ライフサイエンスコーパス: ring finger

1 r), or type 3 (index finger shorter than the ring finger).

2 all nodule on the volar surface of his right ring finger.

3 fold increase in affinity between the E2 and RING finger.

4 reased ubiquitylation by Ube2g2 and the gp78 RING finger.

5 the ubiquitination activity of its cytosolic RING finger.

6 L-b was located in the Ub-E2 protein-binding RING finger.

7 tes for ubiquitin-activating enzyme (E1) and RING fingers.

8 ng to understand how deficiency of Mahogunin RING finger 1 (MGRN1) affects cell viability, we uncover

9 We show that muscle RING finger 1 (MuRF1) and MuRF3 act as E3 ubiquitin liga

10 TRIM63 encoding Muscle RING Finger 1 (MuRF1) maintains muscle protein homeostas

11 e in muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MuRF1) mRNA expression, but did significa

12 Deletion of muscle RING finger 1 (MuRF1), an E3 ubiquitin ligase, leads to

13 he E3 ligase atrogenes, atrogin-1 and muscle ring finger 1 (MuRF1), mediate muscle protein breakdown

14 rg275Trp, is located in the highly conserved RING finger 1 domain of PARK2, which encodes an E3 ubiqu

15 Human UHRF1 (ubiquitin-like PHD and RING finger 1) functions to maintain CpG DNA methylation

16 s, mRNA levels of ubiquitin, muscle-specific ring finger 1, and atrogin-1/muscle atrophy F-box were l

17 Expression of muscle RING-finger 1 (MuRF1), a ubiquitin ligase, is markedly i

18 phenomenon by which the E3 ligase mahogunin ring finger-1 (MGRN1) translocates to the nucleus in an

19 es, muscle atrophy factor (MAFbx) and muscle ring finger-1 (MuRF-1).

20 , as mRNA expression of the atrogenes muscle RING finger-1 (MuRF1) and atrogin-1 were 1.2- and 1.3-fo

21 g muscle atrophy-associated genes for muscle ring finger-1 (MuRF1) and atrogin1 were measured.

22 ttractin, Atrn/mg) and mahoganoid (Mahogunin Ring Finger-1, Mgrn1/md) are mutations epistatic to A(y)

23 d muscle-enriched E3 ubiquitin ligase muscle RING-finger-1 (MuRF1) expression, which may involve prot

24 The E3 ligase RING finger 168 (RNF168), mutated in the human radiosens

25 thermore, increased levels of K63 and muscle RING finger 2 (MuRF2) protein could also be important en

26 We have identified a PDZ domain containing RING finger 3 (PDZRN3) as a synapse-associated E3 ubiqui

27 E3 ubiquitin ligases RING finger 43/zinc and RING finger 3 (RNF43/ZNRF3).

28 e transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (

29 gulated by the E3 ubiquitin ligases zinc and ring finger 3 (ZNRF3) and ring finger protein 43 (RNF43)

30 o stabilize the membrane-associated zinc and ring finger 3 (ZNRF3).

31 we show that the noncanonical Polycomb group RING finger 3/5 (PCGF3/5)-PRC1 complex initiates recruit

32 and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators

33 Ubiquitin E3 ligase ring finger 43 (RNF43) has been suggested as a negative

34 ) and the transmembrane E3 ubiquitin ligases RING finger 43/zinc and RING finger 3 (RNF43/ZNRF3).

35 ealed that p47 interacts with polycomb group ring finger 5 (PCGF5) protein, Src protein tyrosine kina

36 ARF binding protein 1 (GGA1), polycomb group ring finger 5 (PCGF5), actin gamma 1 (ACTG1), and unc-13

37 show that the PRC1 component polycomb group ring finger 6 (Pcgf6) is required to maintain embryonic

38 D14, proteasome subunit beta type 1 (PSMB1), ring finger and CCCH-type domain 1 (RC3H1), and tumor pr

39 lization with ICP0 was dependent on the ICP0 RING finger and did not occur when proteasome activity w

40 The PLR-1 RING finger and protease-associated (PA) domain are esse

41 The zinc RING finger and sequences near the C terminus are necess

42 CD2AP.Cbl-3/c complex required a functional ring finger and TKB domain in Cbl-3/c.

43 Because these Ring finger and U-box E3s with UbcH5 target proteins for

44 Ring finger and WD domain 2 (RFWD2, also termed COP1) is

45 RING finger and WD repeat domain 3 (RFWD3) was initially

46 We identify cellular E3 ubiquitin ligase ring-finger and CHY zinc-finger domain-containing 1 (RCH

47 Surprisingly, both the zinc knuckle and the RING finger are needed for RNA-binding activity.

48 sequences near the C terminus, and the zinc RING finger, are necessary for inhibiting the human beta

49 thylated CpG via its conserved SRA (SET- and RING finger-associated) domain.

50 SET and RING-finger-associated (SRA) domain is involved in estab

51 clear corepressor with conserved domains for RING finger, B boxes, leucine zipper alpha helical coile

52 MDM2 via its C-terminal RING finger can bind to the Basic region of ATF3 and med

53 Checkpoint with FHA and Ring Finger (CHFR) is hypothesized to mediate a delay in

54 rotein ICP0 is an E3 ubiquitin ligase of the RING finger class that degrades several cellular protein

55 e 1 (HSV-1) is an E3 ubiquitin ligase of the RING finger class that is required for efficient lytic i

56 XB3 is a RING finger-containing E3 ubiquitin ligase that has been

57 ponsive genes1 (HOS1) locus, which encodes a RING finger-containing E3 ubiquitin ligase.

58 rdingly, Ufd2p has all of the hallmarks of a RING finger-containing ubiquitin ligase: it associates w

59 based overexpression screen and identified a Ring-finger-containing protein, RNF34, as a specific E3

60 onstrate that Bmi1 interacts with Gata6 in a Ring finger-dependent manner to confer protection agains

61 ly, UBE2D1 (UbcH5a) and UBE2E1 (UbcH6), in a RING finger-dependent manner.

62 owing gluing, with the representation of the ring finger (digit 4) shifted towards the little finger

63 ons of the zinc coordination residues of the RING finger domain abrogates TGF-beta resistance, but no

64 rophobic pocket can be regulated through the RING finger domain and that increases in pocket affinity

65 Mapping of Not4 identified the RING finger domain as essential for H3K4me3, suggesting

66 We demonstrate that disruption of the ORF61p RING finger domain by amino acid substitution (Cys19Gly)

67 of 49 patients; all of these cases harbored RING finger domain c-Cbl mutations.

68 tin-like (UBL) domain, a zinc knuckle, and a RING finger domain characteristic of some ubiquitin liga

69 polymerase-associated domain in PolH and the RING finger domain in Pirh2.

70 hemical analyses further show that the yBre1 RING finger domain is essential for H2B ubiquitylation b

71 dition, we demonstrate that an intact ORF61p RING finger domain is necessary for E3 ubiquitin ligase

72 Thus, a correctly folded RAG1 RING finger domain is required for normal V(D)J recombin

73 nfection, (v) ICP0 carrying mutations in the RING finger domain is stable both early and late in infe

74 key function of ICP0 that requires an intact RING finger domain is that of an ubiquitin E3 ligase: IC

75 In contrast, the C381A Ring finger domain mutant functions like WT c-Cbl.

76 ues required for the interaction between the RING finger domain of ICP0 and UBE2D1, and we report tha

77 t (i) consistent with previous findings, the RING finger domain of ICP0 is required for the activatio

78 etion of ICP0 or mutations in the N-terminal RING finger domain of ICP0 results in the absence of ICP

79 The RING finger domain of ICP0 was required for degradation

80 1-PIASy interaction but do not depend on the RING finger domain of PIASy.

81 main (CRD) of frizzled and the intracellular RING finger domain of RNF43.

82 The RING finger domain of Yvh1, but not its phosphatase doma

83 Mutations in the Cbl family RING finger domain or linker sequence constitute importa

84 heckpoint with Forkhead-associated (FHA) and RING finger domain protein (CHFR), an E3 ubiquitin ligas

85 The central region of Pirh2 harbors a RING finger domain that is critical for its ubiquitin li

86 domain of p53, and (iii) a C-terminal C2H2C4 RING finger domain that is required for E2 enzyme-bindin

87 otein interactions via its TRAF domain and a RING finger domain that possesses non-conventional E3 ub

88 n addition, DIAP2 also requires a functional RING finger domain to block cell death and target drICE

89 ICP0 has a RING finger domain with E3 ubiquitin ligase activity tha

90 a protein of 581 amino acids that contains a RING finger domain, a B-box, and two coiled-coil regions

91 TRIM37 contains a RING finger domain, a hallmark of E3 ubiquitin ligases,

92 diate these processes, it requires its C3HC4 RING finger domain, a tertiary structural fold that is c

93 tyrosine kinase binding domain, a catalytic RING finger domain, and a C-terminal proline-rich domain

94 iquitin ligase activity of the purified RAG1 RING finger domain, and the tertiary structure of the do

95 ximity to their N termini that consists of a RING finger domain, followed by one or two B box domains

96 omain (PHD) of UHRF1 (ubiquitin-like PHD and RING finger domain-containing protein 1) operates as a f

97 Specifically, we identified a RING finger domain-containing protein, RINCK (for RING-f

98 TRIM21 is a RING finger domain-containing ubiquitin E3 ligase whose

99 components requires BRCA1's BRCT but not the ring finger domain.

100 on of similarity between these proteins is a RING finger domain.

101 lates protein sumoylation independent of the RING finger domain.

102 i-spanning membrane protein with a cytosolic RING finger domain.

103 Flag-gp78), but not Flag-gp78 mutated in its RING-finger domain (Flag-RINGmut) with deficient ubiquit

104 Deletion of the enzyme's N-terminal RING-finger domain almost completely abolishes fiber for

105 hock protein 90 and did not require the MDM2 RING-finger domain and p53 ubiquitination.

106 Ubiquitination of lysines in Hrd1's RING-finger domain is required for substrate retrotransl

107 protein family, which contain a cluster of a RING-finger domain, a B box/coiled-coil domain and a SPR

108 UMO-interacting motif (SIM) and a C-terminal RING-finger domain.

109 indicates that checkpoint with forkhead and ring finger domains (CHFR), a recently identified mitoti

110 or ubiquitin-like protein containing PHD and RING finger domains 1 (uhrf1) in zebrafish leads to a re

111 Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential regulator

112 Ubiquitin-like, containing PHD and RING finger domains 1 (uhrf1) is regulated at the transc

113 mutations in the ubiquitin-like with PHD and ring finger domains 1 (uhrf1) or DNA methyltransferase 1

114 DNMT1) and ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) proteins.

115 n ligase UHRF1 (Ubiquitin-like, with PHD and RING finger domains 1) directly participates in the inte

116 UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) has a well-established role in ep

117 port that UHRF1 (ubiquitin-like with PHD and RING finger domains 1) interacts with TIP60 both in vitr

118 UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is a multi-domain protein associa

119 UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is required for maintenance methy

120 in UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1), also known as NP95 in mouse and

121 E3 ligase UHRF1 (ubiquitin-like with PHD and RING finger domains 1), which is commonly upregulated in

122 by Uhrf1 (Ubiquitin-like, Containing PHD and RING Finger Domains 1).

123 e identified the ubiquitin-like with PHD and ring finger domains 2 (UHRF2) gene as an important media

124 As a result, the juxtaposition of PA and RING finger domains across a lipid bilayer facilitates t

125 effect by targeting cysteine residues in the RING finger domains of histone E3 ubiquitin ligase, ther

126 und that arsenite could bind directly to the RING finger domains of RNF20 and RNF40 in vitro and in c

127 The ubiquitin-like, containing PHD and RING finger domains protein 1 (UHRF1) is essential for m

128 UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to hemimethylated

129 ally defined by a C4HC3 consensus similar to RING finger domains.

130 CULLIN (CUL)4-associated factor in a Cullin4-RING Finger E3 Ligase (CRL4) that mediates light-depende

131 The RING finger E3 ligase GRAIL is thought to selectively fu

132 se-6-phosphate dehydrogenase and ER-anchored RING finger E3 ligase in the activation of unfolded prot

133 s, MAF=up to 0.78%) in RNF186, a single-exon ring finger E3 ligase with strong colonic expression, pr

134 a new mechanism in which an uncharacterized RING finger E3 ligase, PPP1R11, directly ubiquitinates T

135 ates that Vpx recruits SAMHD1 to the Cullin4-Ring Finger E3 ubiquitin ligase (CRL4) by facilitating a

136 Although BBS11/TRIM32 represents a RING finger E3 ubiquitin ligase also involved in heredit

137 We identify SIAH2, a RING finger E3 ubiquitin ligase associated with the cell

138 The RBCC/TRIM family RING finger E3 ubiquitin ligase Nrdp1 mediates the ubiqu

139 Our previous studies indicate that the RING finger E3 ubiquitin ligase Nrdp1, a protein lost in

140 We identified the RING finger E3 ubiquitin ligase PIR2/Rnf144b as a direct

141 ed phosphoproteomics, we have identified the RING finger E3 ubiquitin ligase RNF157 as a target at th

142 The RING finger E3 ubiquitin ligase Siah2 is implicated in c

143 ICP0 is a RING finger E3 ubiquitin ligase that induces the degrada

144 Gp78 (also known as AMFR or RNF45) is a RING finger E3 ubiquitin ligase that is integral to the

145 TMEM129 is an unconventional C4C4-type RING finger E3 ubiquitin ligase that resides within a co

146 Roquin-1, a RING finger E3 ubiquitin ligase, functions as a modulato

147 Here, we found that Pirh2, a RING finger E3 ubiquitin ligase, promotes the proteasome

148 In this study, we identified an FHA domain RING finger E3 ubiquitin ligase, RNF8, and an E2-conjuga

149 ma-associated herpesvirus (KSHV) encodes two RING finger E3 ubiquitin ligases (MIR1 and MIR2) that me

150 ed the entire inventory of membrane-spanning RING finger E3 ubiquitin ligases localized to the ER.

151 Core histones can be ubiquitinated by RING finger E3 ubiquitin ligases, among which the RNF20-

152 suggest arsenite as a general inhibitor for RING finger E3 ubiquitin ligases.

153 old unrelated to previously observed HECT or RING-finger E3 ligases.

154 in-proteasome pathway involving the IBR-type RING-finger E3 ubiquitin ligase IBRDC2, and genetic corr

155 COP1 is a Ring-Finger E3 ubiquitin ligase that is involved in plan

156 We report that IBRDC2, an IBR-type RING-finger E3 ubiquitin ligase, regulates the levels of

157 an ubiquitinated protein and targeted by the RING-finger E3 ubiquitin-protein ligase constitutive pho

158 3s tested including multimeric and monomeric Ring finger E3s (MuRF1, Siah2, Parkin, APC, and SCF(beta

159 s spectrometry, that the U-box E3, CHIP, and Ring finger E3s, MuRF1 and Mdm2, with the E2, UbcH5, for

160 on observed when Ube2g2 is paired with other RING finger E3s.

161 ese zinc ligands form a pair of cross-braced ring fingers encapsulated within a third zinc finger in

162 (HEI10) (CCNB1IP1) was first described as a RING-finger family ubiquitin ligase that regulates cell

163 are associated with zinc finger (C3HC4-type RING finger) family protein and AOX1A (alternative oxida

164 PCGF1 encodes one of six human Polycomb RING finger homologs that are linked to transcriptional

165 ereby allosteric effects on an E2 enhance E2-RING finger interactions and, consequently, ubiquitylati

166 in kinase and that an ICP0 with mutations in RING finger is stable.

167 ul4B), a scaffolding component of the Cullin ring finger ligase family of ubiquitin E3 ligases.

168 e residues makes it highly probable that the RING finger-like domain coordinates two zinc ions, analy

169 BBP6) plays a facilitating role, through its RING finger-like domain, in the ubiquitination of p53 by

170 The RING finger-like structure of the PHD domain is required

171 ng Rnf12 encoding the ubiquitin ligase RLIM (RING finger LIM-domain-interacting protein).

172 biquitin ligase really interesting new gene (RING) finger LIM domain-interacting protein (RLIM)/RING

173 These data suggest that RING finger-mediated p53 inhibition and MDMX interaction

174 nteraction could be mapped to the C-terminal RING finger motif of RNF217.

175 tudied subunit in Smc5/6, contains a SP-like-RING finger motif on the C-terminus and was identified a

176 within the kinase domain and an intact MEKK1 RING finger motif.

177 Muscle ring finger (MuRF) proteins have been implicated in tran

178 Muscle ring finger (MuRF)1 is a muscle-specific protein implica

179 Here, we show that CD4(+) T cells from Cbl-b RING finger mutant knockin or Cbl-b-deficient mice show

180 Using the c-Cbl RING finger mutant mouse as a model of a myeloproliferat

181 by the similarity between Cbl-b(-/-) and its RING finger mutant NKT cells.

182 i) in cells infected with both wild type and RING finger mutant only the wild-type ICP0 is rapidly de

183 1H, a linker region mutant, and CBL-C384R, a RING finger mutant, lead to enhanced GM-CSF signaling.

184 and gp78, but not its functionally inactive RING-finger mutant, resulted in enhanced CYP3A4 loss gre

185 Our study indicates that CBL linker and RING finger mutants lead to enhanced GM-CSF signaling du

186 Furthermore, we show that RING finger mutants that are unable to interact with UBE

187 RING finger mutants were unable to reactivate transcript

188 nae subfamily members, bICP0 contains a zinc RING finger near its amino terminus that is necessary fo

189 The RING finger nuclear factor RNF168 is required for recrui

190 erved cysteine residue in the C(3)HC(4) zinc RING finger of bICP0 has dramatic effects on the growth

191 The C(3)HC(4) zinc RING finger of bICP0 is crucial for activating viral tra

192 tion (51st amino acid) in the C(3)HC(4) zinc RING finger of bICP0.

193 le amino acid mutation in the C(3)HC(4) zinc RING finger of bICP0.

194 e mutations are in the linker region and the RING finger of CBL, leading to a loss of E3 ligase activ

195 Here, we warmed the index and ring fingers of each hand while cooling the middle finge

196 of ROR1 inhibited expression of the polycomb ring-finger oncogene, Bmi-1, and other genes associated

197 vein, viruses that have mutations in ICP0's RING finger or are deleted for the gene are sensitive to

198 n (Ub)-protein conjugates formed by purified ring-finger or U-box E3s with the E2, UbcH5, resist degr

199 g finger), type 2 (index finger equal to the ring finger), or type 3 (index finger shorter than the r

200 protein docking complex PEX13-PEX14 and the (RING)-finger peroxin PEX2.

201 ha2 isoform is necessary for muscle-specific ring finger protein 1 (MuRF1) up-regulation and myofiber

202 Muscle RING finger protein 1 (MuRF1), a muscle-specific ubiquit

203 the proteins of the Polycomb complex is the Ring finger protein 1 (RING1).

204 of atrogin-1/MAFbx or MurF1 (muscle-specific RING finger protein 1).

205 WWP1 forms a protein complex with RING finger protein 11 (RNF11), a negative regulator of

206 We identify RING finger protein 113A (RNF113A) as the E3 ligase resp

207 finger LIM domain-interacting protein (RLIM)/RING finger protein 12 (Rnf12), which serves as a major

208 We identify a unique cofactor, RING finger protein 126 (RNF126), verify its interaction

209 ranscriptionally represses the expression of RING finger protein 144A (RNF144A), an uncharacterized g

210 identify a poorly characterized RBR protein, Ring Finger protein 144A (RNF144A), as the first, to our

211 nd nitrosylation of, the epigenetic modifier ring finger protein 1A (RING1A) as assessed by immunosta

212 (EZH2), suppressor of zeste 12 (SUZ12), and ring finger protein 2 (RNF2) from (and concomitant recru

213 w that monoubiquitination of H2AX induced by RING finger protein 2 (RNF2) is required for the recruit

214 identify the histone H2B E3 ubiquitin ligase ring finger protein 20 (RNF20) as an additional chromati

215 of histone H3 at Lys4 and Lys79 by targeting ring finger protein 20 (RNF20) for proteasomal degradati

216 eotide polymorphism within the gene encoding RING finger protein 207 (RNF207) and the QT interval.

217 o6 (anocatmin 6; chromosome 15), and Rnf220 (Ring finger protein 220; chromosome 4) were considered c

218 f43 (RING finger protein 43) and Znrf3 (zinc/RING finger protein 3) (RZ) are two closely related tran

219 Ring finger protein 4 (RNF4) is a SUMO-targeted ubiquiti

220 Keap1 but contained modified Nrf2 as well as RING finger protein 4 (RNF4), a poly-SUMO-specific E3 ub

221 AT1 phosphorylation, we went on to show that RING finger protein 4 depletion stabilizes PML and is co

222 t recruitment of E3 ubiquitin-protein ligase RING finger protein 4 resulted in ubiquitin-mediated deg

223 the SUMO-targeted ubiquitin E3 ligase, RNF4 (RING finger protein 4) (1).

224 Here we show that RNF4 (RING finger protein 4), a SUMO-dependent ubiquitin E3-li

225 at SUMO3 is important for the recruitment of RING finger protein 4, a poly-SUMO-dependent E3 ubiquiti

226 onjugating enzyme UBC9-mediated SUMOylation, RING finger protein 4-mediated (RNF4-mediated) polyubiqu

227 ng platform for ubiquitin E3 ligases such as ring finger protein 4.

228 We also found that the ring finger protein 41 (RNF41) as an E3 ligase ubiquitin

229 n ligases zinc and ring finger 3 (ZNRF3) and ring finger protein 43 (RNF43), which are disrupted in c

230 Rnf43 (RING finger protein 43) and Znrf3 (zinc/RING finger prot

231 he TRP120-interacting protein polycomb group ring finger protein 5 (PCGF5) to the inclusion, indicati

232 phospho-MDC1) or E3 ubiquitin-protein ligase ring finger protein 8 (RNF8), two factors involved in DS

233 Moreover, we have found that RNF8 (ring finger protein 8), an E3 ubiquitin ligase, regulate

234 Human RNF217 codes for a highly conserved RING finger protein and is mainly expressed in testis an

235 region that is predicted to contact the ROC1 RING finger protein by structural studies.

236 n ligase comprised of the cullin Rtt101, the RING finger protein Hrt1, and the adaptor protein Mms1.

237 In this regard we show that TRAF2, a RING finger protein implicated in ubiquitylation, select

238 We demonstrate that RING finger protein MSL2 in the MOF-MSL complex is a his

239 o heterodimers of either Cullin 2 (Cul2) and RING finger protein Rbx1 or Cullin 5 (Cul5) and Rbx2.

240 Using this strategy, we identified the RING finger protein RNF181 as an interactor of CARD11, a

241 sed of elongin C (Elc1), Ela1, Cul3, and the RING finger protein Roc1 (Rbx1) mediates this process in

242 The RING finger protein Z has been identified as the driving

243 We have identified a RING finger protein, AO7/RNF25, as a ubiquitin ligase fo

244 lister encodes a RING finger protein, LISTERIN, which functions as an E3

245 We identified a conserved transmembrane RING finger protein, PLR-1, that governs the response to

246 proof-of-concept study in a muscle-specific ring finger protein-1 (MuRF-1) knockout mouse model, we

247 Osteoblast depletion of the atrogene muscle ring finger protein-1 (MuRF1) protected against gluco- a

248 d, whereas the expression of muscle-specific RING finger protein-1 and atrogin-1, muscle atrophy mark

249 p-based cloning revealed that SIS3 encodes a RING finger protein.

250 strate-targeting subunit, Skp1, and the ROC1 RING finger protein.

251 The Really Interesting New Gene (RING) Finger Protein 4 (RNF4) represents a class of ubiq

252 effectors (fold-change messenger RNA: muscle RING-finger protein 1 = 5.7, atrogin-1 = 2.8; caspase-3

253 Muscle-specific ubiquitin ligases (muscle RING-finger protein 1 and atrogin-1), caspase-3 activity

254 dotoxemia, proinflammatory cytokines, muscle RING-finger protein 1, and atrogin-1 were not significan

255 utations in MKRN3, the gene encoding makorin RING-finger protein 3, in 5 of the 15 families; both sex

256 The RING-finger protein PAR-2 becomes enriched on the poster

257 finger domain-containing protein, RINCK (for RING-finger protein that interacts with C kinase) from a

258 ble to phosphorylate TdRF1 in vitro, and the RING-finger protein WHEAT VIVIPAROUS-INTERACTING PROTEIN

259 nteracts with CUL3 independent of a bridging RING-finger protein; and (iv) can engage the neddylated

260 RING finger proteins constitute the large majority of ub

261 es by regulating the association between the RING finger proteins HEI10 and RNF212 and components of

262 naling and reveal roles for mutations in the RING finger proteins in cancer.

263 We describe two RING finger proteins in the fission yeast Schizosaccharo

264 complex (termed HULC) that also contains two RING finger proteins Rfp1 and Rfp2, sharing homology wit

265 alphaherpesviruses also express ICP0-related RING finger proteins, but these have limited homology ou

266 hereas other gene families, bHLH, F-box, and RING finger proteins, showed more typical levels of dive

267 tes and members of the Zip3/RNF212 family of RING finger proteins, which in turn stabilize MutSgamma.

268 RING-finger proteins commonly function as ubiquitin liga

269 ence, we describe a family of SIM-containing RING-finger proteins that potentially regulates eukaryot

270 Several ring between ring fingers (RBR) -domain proteins, such as Parkin and

271 P1-like homolog SKR-1, the cullin CUL-1, and ring finger RBX homologs yielded similar heterochronic p

272 100 by the ubiquitin ligase expressed by the RING finger (RF), and it blocks silencing of viral DNA m

273 BMI1 consists of a ring finger (RF), helix-turn-helix-turn-helix-turn (HT),

274 The human RING finger (RNF) E3 ubiquitin ligases, RNF8 and RNF168,

275 ery of ubiquitin, E1-like, E2-like and small-RING finger (srfp) protein components in the Aigarchaeot

276 sub-complex including the cullin domain and RING finger subunits Apc2 and Apc11, respectively, and a

277 se structural relationship of PHD fingers to RING fingers suggests that other PHD domain-containing p

278 further observe that restoration of Nrdp1, a RING finger type E3 ubiquitin ligase whose suppression i

279 fied as type 1 (index finger longer than the ring finger), type 2 (index finger equal to the ring fin

280 e these rearrangements and find that COP1, a RING-finger-type ubiquitin E3 ligase, is required for de

281 active beta-catenin in the Wnt-on phase by a RING finger ubiquitin E3 ligase, Casitas B-lineage lymph

282 d to anergy in lymphocytes), a transmembrane RING finger ubiquitin E3 ligase, initially described as

283 itor of apoptosis protein (IAP) family and a RING finger ubiquitin ligase (E3), has been proposed to

284 ed that the endoplasmic reticulum-associated RING finger ubiquitin ligase gp78 can mediate the preass

285 Proteomic analysis revealed that RNF8, a RING finger ubiquitin ligase that plays an important rol

286 The activity of RING finger ubiquitin ligases (E3) is dependent on their

287 highlight the function of two transmembrane RING finger ubiquitin ligases in modulating Wnt signalin

288 tylation of the surrounding chromatin by the RING finger ubiquitin ligases RNF8 and RNF168.

289 Cbl is a member of a family of RING finger ubiquitin ligases that negatively regulate s

290 gases (CRLs) constitute the largest group of RING finger ubiquitin ligases.

291 e Saccharomyces cerevisiae protein Asr1 is a RING finger ubiquitin-ligase that binds directly to RNA

292 ig-1 and Insig-2 bind another membrane-bound RING-finger ubiquitin ligase called Trc8.

293 lack E3 activity but recruit Slx8, an active RING-finger ubiquitin ligase, through a RING-RING intera

294 not Insig-2, recruits gp78, a membrane-bound RING-finger ubiquitin ligase.

295 rates an amino acid substitution in the RAG1 RING finger/ubiquitin ligase domain (C325Y in murine RAG

296 We stimulated the index, middle, and ring fingers when the middle finger either was or was no

297 he most prominent of which appears to be the RING finger, which confers E3 ubiquitin ligase activity.

298 ratings pressed onto the stationary index or ring finger, with auditory feedback provided to signal c

299 arenavirus-like particles requires the virus RING finger Z protein and surface glycoprotein precursor

300 The arenavirus small RING finger Z protein has been shown to be the main driv