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   1 risk groups to maintain a favourable benefit-risk ratio.                                             
     2 hose patients who will have the best benefit/risk ratio.                                             
     3 rmacotherapy, to maximize the benefit versus risk ratio.                                             
     4 xcess cancer risk and lower MPI's benefit-to-risk ratio.                                             
     5 erapy) continues to have a favorable benefit-risk ratio.                                             
     6 odels were used to summarize odds ratios and risk ratios.                                            
     7       We used a random-effects model to pool risk ratios.                                            
     8  robust standard errors was used to estimate risk ratios.                                            
  
    10 s rate decreased from 0.24 to 0.10 (adjusted risk ratio 0.44, 95% confidence interval [CI] 0.26-0.75)
    11 n of sepsis and death) in the treatment arm (risk ratio 0.60, 95% confidence interval 0.48-0.74), wit
  
    13 th C (24.6%, 25.6%, and 36.4%, respectively; risk ratio 0.68 [95% confidence interval: 0.53-0.87] for
    14 ion arm died in their first 28 days of life (risk ratio 0.76, 95% CI 0.64 to 0.90, p = 0.0018; risk d
    15 CA-ineligible individuals (adjusted incident risk ratio 0.78, 95% CI 0.56-0.95, p=0.020) and were les
  
  
    18 with 66 (10%) in the placebo group (adjusted risk ratio 0.93 (95% CI 0.68-1.27); 73 (11%) infants in 
    19  after adjustment for potential confounders (risk ratio 0.94 per TTV log level; 95% confidence interv
  
    21  hepatitis B surface antigen seropositivity (risk ratio = 0.3, 95% confidence interval 0.2-0.4) or in
    22 l 0.2-0.4) or infant HBV DNA seropositivity (risk ratio = 0.3, 95% confidence interval 0.2-0.5) at 6-
  
  
    25  with decreased risk of all-cause mortality (risk ratio = 0.74, 95% confidence intervals: 0.55, 0.99)
  
    27 ngle-organ failure (4.7% vs 20.3%; P = .007; risk ratio, 0.15; 95% CI, 0.03-0.60) and new-onset multi
    28 % IRS protection reduced preterm birth risk (risk ratio, 0.35; 95% confidence interval, .15-.84), wit
    29 ple-organ failure (15.6% vs 39.1%; P = .008; risk ratio, 0.40; 95% CI, 0.20-0.77) were also lower aft
  
    31  a trend toward a reduction in constipation (risk ratio, 0.50 [95% CI, 0.25-1.01]; p = 0.05; low-qual
    32  detection included exclusive breastfeeding (risk ratio, 0.57; 95% confidence interval, .47-.67), tre
    33 lower ventilator-associated pneumonia rates (risk ratio, 0.58; 95% CI, 0.51-0.67; I2 = 0%), but there
    34 s associated with a 41% mortality reduction (risk ratio, 0.59; 95% CI, 0.48-0.73) and a 30% reduction
    35 otal ALI events by 41% (94 versus 56 events; risk ratio, 0.59; 95% confidence interval, 0.38-0.93; P=
  
  
    38 ups (risk ratio, 0.84; 95% CI, 0.77-0.92 and risk ratio, 0.64; 95% CI, 0.52-0.78, respectively), but 
    39 mab decreased the frequency of RV illnesses (risk ratio, 0.64; 95% confidence interval, 0.49-0.84).  
  
  
  
  
  
    45  associated with 18% reduction in mortality (risk ratio, 0.82; 95% CI, 0.70-0.96; p = 0.01) and a 35%
  
    47 y in the intermediate- and high-risk groups (risk ratio, 0.84; 95% CI, 0.77-0.92 and risk ratio, 0.64
  
    49 e to the noncooled group (adjusted posterior risk ratio, 0.86; 95% credible interval, 0.58-1.29).    
    50 ntive antifungal did not decrease mortality (risk ratio, 0.88; 95% CI, 0.74-1.04; p = 0.14) but signi
    51  all covariate models (fully adjusted model: risk ratio, 0.89; 95% CI, 0.83-0.95), but associations w
  
    53 ative benefits of SC were clear at 6 months (risk ratio, 0.905; 95% CI, 0.898-0.913), with continued 
  
  
    56  were found in terms of all-cause mortality (risk ratio, 0.90; 95% confidence interval, 0.71-1.15; P=
    57 lar for HFmrEF and HFrEF and lower in HFpEF (risk ratio, 0.91 [0.89-0.93] versus HFmrEF and risk rati
  
    59 f 171 (31.6%) cooled for 120 hours (adjusted risk ratio, 0.92 [95% CI, 0.68-1.25]; adjusted absolute 
    60 2 (31.5%) cooled to 32.0 degrees C (adjusted risk ratio, 0.92 [95% CI, 0.68-1.26]; adjusted absolute 
  
    62  no reduction in tolerance of enteral feeds (risk ratio, 0.94 [95% CI, 0.62-1.42]; p = 0.77; low-qual
    63 n rate with ezetimibe compared with placebo (risk ratio, 0.95; 95% confidence interval, 0.90-0.99; P=
    64 mbolysis group and 48% in the control group; risk ratio, 0.96; 95% confidence interval [CI], 0.82 to 
    65 .30; I2 = 0%), ventilator-associated events (risk ratio, 0.97; 95% CI, 0.65-1.43), or mortality (risk
    66 r continuation of antidepressant medication (risk ratio: 0.674; 95% CI=0.482-0.943; number needed to 
    67 antidepressants alone or treatment as usual (risk ratio: 0.811; 95% CI=0.685-0.961; number needed to 
    68 time image integration (R(2)=0.21; P=0.0006; risk ratio=0.49 [0.33-0.74]), and the use of multipolar 
    69 plete LAVA elimination (R(2)=0.29; P<0.0001; risk ratio=0.52 [0.38-0.70]), the use of real-time image
  
  
  
    73 pared to 13 (0.20%) in the intervention arm (risk ratio 1.24, 95% CI 0.53 to 2.90, p = 0.6176; 1 deat
  
    75 d with 29% of patients in the POWeR+F group (risk ratio 1.56, 0.96-2.51; p=0.070) and 32% of patients
  
    77 sk of low birth weight in newborns (adjusted risk ratio = 1.15, 95% confidence interval (CI): 1.01, 1
  
    79 not of hospitalization without an infection (risk ratio = 1.4, 95% confidence interval: 0.9, 2.1, P =
  
    81 sed with the number of microemboli (adjusted risk ratio, 1.03/microembolus/hr; 95% CI, 1.01-1.05) and
  
    83 therapy did not decrease treatment failures (risk ratio, 1.13; 95% CI, 0.92 to 1.38; P = 0.23), and n
    84 0.51), and 30-day postimplant complications (risk ratio, 1.18; 95% confidence interval, 0.87-1.60; P=
    85 d for race/ethnicity, age, and sex (adjusted risk ratio, 1.23; 95% CI, 1.08-1.15; and 1.62; 95% CI, 1
    86 1-1.15; P=0.41), composite efficacy outcome (risk ratio, 1.24; 95% confidence interval, 0.65-3.37; P=
    87 dies indicated that those with SDB were 26% (risk ratio, 1.26; 95% CI, 1.05-1.50) more likely to deve
    88 r numbers of all genital HPV types (relative risk ratio, 1.26; 95% confidence interval, 1.03-1.54) an
  
  
  
    92 95% CI, 1.76-3.68) and microbleeds (adjusted risk ratio, 1.43; 95% CI, 1.18-1.72) and a greater 5-yea
    93 s among those with asthma in crude analyses (risk ratio, 1.48; 95% CI, 1.24-1.36; and 1.97; 95% CI, 1
    94 thma, by 50% and 20%, respectively (weighted risk ratio, 1.5 and 1.2; 95% confidence interval, 1.2-1.
  
    96 1.57 [95% CI, 1.07-2.31]) or antibiotic use (risk ratio, 1.65 [95% CI, 1.15-2.37]) and exposure to be
    97  treatment with a 66% increase in mortality (risk ratio, 1.66; 95% CI, 1.06-2.59; p = 0.03) and a mar
    98 e to beta-lactams/beta-lactamase inhibitors (risk ratio, 1.78 [95% CI, 1.24-2.56]) and carbapenems (r
    99 ns were associated with all-cause mortality (risk ratio, 1.78; 95% CI, 1.01-3.15; I = 43%) and unfavo
  
  
   102 th benign lesions, 51 (36%) with correlates (risk ratio, 1.92; 95% CI: 1.001, 3.695; two-tailed P = .
   103 f a restorative intervention almost doubled (risk ratio, 1.98; 95% CI, 1.68-2.33) in high caries risk
  
   105 % vs. 7.2%; absolute risk difference: +2.4%; risk ratio: 1.32; 95% confidence interval: 1.10 to 1.59;
   106 (91 of 351) in the control group (p = 0.002; risk ratio: 1.43; 95% confidence interval: 1.14 to 1.78)
   107  95% CI=-0.57 to -0.06), and responder rate (risk ratio: 1.52, 95% CI=1.29 to 1.78; number-needed-to-
  
  
   110 r risk of hospitalization with an infection (risk ratio = 2.8, 95% confidence interval: 1.3, 5.9, P <
  
   112 , 1.78 [95% CI, 1.24-2.56]) and carbapenems (risk ratio, 2.13 [95% CI, 1.49-3.06]) during the ICU sta
  
   114  43%) and unfavorable Glasgow Outcome Scale (risk ratio, 2.49; 95% CI, 1.72-3.58; I = 81%) at greater
   115 k of incident subcortical infarcts (adjusted risk ratio, 2.54; 95% CI, 1.76-3.68) and microbleeds (ad
  
  
   118 ad a significant positive effect on NP role (risk ratio=2.33; 95% CI: 1.06-5.13); with a one unit inc
  
  
   121  with a 3-fold increase in 30-day mortality (risk ratio, 3.16 [95% confidence interval, 1.96-5.09]). 
   122 % vs. 0.7%; absolute risk difference: +1.7%; risk ratio: 3.15; 95% confidence interval: 1.87 to 5.30;
   123 nonsignificant risk of LTBI among diabetics (risk ratio, 4.40; 95% confidence interval [CI], 0.50-38.
   124  0.0001), higher body mass index (prevalence risk ratio 40.5/4.8, 8.4, p < 0/0001),higher HOMA-IR (3.
  
   126 al problems included consumption of cassava (risk ratio 5.68, 95% CI 3.22-10.03), perinatal complicat
  
   128 .02), higher waist circumference (prevalence risk ratio 83.3/20.3, 4.1, p < 0.0001), higher body mass
  
  
   131  significantly with age (adjusted prevelance risk ratio [adjPRR] = 0.53; 95% confidence interval [CI]
   132 erinatal death (0.08% versus 0.26%; adjusted risk ratio [adjRR] 0.33; 95% CI 0.13-0.80, P = 0.015) an
  
  
   135 ation are evaluated by estimating detectable risk ratios and necessary sample sizes for different stu
   136 We also quantified differences with relative risk ratios and relative and slope indices of inequality
  
  
  
   140 ures was performed and odds ratios, relative risk ratios, and 95% confidence intervals were estimated
   141  BSGI, annual screening benefit-to-radiation risk ratios are estimated to be 5 for women 40-49 years 
   142 d with an increased risk of asthma (adjusted risk ratio (aRR) = 1.22, 95% confidence interval (CI): 1
   143 le models were used to estimate the adjusted risk ratio (aRR) for receiving an HCV antibody test, and
  
   145 red to 7.7% among uninfected women (adjusted risk ratio [aRR] 1.14 [95% confidence interval (CI): 0.9
  
   147 ; 95% CI, -5.63 to -4.10; P < .001; adjusted risk ratio [ARR], 0.21; 95% CI, 0.15 to 0.29; P < .001).
   148  use between black and white women (adjusted risk ratio [aRR], 0.51; 95% CI, 0.35 to 0.74) but not in
  
   150 vely associated with HIV infection (adjusted risk ratio [aRR], 2.4; 95% confidence interval [CI], 1.4
   151 .9% among those >/=80 years of age (adjusted risk ratio [aRR]: 2.01; 95% confidence interval [CI]: 1.
  
   153  before and 13% after ACA; adjusted relative risk ratio [ARRR], 0.44; 95% confidence interval [CI], .
   154 ear regression was used to estimate adjusted risk ratios (aRRs) and 95% CIs, after adjusting for mate
   155 n, clinical improvement at 1 week (corrected risk ratios [cRR], 3.5 [2.3-3.8]; P = 0.001) was predict
  
  
   158 e in the likelihood of nutritional recovery (risk ratio for amoxicillin vs. placebo, 1.05; 95% confid
  
  
  
   162 lend further support to the positive benefit-risk ratio for ibrutinib in relapsed or refractory mantl
   163 tamin A supplementation on mortality by sex; risk ratio for mortality at 6 months for boys was 1.08 (
  
   165   Intraocular bleeding events and associated risk ratio for novel oral anticoagulants compared with w
  
  
  
  
  
  
  
  
   174 ups will be extremely challenging to detect (risk ratios for preterm birth of 0.9 to 1.0) and will re
  
  
   177 independent variable) on deviation of pooled risk ratios from study baseline (dependent variable).   
  
   179 ies than in trading (age-adjusted prevalence risk ratio in men 0.64, 95% CI 0.44-0.97; women 0.53, 0.
  
  
  
   183 ention studies included, the pooled relative risk ratio of AD in those treated with synbiotics compar
  
  
   186 m over time, which may affect the benefit-to-risk ratio of guideline-recommended antithrombotic thera
   187 Western immigrants had a significantly lower risk ratio of hospital attendance for anaphylaxis compar
  
   189 utcomes were cumulative incidence (risk) and risk ratio of new-onset psychiatrist-diagnosed depressio
   190 nts should carefully consider the benefit-to-risk ratio of olanzapine and its additional, prophylacti
   191 s to be better informed about the benefit-to-risk ratio of procedures, and guide allotment of limited
  
   193 icant impacts on E. coli concentration, with risk ratios of 1.38 (95% CI = 1.16, 1.65), 1.07 (95% CI:
   194 ic IgE to cat >= 3.5 kU/l presented relative risk ratios of 11.4 (95% CI 6.7-19.2), 18.8 (8.2-42.8), 
   195 ocardial infarction patients, HRT had pooled risk ratios of 3.53 (95% confidence interval [CI], 2.54-
   196 Purpose To estimate the benefit-to-radiation risk ratios of mammography alone, breast-specific gamma 
   197 diation VII report, the benefit-to-radiation risk ratios of mammography alone, BSGI alone, and mammog
   198    Compared with threshold 500, the 24 month risk ratios of virological failure (viral load more than
   199 death and of AIDS-defining illness or death, risk ratios of virological failure, and mean differences
   200 in the Bruneck Study, multivariable adjusted risk ratios per one-SD higher log miR-122 were 1.60 (95%
   201    The hazard ratio (HR) point estimates and risk ratio point estimates corresponding to odds ratios 
  
   203 d with a substantial reduction in mortality [risk ratio (RR) 0.63, 95% confidence interval (CI) 0.49-
   204 mulative incidence of AR was lower in eHF-C (risk ratio (RR) 0.77, 95% CI 0.59-0.99]) and the AR prev
   205 to patients without AR (age and sex-adjusted risk ratio (RR) 3.04; 95% confidence interval (95%CI) 2.
   206 Ds after 4 years among women (for back MSDs, risk ratio (RR) = 1.58, 95% confidence interval (CI): 1.
  
  
   209 n was extracted; summary mean difference and risk ratio (RR) estimates were synthesized under a rando
  
  
  
   213 enszel test or inverse variance to calculate risk ratio (RR) or mean difference (MD) with 95% confide
  
  
   216 compliance aids (9.3% and 3.1% respectively, risk ratio (RR)=3.9, 95% confidence interval (CI) 2.4 to
  
   218 ct comparisons showed that use of metformin (risk ratio [RR] 0.49, 95% CI 0.25-0.97) was associated w
   219 lure when using e-POCT compared to ALMANACH (risk ratio [RR] 0.57, 95% CI 0.38, 0.85, p = 0.005).    
   220 -agent prophylaxis (190/12,834, 1.48%; crude risk ratio [RR] 0.64, 95% CI 0.49, 0.85; adjusted RR 0.6
  
   222 d with a significant reduction in morbidity (risk ratio [RR] 0.76, 95% confidence interval [CI] 0.66-
  
  
   225 s greater in areas with higher PM2.5 levels (Risk ratio [RR] 1.041, 95% Confidence Interval [CI], 1.0
  
   227 ntion group versus 40% in the control group, risk ratio [RR] 1.08 [95% CI 0.94 to 1.24; p = 0.252]; d
   228 th standard repair vs 34/435 [8%] with mesh, risk ratio [RR] 1.08, 95% CI 0.68 to 1.72; p=0.73; graft
  
  
   231 th an increased risk of all-cause mortality (risk ratio [RR] 1.14 [95% CI 1.05-1.24] for streptokinas
   232  associated with increased plaque formation (risk ratio [RR] 1.24, 95% confidence interval [CI] 1.07-
   233 n the standard of care arm, both at 1 month (risk ratio [RR] 1.33, 95% CI 1.17-1.51, p < 0.001) and a
   234 ence in HIV-positive men of any tobacco use (risk ratio [RR] 1.41 [95% CI 1.26-1.57]) and tobacco smo
   235 edictors of non-testing included being male (risk ratio [RR] 1.52, 95% CI 1.48-1.56), single marital 
   236  period of high influenza virus circulation (risk ratio [RR] = 0.56, 95% confidence interval [CI], .4
   237  against clinical respiratory illness (CRI) (risk ratio [RR] = 0.59; 95% confidence interval [CI]:0.4
   238 =10 years were less likely to have a result (risk ratio [RR] = 0.72; 95% CI, 0.64-0.81 and RR = 0.49;
   239 .3%) vs 8407 of 43314 (19.4%), respectively (risk ratio [RR] = 0.84; 95% CI, 0.81-0.87; P < .001).   
   240 f-care arm (delivery versus standard of care risk ratio [RR] = 1.07, 95% CI 0.99-1.15, P = 0.10; coup
   241 as associated with a high colonization risk (risk ratio [RR] = 1.63; 95% CI, 1.19, 2.24 and RR = 1.58
   242 oved alanine aminotransferase normalization (risk ratio [RR] = 2.3, 95% confidence interval [CI] 1.7-
   243 had a higher risk for dual-strain infection (risk ratio [RR] = 9.20, 95% CI = 2.05-41.32), as did peo
   244 0.21; calculation impairment 22% versus 26%, risk ratio [RR] [95% CI] = 0.86 [0.67-1.11], p = 0.24). 
   245 ith a lower risk of type 2 diabetes overall (risk ratio [RR] per interquintile range 0.65, 95% CI 0.6
  
  
   248 and provided greater spectacle independence (risk ratio [RR], 0.51; 95% CI, 0.36-0.71) and moderate q
  
   250 ths was associated with reduced egg allergy (risk ratio [RR], 0.56; 95% CI, 0.36-0.87; I2 = 36%; P = 
   251  failure in comparison with head-box oxygen (risk ratio [RR], 0.59; 95% CI, 0.48-0.72; number needed 
   252  with decreased risk of all-cause mortality (risk ratio [RR], 0.86 [95% CI, 0.80 to 0.93]; I2 = 0%; a
   253  with a reduction in total cancer mortality (risk ratio [RR], 0.86 [CI, 0.82 to 0.91]; 13 studies) an
  
   255 intubated (411/1135 [36%] vs 460/1135 [41%]; risk ratio [RR], 0.89 [95% CI, 0.81-0.99]; P = .03).    
  
   257  did not differ between groups at 12 months (risk ratio [RR], 1.01 [95% CI, 0.87 to 1.18]) and 24 mon
   258 nd any breastfeeding for less than 3 months (risk ratio [RR], 1.07 [95% CI, 1.03-1.11]; 26 studies [n
   259 cantly higher with CHWs vs MUMs: 87% vs 82% (risk ratio [RR], 1.1 [95% CI, 1.0-1.1]; P < .0001).     
   260 with higher odds of having conduct problems (risk ratio [RR], 1.42; 95% CI, 1.25-1.62) and hyperactiv
   261 847) were at increased risk for incident RA (risk ratio [RR], 1.72; 95% CI, 1.25-2.37) and/or IBD (CD
   262 luding having no educational qualifications (risk ratio [RR], 1.86 [95% CI, 1.69-2.04]), having a hig
   263 VR was associated with a higher risk of PPI (risk ratio [RR], 2.18; 95% confidence interval [CI], 1.2
   264 esence, compared with patients without CMBs (risk ratio [RR], 2.36; 95% CI, 1.21-4.61; P = .01).     
   265 ents to be diagnosed with melanoma (adjusted risk ratio [RR], 2.4; 95% CI, 1.7-3.4; P < .001) and to 
   266 ing done everything that was possible (crude risk ratio [RR], 3.5; 95% CI, 2.3 to 5.1) and for having
   267 h an increased risk of future heart failure (risk ratio [RR], 4.19; 95% confidence interval [CI], 2.0
   268 following: Breslow thickness exceeding 2 mm (risk ratio [RR], 9.64; 95% CI, 1.30-71.52), invasion bey
   269 tients with SMR (17 studies, 26359 patients; risk ratio [RR],1.79; 95% CI, 1.47-2.18; P < .001, I2 = 
   270 ients who received warfarin (10.7% vs. 1.8%; risk ratio [RR]: 6.09; 95% confidence interval [CI]: 1.8
   271  low-volume hospitals (low tercile: relative risk ratio (RRR) = 2.57, P = 0.002; high tercile: RRR = 
   272 patients who were aged 16-30 years (relative risk ratio [RRR] 1.21, 95% CI 1.19-1.23) or older than 9
   273 with immunocompetent comorbidities (relative risk ratio [RRR], 0.93; 95% confidence interval [CI], .6
  
   275  and interactions were estimated as adjusted risk ratios (RRs) and 95% confidence intervals (CIs).   
  
   277 as used to calculate unadjusted and adjusted risk ratios (RRs) and associated 95% confidence interval
   278    Log-binomial models were used to estimate risk ratios (RRs) and corresponding 95% CIs for severe i
   279 ersus ranibizumab are presented as estimated risk ratios (RRs) and mean differences (MDs) with 95% co
   280 s that reported the odds ratios (ORs) and/or risk ratios (RRs) for adverse events with and without un
   281 standardized mean differences (Hedges g) and risk ratios (RRs) for adverse events, were assessed in a
  
   283 andard errors were used to estimate adjusted risk ratios (RRs) to model risk of delay in definitive s
  
  
   286  time and associations with social position (risk ratios [RRs] and 95% confidence intervals) were ana
   287  the minimum strength of association, on the risk ratio scale, that an unmeasured confounder would ne
  
  
   290 h spontaneous vaginal delivery, the adjusted risk ratio was 1.33 (95% CI: 1.02, 1.75) for elective ce
  
   292 ial regression, the corresponding unadjusted risk ratio was 1.40 (95% confidence interval (CI): 1.30,
  
   294 MBq) BSGI has estimated benefit-to-radiation risk ratios well in excess of 1 for screening of asympto
  
  
   297 as standardized mean difference /Hedges g or risk ratio, were compared separately for combinations wi
  
  
  
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