ライフサイエンスコーパス: ring-closing

1 ig iodoetherification enabled regioselective ring-closing alkene metatheses to afford the 5- as well

2 s aldol reaction conjoined with a relay-type ring-closing alkene metathesis is reported.

3 Ring-closing alkene metathesis of allylsilanes provides

4 of a highly enolizable beta-keto-lactone, a ring closing alkyne metathesis and a modified Stille cou

5 neous molybdenum(VI) catalyst was applied to ring closing alkyne metathesis and cyclooligomerization

6 rmediate and macrocyclization using Furstner ring-closing alkyne metathesis.

7 sequence involving ring closing-ring opening-ring closing and cross metathesis (RC-RO-RC-CM) occurred

8 lexes to promote an assortment of asymmetric ring-closing (ARCM) and ring-opening (AROM) metathesis r

9 ility of in situ imine formation followed by ring-closing, but support instead hydrogen-bond assisted

10 methylene aziridine promotes a ring-opening/ring-closing cascade that efficiently transfers chiralit

11 Key steps include a TMSOTf-induced ring-closing cascade to form the ABC rings of tetracycle

12 erate an acyclic 1,3-diene which can undergo ring closing diene metathesis between the isolated olefi

13 The key step, a ring-closing dienyne metathesis (RCDEYM) reaction, has b

14 ism is proposed that involves a ring-opening/ring-closing (Dimroth) rearrangement.

15 ial one-pot two-directional cross-metathesis/ring-closing double aza-Michael process.

16 and is often used in organic synthesis as a ring-closing effect.

17 on the use of the Stewart Grubbs catalyst in ring closing enyne metatheses.

18 The ring closing enyne metathesis of substrates with proparg

19 tions, followed by a ruthenium(II)-catalyzed ring closing enyne metathesis reaction.

20 Ring closing enyne metathesis to form 10-15-membered rin

21 In the presence of the Grubbs II catalyst, ring-closing enyne metathesis of the PK cycloaddition pr

22 a base-catalyzed alkynyl silane alcoholysis/ring-closing enyne metathesis sequence for facile constr

23 rocyclic ring opening, and 6pi-electrocyclic ring-closing events, constitutes a robust method for pro

24 Methodology for the ring-closing iodoamination of bishomoallylic amines foll

25 n of 3a from EB, CO, and 1 is rapid, lactone ring closing is rate-determining.

26 try of the observed products, a ring-opening/ring-closing mechanism is proposed and supported by the

27 hly efficient in macrocyclizations involving ring-closing metatheses (RCM), whereas the complex featu

28 ng the unsubstituted parent, was accessed by ring-closing metatheses of alpha,alpha-diallylacetonitri

29 Ring-closing metatheses provide efficient access to the

30 Asymmetric ring closing metathesis (ARCM) of a challenging class of

31 m of precatalyst and PAG was capable of both ring closing metathesis (RCM) and ring opening metathesi

32 erivatives based on selective alkylation and ring closing metathesis (RCM) by exploiting the four pos

33 eactions of COE and norbornadiene (NBD), and ring closing metathesis (RCM) reactions of diethyl diall

34 synthesized through an asymmetric allylation/ring closing metathesis (RCM) sequence.

35 ied out through the use of an esterification-ring closing metathesis (RCM) strategy.

36 h a suitable side chain tether introduced by ring closing metathesis (RCM).

37 atalyst was shown to catalyze various olefin ring closing metathesis and hydrosilylation reactions in

38 16-epi-luffarin L (2) by a silicon-tethered ring closing metathesis as a key step has been achieved.

39 rate that their synthesis can be achieved by ring closing metathesis of readily accessible precursors

40 ermally mediated Overman rearrangement and a ring closing metathesis reaction of allylic trichloroace

41 The synthesis relied on an acylation-ring closing metathesis sequence.

42 re the result of a tandem cycloisomerization-ring closing metathesis sequence.

43 ogram directed to the possible adaptation of ring closing metathesis to a total synthesis of vinigrol

44 ed a cascade Takai-Utimoto ester olefination/ring closing metathesis to construct ring Y, a hydroxydi

45 used benzofuran and 2) a cascade ene-yne-ene ring closing metathesis to forge the tetracyclic morphin

46 that ultimately was subjected to diene-diene ring closing metathesis to form the macrocycle.

47 h the Grb7-SH2 domain, both before and after ring closing metathesis to show that the closed staple i

48 Ring closing metathesis using difluorinated 1,7-enyne ca

49 re discussed based on asymmetric allylation, ring closing metathesis, and aldol reactions.

50 cycle was realized by a highly (E)-selective ring-closing metathesis (35 --> 37).

51 carbenes and their application to asymmetric ring-closing metathesis (ARCM) are reported.

52 The first examples of catalytic asymmetric ring-closing metathesis (ARCM) reactions of enol ethers

53 y performing a domino cross enyne metathesis/ring-closing metathesis (CEYM/RCM) in the presence of st

54 idemniserinolipid B utilizing a ketalization/ring-closing metathesis (K/RCM) strategy is described.

55 e and terminal arylalkynes followed by enyne ring-closing metathesis (RCM) and Heck cyclization affor

56 The feasibility of ring-closing metathesis (RCM) as a synthetic entry to 10

57 action, followed by Fischer indolization and ring-closing metathesis (RCM) as key steps.

58 -11)NH(2) analogues on solid phase utilizing ring-closing metathesis (RCM) between the side chains of

59 and titanium assisted cross-metathesis (CM)/ring-closing metathesis (RCM) cascade has been used to s

60 Ring-closing metathesis (RCM) catalyzed by a second-gene

61 tituted piperidinone D-rings were formed via ring-closing metathesis (RCM) followed by a 1,4-addition

62 To this end, the catalytic process known as ring-closing metathesis (RCM) has allowed access to coun

63 opening metathesis polymerization (ROMP) and ring-closing metathesis (RCM) have been investigated.

64 Catalytic ring-closing metathesis (RCM) is a widely used method fo

65 gue (5) were synthesized in good yield using ring-closing metathesis (RCM) methods.

66 = 3, 2) has been developed that involves the ring-closing metathesis (RCM) reaction of cis-2,6-dialke

67 embedded bicyclic lactone, and an efficient ring-closing metathesis (RCM) reaction to generate the m

68 on of allylic hydroxyl group followed by the ring-closing metathesis (RCM) reaction with Grubbs catal

69 oups was synthesized, cross-linked using the ring-closing metathesis (RCM) reaction, and the core was

70 de and monoaryloxide complexes promote enyne ring-closing metathesis (RCM) reactions, affording the c

71 A tandem cross metathesis (CM)--ring-closing metathesis (RCM) sequence to form cyclic si

72 bond formations, one etherification, and one ring-closing metathesis (RCM) step, using readily availa

73 C1-C21 bond and the second approach using a ring-closing metathesis (RCM) strategy to form the C10-C

74 ied out through the use of an esterification-ring-closing metathesis (RCM) strategy.

75 A phosphate tether-mediated ring-closing metathesis (RCM) study to the synthesis of

76 centerpiece of the strategy is a sequential ring-closing metathesis (RCM) that forms an unsaturated

77 lyldiphenylphosphonate esters and subsequent ring-closing metathesis (RCM) to access P-chiral P-heter

78 ntheses involve cobalt-complexation-promoted ring-closing metathesis (RCM) to generate ynolides, foll

79 F3.Et2O-mediated Et3SiH reduction and olefin ring-closing metathesis (RCM) using Ru(II) catalysts.

80 Ring-closing metathesis (RCM) was employed to join carbo

81 struction of the central macrolide employing ring-closing metathesis (RCM), followed by selective pro

82 ghly efficient and selective for macrocyclic ring-closing metathesis (RCM).

83 A tandem ruthenium-catalyzed olefin ring-closing metathesis (RCM)/Kharasch addition allows f

84 metathesis involving ring-opening metathesis-ring-closing metathesis (ROM-RCM) of a bicyclo[2.2.2]oct

85 l 2-allyl-4-fluorophenyl auxiliary for relay ring-closing metathesis (RRCM) was developed, which incr

86 n reaction pathways (ring-opening metathesis/ring-closing metathesis [ROM/RCM] cascade vs ring-closin

87 ropic [1,3]-shift followed by a second enyne ring-closing metathesis allowed the formation of a highl

88 Other key steps include a ring-closing metathesis and a selective olefin oxidation

89 The application in sequence of ring-closing metathesis and an intramolecular Heck react

90 etic macrocycles has been accomplished using ring-closing metathesis and enyne tandem cross-metathesi

91 The C-Glc Ser was available by a ring-closing metathesis and hydroalkoxylation route.

92 The enyne ring-closing metathesis and relay metathesis provides th

93 esis of the eight-membered analogues involve ring-closing metathesis and Sharpless asymmetric dihydro

94 ment of a strategy consisting of allylsilane ring-closing metathesis and subsequent S(E)' electrophil

95 use of ruthenium catalysts, first in azepine ring-closing metathesis and then in alkene isomerization

96 hese products served as substrates for enyne ring-closing metathesis and, consequently, as precursors

97 Here, a ring-closing metathesis approach is utilized to synthesi

98 ment of an iterative reductive aromatization/ring-closing metathesis approach.

99 OM transformations that occur in tandem with ring-closing metathesis are described.

100 ed macrocyclic dienediyne was achieved using ring-closing metathesis as a key step.

101 errier rearrangement, Grignard addition, and ring-closing metathesis as key steps.

102 We initially investigated a ring-closing metathesis based synthetic strategy to form

103 idine fragment are depicted, both relying on ring-closing metathesis but differing in the substitutio

104 Ring-closing metathesis can be performed on the N-protec

105 pyl ketenethioacetal, (2) an efficient enyne ring-closing metathesis cascade reaction in a challengin

106 The new sequence is an alternative to the ring-closing metathesis for the synthesis of carbohydrat

107 ess, the alternative approach was based on a ring-closing metathesis from the corresponding N-allyl-s

108 In the second stage of the tandem strategy, ring-closing metathesis generates the nitrogen heterocyc

109 termediates in the catalytic carbonyl-olefin ring-closing metathesis has been obtained.

110 The aromatizing ring-closing metathesis has been shown to take place ins

111 Conformational restriction by ring-closing metathesis increased the specificity of res

112 cyclic ring system via alcohol oxidation and ring-closing metathesis is also described.

113 uencing the diastereochemical outcome of the ring-closing metathesis is also presented, revealing tha

114 The utility of the Mo-catalyzed AROM/ring-closing metathesis is demonstrated through an enant

115 and macrocyclic nitrogen heterocycles using ring-closing metathesis is described.

116 yl moieties followed by a diastereoselective ring-closing metathesis is described.

117 l boronic esters and homoallylic alcohols by ring-closing metathesis is reported.

118 However, a sequential enyne ring-closing metathesis of a diyne moiety and metallotro

119 A key catalytic ring-closing metathesis of an achiral triene is used to

120 stituted monobenzofused 1,4-azaborines using ring-closing metathesis of an enamine-containing diene a

121 as 25 ppm can lead to 100% conversion in the ring-closing metathesis of diethyl diallylmalonate.

122 The ring-closing metathesis of enediynes induces a facile me

123 benzo[b]phosphole-1-oxide, itself derived by ring-closing metathesis of phenylstyrylvinylphosphine ox

124 acids derivatives, are readily prepared via ring-closing metathesis of sulfinimine-derived N-sulfiny

125 15-membered macrocyclic PIs were prepared by ring-closing metathesis of the corresponding linear PIs.

126 )amide to tert-butyl sorbate was followed by ring-closing metathesis of the resultant N-alkenyl beta-

127 opane to make two rings, and group-selective ring-closing metathesis of the resulting divinylcyclopen

128 ve been prepared via two key steps involving ring-closing metathesis of vinyl chlorides and regiosele

129 Ring-opening/ring-closing metathesis on cyclobutene-containing substr

130 vity are highlighted by cross metathesis and ring-closing metathesis on diverse peptide substrates.

131 Ru-catalyzed ring-closing metathesis performed on the diallylated aro

132 lkenylamide containing peptides, prepared as ring-closing metathesis precursors, showed that the high

133 -amino acid derivatives could be accessed by ring-closing metathesis presenting a viable strategy to

134 studies include development of an efficient ring-closing metathesis procedure to prepare macrocyclic

135 y such initiating neophylidenes in promoting ring-closing metathesis processes, are disclosed.

136 f this arrangement through esterification or ring-closing metathesis produces the closed-knot complex

137 ing reactions include Nazarov cyclization, a ring-closing metathesis promoted with complete diastereo

138 n and a highly chemo- and diastereoselective ring-closing metathesis protocol for the formation of th

139 A high-performing ring-closing metathesis protocol has been achieved by si

140 Ring-closing metathesis provided access to a twelve-memb

141 ctrophilic alpha-chloro sulfide, and last by ring-closing metathesis reaction as the key steps.

142 rbon bond is enabled by a microwave-assisted ring-closing metathesis reaction between two terminal ol

143 c approach highlights a remarkably efficient ring-closing metathesis reaction catalyzed by Nolan ruth

144 d-generation approach, a tandem ring-opening/ring-closing metathesis reaction effected an overall [2.

145 icient molybdenum-catalyzed enantioselective ring-closing metathesis reaction for the desymmetrizatio

146 yclic nucleosides, have been developed via a ring-closing metathesis reaction from d-ribose in eight

147 Overman rearrangement and a Ru(II)-catalyzed ring-closing metathesis reaction has been developed for

148 discovery of an efficient and selective bis ring-closing metathesis reaction leading to peptides bea

149 ombination of Ichikawa's rearrangement and a ring-closing metathesis reaction of allyl carbamates is

150 e we demonstrate a catalytic carbonyl-olefin ring-closing metathesis reaction that uses iron, an Eart

151 e key intermediates, as well as Ru-catalyzed ring-closing metathesis reaction to construct the key tr

152 A key step in the synthesis was a ring-closing metathesis reaction to prepare the macrocyc

153 ved from D-glucose, followed by a sequential ring-closing metathesis reaction using Grubbs catalysts,

154 NMR studies confirmed that the ring-closing metathesis reaction yielded a single produc

155 action, an Overman rearrangement reaction, a ring-closing metathesis reaction, and an amination react

156 The synthesis features a challenging ring-closing metathesis reaction, followed by eliminatio

157 which is advantageously synthesized using a ring-closing metathesis reaction.

158 actical approach based on esterification and ring-closing metathesis reaction.

159 laced by a carbon-carbon bond derived from a ring-closing metathesis reaction.

160 ficant influence on the E:Z ratio during the ring-closing metathesis reaction.

161 aldols, Yamaguchi esterification, and Grubbs ring-closing metathesis reaction.

162 is are surveyed, with particular emphasis on ring-closing metathesis reactions and annulation reactio

163 yclizations of bis(vinyl boronate esters) or ring-closing metathesis reactions followed by complexati

164 We describe how our investigations of ring-closing metathesis reactions in epothilone settings

165 lass pellets used in a sequence of catalytic ring-closing metathesis reactions mediated by various su

166 A study of the ring-closing metathesis reactions of two bis(enynes) is

167 Olefin cross- and ring-closing metathesis reactions run in the presence of

168 alyst-controlled stereoselective macrocyclic ring-closing metathesis reactions that generate Z-enoate

169 hesis include diastereoselective Nazarov and ring-closing metathesis reactions, and a highly efficien

170 catalyst modification necessary) to perform ring-closing metathesis reactions, generating 14- to 21-

171 trategy using intramolecular Diels-Alder and ring-closing metathesis reactions.

172 ctrocyclization sequence and others based on ring-closing metathesis reactions.

173 metathesis and enyne tandem cross-metathesis-ring-closing metathesis reactions.

174 Of these, ring-closing metathesis represented by the conversion of

175 Iron(III)-catalyzed carbonyl-olefin ring-closing metathesis represents a new approach toward

176 After protection of the amine, a ring-closing metathesis results in a multifunctional eig

177 d dihydropyran rings was constructed via the ring-closing metathesis route.

178 an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.

179 ates by a Suzuki coupling-Wittig olefination-ring-closing metathesis sequence allowed a convergent an

180 A ring-closing metathesis served for construction of the s

181 catalysts initiate the key enantioselective ring-closing metathesis step in the total synthesis of q

182 t the piperidine core and a silicon-tethered ring-closing metathesis strategy to install the Z exocyc

183 A highly efficient, Z-selective ring-closing metathesis system for the formation of macr

184 yclic core of Vaniprevir (MK-7009) utilizing ring-closing metathesis technology.

185 de pyrrolide (MAP) complex and a macrocyclic ring-closing metathesis that affords a trisubstituted al

186 d a relatively rare application of catalytic ring-closing metathesis to access an 11-membered ring st

187 and 10 (obtained from D-ribose) followed by ring-closing metathesis to afford enol ether 8, whose el

188 The isomerization can be combined with ring-closing metathesis to afford the synthesis of exocy

189 Use was also made of ring-closing metathesis to bring about the conversion of

190 trategically forge the C1-C2 bond, and (3) a ring-closing metathesis to build the bridging bicyclo[4.

191 o alcohol functionality of conduramine E and ring-closing metathesis to construct its carbocyclic cor

192 d assemble the diazatricycloundecane core, a ring-closing metathesis to construct the 13-membered rin

193 riate allyl bromide provides a precursor for ring-closing metathesis to deliver the oxepinochromone r

194 e aldol reaction provided a diene useful for ring-closing metathesis to form an oxonene, which was ul

195 y substituted cyclobutanols; (ii) the use of ring-closing metathesis to form the pendant five-membere

196 terically encumbered tetrahydropyran ring, a ring-closing metathesis to generate the C(4a-13-20a) mac

197 glycinol derivatives was followed by Grubbs' ring-closing metathesis to generate the key lactam inter

198 e previously reported that the employment of ring-closing metathesis to introduce a single all-hydroc

199 Additional key steps include ring-closing metathesis to prepare the D-ring and Bosch-

200 functionalized aminodienes, which underwent ring-closing metathesis to provide chiral C5-C6 disubsti

201 turally occurring monoterpene myrcene (1) by ring-closing metathesis using Grubbs second generation c

202 Ring-closing metathesis was a key reaction used to form

203 An E-selective ring-closing metathesis was used to access the 10-member

204 Ring-closing metathesis was used to construct the strain

205 tereoselective Grignard reaction followed by ring-closing metathesis was used.

206 phosphonate derived from (S)-lactic acid and ring-closing metathesis were the key reactions during th

207 1]tridecenes were synthesized by E-selective ring-closing metathesis where their absolute stereochemi

208 In particular, ring-closing metathesis with the Hoveyda-Grubbs catalyst

209 ng a tethered olefinic site followed by RCM (ring-closing metathesis) is described.

210 ophilic addition to an N-acyl iminium ion, a ring-closing metathesis, a diastereoselective hydroborat

211 e base and the carbocyclic sugar moiety, via ring-closing metathesis, allowed for a facial selective

212 acrocyclic PIs were designed, synthesized by ring-closing metathesis, and evaluated alongside with 10

213 blishes the stereochemistry of the product), ring-closing metathesis, and simple functional group con

214 into C-ribosides 29a,b via the Ru-catalyzed ring-closing metathesis, followed by a diastereoselectiv

215 owed by a conjugate addition-elimination and ring-closing metathesis, has been developed.

216 Olefin-cross metathesis, ring-closing metathesis, palladium-catalyzed Meinwald re

217 d-catalyzed Suzuki coupling and Ru-catalyzed ring-closing metathesis, thus representing a practical m

218 is inclusion complex was subjected to olefin ring-closing metathesis, which was observed to proceed u

219 the C4' stereocenter, and a highly efficient ring-closing metathesis-allylic oxidation sequence to fo

220 A ring-closing metathesis-based strategy has allowed acces

221 ion of a higher-order dimethylcuprate upon a ring-closing metathesis-derived alpha,beta-unsaturated v

222 Ring-closing metathesis-mediated incorporation of an int

223 or aminohydroxylation protocols followed by ring-closing metathesis.

224 ometallic addition, and a Z-selective alkene ring-closing metathesis.

225 ring stapled peptide by means of macrocyclic ring-closing metathesis.

226 oyl-protected carbocyclic bis-allyl ureas by ring-closing metathesis.

227 onic acid-controlled Z-selective macrocyclic ring-closing metathesis.

228 carbon macrocyclic ring system was formed by ring-closing metathesis.

229 yclononene substructure could be realized by ring-closing metathesis.

230 as the five-membered ring was formed through ring-closing metathesis.

231 d six-membered cyclic phosphonates using the ring-closing metathesis.

232 ared from optically pure acyclic acetals via ring-closing metathesis.

233 center, and the lactone moiety was formed by ring-closing metathesis.

234 homoallylglycine building blocks followed by ring-closing metathesis.

235 n metathesis, including cross-metathesis and ring-closing metathesis.

236 d by homodimerization, cross metathesis, and ring-closing metathesis.

237 Tsuji-Trost allylic amination reaction and a ring-closing metathesis.

238 ablish the E,Z-diene part, an ester-tethered ring-closing metathesis/base-induced eliminative ring op

239 ization step was achieved using a sequential ring-closing metathesis/olefin isomerization reaction.

240 ring-closing metathesis [ROM/RCM] cascade vs ring-closing metathesis/ring-opening metathesis [RCM/ROM

241 is diene unit was accomplished with a tandem ring-closing metathesis/silicon-assisted intramolecular

242 addition were observed to undergo efficient ring-closing-metathesis (RCM) reaction in the presence o

243 Net conrotatory ring closing occurred in 5.0 +/- 0.5% of the released tr

244 hitecture in high yield ( 75%) via efficient ring closing of rationally designed metallosupramolecula

245 s-1,4-diacetoxy-2-butene and the macrocyclic ring-closing of a 14-membered lactone.

246 mark olefin metathesis reactions such as the ring-closing of diethyldiallyl and diethylallylmethallyl

247 xhibiting pseudo-first-order kinetics in the ring-closing of diethyldiallyl malonate.

248 of duplex DNA in catalyzing ring-opening and ring-closing of M1dG and N2OPdG.

249 c ring-opening of cyclobutene, electrocyclic ring-closing of Z-hexatriene, the [1,5]-H shift in Z-pen

250 g ratio between symmetry-allowed disrotatory ring closing (of which the trapped diradicaloid structur

251 ition to a tert-butanesulfinyl aldimine, and ring closing olefin metathesis as key steps.

252 lycyclic aromatic hydrocarbons (PAHs) by the ring-closing olefin metathesis (RCM) of pendant olefins

253 thyl, alpha-alkenyl amino acids and (ii) the ring-closing olefin metathesis (RCM) of the resulting re

254 The syntheses of these macrocycles feature ring-closing olefin metathesis (RCM) reactions catalyzed

255 at C-3' and N-1' on the tricyclic core via a ring-closing olefin metathesis (RCM) strategy with the s

256 om [(ArylNCH2CH2)3N]Mo(NB(C6F5)3) with PMe3, ring-closing olefin metathesis (RCM) was employed to joi

257 t joining of the overhand knot end groups by ring-closing olefin metathesis affords a single enantiom

258 c polymer backbone using ruthenium-catalyzed ring-closing olefin metathesis to afford a molecular cha

259 the all-carbon quaternary stereocenter and a ring-closing olefin metathesis to concomitantly form the

260 The ligand strands can be cyclized by ring-closing olefin metathesis to form a molecular trefo

261 nd:metal complexes is covalently captured by ring-closing olefin metathesis to form topologically chi

262 idation, regioselective epoxide opening, and ring-closing olefin metathesis using Grubbs' catalyst as

263 on of (+/-)-1-(benzyloxy)-3-buten-2-ol and a ring-closing olefin metathesis with Grubbs' catalyst.

264 een synthesized based on macrocyclization by ring-closing olefin metathesis.

265 cked molecular architectures are produced by ring-closing olefin metathesis.

266 c2]daisy-chain dimer via ruthenium-catalyzed ring-closing olefin metathesis.

267 wed by elaboration of the C-3 side-chain and ring-closing olefin metathesis.

268 iron(II), or cobalt(II) cations, followed by ring-closing olefin metathesis.

269 bsequent covalent capture of the catenane by ring-closing olefin metathesis.

270 substituents synthesized by alkyne coupling/ring closing or palladium-catalyzed ipso-arylation chemi

271 rominated tetralone motif was generated in a ring-closing protocol.

272 of 7e (R(1) = NMe2, R(2) = H) for which the ring-closing quantum yield increased 10-fold upon switch

273 The yields of the ring closing reaction highly depend on the metal (Cu or

274 e synthesized using an oxidative Glaser-type ring closing reaction.

275 ins why additional base does not lead to the ring-closing reaction as observed with 2-chloro-5-nitrop

276 method is based on the Lewis acid-catalyzed ring-closing reaction between substituted orthoesters an

277 A succeeding methanolysis and concomitant ring-closing reaction gives the tetrazinanone.

278 easily undergoes an endocyclic, sigmatropic ring-closing reaction to form the final 2H-chromene prod

279 in which the cyclopentane ring is formed by ring closing reactions (C=C and C-C formation) and metho

280 nyltellurophene (3) were synthesized through ring closing reactions of 1,4-substituted butadiyne.

281 upling reactions, and (3) the development of ring closing reactions to form the desired macrocyclic p

282 viable catalysts for several representative ring-closing reactions to give products in good yields i

283 e transition states for the ring-opening and ring-closing reactions, and both transition states contr

284 E-selective cross-metathesis and macrocyclic ring-closing reactions, where E-butene serves as the met

285 sive in the observed outcome of irreversible ring-closing reactions.

286 e acid-catalyzed or spontaneous ring-opening-ring-closing rearrangement to yield fused polyheterocycl

287 ynthesis route featuring an iterative double ring-closing reductive amination reaction.

288 A tandem metathesis sequence involving ring closing-ring opening-ring closing and cross metathe

289 ze, with results indicating that a four-unit ring-closing segment was appropriate.

290 l)methyl)pent-4-enylamine (12) as one of two ring-closing segments.

291 provides a viable alternative route for the ring-closing step in the mechanism of benzannulation; (c

292 Yields for the ring-closing step were generally high, ranging from 51%

293 result from two consecutive ring-opening and ring-closing steps.

294 on, in cis-stilbene it leads to an ultrafast ring-closing to form 4a,4b-dihydrophenanthrene.

295 , but support instead hydrogen-bond assisted ring-closing to prodrugs.

296 ated to be 6.9 from the pH dependence of its ring-closing to the pyrimidopurinone derivative 1.

297 s proposed based on relative energies of the ring-closing transition structures.

298 on state) and symmetry-forbidden conrotatory ring closing (whose transition state is nearby) can be i

299 ive nucleophilic addition and intramolecular ring-closing with dihalo electrophiles.

300 e and the first one ever of a macrolide by a ring-closing Wittig olefination of a stabilized phosphor