistical steps were used in order to create

250 The method is based on rigorous statistical tests and does not require any pres

251 ility, we also provide a framework to enable rigorous statistical tests of significance in interventi

252 ger database of supernovae so we can perform rigorous statistical tests to check whether these 'stand

253 eous nature of the current evidence, further rigorous studies are needed to determine the association

254 mation of toxic byproducts during treatment, rigorous studies examining byproduct formation are lacki

255 he semantic PPA variant (sv-PPA), applying a rigorous study design to a large, homogeneous sv-PPA coh

256 may be achieved with 30 scans although more rigorous study on this element is necessary.

257 By undertaking a rigorous study using blood-mimicking fluid suspensions o

258 lizing these questions and admitting them to rigorous study.

259 es have long been the subject of intense and rigorous study; indeed, the promise of the potential to

260 Here, we used a rigorous subcellular fractionation approach to compare A

261 This strategy had to be both practical and rigorous such that tOPV withdrawal could be reasonably e

262 However, there has never been rigorous support for the maintenance of this relationshi

263 dation for implementation of a statistically rigorous system for real-time forecast of seasonal outbr

264 ation a practical requirement for almost any rigorous systematic analysis.

265 s of protein flexibility form the basis of a rigorous taxonomy for the description and classification

266 ocarbon simulation methods and can provide a rigorous test of demographic predictions derived from a

267 dge of the nuclear structure has prevented a rigorous test of strong-field QED.

268 gnostic and management decisions can undergo rigorous testing for efficacy.

269 of repertoire sequencing data and allow for rigorous testing of other clonal grouping algorithms.

270 lp bridge this divide, as it would allow for rigorous testing of the role that biotic interactions pl

271 stence of these patterns in diverse systems, rigorous testing, intensive time-series datasets and imp

272 proven, and as such, a hypothesis in need of rigorous testing.

273 other interventions) are seldom subjected to rigorous testing; instead, they are often implemented on

274 Here we introduce a set of rigorous tests for adherence to Benford's law and apply

275 ss models to a given tree, thereby providing rigorous tests of biological hypotheses regarding patter

276 Our method proves to be more rigorous than NIST's suite and Borel-Normality criterion

277 For this reason, these procedures are less rigorous than those for drug/device clinical trials.

278 cting with a lipid bilayer and demonstrate a rigorous theoretical formalism and analysis method for c

279 We also provide rigorous theoretical foundations for our algorithms in t

280 ions of invisibility cloaks have been led by rigorous theories and such cloak structures, in general,

281 Though theoretically rigorous, this model, which we here refer to as the cont

282 ater than 95% confidence that they satisfy a rigorous threshold for FTQEC (diamond norm </=6.7 x 10(-

283 mmendations is intended to be scientifically rigorous, to positively influence health outcomes, and t

284 aracterized and consistently manufactured to rigorous tolerances of purity, potency and safety.

285 New rigorous tools for diagnosis could allow better characte

286 th the neural reuse view and offers a set of rigorous tools to fully engage in Anderson's (2014) rese

287 Photodocumentation of wounds and rigorous tracking of outcomes up to 30 days postdischarg

288 n physicians' experience of the increasingly rigorous training, testing, and licensing processes intr

289 numerically studied in time domain using the rigorous transfer matrix method in combination with anal

290 manifestation of its symptoms, necessitating rigorous treatment following diagnosis.

291 on the design and analysis of scientifically rigorous tumour phylogeny studies.

292 nds critically on its conformational state a rigorous understanding of the correlation between struct

293 We obtain a rigorous upper bound on the resistivity [Formula: see te

294 ly, our results show for the first time that rigorous use of computational techniques can lead to dis

295 We here perform a rigorous validation of 13 anti-ERbeta antibodies, using

296 Careful optimization and rigorous validation of CE-MS protocols are crucial for d

297 Rigorous validation of the algorithm is detailed, using

298 duct observational clinical studies requires rigorous validation.

299 portance of natural capital, but consistent, rigorous valuation approaches compatible with the pricin

300 A rigorous work-up can exclude alternative causes of left