ライフサイエンスコーパス: rimcazole

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1 ine and tetrabenazine) and DAT (GBR12909 and rimcazole).

2 killing by the sigma (sigma) receptor ligand rimcazole.

3 injected with water and treated animals with rimcazole (26 mg/kg) in water.

4 ed a series of irreversible ligands based on rimcazole (9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]c

5 Rimcazole, a putative sigma2 receptor antagonist, and ot

6 ma(1) receptors in the behavioral actions of rimcazole, a series of analogues was synthesized.

7 Intraperitoneal injection of rimcazole, a sigma ligand, into male rats increased plas

8 Rimcazole, a sigma(1) receptor antagonist that binds to

9 Taken together, these results suggest that rimcazole activates noradrenergic neurons projecting to

10 suggestion was confirmed by the finding that rimcazole also increased concentrations of the norepinep

11 These novel rimcazole analogues may provide important tools with whi

12 further this class of compounds, a series of rimcazole analogues was designed and synthesized.

13 ng affinities at the dopamine transporter of rimcazole and cocaine are comparable, rimcazole only dep

14 a involvement may assist the re-profiling of rimcazole and other sigma ligands as cancer therapeutics

15 ies on an emerging group of benztropine- and rimcazole-based compounds provide hope that replacement

16 molecular interaction of the benztropine and rimcazole compounds with their target, the dopamine tran

17 Thus, the induction of HIF-1alpha by rimcazole contributes to tumour cell killing.

18 piperazine nitrogen was unsubstituted, as in rimcazole, demonstrated relatively low binding affinity

19 Since rimcazole does not share the behavioral profile of cocai

20 We now report that rimcazole elevates hypoxia inducible factor-1alpha (HIF-

21 Rimcazole failed to inhibit pentazocine c-fos induction.

22 3,5-Dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) has been characterized as a sigma receptor an

23 l p53 protein may enhance death induction by rimcazole in part through greater induction of HIF-1alph

24 Concurrently, rimcazole increased concentrations of dopamine and 3,4-d

25 pha knockdown by RNA interference attenuates rimcazole-induced cell death in both cell types.

26 otic mode as HIF-1alpha knockdown attenuates rimcazole-induced death to comparable extents in p53 mut

27 p53 is not required, however, for the rimcazole-induced engagement of HIF-1alpha in proapoptot

28 Rimcazole inhibited PCP c-fos induction in the cingulate

29 we aimed to assess whether the sigma-ligand rimcazole inhibits growth of A375M melanoma xenografts i

30 Furthermore, although rimcazole kills HCT-116p53-/- cells, it has a more poten

31 ter of rimcazole and cocaine are comparable, rimcazole only depressed locomotor activity in mice and

32 specific drugs namely i.e., tenofovir (Tef), rimcazole (RA) is demonstrated here, for the first time,

33 Rimcazole strongly inhibited the growth of A375M melanom

34 ing the sigma-1 agonist (+)-pentazocine with rimcazole substantially reduces the accumulation of HIF-

35 ut effect per se, but blocked the ability of rimcazole to increase concentrations of MHPG in the PVN

36 melanoma xenografts in nude mice and whether rimcazole treatment changes (18)F-FDG uptake in vivo.

37 -1alpha levels are consistently higher after rimcazole treatment in HCT-116p53+/+ cells.

38 Rimcazole treatment resulted in a greater than 4-fold re

39 Antitumor activity of rimcazole was accompanied by a transient increase of the

40 amen revealed that aromatic substitutions on rimcazole were not well tolerated, generally, with signi

41 veral of the compounds were more potent than rimcazole with affinities ranging from 97 nM to >6 micro

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