ライフサイエンスコーパス: risk allele

1 .04] per 1000euro/mo increase and additional risk allele).

2 ive model (high-risk genotype defined by two risk alleles).

3 y magnify the diabetes risk conferred by the risk allele.

4 gnificantly lower than in cells carrying the risk allele.

5 expression in comparison to that of the non-risk allele.

6 ell lines from healthy controls carrying the risk allele.

7 ically reduced enhancer activity with the AF risk allele.

8 gous for the nonrisk allele, but not for the risk allele.

9 o understand the functional impact of the at-risk allele.

10 rrelated with the level of expression of the risk allele.

11 for incident coronary events per additional risk allele.

12 zophrenic patients carrying the rs6039769 at-risk allele.

13 ls exclusively from subjects carrying asthma-risk alleles.

14 n, especially in patients homozygous for the risk alleles.

15 a developing than participants with no TMCO1 risk alleles.

16 nscription factor-binding disruption by ADHD risk alleles.

17 ge, or a decade older, without APOE epsilon4 risk alleles.

18 omains were associated with established LOAD risk alleles.

19 hy and 2% of population controls carried two risk alleles.

20 rican Americans with either one or two APOL1 risk alleles.

21 f the odds ratio multiplied by the number of risk alleles.

22 resilience in carriers of disease-associated risk alleles.

23 nificantly lower in kidneys of subjects with risk alleles.

24 diameter (difference per additional average risk allele 0.09 mm [95% CI: 0.05, 0.13]).

25 eta=-0.11 micromol/L per genetic risk scores risk allele; 95% confidence interval, -0.188 to -0.033;

26 Homozygotes for the PSC disease risk allele (AA) showed significantly lower CD28 mRNA ex

27 We propose that the cancer risk alleles act to increase MAP3K1 expression in vivo a

28 This result, taken with other identified risk alleles, allows precise genetic counseling for the

29 Individuals carrying the rs7090445-C risk allele also have reduced ARID5B expression.

30 t of the association between the rs9277378*A risk allele and NKTCL susceptibility (OR 2.38, p value f

31 For patients with 2 CFH risk alleles and 1 or 2 ARMS2 risk alleles, no treatment

32 tween an individual's polygenic score for PD risk alleles and disease age at onset.

33 ritable, polygenic traits, which often share risk alleles and for which nonrandom mating has been sug

34 Patients with 2 CFH risk alleles and no ARMS2 risk alleles progressed more w

35 For patients with 0 or 1 CFH risk alleles and no ARMS2 risk alleles, neither zinc-con

36 , to our knowledge, to identify specific CAD risk alleles and potential genetic factors contributing

37 observations from genetically defined autism risk alleles and rodent model, these findings suggest a

38 Apolipoprotein L-1 (APOL1) high-risk alleles and the glutathione-S-transferase-mu1 (GSTM

39 gration does not explain the distribution of risk alleles and the worldwide pattern of allele frequen

40 M transcript produced primarily by the "LOAD-risk" allele and a shorter CD33m isoform lacking the sia

41 y differences in response inhibition between risk-allele and non-risk allele carriers in children suf

42 r was there a copy number difference between risk-allele and only-ancestral allele carriers.

43 .02] per 1000euro/mo increase and additional risk allele) and for incident coronary events (hazard ra

44 tations can be expected to share some common risk alleles, and therefore pathophysiological mechanism

45 We demonstrated that type 2 diabetes risk alleles are associated with decreased ADCY5 express

46 These findings indicate that APOL1 risk alleles are associated with exaggerated age-related

47 APOL1 risk alleles are associated with higher SBP and earlier

48 Risk alleles are associated with reduced expression of t

49 py-naive South-African blacks with two APOL1 risk alleles are at very high risk for developing HIV-as

50 for diseases of complex inheritance because risk alleles are few relative to the vast set of benign

51 rect evidence demonstrating that these APOL1 risk alleles are pathogenic is still lacking because the

52 AD and MD and to determine whether polygenic risk alleles are shared with neuropsychiatric traits or

53 The previously identified asthma risk alleles are the ones susceptible to environmental i

54 pic overlap among common diseases that share risk alleles, as well as between Mendelian diseases and

55 rs662463 is a cis-eQTL for CDKN2B, with the risk allele associated with lower expression, and sugges

56 tive trait locus (eQTL) for IFITM3, with the risk allele associated with lower mRNA expression.

57 s with IBD, particularly in those with CARD9 risk alleles associated with IBD.

58 ociated loci, TSPAN15 and SLC44A2, with lead risk alleles associated with odds ratio for disease of 1

59 The G-risk allele, associated with increased CDCA7L expression

60 interest, we hypothesized that summation of risk-allele-associated gene expression, namely a transcr

61 The Alzheimer disease (AD) APOEepsilon4 risk allele associates with an earlier age at onset and

62 This study assessed the APOL1 risk alleles' association with blood pressure traits in

63 APOL1 risk alleles' association with blood pressure-related tr

64 ological treatment outcomes as well as their risk allele associations.

65 We conclude that the RCC risk allele at 12p12.1 maps to rs7132434, a functional v

66 determined that the sequence containing the risk allele at rs17319721 is a transcription factor 7-li

67 ha (TFAP2a), which bound robustly to the non-risk allele at rs2595104, but not to the risk allele, in

68 The risk allele at rs56048322 affects splicing of PTPN22, re

69 The diabetes risk allele at TCF7L2 was associated with a stronger eff

70 We identified 138 individuals with risk alleles at 15 STR disease loci.

71 lder siblings among carriers of known asthma risk alleles at 17q21 (e.g., rs8076131) (adjusted odds r

72 Rare homozygous carriers of the risk alleles at both loci are predicted to have 3.3-3.7

73 Finally, we show that risk alleles at rs11203203 and rs80054410, two T1D-assoc

74 Children with risk alleles at the 17q21 genetic locus who wheeze durin

75 etween a genetic risk score composed of high-risk alleles at the 49 single nucleotide polymorphisms a

76 A high burden of disease risk alleles at these loci was associated with earlier a

77 asing) associations among 11 type 2 diabetes risk alleles (at P < 0.05).

78 Per additional risk allele, body mass index increased 0.04 Standard Dev

79 podocyte-specific expression of either APOL1 risk allele, but not of the G0 allele, develop functiona

80 be mediated by a small number of shared high-risk alleles, but rather has a complex genetic architect

81 ve APOL1HDL from donors with no or two APOL1 risk alleles by size-exclusion chromatography and analys

82 Our results suggest that the T2DM risk allele C is associated with higher islet zinc level

83 Risk alleles can individually be common or rare, and can

84 CTCF binding in promoter-binding assays, and risk allele carriage diminished transcriptional correlat

85 esponse to conditioned reward stimuli in the risk allele carriers compared with major allele carriers

86 pendent subject groups demonstrated that T2D-risk allele carriers displayed reduced levels of STARD10

87 ponse inhibition between risk-allele and non-risk allele carriers in children suffering from ADHD and

88 to impulse control and taste responsiveness, risk allele carriers of FTO exhibit dose-dependent incre

89 Our results show that obesity-related risk allele carriers of FTO gene show dose-dependent inc

90 using functional magnetic resonance imaging, risk allele carriers of rs17689918 showed aberrant diffe

91 Healthy risk allele carriers showed a significant deficit of the

92 Furthermore, increased T2D risk in MTNR1B risk allele carriers was more pronounced in early risers

93 eta1 upregulation in the vasculature of 9p21 risk allele carriers.

94 striatum was significantly diminished in the risk allele carriers.

95 nhibitor sildenafil compared with homozygous risk allele carriers.

96 Risk-allele carriers showed a changed NoGo anteriorizati

97 proband and the relatives of the identified risk-allele carriers.

98 ression of the human APOL1 G1 and G2 disease risk alleles caused near-complete lethality in D. melano

99 lls from healthy subjects homozygous for the risk allele (CC) compared with memory CD4(+) T cells bea

100 pattern of differential injury by the APOL1 risk alleles compared with the nonrisk alleles across ev

101 At rs79965208, the A risk allele connected adjacent GGAA repeats by convertin

102 gether, these data suggest that rs11708067-A risk allele contributes to type 2 diabetes by disrupting

103 The UBE2L3 risk allele correlated with increased circulating plasma

104 iple genes in the vicinity of any single CKD risk allele correlated with renal function, potentially

105 nucleotide polymorphisms on stroke risk per risk allele, corresponding to a one allele increase in t

106 The risk allele count (genetic load) exhibits an acceleratin

107 (PRS) for cases and controls by summing the risk allele counts for the variants weighted by their na

108 o a decreased TREM1/TREM2 ratio with a TREM1 risk allele, decreased TREM2 expression with CD33 suppre

109 In conclusion, GSTM1 null and APOL1 high-risk alleles deleteriously affect CKD progression among

110 ween different populations revealed opposing risk alleles, different gender effects, and response to

111 Furthermore, the risk allele disrupts a CpG site that undergoes different

112 The rs2271338 risk allele disrupts binding of YY1 transcription factor

113 se the majority of individuals who carry HLA risk alleles do not develop hypersensitivity, other para

114 aled an association between Brugada syndrome risk allele dosage and HEY2 expression (beta=+0.159; P=0

115 e, as well as a positive association between risk-allele dosage and symptom severity, whereas neuroty

116 ward circuit as a function of increased OXTR risk-allele dosage, as well as a positive association be

117 ocusing on how connectivity varies with OXTR risk-allele dosage.

118 In addition, the putative risk alleles, DRB1*15:01 and DQB1*06:02, are associated

119 for by numerous factors, including multiple risk alleles, epistasis, and epigenetic effects such as

120 usion, abstinent smokers with the withdrawal risk allele experienced greater alleviation of their urg

121 wide association studies, although the known risk alleles explain only a small proportion of the heri

122 e secondary structure of the paRNA, with the risk allele facilitating the assembly of the microRNA-gu

123 We investigated one in detail, a risk allele for ankylosing spondylitis, and provide dire

124 ards longer lifespan in individuals with the risk allele for depressive symptoms in men (odds ratio (

125 owed an interaction only with the GRSWC (per risk allele for each soft drink serving per day: -0.06 k

126 ns only with the GRSBMI and GRSComplete [per risk allele for each soft drink serving per day: 0.05 cm

127 ntly lower with higher copy number of the RA risk allele for rs17611, suggesting increased turnover o

128 Carriers of the risk allele for rs74315329 were identified using whole-g

129 nd climatic variables to the distribution of risk alleles for 21 diseases.

130 Children with risk alleles for both genes were at higher risk for EoE

131 examined control and T1D subjects with these risk alleles for CD4 T-cell responses to the same natura

132 Mean age decreased with the number of risk alleles for CFH (P < .001), ARMS2 (P < .001), and C

133 We sought risk alleles for clozapine-associated neutropenia in a s

134 There is growing evidence of shared risk alleles for complex traits (pleiotropy), including

135 rosis (FAM13A and DSP) but that had opposite risk alleles for COPD.

136 for each individual by summing the number of risk alleles for each SNP weighted by the respective eff

137 for each individual by summing the number of risk alleles for each SNP weighted by the respective eff

138 he genetic risk score representing all known risk alleles for inflammatory bowel disease showed stron

139 ormed to compare the 2 groups and identified risk alleles for IVIG resistance.

140 al specific variants as primary contributory risk alleles for nonsyndromic clefting in humans.

141 ate experimental proof of causality of these risk alleles for renal disease.

142 Numerous risk alleles for systemic lupus erythematosus (SLE) have

143 those with deficient vitamin D status and 2 risk alleles for the CFH and CFI genotypes, suggesting a

144 results, nor did evaluation of the number of risk alleles formed by the two SNPs.

145 Furthermore, a comparison of risk allele frequencies and genetic risk scores suggeste

146 However, higher risk allele frequencies and population-attributable risk

147 4, between the genes LINC01142 and METTL11B (risk allele frequency = 8.1%; odds ratio [OR]: 1.26; p =

148 The overall risk allele frequency for these SNPs ranged from 12% to

149 1.18) and a P-value of 4.63 x 10 (-) (8) The risk allele frequency for this SNP is zero in European-a

150 Risk allele frequency in whites (0.43) was greater than

151 ive disease model with 100% penetrance and a risk allele frequency of 5%.

152 cluded an association between the rs2007044 (risk allele G) within CACNA1C and poorer working memory

153 0; P = 0.0005) but not subjects carrying the risk allele (G) (P = 0.76).

154 ld type allele (G0) or the predominant APOL1 risk allele (G1) in different tissues.

155 We could demonstrate that the minor risk allele goes along with the increased expression of

156 Carriers of the risk allele had reduced numbers of CD8(+) T cells in the

157 , non-Hispanic white participants with TMCO1 risk alleles had a 12% higher cumulative frequency of gl

158 In conclusion, blacks with two APOL1 risk alleles had the highest risk for albuminuria and eG

159 that individuals with more diabetes genetic risk alleles have a higher risk of developing DR.

160 Although several at-risk alleles have been identified, they do not completel

161 Such autoimmune risk alleles have recurrently evolved at the DANGEROUS M

162 Among new and previously identified class II risk alleles (HLA-DRB1*15:01, HLA-DRB1*13:03, HLA-DRB1*0

163 The risk alleles impair glucose-induced insulin secretion an

164 entify a common TBX6 haplotype as the second risk allele in all 17 carriers of TBX6 null mutations (P

165 expression being slightly biased toward the risk allele in heterozygotes.

166 s2595104 region and editing of the rs2595104 risk allele in human stem-cell-derived cardiomyocytes re

167 ect -1.24 years of maternal life per imputed risk allele in parent; sex difference, P=0.011), and a l

168 earlier for homozygous carriers of the A69S risk allele in the age-related maculopathy susceptibilit

169 r transplant and the presence of the SHROOM3 risk allele in the donor correlated with increased allog

170 A functional risk allele in the MET promoter, enriched in subgroups o

171 In addition to known risk alleles in 349 brains (23.9% of 1461 undergoing exo

172 proved to be a valuable tool for identifying risk alleles in a rare disease with complex genetics.

173 onate occurrence of known RA, CD, UC, or T1D risk alleles in AD.

174 Analysis of the expression of genes with risk alleles in cells of hematopoietic origin demonstrat

175 Patients carrying 4 risk alleles in CFH and ARMS2 developed neovascular AMD

176 e importance of both rare and common genetic risk alleles in familial and sporadic disease.

177 Genetic studies demonstrated the presence of risk alleles in the genes ANRIL and CAMTA1/VAMP3 that ar

178 e disorder as well as the persistence of its risk alleles in the modern human genome.

179 non-risk allele at rs2595104, but not to the risk allele, in cardiomyocytes.

180 eterozygous for rs6590330 confirmed that the risk allele increased binding to the active form of STAT

181 The rs140490 risk allele increased UBE2L3 expression in B cells and m

182 ollowing results were found as the number of risk alleles increased from 0 to 1 to 2.

183 nd ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 prom

184 a transcriptional silencer for CDC42 and the risk allele increases expression of CDC42.

185 cells, consistent with evidence that the T2D risk allele increases islet MTNR1B expression.

186 rom the cumulative effect of multiple common risk alleles individually of small effect size rather th

187 ovide the surprising insight that the MTNR1B risk allele influences dynamics of melatonin secretion,

188 DNA-nuclear protein interactions, where the risk allele is associated with increased SLC4A7 expressi

189 Finally, the rs7090445-C risk allele is preferentially retained in HD-ALL blasts

190 t demonstration that the expression of APOL1 risk alleles is causal for altered podocyte function and

191 However, the functional consequence of these risk alleles is unknown.

192 Thus reduced gene expression driven by CRHR1 risk allele leads to a phenotype characterized by fear s

193 The NME8 locus influenced PTK2B and the CD33 risk allele led to greater TREM2 expression.

194 who were informed that they carried the FTO risk allele (level 3 AT/AA carriers) than in the nonpers

195 ing and immunoblotting demonstrated that the risk allele locally conferred reduced expression of SEL1

196 comparing men carrying 2 (high-risk) vs 0-1 risk allele (low-risk).

197 enerating a novel hypothesis that the MTNR1B risk allele may extend the duration of endogenous melato

198 tics of T1D, suggesting that most of the T1D risk alleles mediate their effect by influencing express

199 Alleles previously considered to be obesity risk alleles might in fact function as plasticity allele

200 lleles, n=176), and low-risk black (zero/one risk allele, n=1154).

201 e white (n=1700), high-risk black (two APOL1 risk alleles, n=176), and low-risk black (zero/one risk

202 ts with 0 or 1 CFH risk alleles and no ARMS2 risk alleles, neither zinc-containing treatment altered

203 nts with 2 CFH risk alleles and 1 or 2 ARMS2 risk alleles, no treatment was better than placebo (48.4

204 whereas current smoking and presence of >/=1 risk allele of CFH-rs1061170 or ARMS2-rs10490924 were as

205 xpressed in subjects homozygous for the high-risk allele of lead SNP rs60131261 than subjects homozyg

206 Additionally, the risk allele of rs17689918 led to less flight behavior du

207 unctional variants, we demonstrated that the risk allele of rs4728142, a variant in the promoter amon

208 r large HDL particle numbers, such that each risk allele of the genetic risk scores was associated wi

209 The risk allele of the most likely causal SNP, rs6927172, is

210 d from the percentage of the carriers of the risk allele of the variant who had high IOP (ocular hype

211 Female sex and the presence of both risk alleles of CFH-rs1061170 or ARMS2-rs10490924 were i

212 Compared with noncarriers, carriers of 4 risk alleles of rs10741657 and rs4588 had lowest concent

213 A genetic risk score derived from the sum of risk alleles of the 3 SNPs also showed a significant int

214 sion of ESR1, RMND1 and CCDC170, whereas the risk alleles of the strongest candidates for the remaini

215 The risk alleles of these SNPs were proved to be associated

216 tissues and breast tumors showed that the g (risk) allele of rs10941679 was associated with increased

217 Patients homozygous for the A (risk) allele of rs13017968 had higher rates of coronary

218 ng possible effects of the MAD1L1 rs11764590 risk allele on reward systems functioning in healthy adu

219 ombined effects of GSTM1 null and APOL1 high-risk alleles on clinical outcomes in 682 AASK participan

220 emonstrate the overall enrichment of disease risk alleles on gene regulatory regions, they are not de

221 iduals with the growing number (>/=8) of the risk alleles on gout associated loci.

222 genetics analyses defined the effect of T1D risk alleles on levels of gene expression and provide no

223 studies to examine the effect of non-HLA T1D risk alleles on regulating expression levels of genes in

224 The per-risk allele OR (95% CI) of rs4977574 for MI was 1.44 (1.

225 transcription factor TCF7L2 to the rs6983267 risk allele over the non-risk.

226 GRS) was calculated by summing the number of risk alleles over all SNPs.

227 f IL-12p70 in patients with pSS carrying the risk allele (P = .016).

228 0131261 than subjects homozygous for the low-risk allele (P = 0.006).

229 association with MDS did not differ by Y204H risk allele (P = 0.89).

230 -18.3) years earlier than patients with zero risk alleles (P < .001).

231 ogenic CNVs carry an excess burden of common risk alleles (P=2.25 x 10(-17)) defined from a genome-wi

232 r samples revealed that carriers of the 9p21 risk allele possess a significantly higher burden of imm

233 Single-center studies have shown that 4q25 risk alleles predict recurrence of AF after catheter abl

234 The risk allele predicted higher transcriptional levels of P

235 nd sexual abuse in interaction with an FKBP5 risk allele previously associated with vulnerability to

236 The frequencies of 13 risk alleles previously associated with POAG or with opt

237 Homozygotes for the risk allele produced more than four times more transcrip

238 atients with 2 CFH risk alleles and no ARMS2 risk alleles progressed more with zinc-containing treatm

239 cture of schizophrenia is complex, involving risk alleles ranging from common alleles of weak effect

240 n four separate enhancer elements, and their risk alleles reduce expression of ESR1, RMND1 and CCDC17

241 le to this locus, suggesting that the common risk alleles reside in nearby regulatory elements.

242 In one such example, T2D risk alleles residing in a muscle stretch/super enhancer

243 n primary adipocytes from a patient with the risk allele restored IRX3 and IRX5 repression, activated

244 k for MI was determined by counting the 9p21 risk alleles; results were provided to each participant

245 The heavy smoking risk allele (rs16969968*A; frequency=28% (EA) and 6% (AA

246 tently demonstrated that the 1q42.1 melanoma risk allele (rs3219090[G]) is correlated with higher PAR

247 The risk allele rs3761581G was associated with a 58.6% reduc

248 tion in gene expression (P = 0.017), and the risk alleles rs3761581G and rs2235312T were associated w

249 sues, such as the correlation between asthma risk allele, rs7216389-T and Gasdermin-B (GSDMB) in plac

250 ious studies have suggested that the obesity-risk allele rs8050136 in the first intron of FTO alters

251 When in trans with the RET intron 1 enhancer risk allele, rs9282834 increases the risk of HSCR from 1

252 Furthermore, fibroblasts with the risk allele showed greater induction of IL-6 secretion b

253 major mood disorders; subjects carrying the risk allele showed impaired cognitive abilities, increas

254 us (P0.05), with BD subjects carrying the T (risk) allele showing decreased fractional anisotropy com

255 Here we show that risk alleles spanning multiple genes across the 10q24.32

256 Here we argue that the existence of risk alleles specific to a single diagnostic category is

257 alyses further showed that the schizophrenia risk allele (T) of rs3782206 was associated with poorer

258 bly, within and across independent loci, T2D risk alleles that overlap with RFX footprints uniformly

259 Using an integrative analysis of RA risk alleles, the transcriptome and methylome in RA FLS,

260 ric genetics is detection of multiple common risk alleles through very large genome-wide association

261 16%; 95% CI, 11.6%-19.5%) homozygous for the risk allele (TT at rs924607).

262 C2 expression associated with the homozygous risk allele (TT) of rs9517723 could induce overactivatio

263 nsmembrane and coiled-coil domains 1 (TMCO1) risk alleles using Kaplan-Meier and Cox proportional haz

264 The apolipoprotein E (APOE) risk allele (varepsilon4) is associated with higher tota

265 th 11-fold induction of transcription by the risk allele versus 8-fold by the control allele (pdiffer

266 jects, especially those with only one HLA-DQ risk allele, very frequently made an IL-10 response, a c

267 The effect size of one risk allele was 1.4 +/- 0.3 vs. 2.2 +/- 0.44 kg/m(2) in

268 The disease-risk allele was also associated with up-regulated humora

269 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, P

270 We subsequently determined that the CD risk allele was associated with altered colonic mucosal

271 Functional studies identified that the risk allele was associated with increased basal IL-6 mRN

272 The risk allele was found to have decreased IRF3 binding and

273 in tumors with one germline and one somatic risk allele was indistinguishable from those with purely

274 A count of these risk alleles was strongly associated with 25OHD (n=2347,

275 A count of risk alleles was tested for association with 25OHD level

276 d its further positive modulation by the SNP risk-allele was shown in vitro.

277 TGFBR3-CDC7 (P = 0.002; odds ratio, 6.71 per risk allele) was the only SNP associated with VF progres

278 larities between IA(g7) and human HLA-DQ T1D risk alleles, we examined control and T1D subjects with

279 For CHRNA3-CHRNA5 risk alleles, we replicated association with smoking beh

280 n down the frequency of many prostate cancer risk alleles; we estimate the coupling between selection

281 ican Americans with none, one, and two APOL1 risk alleles were 38%, 43%, and 19%, respectively; 38% o

282 APOL1 risk alleles were associated under an additive model wit

283 Risk alleles were associated with lower FBXO33 expressio

284 APOL1 risk alleles were associated with overall SBP (pcom = 7.

285 For 18 loci, schizophrenia risk alleles were associated with poorer cognitive perfo

286 Candidate risk alleles were confirmed by matrix-assisted laser des

287 APOL1 risk alleles were genotyped and the kidney findings were

288 de polymorphisms determining APOL1 G1 and G2 risk alleles were genotyped in BioMe and imputed in BioV

289 Unexpectedly, the 20p11.22 IS risk alleles were previously associated with protection

290 ociation was detected between the known POAG risk alleles when the OHTS cohort was examined as a whol

291 xpression in individuals carrying the asthma-risk alleles, where ORMDL3 negatively regulated interleu

292 d by caspase processing of the ATG16L1-T300A risk allele, whereas canonical autophagy remains unaffec

293 EWSR1-FLI1 preferentially bound to the A risk allele, which increased global and allele-specific

294 ese disorders could represent causal disease risk alleles whose effect may be modifiable by vitamin D

295 We estimated the relationship of the PAI-1 risk allele with FEV1/FVC by multivariate linear regress

296 zygosity and average allele frequency of the risk alleles with distance from Africa and 9 environment

297 ed with T2D (odds ratio 1.07 [1.06-1.09] per risk allele), with a stronger effect observed in nonobes

298 Identification of an endometrial cancer risk allele within a member of the PI3K/AKT signaling pa

299 ted MN was initially found to associate with risk alleles within HLA-DQA1, but subsequent studies hav

300 letion variant, GCTGT-->A (in which A is the risk allele), yielded a shorter transcript that escaped