ライフサイエンスコーパス: risk

1 le age may be positively associated with ALS risk.

2 etermine the association of migration on CVD risk.

3 idal behaviours converging to this increased risk.

4 .20-27.83) scales in association with asthma risk.

5 ociated with insulin resistance and diabetes risk.

6 ngth (GS) is associated with lower mortality risk.

7 ved symptom control and reduced exacerbation risk.

8 ic testing for screening individuals at high risk.

9 and therefore pose a potential public health risk.

10 direct conjugation, a previously overlooked risk.

11 ding the donor pool without additional donor risks.

12 ortality in the randomized studies (relative risk, 0.93; 95% CI, 0.77-1.13; I = 0.0%) or observationa

13 campaign in the SLSJ region (relative B-IMD risk: 0.22; P = .04).

14 bivalirudin (7 [2.1%] vs 7 [0.7%]; relative risk, 2.87; 95% CI, 1.01-8.17; P = .04) but not with hep

15 igh chemotherapy-induced nausea and vomiting risk (32.4% [n = 106795]).

16 Comorbidity-based risk adjustment should be strongly considered by the CDC

17 After risk adjustment, transfusion and sepsis were associated

18 that individuals with more diabetes genetic risk alleles have a higher risk of developing DR.

19 bly, within and across independent loci, T2D risk alleles that overlap with RFX footprints uniformly

20 ants of sex differences in rehospitalization risk among conditions.

21 to be associated with a 38% excess fracture risk among T2DM patients in the early stages of the dise

22 ngs suggest that lithium may reduce melanoma risk and associated mortality.

23 es as a major factor in determining migraine risk and characteristics, which accounts for sex differe

24 Our aim was to examine the risk and determinants of HCC in patients cured with DAA.

25 tool may allow for estimation of circulatory risk and improve the triage of survivors of cardiac arre

26 anding of disease mechanisms contributing to risk and resilience.

27 and inappropriate inflammation increase the risk and severity of mood disorders; however, only recen

28 patients are at high or prohibitive surgical risk and, therefore, an open surgical procedure may not

29 port conducting randomized trials to explore risks and benefits of OAT resumption after ICH.

30 ed of analyses to identify and prevent spill risks and mitigate potential environmental damage.

31 valence of Lynch syndrome, associated cancer risks and pathogenicity of several variants in the Icela

32 imes during the life course, target multiple risks, and build on existing delivery platforms for feas

33 Given that only 17.9% of these high-risk areas are formally protected and only 8.9% have str

34 interrupting polio transmission in the high-risk areas.

35 -e4 dose and age both consistently increased risk, as did lower education, subjective memory concerns

36 these disparities in gastrointestinal cancer risk, as well as approaches that apply precision medicin

37 d by children and to perform a more accurate risk assessment of children's exposure to mycotoxins mix

38 enotoxicants and can serve as biomarkers for risk assessment.

39 for circulatory-disease mortality radiation risk at doses <0.5 Gy.

40 plays a vital role in their host seeking and risk aversion processes.

41 core, the MEESSI-AHF (Multiple Estimation of risk based on the Emergency department Spanish Score In

42 eduction) and harms (e.g., overdiagnosis) of risk-based screening strategies using these models.

43 merging issues, including new populations at risk because of travel or relocation, occupation, or imm

44 This study used state-level Youth Risk Behavior Surveillance System (YRBSS) data from Janu

45 Little progress has been made searching for risk-causative variants in candidate genes; therefore, m

46 is evaluated survival experience between the risk classes.

47 s reduced on average, but bias in the energy risk coefficient was unchanged.

48 increased PD-1 and PD-L2 expression in high-risk cSCC.

49 therapy was two (2-5), 38 patients had high-risk cytogenetics, 17 were unresponsive to all previous

50 ng system score, increased incidence of high-risk cytogenetics, and higher revised international stag

51 Compared with the standard risk deceased organ donor, the PHS donor was younger, ma

52 ure or disease recurrence, or died (absolute risk difference -1.4%, 95% CI -7.0 to 4.3; hazard ratio

53 mplicates inequities and extrinsic mortality risk - documenting more future-oriented thinking among l

54 ctions on both the additive (relative excess risk due to interaction, 5.06; 95% CI, 1.33-11.04) and m

55 ns have been raised about potential fracture risk, especially at the hip, spine and wrist.

56 eveloped a predictive model based on genetic risk, established clinical risk factors, and diagnostic

57 Risk estimates associated with current or recent use of

58 Median risk estimates from Monte Carlo simulations ranged from

59 vels (extreme 75th percentile for cumulative risk exposure between ages 6 and 24 years) of systolic B

60 in combination with an additional metabolic risk factor (hypertension, dyslipidemia, or diabetes) (a

61 t iron deficiency is a common and consistent risk factor for anemia globally and that anemia control

62 soriasis is now recognized as an independent risk factor for coronary heart disease and cardiovascula

63 epressive disorder (MDD) in the elderly is a risk factor for dementia, but the precise biological bas

64 tudies have shown that sarcopenia is a novel risk factor for developing NAFLD.

65 A is a hepatic secretory protein and a novel risk factor for diabetes.

66 s, the importance of biliary strictures as a risk factor for graft failure, and does not validate oth

67 Antibiotic therapy is a major risk factor for the development of diarrhea and colitis

68 Finally, SNP rs11265269 was identified as a risk factor of BPD (OR 1.8, p = 5.3 x 10(-5)), independe

69 ive learning (-0.140 standard deviations per risk factor, p < 0.0001) and remained significant after

70 vernutrition, a confirmed independent cancer risk factor, remain poorly understood.

71 lic fatty liver disease) or is a significant risk factor, such as reflux esophagitis and gallstones.

72 turated fat and cholesterol were significant risk factors across ethnic/racial populations (p-trends

73 sence of hypoxia are the three main clinical risk factors and are more predictive of poor outcomes th

74 Nonlaboratory-based risk factors and lipids measured in adolescence independ

75 g the functional validation of known genetic risk factors and potentially pathogenic alleles identifi

76 r nonurgent and urgent ocular conditions and risk factors associated with ED use for nonurgent and ur

77 between decreasing number of cardiovascular risk factors at target and major adverse cardiovascular

78 derstanding of pathophysiology and important risk factors both for the development of ARDS and for im

79 Only 4.4% had all 5 risk factors controlled and 42.4% had >/=3 risk factors

80 5 risk factors controlled and 42.4% had >/=3 risk factors controlled.

81 ent identification of immune-related genetic risk factors for AD, including coding variants in the ge

82 neuronal sodium channel NaV1.2 are important risk factors for autism spectrum disorder (ASD), develop

83 To identify incidence of and risk factors for calcifications of intraocular lenses (I

84 These traits are risk factors for cardiovascular disease even below the d

85 d a prospective case-control study to assess risk factors for carriage of MCRPEC in rectal swabs from

86 holangitis, two cholangiopathies regarded as risk factors for CCA.

87 We examined potential risk factors for changes in objectively assessed sleep d

88 opportunistic infections; and lifestyle are risk factors for HIV-associated atherosclerosis.

89 r graft failure, and does not validate other risk factors for IC found in smaller studies.

90 Future studies should explore risk factors for increased AL in Chinese Americans and p

91 Among patients without known risk factors for iron deficiency, gastric acid inhibitor

92 Obesity and type 2 diabetes are significant risk factors for malignancies, being associated with chr

93 MRD) and genetic abnormalities are important risk factors for outcome in acute lymphoblastic leukemia

94 Risk factors for RVAD implantation and the combined end

95 CAC might be considered in individuals with risk factors in early adulthood to inform discussions ab

96 prised entirely of adult nonlaboratory-based risk factors is equivalent to an approach that additiona

97 in ADHD is independent of, or explained by, risk factors may provide etiological insight.

98 nherited forms of early-onset AD and genetic risk factors that provide insights about molecular patho

99 ntribution of social, biologic, and clinical risk factors to RSV mortality in low-income regions is u

100 in) use and patient mortality, adjusting for risk factors typically associated with poor treatment ou

101 Thirteen independent risk factors were identified in the derivation cohort an

102 based on genetic risk, established clinical risk factors, and diagnostic biomarkers.

103 The number of early life risk factors, including high levels (extreme 75th percen

104 associated with conventional cardiovascular risk factors, stroke, and chronic kidney disease.

105 (-5)), independently of the robust antenatal risk factors.

106 ificant after adjustment for contemporaneous risk factors.

107 regarding their oral health status and OSCC risk factors.

108 y (MD) is one of the strongest breast cancer risk factors.

109 ct to chlamydia and gonorrhea prevalence and risk factors.

110 five filter for oral bioavailability, ADMET risk filter for drug like features, and synthetic access

111 centrations of MMP-8 are associated with the risk for and outcome of cardiovascular diseases (CVDs).

112 The risk for any adverse birth outcome was lower among infan

113 result in more accurate reclassification of risk for ASCVD events among these individuals.

114 milar mechanisms contribute to the increased risk for calcium oxalate stone formation observed in pat

115 NOD2 with current smoking in relation to the risk for CD (frameshift variant fs1007insC; rs5743293).

116 gnosis, especially with regard to arrhythmia risk for certain subtypes.

117 prenatal stress is reported to increase the risk for children to develop autism spectrum disorder (A

118 king </=1 glass/week had significantly lower risk for clinical AL progression than non-drinkers (RR =

119 rphology, and increasing size with increased risk for covert malignancy.

120 ent cystic fibrosis (PI-CF) are at increased risk for developing diabetes.

121 The population at risk for HBV reactivation includes those who either curr

122 mans revealed that the effects of smoking on risk for IBD depend on genetic variants.

123 Obesity increases risk for liver toxicity by the anti-leukemic agent aspar

124 Findings point to neural signatures of risk for maintaining PTSD symptoms after trauma exposure

125 tinued, the targeting of settlements at high risk for polio transmission with routine immunization (R

126 though SRL + MPA was associated with a lower risk for posttransplant malignancy in kidney allograft r

127 value for identifying people at the highest risk for progressing to active tuberculosis (TB) and hav

128 CT findings were investigated to predict the risk for PTB.

129 up of patients with breast cancer who are at risk for receiving nonguideline breast cancer treatment,

130 is associated with a 5-fold increase in the risk for stroke.

131 reated with cranial radiation therapy are at risk for subsequent CNS tumors.

132 cus genetic variants are associated with the risk for systemic lupus erythematosus (SLE); however, it

133 to ruminant farming systems, and associated risks for food security posed by rumen fluke infection,

134 fined living bacteria entails uncontrollable risks for infectious and metabolic or malignant diseases

135 PA, SRL regimens were associated with higher risks for patient death and graft loss, although SRL + M

136 ranscriptional regulation by the psychiatric risk gene TCF4 enhances NMDA receptor-dependent early ne

137 iated muscle and may also be a schizophrenia risk gene.

138 ulosis transmission must be targeted to high-risk groups and settings.

139 ) to classify patients into low-risk or high-risk groups based on the 52-gene signature.

140 Participants' CVD and CKD risk groups had multiplicative predictive effects, with

141 risk of death and return on investment, high-risk groups of the three age group subpopulations can be

142 get for preventing colorectal cancer in high-risk groups such as those with familial adenomatosis pol

143 nterventions are cost saving for all age and risk groups.

144 y and disease control in the setting of high risk, heavily pretreated patients.

145 1.0-5.8; P = .047), and exposure to all 3 at-risk housing types (adobe, mud, and thatched roof) (aOR

146 , epigenetic downregulation of HLA-E by high-risk HPV E7 may contribute to virus-induced immune evasi

147 with HIV on ART had lower prevalence of high-risk HPV than did those not on ART (adjusted odds ratio

148 onitis (7.9% v 3.5%, P = .039) and a reduced risk in adjusted analyses (odds ratio, 0.41; 95% CI, 0.1

149 association of LC n-3 PUFAs with nonfatal MI risk in Costa Rican Hispanics.We analyzed cross-sectiona

150 biomarker of cerebral and systemic vascular risk in patients with OSA requiring further comprehensiv

151 eatment for osteoporosis and reduce fracture risk in postmenopausal women by up to 50%.

152 CC genotype had significantly lower relapse risk in the GO arm than in the No-GO arm (26% v 49%; P <

153 bolomic signatures of cardiovascular disease risk (including branched-chain amino acids, select unsat

154 7; p=0.024) for a lag of 2 wk; the estimated risk increased successively beyond this SST threshold.

155 Pancreas donor risk index (PDRI) was highest in high volume centers: 1.

156 t match quality was estimated from the donor risk index.

157 Intermediate-risk patients (2 risk indicators; n = 5,292; 30%) had a 2.2% (95% confide

158 These results translate risk into potential mechanisms of pathogenesis.

159 ted people among whom cardiovascular disease risk is elevated and liver disease is common.

160 data indicate that stress-associated suicide risk is elevated in carriers of the GABRA6 rs3219151 T a

161 tool for accurate estimation of AAA rupture risk is still not available.

162 r tortuosity increased significantly in high-risk lesions, whereas diameter decreased significantly i

163 Men with low-risk, localised prostate cancer (Gleason pattern 3) who

164 udies to date have not identified any robust risk loci for diabetic retinopathy (DR).

165 l practice appointments might thus provide a risk marker for vulnerability and poor health outcomes.

166 ne methods to populations with the increased risk, may reduce the observed disparities for digestive

167 ible mechanisms, provide recommendations for risk mitigation, address the advantages and disadvantage

168 th thoughtful study design to ensure maximal risk mitigation.

169 ight extend survival of patients with higher-risk myelofibrosis.

170 it of anticoagulation outweighs the bleeding risk (net clinical benefit) has been shown to be approxi

171 ound between TRT and overall prostate cancer risk (odds ratio [OR], 1.03; 95% CI, 0.90 to 1.17).

172 d associations between male circumcision and risk of acquisition of HIV and sexually transmitted infe

173 r blockers might be associated with a lesser risk of acute pancreatitis, and that the protective asso

174 Longstanding diabetes might increase the risk of acute rejections.

175 lementation leads to a large increase in the risk of advanced AMD in some genotype subgroups.

176 t patients; however, some GBCAs have a small risk of adverse effects, including nephrogenic systemic

177 The prevalence and relative risk of AF in relatives of patients with AF, as well as

178 Two questions that presented the risk of AK as not progressing to cancer had the lowest p

179 New onset AF was associated with increased risk of all outcomes.

180 Risk of all-cause and cause-specific mortality was asses

181 IDs, was associated with a further increased risk of AMI.

182 .001) but was not associated with increased risk of any of the other secondary outcomes.

183 Polygenic risk of autism and ADHD is associated with number of chi

184 he enhanced host catabolic activity with the risk of being eliminated by the cell's cytosolic immune

185 full-text screenings, data extractions, and risk of bias (ROB) assessments.

186 Risk of bias and heterogeneity were assessed.

187 Risk of bias was assessed using criteria from the Cochra

188 nger age and risk of definitive treatment or risk of biochemical recurrence after delayed RP.

189 GPI use was associated with increased risk of bleeding in both treatment arms.

190 e prospective cohort study, we evaluated the risk of breast cancer in relation to indoor heating and

191 mellitus and prediabetes and those with high risk of cardiovascular disease, stroke, heart failure, a

192 hanges in dietary inflammatory potential and risk of colorectal cancer (CRC) in 87,042 postmenopausal

193 LDL-C >/=190 mg/dL, pravastatin reduced the risk of coronary heart disease by 27% (P=0.033) and majo

194 .037) during the initial trial phase and the risk of coronary heart disease death, cardiovascular dea

195 6, P < .0001) were associated with increased risk of DCGF; however, later-onset dysfunction requiring

196 Based on risk of death and return on investment, high-risk groups

197 We determined the age- and sex-adjusted risk of death for each type of synucleinopathy, the medi

198 status, and AF treatment, as well as 2-year risk of death, hospitalization, thromboembolic events, h

199 ntifies patients with very severe AS at high risk of death.

200 nts with cirrhosis, statin use decreased the risk of decompensation, mortality, and HCC in a dose-dep

201 An increased risk of definite AST was associated with shorter than wi

202 nificant association between younger age and risk of definitive treatment or risk of biochemical recu

203 WDTC treated with RAI had an increased early risk of developing AML and CML but no other hematologic

204 diabetes genetic risk alleles have a higher risk of developing DR.

205 ons in Sox4 are associated with an increased risk of developing type 2 diabetes.

206 owever, extraction was associated with lower risk of device infections at 5 years.

207 center volumes were associated with a higher risk of early pancreas graft failure at 3 months.

208 ry months 13-24 as the reference period, the risk of ED visit or hospitalization in the 0- to 12-mont

209 Risk of fatal CHD was similarly higher for sepsis than n

210 A number of factors can increase the risk of FGR, one of which is poor maternal diet.

211 ver health may be important for reducing the risk of future CHF events, particularly among HIV and he

212 were screened and 32 518 (34%) were at high risk of having COPD.

213 ity index and DNAemia may help to assess the risk of HCMV fetal transmission.

214 1982-2012), there was no association between risk of hearing loss and hair color (for black hair vs.

215 ndex (BMI) are independently associated with risk of heart failure (HF).

216 Although the risk of HF remained elevated among those with cAVB in th

217 The only factor associated with increased risk of IC within 6 months was Roux-en-Y hepaticojejunos

218 of these 9.5 million (69.3%) pregnancies at risk of infection (and 53.4% [16.3 million/30.6 million]

219 acute colitis was associated with decreased risk of IRA failure (HR=0.6, 95% CI 0.4-0.97).

220 was associated with an increased subsequent risk of iron deficiency.

221 of malaria infection during pregnancy on the risk of low birthweight (LBW; <2,500 g) may depend upon

222 gy for the management of individuals at high risk of melanoma.

223 r pollution is associated with the increased risk of metabolic syndrome.

224 eated with a partial nephrectomy had reduced risk of mortality (hazard ratio, 0.55; 95% CI, 0.49 to 0

225 GBS disease in NE and significant increased risk of mortality provides evidence that GBS infection c

226 bined with sarcopenia presented the greatest risk of mortality.

227 Patients with psoriasis have an increased risk of myocardial infarction, and psoriasis is now reco

228 hould be close monitoring, for the increased risk of neurocognitive events in the ongoing outcome stu

229 of drugs with anti-inflammatory effects and risk of new-onset depression and anxiety among adult pat

230 without PBC is increased irrespective of the risk of PBC development.

231 patients with infection who are at elevated risk of poor outcomes.

232 Our objective was to assess the risk of posttransplant cancer in this patient group.

233 Based on multivariable analysis, the risk of primary nonadherence was 16 percentage points lo

234 benefit patients with breast cancer at high risk of recurrence.

235 We identified low but escalating risk of severe M. chimaera infection associated with hea

236 estricted to prophylaxis in neonates at high risk of severe RSV disease.

237 ith carotid atherosclerosis, as well as with risk of stroke in this population.

238 rtality </=5.7%, those with a SPRM-predicted risk of sudden death below the median had no reduction i

239 y among female patients, to help monitor for risk of worsening fibrosis during MTX therapy.

240 re pooled, they were associated with reduced risks of >/=30% decline in eGFR (hazard ratio [HR]: 0.77

241 ers, current smokers had significantly lower risks of BCC (hazard ratio = 0.6; 95% confidence interva

242 Risks of disease-related outcomes and 5-year recurrence-

243 the predictive models, capturing the future risks of GDM in the temporally aggregated EHRs.

244 Comparably lower risks of intraocular bleeding with novel oral anticoagul

245 streptococcal throat infection had elevated risks of mental disorders, particularly OCD and tic diso

246 interval = 0.4-0.9) but significantly higher risks of SCC (hazard ratio = 2.3; 95% confidence interva

247 ng status, educate patients regarding ocular risks of smoking, and discuss with patients smoking cess

248 To assess patterns of use and relative risks of systemic agents for moderate to severe psoriasi

249 sent, therapies are not guided by individual risk or disease biology.

250 notypes (SAMS) to classify patients into low-risk or high-risk groups based on the 52-gene signature.

251 are Act regulations that carry a significant risk or specific threat to animal welfare.

252 ion at the WNT16 and RSPO3 loci and fracture risk (P = 0.004 and 4.0 x 10-4, respectively).

253 Intermediate-risk patients (2 risk indicators; n = 5,292; 30%) had a

254 s used to discriminate between high- and low-risk patients and to select the most important prognosti

255 In very high-risk patients receiving combination haploidentical singl

256 cal, and imaging biomarkers to identify high-risk patients, and clinical trials evaluating novel ther

257 k (score >/=25), but not in those with lower risk profiles (pinteraction=0.007), and exerted a signif

258 Diagnosis with favorable-risk prostate cancer.

259 define serum inflammatory and cardiovascular risk proteins, we used an OLINK high-throughput proteomi

260 , compared with LMWH (16%; ratio of averaged risk [RAR]: 3.2; 95% confidence interval [CI]: 1.5 to 7.

261 s rate decreased from 0.24 to 0.10 (adjusted risk ratio 0.44, 95% confidence interval [CI] 0.26-0.75)

262 a trend toward a reduction in constipation (risk ratio, 0.50 [95% CI, 0.25-1.01]; p = 0.05; low-qual

263 no reduction in tolerance of enteral feeds (risk ratio, 0.94 [95% CI, 0.62-1.42]; p = 0.77; low-qual

264 ad a significant positive effect on NP role (risk ratio=2.33; 95% CI: 1.06-5.13); with a one unit inc

265 ear regression was used to estimate adjusted risk ratios (aRRs) and 95% CIs, after adjusting for mate

266 confidence interval: -0.3% to 4.6%) absolute risk reduction.

267 -driven approach to early intervention in at-risk relatives.

268 inking >1 glass/day had significantly higher risk (RR = 1.50; 95% CI: 1.08 to 1.99).

269 blonde hair, multivariable-adjusted relative risk (RR) = 0.99, 95% confidence interval (CI): 0.90, 1.

270 ude determining the incidence rate, relative risk (RR), and survival probability with respect to NLP

271 hreshold of 16 degrees C revealed a relative risk (RR)=1.14 (95% CI: 1.02, 1.27; p=0.024) for a lag o

272 evious estimates of the utility of polygenic risk score analysis for the prediction of Alzheimer dise

273 ive effect on FEV1/FVC levels in the genetic risk score analysis; were associated with gene expressio

274 e study population identified that the Sokal risk score and duration of IM treatment were significant

275 antly increased bleeding in patients at high risk (score >/=25), but not in those with lower risk pro

276 We examined associations between AF genetic risk scores and ischemic stroke in a separate study of 5

277 w Framingham 10-year coronary artery disease risk scores with an echocardiogram, exercise stress test

278 of lactate levels may have utility in early risk stratification of pediatric sepsis.

279 e, provide a framework for tumor staging and risk stratification, and select candidates for adjuvant

280 alue for patients in several recognized high-risk subgroups.

281 individuals exerted an overriding effect on risk-taking by the entire group, for reasons independent

282 showed weaker functional connectivity in at-risk than control participants (p < .006).

283 ulating C15:0/C17:0 fatty acids with disease risk, therefore, their origin needs to be determined to

284 nclude the lack of identification of optimal risk thresholds, as this requires additional information

285 e saddleback tortoises occur increases their risk to fall on their back while walking.

286 mild range as they may interact with genetic risk to produce negative long-term health consequences s

287 l novel prognostic biomarker to predict high-risk tumors before they metastasize.

288 th shearwaters having the highest extinction risk under current mortality rates.

289 which could be attributed to the APOL1 renal risk variants.

290 46% of mortality risk was explained by multivariable modelling with these

291 Composite maternal risk was lowest with VKA (5%), compared with LMWH (16%;

292 redicted bias in estimated nutrient relative risks was reduced on average, but bias in the energy ris

293 agnosed Respiratory Disease and Exacerbation Risk), was used to assess exposure, breathing problems,

294 sociation between LC n-3 PUFA intake and CVD risk.We determined whether a PCSK9 variant (rs11206510),

295 The predicted prestage 1 and 2 mortality risks were calculated for each patient.

296 l exposure (PE) leads to increased addiction risk which could be mediated by enhanced excitatory syna

297 n foraging was a poor predictor of pesticide risk, which was driven primarily by insecticides.

298 ) has been associated with increased obesity risk, while emotional undereating (EUE) may be protectiv

299 76 years of age with increased breast cancer risk who underwent CE spectral mammography and MR imagin

300 The risk with this action, however, is seizure recurrence.